1> 1== M63632 1 Lampetra japonica rhodopsin <>[BBRC174,1125-1132'91] 2--------------------MNGTE--------------------------GDNF----- 3---YVP----F-SNKTGLARSPY----------------EYPQY-------YLAEPWK-- 4-------YSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANLFMVLF 5G-FTVTMYTSMN-GYFV--FGPTMCSIEGFFATLGGEVALWSLVVLAIERYIVICKPMGN 6-FRFGNTHAIMGVAFTWIMALAC-AAPPLVG-W-----SRYIPEGMQCSCGPDYYTLNPN 7FNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTV----KEAAAAQQ--------------- 8------------------------------------------------------------ 9------------------------------------------------------------ 10---------------------------ESASTQKAEKEVTRMVVLMVIGFLVCWVPYASV 11AFYIFTHQGS---DFGATFMTLPAFFAKSSALYNPVIYILMNKQFRNCMITTLCC----- 12--GKNPLGD-DE--SGASTSKTEVSSVS--TSPV-------------------------- 13----------------------------------------------SPA----------- 14--- 15> 2== U22180 1 rat opsin <rod>[J.Mol.Neurosci.5(3),207-209'94] 16--------------------MNGTE--------------------------GPNF----- 17---YVP----F-SNITGVVRSPF----------------EQPQY-------YLAEPWQ-- 18-------FSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFG 19G-FTTTLYTSLH-GYFV--FGPTGCNLEGFFATLGGEIGLWSLVVLAIERYVVVCKPMSN 20-FRFGENHAIMGVAFTWVMALAC-AAPPLVG-W-----SRYIPEGMQCSCGIDYYTLKPE 21VNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTV----KEAAAQQQ--------------- 22------------------------------------------------------------ 23------------------------------------------------------------ 24---------------------------ESATTQKAEKEVTRMVIIMVIFFLICWLPYASV 25AMYIFTHQGS---NFGPIFMTLPAFFAKTASIYNPIIYIMMNKQFRNCMLTSLCC----- 26--GKNPLGD-DE--ASATASKTE-------TSQV-------------------------- 27----------------------------------------------APA----------- 28--- 29> 3== M92038 1 chicken green sensitive cone opsin <retina>[PNAS89,5932-5936'9 30--------------------MNGTE--------------------------GINF----- 31---YVP----M-SNKTGVVRSPF----------------EYPQY-------YLAEPWK-- 32-------YRLVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACF 33G-FTVTFYTAWN-GYFV--FGPVGCAVEGFFATLGGQVALWSLVVLAIERYIVVCKPMGN 34-FRFSATHAMMGIAFTWVMAFSC-AAPPLFG-W-----SRYMPEGMQCSCGPDYYTHNPD 35YHNESYVLYMFVIHFIIPVVVIFFSYGRLICKV----REAAAQQQ--------------- 36------------------------------------------------------------ 37------------------------------------------------------------ 38---------------------------ESATTQKAEKEVTRMVILMVLGFMLAWTPYAVV 39AFWIFTNKGA---DFTATLMAVPAFFSKSSSLYNPIIYVLMNKQFRNCMITTICC----- 40--GKNPFGD-EDVSSTVSQSKTEVSSVS--SSQV-------------------------- 41----------------------------------------------SPA----------- 42--- 43> 4=p A45229 opsin, green-sensitive (clone GFgr-1) - goldfish 44--------------------MNGTE--------------------------GKNF----- 45---YVP----M-SNRTGLVRSPF----------------EYPQY-------YLAEPWQ-- 46-------FKILALYLFFLMSMGLPINGLTLVVTAQHKKLRQPLNFILVNLAVAGTIMVCF 47G-FTVTFYTAIN-GYFV--LGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVVCKPMGS 48-FKFSSSHAFAGIAFTWVMALAC-AAPPLFG-W-----SRYIPEGMQCSCGPDYYTLNPD 49YNNESYVIYMFVCHFILPVAVIFFTYGRLVCTV----KAAAAQQQ--------------- 50------------------------------------------------------------ 51------------------------------------------------------------ 52---------------------------DSASTQKAEREVTKMVILMVFGFLIAWTPYATV 53AAWIFFNKGA---DFSAKFMAIPAFFSKSSALYNPVIYVLLNKQFRNCMLTTIFC----- 54--GKNPLGD-DE-SSTVSTSKTEVSS-------V-------------------------- 55----------------------------------------------SPA----------- 56--- 57> 5=p B45229 opsin, green-sensitive (clone GFgr-2) - goldfish 58--------------------MNGTE--------------------------GNNF----- 59---YVP----L-SNRTGLVRSPF----------------EYPQY-------YLAEPWQ-- 60-------FKLLAVYMFFLICLGLPINGLTLICTAQHKKLRQPLNFILVNLAVAGAIMVCF 61G-FTVTFYTAIN-GYFA--LGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVVCKPMGS 62-FKFSSTHASAGIAFTWVMAMAC-AAPPLVG-W-----SRYIPEGIQCSCGPDYYTLNPE 63YNNESYVLYMFICHFILPVTIIFFTYGRLVCTV----KAAAAQQQ--------------- 64------------------------------------------------------------ 65------------------------------------------------------------ 66---------------------------DSASTQKAEREVTKMVILMVLGFLVAWTPYATV 67AAWIFFNKGA---AFSAQFMAIPAFFSKTSALYNPVIYVLLNKQFRSCMLTTLFC----- 68--GKNPLGD-EE-SSTVSTSKTEVSS-------V-------------------------- 69----------------------------------------------SPA----------- 70--- 71> 6== L11864 1 Carassius auratus blue cone opsin <retina>[Biochemistry32,208- 72--------------------MKQVPEF------------------------HEDF----- 73---YIPIPLDI-NNLS--AYSPF----------------LVPQD-------HLGNQGI-- 74-------FMAMSVFMFFIFIGGASINILTILCTIQFKKLRSHLNYILVNLSIANLFVAIF 75G-SPLSFYSFFN-RYFI--FGATACKIEGFLATLGGMVGLWSLAVVAFERWLVICKPLGN 76-FTFKTPHAIAGCILPWISALAA-SLPPLFG-W-----SRYIPEGLQCSCGPDWYTTNNK 77YNNESYVMFLFCFCFAVPFGTIVFCYGQLLITL----KLAAKAQA--------------- 78------------------------------------------------------------ 79------------------------------------------------------------ 80---------------------------DSASTQKAEREVTKMVVVMVLGFLVCWAPYASF 81SLWIVSHRGE---EFDLRMATIPSCLSKASTVYNPVIYVLMNKQFRSCMM-KMVC----- 82--GKN-IEE-DE--ASTSSQVTQVSS-------V-------------------------- 83----------------------------------------------APEK---------- 84--- 85> 7== M13299 1 human BCP <>[Science232(4747),193-202'86] 86--------------------MRKMS--------------------------EEEF----- 87---YL-----F-KNIS--SVGPW----------------DGPQY-------HIAPVWA-- 88-------FYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIF 89S-VFPVFVASCN-GYFV--FGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGN 90-FRFSSKHALTVVLATWTIGIGV-SIPPFFG-W-----SRFIPEGLQCSCGPDWYTVGTK 91YRSESYTWFLFIFCFIVPLSLICFSYTQLLRAL----KAVAAQQQ--------------- 92------------------------------------------------------------ 93------------------------------------------------------------ 94---------------------------ESATTQKAEREVSRMVVVMVGSFCVCYVPYAAF 95AMYMVNNRNH---GLDLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACIM-KMVC----- 96--GKA-MTD-ES--DTCSSQKTEVSTVS--STQV-------------------------- 97----------------------------------------------GPN----------- 98--- 99> 8=opsin, greensensitive human (fragment) S07060 100------------------------------------------------------------ 101------------------------------------------------------------ 102-----------------------------------------------------DLAETVI 103A-STISIVNQVS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGN 104-VRFDAKLAIVGIAFSWIWAAVW-TAPPIFG-W-----SRYWPHGLKTSCGPDVFSGSSY 105PGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAI----RAVAKQQK--------------- 106------------------------------------------------------------ 107------------------------------------------------------------ 108---------------------------ESESTQKAEKEVTRMVVVMVLAFC--------- 109------------------------------------------------------------ 110------------------------------------------------------------ 111------------------------------------------------------------ 112--- 113> 9== K03494 1 human GCP <>[Science232(4747),193-202'86] 114--------------------MAQQWSL------------QRLAGRHPQDSYEDST----- 115---QSSI-FTY-TNSNS-TRGPF----------------EGPNY-------HIAPRWV-- 116-------YHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVI 117A-STISVVNQVY-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGN 118-VRFDAKLAIVGIAFSWIWAAVW-TAPPIFG-W-----SRYWPHGLKTSCGPDVFSGSSY 119PGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAI----RAVAKQQK--------------- 120------------------------------------------------------------ 121------------------------------------------------------------ 122---------------------------ESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFF 123ACFAAANPGY---PFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCIL-QLF------ 124--GKK-VDD-GS--ELSSASKTEVSSV----SSV-------------------------- 125----------------------------------------------SPA----------- 126--- 127> 10== Z68193 1 human Red Opsin <>[] 128--------------------MAQQWSL------------QRLAGRHPQDSYEDST----- 129---QSSI-FTY-TNSNS-TRGPF----------------EGPNY-------HIAPRWV-- 130-------YHLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVI 131A-STISIVNQVS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGN 132-VRFDAKLAIVGIAFSWIWSAVW-TAPPIFG-W-----SRYWPHGLKTSCGPDVFSGSSY 133PGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAI----RAVAKQQK--------------- 134------------------------------------------------------------ 135------------------------------------------------------------ 136---------------------------ESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFF 137ACFAAANPGY---AFHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCIL-QLF------ 138--GKK-VDD-GS--ELSSASKTEVSSV----SSV-------------------------- 139----------------------------------------------SPA----------- 140--- 141> 11== M92036 1 Gecko gecko P521 <retina>[PNAS89,6841-6845'92] 142--------------------MTEAWNV------------AVFAARRSRDD-DDTT----- 143---RGSV-FTY-TNTNN-TRGPF----------------EGPNY-------HIAPRWV-- 144-------YNLVSFFMIIVVIASCFTNGLVLVATAKFKKLRHPLNWILVNLAFVDLVETLV 145A-STISVFNQIF-GYFI--LGHPLCVIEGYVVSSCGITGLWSLAIISWERWFVVCKPFGN 146-IKFDSKLAIIGIVFSWVWAWGW-SAPPIFG-W-----SRYWPHGLKTSCGPDVFSGSVE 147LGCQSFMLTLMITCCFLPLFIIIVCYLQVWMAI----RAVAAQQK--------------- 148------------------------------------------------------------ 149------------------------------------------------------------ 150---------------------------ESESTQKAEREVSRMVVVMIVAFCICWGPYASF 151VSFAAANPGY---AFHPLAAALPAYFAKSATIYNPVIYVFMNRQFRNCIM-QLF------ 152--GKK-VDD-GS--EASTTSRTEVSSVS--NSSV-------------------------- 153----------------------------------------------APA----------- 154--- 155> 12== M62903 1 chicken visual pigment <>[BBRC173,1212-1217'90] 156--------------------MA-AWEA------------AFAARRRHEE--EDTT----- 157---RDSV-FTY-TNSNN-TRGPF----------------EGPNY-------HIAPRWV-- 158-------YNLTSVWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGETVI 159A-STISVINQIS-GYFI--LGHPMCVVEGYTVSACGITALWSLAIISWERWFVVCKPFGN 160-IKFDGKLAVAGILFSWLWSCAW-TAPPIFG-W-----SRYWPHGLKTSCGPDVFSGSSD 161PGVQSYMVVLMVTCCFFPLAIIILCYLQVWLAI----RAVAAQQK--------------- 162------------------------------------------------------------ 163------------------------------------------------------------ 164---------------------------ESESTQKAEKEVSRMVVVMIVAYCFCWGPYTFF 165ACFAAANPGY---AFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCIL-QLF------ 166--GKK-VDD-GS--EVST-SRTEVSSVS--NSSV-------------------------- 167----------------------------------------------SPA----------- 168--- 169> 13== S75720 1 chicken P-opsin <>[Science267(5203),1502-1506'95] 170--------------------MSSNSSQA-----------------------PPNG----- 171------------------TPGPF----------------DGPQW------PYQAPQST-- 172-------YVGVAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLVTLC 173G-SSVSLSNNIN-GFFV--FGRRMCELEGFMVSLTGIVGLWSLAILALERYVVVCKPLGD 174-FQFQRRHAVSGCAFTWGWALLW-SAPPLLG-W-----SSYVPEGLRTSCGPNWYTGGS- 175-NNNSYILSLFVTCFVLPLSLILFSYTNLLLTL----RAAAAQQK--------------- 176------------------------------------------------------------ 177------------------------------------------------------------ 178---------------------------EADTTQRAEREVTRMVIVMVMAFLLCWLPYSTF 179ALVVATHKGI---IIQPVLASLPSYFSKTATVYNPIIYVFMNKQFQSCLLEMLCCGYQPQ 180RTGKA--------SPGTPGPHADVTAAGL-RNKV-------------------------- 181----------------------------------------------MPAHPV-------- 182--- 183> 14== M17718 1 D.melanogaster Rh3 <>[J.Neurosci.7,1550-1557'87] 184-----MESGNVSS-----SLFGNVSTA-------------LRPEARL----SAET----- 185------RLLGW--------NVPP----------------EELR--------HIPEHWLTY 186PEPPESMNYLLGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILVINLAFCDFMMMVK 187--TPIFIYNSFH-QGYA--LGHLGCQIFGIIGSYTGIAAGATNAFIAYDRFNVITRPMEG 188--KMTHGKAIAMIIFIYMYATPW-VVACYTETW-----GRFVPEGYLTSCTFDYLT--DN 189FDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQAKK-------------- 190------------------------------------------------------------ 191--------------------------------------MNVESL---------------- 192------------------RS------NVDKNKETAEIRIAKAAITICFLFFCSWTPYGVM 193SLIGAFGDKT---LLTPGATMIPACACKMVACIDPFVYAISHPRYRMELQKRCPWLAL-- 194----NEKAP-ES-SAVASTSTTQEPQQ---TTAA-------------------------- 195------------------------------------------------------------ 196--- 197> 15== X65879 1 Drosophila pseudoobscura Dpse\Rh3 <>[Genetics132(1),193-204'92 198-----MEYHNVS------SVLGNVSSV-------------LRPDARL----SAES----- 199------RLLGW--------NVPP----------------DELR--------HIPEHWLIY 200PEPPESMNYLLGTLYIFFTVISMIGNGLVMWVFSAAKSLRTPSNILVINLAFCDFMMMIK 201--TPIFIYNSFH-QGYA--LGHLGCQIFGVIGSYTGIAAGATNAFIAYDRYNVITRPMEG 202--KMTHGKAIAMIIFIYLYATPW-VVACYTESW-----GRFVPEGYLTSCTFDYLT--DN 203FDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQAKK-------------- 204------------------------------------------------------------ 205--------------------------------------MNVDSL---------------- 206------------------RS------NVDKSKEAAEIRIAKAAITICFLFFASWTPYGVM 207SLIGAFGDKT---LLTPGATMIPACTCKMVACIDPFVYAISHPRYRMELQKRCPWLAI-- 208----SEKAP-ES-RAAISTSTTQEQQQ---TTAA-------------------------- 209------------------------------------------------------------ 210--- 211> 16== M17730 1 D.melanogaster Rh4 opsin <>[J.Neurosci.7,1558-1566'87] 212-----MEP------------LCNASEP------------PLRPEAR--SSGNGDL----- 213------QFLGW--------NVPP----------------DQIQ--------YIPEHWLTQ 214LEPPASMHYMLGVFYIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIMCLK 215--APIF--NSFH-RGFAIYLGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPMNR 216--NMTFTKAVIMNIIIWLYCTPW-VVLPLTQFW-----DRFVPEGYLTSCSFDYLS--DN 217FDTRLFVGTIFFFSFVCPTLMILYYYSQIVGHVFSHEKALREQAKK-------------- 218------------------------------------------------------------ 219--------------------------------------MNVESL---------------- 220------------------RS------NVDKSKETAEIRIAKAAITICFLFFVSWTPYGVM 221SLIGAFGDKS---LLTQGATMIPACTCKLVACIDPFVYAISHPRYRLELQKRCPWLGV-- 222----NEKSG-EI-SSAQSTTTQEQQQ----TTAA-------------------------- 223------------------------------------------------------------ 224--- 225> 17== X65880 1 Drosophila pseudoobscura Dpse\Rh4 <>[Genetics132(1),193-204'92 226-----MDA------------LCNASEP------------PLRPEARM-SSGSDEL----- 227------QFLGW--------NVPP----------------DQIQ--------YIPEHWLTQ 228LEPPASMHYMLGVFYIFLFFASTLGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIMCLK 229--APIFIYNSFH-RGFA--LGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPMNR 230--NMTFTKAVIMNIIIWLYCTPW-VVLPLTQFW-----DRFVPEGYLTSCSFDYLS--DN 231FDTRLFVGTIFLFSFVVPTLMILYYYSQIVGHVFNHEKALREQAKK-------------- 232------------------------------------------------------------ 233--------------------------------------MNVESL---------------- 234------------------RS------NVDKSKETAEIRIAKAAITICFLFFVSWTPYGVM 235SLIGAFGDKS---LLTPGATMIPACTCKLVACIEPFVYAISHPRYRMELQKRCPWLGV-- 236----NEKSG-EA-SSAQSTTTQEQTQQ---TSAA-------------------------- 237------------------------------------------------------------ 238--- 239> 18== D50584 1 Hemigrapsus sanguineus opsin BcRh2 <compound eye>[J.Exp.Biol.1 240--------------------MTNATGP------------QMAYYGAA----SMD------ 241--------FGYPEGVSIVDFVRP----------------EIKP--------YVHQHWYNY 242PPVNPMWHYLLGVIYLFLGTVSIFGNGLVIYLFNKSAALRTPANILVVNLALSDLIMLTT 243N-VPFFTYNCFSGGVWM--FSPQYCEIYACLGAITGVCSIWLLCMISFDRYNIICNGFNG 244-PKLTTGKAVVFALISWVIAIGC-ALPPFFG-W-----GNYILEGILDSCSYDYLT--QD 245FNTFSYNIFIFVFDYFLPAAIIVFSYVFIVKAIFAHEAAMRAQAKK-------------- 246------------------------------------------------------------ 247--------------------------------------MNVSTL---------------- 248------------------RS-------NEADAQRAEIRIAKTALVNVSLWFICWTPYALI 249SLKGVMGDTS---GITPLVSTLPALLAKSCSCYNPFVYAISHPKYRLAITQHLPWFCV-- 250--HETETKS-ND-DSQSNSTVAQDKA---------------------------------- 251------------------------------------------------------------ 252--- 253> 19== D50583 1 Hemigrapsus sanguineus opsin BcRh1 <compound eye>[J.Exp.Biol.1 254--------------------MANVTGP------------QMAFYGSG----AAT------ 255--------FGYPEGMTVADFVPD----------------RVKH--------MVLDHWYNY 256PPVNPMWHYLLGVVYLFLGVISIAGNGLVIYLYMKSQALKTPANMLIVNLALSDLIMLTT 257N-FPPFCYNCFSGGRWM--FSGTYCEIYAALGAITGVCSIWTLCMISFDRYNIICNGFNG 258-PKLTQGKATFMCGLAWVISVGW-SLPPFFG-W-----GSYTLEGILDSCSYDYFT--RD 259MNTITYNICIFIFDFFLPASVIVFSYVFIVKAIFAHEAAMRAQAKK-------------- 260------------------------------------------------------------ 261--------------------------------------MNVTNL---------------- 262------------------RS-------NEAETQRAEIRIAKTALVNVSLWFICWTPYAAI 263TIQGLLGNAE---GITPLLTTLPALLAKSCSCYNPFVYAISHPKFRLAITQHLPWFCV-- 264--HEKDPND-VE-ENQSSNTQTQEKS---------------------------------- 265------------------------------------------------------------ 266--- 267> 20== K02320 1 D.melanogaster opsin <>[Cell40,851-858'85] 268-----MESFA---------VAAAQLGP------------HFAPLS--------------- 269-------------NGSVVDKVTP----------------DMAH--------LISPYWNQF 270PAMDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMIT 271N-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAG 272-RPMTIPLALGKM---------------------------YVPEGNLTSCGIDYLE--RD 273WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKK-------------- 274------------------------------------------------------------ 275--------------------------------------MNVKSL---------------- 276------------------RS-------SEDAEKSAEGKLAKVALVTITLWFMAWTPYLVI 277NCMGLFKF-E---GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCCVF-- 278--GKVDDGK-SS-DAQSQATASEAESKA-------------------------------- 279------------------------------------------------------------ 280--- 281> 21== K02315 1 D.melanogaster ninaE <>[Cell40,839-850'85] 282-----MESFA---------VAAAQLGP------------HFAPLS--------------- 283-------------NGSVVDKVTP----------------DMAH--------LISPYWNQF 284PAMDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMIT 285N-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAG 286-RPMTIPLALGKIAYIWFMSSIW-CLAPAFG-W-----SRYVPEGNLTSCGIDYLE--RD 287WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKK-------------- 288------------------------------------------------------------ 289--------------------------------------MNVKSL---------------- 290------------------RS-------SEDAEKSAEGKLAKVALVTITLWFMAWTPYLVI 291NCMGLFKF-E---GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCCVF-- 292--GKVDDGK-SS-DAQSQATASEAESKA-------------------------------- 293------------------------------------------------------------ 294--- 295> 22== X65877 1 Drosophila pseudoobscura Dpse\ninaE <>[Genetics132(1),193-204' 296-----MDSFA---------AVATQLGP------------QFAAPS--------------- 297-------------NGSVVDKVTP----------------DMAH--------LISPYWDQF 298PAMDPIWAKILTAYMIIIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMIT 299N-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAG 300-RPMTIPLALGKIAYIWFMSTIWCCLAPVFG-W-----SRYVPEGNLTSCGIDYLE--RD 301WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKK-------------- 302------------------------------------------------------------ 303--------------------------------------MNVKSL---------------- 304------------------RS-------SEDADKSAEGKLAKVALVTISLWFMAWTPYLVI 305NCMGLFKF-E---GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCCVF-- 306--GKVDDGK-SS-EAQSQATTSEAESKA-------------------------------- 307------------------------------------------------------------ 308--- 309> 23== M12896 1 D.melanogaster Rh2 <>[Cell44,705-710'86] 310MERSHLPETP---------FDLAHSGP------------RFQAQSSG------------- 311-------------NGSVLDNVLP----------------DMAH--------LVNPYWSRF 312APMDPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMAS 313Q-SPVMIINFYY-ETWV--LGPLWCDIYAGCGSLFGCVSIWSMCMIAFDRYNVIVKGING 314-TPMTIKTSIMKILFIWMMAVFW-TVMPLIG-W-----SAYVPEGNLTACSIDYMT--RM 315WNPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHEKAMREQAKK-------------- 316------------------------------------------------------------ 317--------------------------------------MNVKSL---------------- 318------------------RS-------SEDCDKSAEGKLAKVALTTISLWFMAWTPYLVI 319CYFGLFKI-D---GLTPLTTIWGATFAKTSAVYNPIVYGISHPKYRIVLKEKCPMCVF-- 320--GNTDEPKPDA-PASDTETTSEADSKA-------------------------------- 321------------------------------------------------------------ 322--- 323> 24== X65878 1 Drosophila pseudoobscura Dpse\Rh2 <>[Genetics132(1),193-204'92 324MERSLLPEPP---------LAMALLGP------------RFEAQTGG------------- 325-------------NRSVLDNVLP----------------DMAP--------LVNPHWSRF 326APMDPTMSKILGLFTLVILIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMAS 327Q-SPVMIINFYY-ETWV--LGPLWCDIYAACGSLFGCVSIWSMCMIAFDRYNVIVKGING 328-TPMTIKTSIMKIAFIWMMAVFW-TIMPLIG-W-----SSYVPEGNLTACSIDYMT--RQ 329WNPRSYLITYSLFVYYTPLFMICYSYWFIIATVAAHEKAMRDQAKK-------------- 330------------------------------------------------------------ 331--------------------------------------MNVKSL---------------- 332------------------RS-------SEDCDKSAENKLAKVALTTISLWFMAWTPYLII 333CYFGLFKI-D---GLTPLTTIWGATFAKTSAVYNPIVYGISHPNDRLVLKEKCPMCVC-- 334--GTTDEPKPDA-PPSDTETTSEAESKD-------------------------------- 335------------------------------------------------------------ 336--- 337> 25== U26026 1 Apis mellifera long-wavelength rhodopsin <>[] 338--------------------MIAVSGP------------SYEAFSYG---GQARF----- 339------------NNQTVVDKVPP----------------DMLH--------LIDANWYQY 340PPLNPMWHGILGFVIGMLGFVSAMGNGMVVYIFLSTKSLRTPSNLFVINLAISNFLMMFC 341M-SPPMVINCYY-ETWV--LGPLFCQIYAMLGSLFGCGSIWTMTMIAFDRYNVIVKGLSG 342-KPLSINGALIRIIAIWLFSLGW-TIAPMFG-W-----NRYVPEGNMTACGTDYFN--RG 343LLSASYLVCYGIWVYFVPLFLIIYSYWFIIQAVAAHEKNMREQAKK-------------- 344------------------------------------------------------------ 345--------------------------------------MNVASL---------------- 346------------------RS-------SENQNTSAECKLAKVALMTISLWFMAWTPYLVI 347NFSGIFNL-V---KISPLFTIWGSLFAKANAVYNPIVYGISHPKYRAALFAKFPSLAC-- 348---AAEPSS-DA-VSTTSGTTTVTDNEK--SNA--------------------------- 349------------------------------------------------------------ 350--- 351> 26== L03781 1 Limulus polyphemus opsin <>[PNAS90,6150-6154'93] 352--------------------MAN----------------QLSYSSLG------------- 353--------WPYQPNASVVDTMPK----------------EMLY--------MIHEHWYAF 354PPMNPLWYSILGVAMIILGIICVLGNGMVIYLMMTTKSLRTPTNLLVVNLAFSDFCMMAF 355M-MPTMTSNCFA-ETWI--LGPFMCEVYGMAGSLFGCASIWSMVMITLDRYNVIVRGMAA 356-APLTHKKATLLLLFVWIWSGGW-TILPFFG-W-----SRYVPEGNLTSCTVDYLT--KD 357WSSASYVVIYGLAVYFLPLITMIYCYFFIVHAVAEHEKQLREQAKK-------------- 358------------------------------------------------------------ 359--------------------------------------MNVASL---------------- 360------------------RA------NADQQKQSAECRLAKVAMMTVGLWFMAWTPYLII 361SWAGVFSSGT---RLTPLATIWGSVFAKANSCYNPIVYGISHPRYKAALYQRFPSLAC-- 362--GSGESGS-DV-KSEASATTTMEEKPK-------------------------------- 363----------------------------------------------IPEA---------- 364--- 365> 27== X07797 1 Octopus dofleini rhodopsin <>[FEBS232(1),69-72'88] 366--------------------MVESTTL-----------------------VNQTW----- 367----------W-YNPTV----------------------------------DIHPHWAKF 368DPIPDAVYYSVGIFIGVVGIIGILGNGVVIYLFSKTKSLQTPANMFIINLAMSDLSFSAI 369NGFPLKTISAFM-KKWI--FGKVACQLYGLLGGIFGFMSINTMAMISIDRYNVIGRPMAA 370SKKMSHRRAFLMIIFVWMWSIVW-SVGPVFN-W-----GAYVPEGILTSCSFDYLS--TD 371PSTRSFILCMYFCGFMLPIIIIAFCYFNIVMSVSNHEKEMAAMAKR-------------- 372------------------------------------------------------------ 373--------------------------------------LNAKEL---------------- 374------------------R--------KAQAGASAEMKLAKISMVIITQFMLSWSPYAII 375ALLAQFGPAE---WVTPYAAELPVLFAKASAIHNPIVYSVSHPKFREAIQTTFPWLLTCC 376QFDEKECED-AN-DAEEEVVASERGGES--RDAAQMKEMMAMMQKMQAQQAAYQPPPPPQ 377GY--PPQGYPPQGAYPPPQGYPPQGYPPQGYPPQGYPPQGAPPQVEAPQGAPPQGVDNQA 378YQA 379> 28== X70498 1 Todarodes pacificus rhodopsin <retina>[FEBS317(1-2),5-11'93] 380--------------------MGRDLRD------------------------NETW----- 381----------W-YNPSI----------------------------------VVHPHWREF 382DQVPDAVYYSLGIFIGICGIIGCGGNGIVIYLFTKTKSLQTPANMFIINLAFSDFTFSLV 383NGFPLMTISCFL-KKWI--FGFAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGRPMAA 384SKKMSHRRAFIMIIFVWLWSVLW-AIGPIFG-W-----GAYTLEGVLCNCSFDYIS--RD 385STTRSNILCMFILGFFGPILIIFFCYFNIVMSVSNHEKEMAAMAKR-------------- 386------------------------------------------------------------ 387--------------------------------------LNAKEL---------------- 388------------------R--------KAQAGANAEMRLAKISIVIVSQFLLSWSPYAVV 389ALLAQFGPLE---WVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPWVLTCC 390QFDDKETED-DK-DAETEIPAGESSDAAPSADAAQMKEMMAMMQKMQQQQAAY----PPQ 391GYAPPPQGYPPQGY--PPQGYPPQGYPPQGYPP---PPQGAPPQ-GAPPAAPPQGVDNQA 392YQA 393> 29== L21195 1 human serotonin 5-HT7 receptor protein <placenta and fetal bra 394--------------------MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPV 395AGSWAPHLLS---EVTASPAPTW----------------DAPPDNASGCGEQIN------ 396--YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVA 397V-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY 398PVRQNGKCMAKMILSVWLLSASI-TLPPLFG-W-----AQNVNDDKVCLISQDF------ 399----GYTIYSTAVAFYIPMSVMLFMYYQIY-------KAARKSAAKHKF----------- 400----------------------PGF-----------------PRVEPDSVIAL------- 401--------NGIVKLQKEV--------------------EECANLSRLLKH---------- 402-----------------ER--------KNISIFKREQKAATTLGIIVGAFTVCWLPFFLL 403STARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNI 404--NRKLSAA-GMHEALKLAERPERPEFVL-QNADYCRK---------------------- 405----------------------------KGHDS--------------------------- 406--- 407> 30== L15228 1 rat 5HT-7 serotonin receptor <>[JBC268,18200-18204'93] 408--------------------M--------------------------------------- 409-----PHLLSGFLEVTASPAPTW----------------DAPPDNVSGCGEQIN------ 410--YGRVEKVVIGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLIVSLALADLSVAVA 411V-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY 412PVRQNGKCMAKMILSVWLLSASI-TLPPLFG-W-----AQNVNDDKVCLISQDF------ 413----GYTIYSTAVAFYIPMSVMLFMYYQIY-------KAARKSAAKHKF----------- 414----------------------PGF-----------------PRVQPESVISL------- 415--------NGVVKLQKEV--------------------EECANLSRLLKH---------- 416-----------------ER--------KNISIFKREQKAATTLGIIVGAFTVCWLPFFLL 417STARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRPTSRSLLQCQYRNI 418--NRKLSAA-GMHEALKLAERPERSEFVL-QNSDHCGK---------------------- 419----------------------------KGHDT--------------------------- 420--- 421> 31=p A47425 serotonin receptor 5HT-7 - rat 422--------------------M--------------------------------------- 423-----PHLLSGFLEVTASPAPTW----------------DAPPDNVSGCGEQIN------ 424--YGRVEKVVIGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLIVSLALADLSVAVA 425V-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY 426PVRQNGKCMAKMILSVWLLSASI-TLPPLFG-W-----AQNVNDDKVCLISQDF------ 427----GYTIYSTAVAFYIPMSVMLFMYYQIY-------KAARKSAAKHKF----------- 428----------------------PGF-----------------PRVQPESVISL------- 429--------NGVVKLQKEV--------------------EECANLSRLLKH---------- 430-----------------ER--------KNISIFKREQKAATTLGIIVGAFTVCWLPFFLL 431STARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNI 432--NRKLSAA-GMHEALKLAERPERSEFVL-QNSDHCGK---------------------- 433----------------------------KGHDT--------------------------- 434--- 435> 32== M83181 1 human serotonin receptor <>[JBC267(11),7553-7562'92] 436-----MDVLSPGQ-------GNNTTSPPA----------PFETGG--------------- 437-------------NTTGISDVTV------------------------------------- 438-----SYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVL 439V-LPMAALYQVL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDY 440VNKRTPRRAAALISLTWLIGFLI-SIPPMLG-WRTPE-DRSDPDA--CTISKDH------ 441----GYTIYSTFGAFYIPLLLMLVLYGRIF-------RAARFRIRK-------------- 442-------------------------TVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNW 443RLGVESKAGGALCANGAVRQG-----------------DDGAALEVIEVHRVGNSKEHLP 444LPSEAGPTPCA--PASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIV 445ALVLPFCESS-C-HMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ 446------------------------------------------------------------ 447------------------------------------------------------------ 448--- 449> 33=p A35181 serotonin receptor class 1A - rat 450-----MDVFSFGQ-------GNNTTASQE----------PFGTGG--------------- 451-------------NVTSISDVTF------------------------------------- 452-----SYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVL 453V-LPMAALYQVL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDY 454VNKRTPRRAAALISLTWLIGFLI-SIPPMLG-WRTPE-DRSDPDA--CTISKDH------ 455----GYTIYSTFGAFYIPLLLMLVLYGRIF-------RAARFRIRK-------------- 456-------------------------TVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDW 457RRCAENRAVGTPCTNGAVRQG-----------------DDEATLEVIEVHRVGNSKEHLP 458LPSESGSNSYA--PACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIV 459ALVLPFCESS-C-HMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR 460------------------------------------------------------------ 461------------------------------------------------------------ 462--- 463> 34== L06803 1 Lymnaea stagnalis serotonin receptor <>[PNAS90,11-15'93] 464-----MANFTFGDLALDVARMGGLASTPS----------GLRSTGLTTPGLSPTG----- 465-------------LVTSDFNDSYGLTGQFINGSHSSRSRDNASANDTSATNMTDDRYWSL 466TVYSHEHLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSLAVADLMVAVL 467V-MPLSVVSEIS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIAMDRYWAVTS-IDY 468IRRRSARRILLMIMVVWIVALFI-SIPPLFG-WRDP--NNDPDKTGTCIISQDK------ 469----GYTIFSTVGAFYLPMLVMMIIYIRIW-------LVARSRIRKDKFQMTKARLKTEE 470TTLVASPKTEYSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKKNRAKKLPEN-- 471-------ANGVNSNSSSS-ER-LKQIQIETAEAFANGCAEEASIAMLERQ-CNNGKKISS 472NDTPYS------------RT-------REKLELKRERKAARTLAIITGAFLICWLPFFII 473ALIGPFVDPE---GIPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQKILFGKYR-- 474------------------------------------------------------------ 475-------------------------------------------------RGHR------- 476--- 477> 35=p A47174 serotonin receptor, 5HTlym receptor - great pond snail 478-----MANFTFGDLALDVARMGGLASTPS----------GLRSTGLTTPGLSPTG----- 479-------------LVTSDFNDSYGLTGQFINGSHSSRSRDNASANDTSATNMTDDRYWSL 480TVYSHEHLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSLAVADLMVAVL 481V-MPLSVVSEIS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIAMDRYWAVTS-IDY 482IRRRSARRILLMIMVVWIVALFI-SIPPLFG-WRDP--NNDPDKTGTCIISQDK------ 483----GYTIFSTVGAFYLPMLVMMIIYIRIW-------LVARSRIRKDKFQMTKARLKTEE 484TTLVASPKTEYSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKKNRAKKLPEN-- 485-------ANGVNSNSSSS-ER-LKQIQIETAEAFANGCAEEASIAMLERQ-CNNGKKISS 486NDTPYS------------RT-------REKLELKRERKAARTLAIITGAFLICWLPFFII 487ALIGPFVDPE---GIPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQKILFGKYR-- 488------------------------------------------------------------ 489-------------------------------------------------RGHR------- 490--- 491> 36== X95604 1 Bombyx mori serotonin receptor <antennae>[InsectBiochem.Mol.Bi 492--------------------MEGAEGQEELDWEALYLRLPLQNCSWNSTGWEPNW----- 493-------------NVTVVPNTTW---------WQASAPFDTPAAL--------------- 494-----VRAAAKAVVLGLLILATVVGNVFVIAAILLERHLRSAANNLILSLAVADLLVACL 495V-MPLGAVYEVV-QRWT--LGPELCDMWTSGDVLCCTASILHLVAIALDRYWAVTN-IDY 496IHASTAKRVGMMIACVWTVSFFV-CIAQLLG-WKDPDWNQRVSEDLRCVVSQDV------ 497----GYQIFATASSFYVPVLIILILYWRIY-------QTARKRIRR-------------- 498-------------------------------RRGATARGGVGPPPVPAGG-ALVAGGG-- 499-------SGGIAAAVVAVIGRPLPTISETTTTGFTNVSSNNTSP---EKQSCANGLEADP 500PTTGYGAVAAAYYPSLVRRKP------KEAADSKRERKAAKTLAIITGAFVACWLPFFVL 501AILVPTCDCE----VSPVLTSLSLWLGYFNSTLNPVIYTVFSPEFRHAFQRLLCGRRVRR 502R----------------------------------------------------------- 503---------------------------------------------RAPQ----------- 504--- 505