1BLASTP 2.0MP-WashU [04-May-2006] [linux26-x64-I32LPF64 2006-05-10T17:22:28] 2 3Copyright (C) 1996-2006 Washington University, Saint Louis, Missouri USA. 4All Rights Reserved. 5 6Reference: Gish, W. (1996-2006) http://blast.wustl.edu 7 8Query= Celegans_dcr1 9 (1845 letters) 10 11Database: swissprot 12 353,658 sequences; 132,868,552 total letters. 13Searching....10....20....30....40....50....60....70....80....90....100% done 14 15 Smallest 16 Sum 17 High Probability 18Sequences producing High-scoring Segment Pairs: Score P(N) N 19 20sp|P34529.2|DCR1_CAEEL RecName: Full=Endoribonuclease dcr-1 9560 0. 1 21sp|Q9VCU9.1|DCR1_DROME RecName: Full=Endoribonuclease Dcr... 1792 1.5e-232 3 22sp|Q9UPY3.2|DICER_HUMAN RecName: Full=Endoribonuclease Di... 2152 6.4e-223 1 23sp|Q8R418.2|DICER_MOUSE RecName: Full=Endoribonuclease Di... 2120 1.6e-219 1 24sp|P84634.1|DCL4_ARATH RecName: Full=Dicer-like protein 4 471 8.6e-72 5 25sp|Q7S8J7.1|DCL1_NEUCR RecName: Full=Dicer-like protein 1... 505 3.0e-69 6 26sp|A4RKC3.2|DCL1_MAGGR RecName: Full=Dicer-like protein 1... 481 3.5e-69 6 27sp|Q0CW42.2|DCL1_ASPTN RecName: Full=Dicer-like protein 1... 464 4.8e-65 6 28sp|Q1DKI1.2|DCL1_COCIM RecName: Full=Dicer-like protein 1... 498 8.4e-64 6 29sp|A2RAF3.2|DCL1_ASPNC RecName: Full=Dicer-like protein 1... 466 5.3e-62 5 30sp|Q09884.1|DCR1_SCHPO RecName: Full=Protein Dicer; AltNa... 415 7.7e-61 4 31sp|A1CBC9.2|DCL1_ASPCL RecName: Full=Dicer-like protein 1... 428 1.2e-60 6 32sp|A1DE13.1|DCL1_NEOFI RecName: Full=Dicer-like protein 1... 457 1.6e-60 6 33sp|Q2VF19.1|DCL1_CRYPA RecName: Full=Dicer-like protein 1... 465 4.2e-60 4 34sp|Q0UI93.2|DCL1_PHANO RecName: Full=Dicer-like protein 1... 490 3.8e-59 5 35sp|Q4WVE3.3|DCL1_ASPFU RecName: Full=Dicer-like protein 1... 466 4.8e-59 6 36sp|Q2U6C4.2|DCL1_ASPOR RecName: Full=Dicer-like protein 1... 474 8.5e-58 4 37sp|Q2UNX5.1|DCL2_ASPOR RecName: Full=Dicer-like protein 2... 396 1.0e-53 5 38sp|Q4WA22.2|DCL2_ASPFU RecName: Full=Dicer-like protein 2... 369 1.7e-51 5 39 40 41>sp|P34529.2|DCR1_CAEEL RecName: Full=Endoribonuclease dcr-1 42 Length = 1845 43 44 Score = 9560 (3370.3 bits), Expect = 0., P = 0. 45 Identities = 1845/1845 (100%), Positives = 1845/1845 (100%) 46 Links = (1) 47 48Query: 1 MVRVRADLQCFNPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQ 60 49 MVRVRADLQCFNPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQ 50Sbjct: 1 MVRVRADLQCFNPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQ 60 51 52Query: 61 GGKRAFFVVEKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVI 120 53 GGKRAFFVVEKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVI 54Sbjct: 61 GGKRAFFVVEKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVI 120 55 56Query: 121 TAQCLLDLIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLT 180 57 TAQCLLDLIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLT 58Sbjct: 121 TAQCLLDLIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLT 180 59 60Query: 181 ASLIKAKVAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLG 240 61 ASLIKAKVAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLG 62Sbjct: 181 ASLIKAKVAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLG 240 63 64Query: 241 IPNFDTVIEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQ 300 65 IPNFDTVIEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQ 66Sbjct: 241 IPNFDTVIEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQ 300 67 68Query: 301 VWEKELGKIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVIR 360 69 VWEKELGKIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVIR 70Sbjct: 301 VWEKELGKIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVIR 360 71 72Query: 361 LFEILETFNPEFQKERMKLEKAEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPD 420 73 LFEILETFNPEFQKERMKLEKAEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPD 74Sbjct: 361 LFEILETFNPEFQKERMKLEKAEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPD 420 75 76Query: 421 YVVGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDR 480 77 YVVGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDR 78Sbjct: 421 YVVGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDR 480 79 80Query: 481 PLDMRSYVQSKGRARRAGSRYVITVEEKDTAAYCSKLPSDIFTRLVPHNQIIPIEENGVT 540 81 PLDMRSYVQSKGRARRAGSRYVITVEEKDTAAYCSKLPSDIFTRLVPHNQIIPIEENGVT 82Sbjct: 481 PLDMRSYVQSKGRARRAGSRYVITVEEKDTAAYCSKLPSDIFTRLVPHNQIIPIEENGVT 540 83 84Query: 541 KYCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELDDNLLPKGRESI 600 85 KYCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELDDNLLPKGRESI 86Sbjct: 541 KYCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELDDNLLPKGRESI 600 87 88Query: 601 AKLLEHIDEEPDEYAPGIAAKVGSSKRKQLYDKKIARALNESFVEADKECFIYAFELERF 660 89 AKLLEHIDEEPDEYAPGIAAKVGSSKRKQLYDKKIARALNESFVEADKECFIYAFELERF 90Sbjct: 601 AKLLEHIDEEPDEYAPGIAAKVGSSKRKQLYDKKIARALNESFVEADKECFIYAFELERF 660 91 92Query: 661 REAELTLNPKRRKFEDPFNYEYCFGFLSAKEIPKIPPFPVFLRQGNMKVRLIVAPKKTTV 720 93 REAELTLNPKRRKFEDPFNYEYCFGFLSAKEIPKIPPFPVFLRQGNMKVRLIVAPKKTTV 94Sbjct: 661 REAELTLNPKRRKFEDPFNYEYCFGFLSAKEIPKIPPFPVFLRQGNMKVRLIVAPKKTTV 720 95 96Query: 721 TAAQLQEIQLFHNYLFTQVLQMCKTGNLEFDGTSNAPLNTLIVPLNKRKDDMSYTINMKY 780 97 TAAQLQEIQLFHNYLFTQVLQMCKTGNLEFDGTSNAPLNTLIVPLNKRKDDMSYTINMKY 98Sbjct: 721 TAAQLQEIQLFHNYLFTQVLQMCKTGNLEFDGTSNAPLNTLIVPLNKRKDDMSYTINMKY 780 99 100Query: 781 VSEVVANMENMPRIPKDEVRRQYKFNAEDYKDAIVMPWYRNLEQPVFYYVAEILPEWRPS 840 101 VSEVVANMENMPRIPKDEVRRQYKFNAEDYKDAIVMPWYRNLEQPVFYYVAEILPEWRPS 102Sbjct: 781 VSEVVANMENMPRIPKDEVRRQYKFNAEDYKDAIVMPWYRNLEQPVFYYVAEILPEWRPS 840 103 104Query: 841 SKFPDTHFETFNEYFIKKYKLEIYDQNQSLLDVDFTSTRLNLLQPRIQNQPRRSRTVSNS 900 105 SKFPDTHFETFNEYFIKKYKLEIYDQNQSLLDVDFTSTRLNLLQPRIQNQPRRSRTVSNS 106Sbjct: 841 SKFPDTHFETFNEYFIKKYKLEIYDQNQSLLDVDFTSTRLNLLQPRIQNQPRRSRTVSNS 900 107 108Query: 901 STSNIPQASASDSKESNTSVPHSSQRQILVPELMDIHPISATLWNVIAALPSIFYRVNQL 960 109 STSNIPQASASDSKESNTSVPHSSQRQILVPELMDIHPISATLWNVIAALPSIFYRVNQL 110Sbjct: 901 STSNIPQASASDSKESNTSVPHSSQRQILVPELMDIHPISATLWNVIAALPSIFYRVNQL 960 111 112Query: 961 LLTDELRETILVKAFGKEKTKLDDNVEWNSLAYATEYEEKQTIIVKKIQQLRDLNQKSIE 1020 113 LLTDELRETILVKAFGKEKTKLDDNVEWNSLAYATEYEEKQTIIVKKIQQLRDLNQKSIE 114Sbjct: 961 LLTDELRETILVKAFGKEKTKLDDNVEWNSLAYATEYEEKQTIIVKKIQQLRDLNQKSIE 1020 115 116Query: 1021 DQERETRENDKIDDGEELFNIGVWDPEEAVRIGVEISSRDDRMDGEDQDTVGLTQGLHDG 1080 117 DQERETRENDKIDDGEELFNIGVWDPEEAVRIGVEISSRDDRMDGEDQDTVGLTQGLHDG 118Sbjct: 1021 DQERETRENDKIDDGEELFNIGVWDPEEAVRIGVEISSRDDRMDGEDQDTVGLTQGLHDG 1080 119 120Query: 1081 NISDEDDELPFVMHDYTARLTSNRNGIGAWSGSESIVPSGWGDWDGPEPDNSPMPFQILG 1140 121 NISDEDDELPFVMHDYTARLTSNRNGIGAWSGSESIVPSGWGDWDGPEPDNSPMPFQILG 122Sbjct: 1081 NISDEDDELPFVMHDYTARLTSNRNGIGAWSGSESIVPSGWGDWDGPEPDNSPMPFQILG 1140 123 124Query: 1141 GPGGLNVQALMADVGRVFDPSTASSSLSQTVQESTVSPPKQLTKEEEQFKKLQNDLLKQA 1200 125 GPGGLNVQALMADVGRVFDPSTASSSLSQTVQESTVSPPKQLTKEEEQFKKLQNDLLKQA 126Sbjct: 1141 GPGGLNVQALMADVGRVFDPSTASSSLSQTVQESTVSPPKQLTKEEEQFKKLQNDLLKQA 1200 127 128Query: 1201 KERLEALEMSEDMEKPRRLEDTVNLEDYGDDQENQEDENTPTNFPKTIDEEIEELSIGAR 1260 129 KERLEALEMSEDMEKPRRLEDTVNLEDYGDDQENQEDENTPTNFPKTIDEEIEELSIGAR 130Sbjct: 1201 KERLEALEMSEDMEKPRRLEDTVNLEDYGDDQENQEDENTPTNFPKTIDEEIEELSIGAR 1260 131 132Query: 1261 KKQEIDDNAAKTDVLERENCEVLPVAINEKSRSFSFEKESKAINGRLIRQRSEEYVSHID 1320 133 KKQEIDDNAAKTDVLERENCEVLPVAINEKSRSFSFEKESKAINGRLIRQRSEEYVSHID 134Sbjct: 1261 KKQEIDDNAAKTDVLERENCEVLPVAINEKSRSFSFEKESKAINGRLIRQRSEEYVSHID 1320 135 136Query: 1321 SDIGLGVSPCLLLTALTTSNAADGMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSF 1380 137 SDIGLGVSPCLLLTALTTSNAADGMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSF 138Sbjct: 1321 SDIGLGVSPCLLLTALTTSNAADGMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSF 1380 139 140Query: 1381 ARSKEVSNCNLYRLGKKLGIPQLIVANKFDAHDSWLPPCYIPTCDFKAPNTDDAEEKDNE 1440 141 ARSKEVSNCNLYRLGKKLGIPQLIVANKFDAHDSWLPPCYIPTCDFKAPNTDDAEEKDNE 142Sbjct: 1381 ARSKEVSNCNLYRLGKKLGIPQLIVANKFDAHDSWLPPCYIPTCDFKAPNTDDAEEKDNE 1440 143 144Query: 1441 IERILDGQVIEEKPENKTGWDIGGDVSKSTTDGIETITFPKQARVGNDDISPLPYNLLTQ 1500 145 IERILDGQVIEEKPENKTGWDIGGDVSKSTTDGIETITFPKQARVGNDDISPLPYNLLTQ 146Sbjct: 1441 IERILDGQVIEEKPENKTGWDIGGDVSKSTTDGIETITFPKQARVGNDDISPLPYNLLTQ 1500 147 148Query: 1501 QHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPSPLLRFIDTPT 1560 149 QHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPSPLLRFIDTPT 150Sbjct: 1501 QHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPSPLLRFIDTPT 1560 151 152Query: 1561 NPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGCYQRLEFLG 1620 153 NPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGCYQRLEFLG 154Sbjct: 1561 NPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGCYQRLEFLG 1620 155 156Query: 1621 DAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYHM 1680 157 DAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYHM 158Sbjct: 1621 DAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYHM 1680 159 160Query: 1681 IEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDSG 1740 161 IEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDSG 162Sbjct: 1681 IEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDSG 1740 163 164Query: 1741 RNLDTTWQVIFHMMRGTIELCCANPPRSPIRELMEFEQSKVRFSKMERILESGKVRVTVE 1800 165 RNLDTTWQVIFHMMRGTIELCCANPPRSPIRELMEFEQSKVRFSKMERILESGKVRVTVE 166Sbjct: 1741 RNLDTTWQVIFHMMRGTIELCCANPPRSPIRELMEFEQSKVRFSKMERILESGKVRVTVE 1800 167 168Query: 1801 VVNNMRFTGMGRNYRIAKATAAKRALKYLHQIEQQRRQSPSLTTV 1845 169 VVNNMRFTGMGRNYRIAKATAAKRALKYLHQIEQQRRQSPSLTTV 170Sbjct: 1801 VVNNMRFTGMGRNYRIAKATAAKRALKYLHQIEQQRRQSPSLTTV 1845 171 172 173>sp|Q9VCU9.1|DCR1_DROME RecName: Full=Endoribonuclease Dcr-1; Short=Protein 174 dicer-1 175 Length = 2249 176 177 Score = 1792 (635.9 bits), Expect = 1.5e-232, Sum P(3) = 1.5e-232 178 Identities = 522/1454 (35%), Positives = 748/1454 (51%) 179 Links = 2-3-(1) 180 181Query: 513 YCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAELLLPINSPIKHAIVLKNPMPNKKTAQM 572 182 YC++LPSD FT+L + E GVT + L LPINSP+KH IV PMP + A+ 183Sbjct: 832 YCARLPSDTFTKLTALWRCTRNERAGVTLFQYTLRLPINSPLKHDIV-GLPMPTQTLARR 890 184 185Query: 573 AVALEACRQLHLEGELDDNLLPKGRESIAKL---LEHIDEEP-DEYAPGIA--AKVGSSK 626 186 AL+AC +LH GELDD L P G+E L E + EP DE ++ + G++K 187Sbjct: 891 LAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPEDEQIVQLSDEPRPGTTK 950 188 189Query: 627 RKQLYDKKIARALNESFVEADKECFIYAFELERFREAELTLNPKRRKFEDPFNYEYCFGF 686 190 R+Q Y K+IA + A C++Y +L N + RK P + + FG 191Sbjct: 951 RRQYYYKRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRGRKIYPPEDAQQGFGI 1010 192 193Query: 687 LSAKEIPKIPPFPVFLRQGNMKVRLIVAPKKTTVTAAQLQEIQLFHNYLFTQVLQMCKTG 746 194 L+ K IPK+ F +F R G +KV L +A ++ +T+ Q+ I F NY FT VL++ K 195Sbjct: 1011 LTTKRIPKLSAFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLNYTFTNVLRLQKFL 1070 196 197Query: 747 NL-EFDGTSNAPLNTLIVPLNKRKDDMSYTINMKYVSEVVANMENMPRIPKDEVRRQYKF 805 198 L + D T N IVP K + I+ +++ + AN MPR DE R+ F 199Sbjct: 1071 MLFDPDSTENC---VFIVPTVKAPAGGKH-IDWQFLELIQANGNTMPRAVPDEERQAQPF 1126 200 201Query: 806 NAEDYKDAIVMPWYRNLEQPVFYYVAEILPEWRPSSKFPDTHFETFNEYFIKKYKLEIYD 865 202 + + ++DA+VMPWYRN +QP ++YVAEI P P S FP ++ TF Y++ KY L I + 203Sbjct: 1127 DPQRFQDAVVMPWYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQN 1186 204 205Query: 866 QNQSLLDVDFTSTRLNLLQPRIQNQPRRSRTVSNSSTSNIPQASASDSKESNTSVPHSSQ 925 206 +Q LLDVD TS RLN L PR N+ + S+ T +K N Q 207Sbjct: 1187 TSQPLLDVDHTSARLNFLTPRYVNRKGVALPTSSEETKR--------AKRENLE-----Q 1233 208 209Query: 926 RQILVPELMDIHPISATLWNVIAALPSIFYRVNQLLLTDELRETILVK-AFGKEKTKLDD 984 210 +QILVPEL +HP A+LW LP I YR+N LLL D++R+ + G+++ + D+ 211Sbjct: 1234 KQILVPELCTVHPFPASLWRTAVCLPCILYRINGLLLADDIRKQVSADLGLGRQQIE-DE 1292 212 213Query: 985 NVEWNSLAYATEYEE--KQTIIVKKIQQLRD--LNQKSIEDQERE-TRENDKID-DGEEL 1038 214 + EW L + E K++ K+ + L+D +N K + D E++ T E ++D D ++ 215Sbjct: 1293 DFEWPMLDFGWSLSEVLKKSRESKQKESLKDDTINGKDLADVEKKPTSEETQLDKDSKD- 1351 216 217Query: 1039 FNIGVWDPEEAVRIGVEISSRDDRMDGEDQDTVGL-TQGLHDGNIS------DEDD--EL 1089 218 D E I + I + + +D +G + + D S DEDD L 219Sbjct: 1352 ------DKVEKSAIELIIEGEEKLQEADDFIEIGTWSNDMADDIASFNQEDDDEDDAFHL 1405 220 221Query: 1090 PFV-----MHDYTARLTSNR-----NGIGAWSGSESIV--PSGWGDWDGP-EP------- 1129 222 P + D R S NG + G +S G G GP +P 223Sbjct: 1406 PVLPANVKFCDQQTRYGSPTFWDVSNGESGFKGPKSSQNKQGGKGKAKGPAKPTFNYYDS 1465 224 225Query: 1130 DNS-PMPFQILGGPGGLNVQA--LMADVGRVFDPSTASSSLSQTVQES-TVSPPKQLTKE 1185 226 DNS + G LN +D V D A + E+ T+ +++ K 227Sbjct: 1466 DNSLGSSYDDDDNAGPLNYMHHNYSSDDDDVADDIDAGRIAFTSKNEAETIETAQEVEKR 1525 228 229Query: 1186 EEQFKKLQ----NDL-LKQAKERLEALEMS-EDMEKPR--RLEDTV-----NLEDYG--- 1229 230 ++Q +Q N+ +Q K L ED ++P R E+++ +E G 231Sbjct: 1526 QKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPATIRYEESIAKLKTEIESGGMLV 1585 232 233Query: 1230 -DDQEN--QEDENTPTNFPKT------------IDEEIEELSIGARKKQEIDD----NAA 1270 234 DQ+ + + K ++E++ +G R++ + D NA 235Sbjct: 1586 PHDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVNEDVLAKKLGDRRELLLSDLVELNAD 1645 236 237Query: 1271 KTDVLERENCEVLPVA-------------INEKSRSFSFEK-------ESKAINGRLIR- 1309 238 E+E V+ ++EK +E+ +KAI ++ 239Sbjct: 1646 WVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERIEIEPPTSTKAITSAILPA 1705 240 241Query: 1310 ----QRSEEYVSHIDSDIGLGVSPCLLLTALTTSNAADGMSLERFETIGDSFLKFATTDY 1365 242 R + V H G SP ++L ALT SNA DG++LER ETIGDSFLK+A T Y 243Sbjct: 1706 GFSFDRQPDLVGHP------GPSPSIILQALTMSNANDGINLERLETIGDSFLKYAITTY 1759 244 245Query: 1366 LYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQLIVANKFDAHDSWLPPCY-IPT- 1423 246 LY T + HEGKLS RSK+V+N NLYRLG++ + + ++A KF+ HD+WLPPCY +P 247Sbjct: 1760 LYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYVPKE 1819 248 249Query: 1424 -----CDFKAPNTDDAEEKDN-EIERILDGQVIEEKPE--NKTGWDIGGDVSKSTTDGIE 1475 250 + K P T + D +I+ + Q+ E E + G + G D 251Sbjct: 1820 LEKALIEAKIP-THHWKLADLLDIKNLSSVQICEMVREKADALGLEQNGGAQNGQLDDSN 1878 252 253Query: 1476 TITFPKQARVGNDDISPLPYNLLTQQHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWM 1535 254 ND +PYNL++Q I DKSIAD VEALIG +L+ GP L M W+ 255Sbjct: 1879 DSC--------NDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIECGPRGALLFMAWL 1930 256 257Query: 1536 GLKVI----QKD---QKSDVPS---PLLRFIDT-----PTNPNASLNFLNNLWQQFQ--- 1577 258 G++V+ Q D Q+ +P P + T PT + L+F N ++ 259Sbjct: 1931 GVRVLPITRQLDGGNQEQRIPGSTKPNAENVVTVYGAWPTPRSPLLHFAPNATEELDQLL 1990 260 261Query: 1578 --FTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGCYQRLEFLGDAVLDYMITRYLFED 1635 262 F + EE +GY+F++R+YL+QA THASY NR+T CYQRLEFLGDAVLDY+ITR+L+ED 263Sbjct: 1991 SGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDCYQRLEFLGDAVLDYLITRHLYED 2050 264 265Query: 1636 SRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYHMIEKFVKLCSERNFDT 1695 266 RQ+SPG LTDLRSALVNNTIFASLAV+ F K F + PGL +I++FV++ E 267Sbjct: 2051 PRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVIDRFVRIQQENG--- 2107 268 269Query: 1696 NFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDSGRNLDTTWQVIFHMMR 1755 270 + +E Y + +EEE D+ ED+EVPKA+GD+FES+AGAI+LDS +LD W V +MM 271Sbjct: 2108 HCISEEYYLLSEEECDDA--EDVEVPKALGDVFESIAGAIFLDSNMSLDVVWHVYSNMMS 2165 272 273Query: 1756 GTIELCCANPPRSPIRELMEFEQSKVRFSKMERILESGKVRVTVEVVNNMRFTGMGRNYR 1815 274 IE + P+SPIREL+E E +F K E++ + +VRVTV+V F G+GRNYR 275Sbjct: 2166 PEIEQFSNSVPKSPIRELLELEPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGRNYR 2225 276 277Query: 1816 IAKATAAKRALKYL 1829 278 IAK TAAK AL+ L 279Sbjct: 2226 IAKCTAAKCALRQL 2239 280 281 Score = 253 (94.1 bits), Expect = 1.5e-232, Sum P(3) = 1.5e-232 282 Identities = 95/376 (25%), Positives = 169/376 (44%) 283 Links = (2)-3-1 284 285Query: 11 FNPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKRAFFVVE 70 286 F PRD+QVELL A ++NTI+ LG S K FIA+ LL+E + G + E 287Sbjct: 15 FTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRARR---HGRVSVYLSCE 71 288 289Query: 71 KVNLVEQQAIHIEV-H-TSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDL 128 290 E +I+ + H T +V Q D + D +HV ++ + L L 291Sbjct: 72 VGTSTEPCSIYTMLTHLTDLRVWQEQP-------DMQIPFDHCWTDYHVSILRPEGFLYL 124 292 293Query: 129 IRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKV 188 294 + L + + +++ ++CH + Q R + ++ + PR+LGL L A 295Sbjct: 125 LETRELLLSSVELIVLEDCHDSAVYQR-IRPLFENHIMPAPPADRPRILGLAGPLHSAGC 183 296 297Query: 189 APEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTVI 248 298 ++L L LE ++ IETASD+V++ +Y ++P+E ++ C FE+ L + D + 299Sbjct: 184 ELQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPFEMDELSLVLADVLN 243 300 301Query: 249 E----IFDETVA--FVNTTTEFHPDL-DL-DPRRPIKDSLKTTRAVFRQLGPWAAWRTAQ 300 302 + D + T +F +L D+ DP+ + + + V ++GPW R A 303Sbjct: 244 THKSFLLDHRYDPYEIYGTDQFMDELKDIPDPKVDPLNVINSLLVVLHEMGPWCTQRAAH 303 304 305Query: 301 VWEKELGKIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKK-----IKSIEALRPYVP 355 306 + + + +K + ++ + T++I + L E + S + + Y 307Sbjct: 304 HFY-QCNEKLKVKTPHERHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIERYSS 362 308 309Query: 356 QRVIRLFEILETFNPE 371 310 +V RL + L F PE 311Sbjct: 363 PKVRRLLQTLRCFKPE 378 312 313 Score = 238 (88.8 bits), Expect = 1.5e-232, Sum P(3) = 1.5e-232 314 Identities = 51/125 (40%), Positives = 76/125 (60%) 315 Links = 2-(3)-1 316 317Query: 382 AEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPDYVVG-ASGRNLASSDSQGLHK 440 318 ++ L A+I+ +Q + A L ++ I +P KF+ Y + +++ H+ 319Sbjct: 490 SDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDRVADPTTEPKEAELEHR 549 320 321Query: 441 RQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDRPLDMRSYVQSKGRARRAGSR 500 322 RQ EVL+RF ++ N LI TSVLEEG+DV +CNLV+++D P RSYVQ KGRAR A + 323Sbjct: 550 RQEEVLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAY 609 324 325Query: 501 YVITV 505 326 +VI V 327Sbjct: 610 HVILV 614 328 329 Score = 44 (20.5 bits), Expect = 4.4e-212, Sum P(3) = 4.4e-212 330 Identities = 10/34 (29%), Positives = 17/34 (50%) 331 Links = 2-(4)-1 332 333Query: 580 RQLHLEGELDDNLLPKGRESIAKLLEHIDEEPDE 613 334 R H + D N L ES ++++ +D+ P E 335Sbjct: 389 RMRHQVDQADFNRLSHTLESKCRMVDQMDQPPTE 422 336 337 338>sp|Q9UPY3.2|DICER_HUMAN RecName: Full=Endoribonuclease Dicer; AltName: 339 Full=Helicase with RNase motif; Short=Helicase MOI 340 Length = 1912 341 342 Score = 2152 (762.6 bits), Expect = 6.4e-223, P = 6.4e-223 343 Identities = 706/2058 (34%), Positives = 1011/2058 (49%) 344 Links = (1) 345 346Query: 11 FNPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKRAFFVVE 70 347 + PR YQVELL+ A NTIV L TGSGKTFIAVLL KE Q+ + GKR F+V 348Sbjct: 32 YTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFSRNGKRTVFLVN 91 349 350Query: 71 KVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLIR 130 351 N V QQ + H+ KVG+ + W +KE+ +Q +H V+++T L++++ 352Sbjct: 92 SANQVAQQVSAVRTHSDLKVGEYSNLEVNASW-TKERWNQEFTKHQVLIMTCYVALNVLK 150 353 354Query: 131 HAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKVAP 190 355 + YL + D+ +L+FDECH A+ HPYR IM KL + PR+LGLTAS++ K P 356Sbjct: 151 NGYLSLSDINLLVFDECHLAI-LDHPYREIM---KLCENCPSCPRILGLTASILNGKCDP 206 357 358Query: 191 EKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTVIEI 250 359 E+L E+++KLE + S ETA+DLV L +Y ++P E+V+ C F G+ ++ ++ 360Sbjct: 207 EELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRS-GL--YERLLME 263 361 362Query: 251 FDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELGKII 310 363 +E + F+N + D K L RAV LGPW A + A + +EL K I 364Sbjct: 264 LEEALNFINDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYI 323 365 366Query: 311 KSQVLPDKTLRFLNMAKTSMITIKRLLEPEM------------KKIKSIEALRPYVPQRV 358 367 K + + +FL T + I L E K IK +E LR Y P 368Sbjct: 324 KHEQ-EELHRKFLLFTDTFLRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYER 382 369 370Query: 359 IRLFEILETFN------------PEFQKERMKLEKAEH------------LSAIIFVDQR 394 371 + FE +E +N E E ++E+ E L IIFV++R 372Sbjct: 383 -QQFESVEWYNNRNQDNYVSWSDSEDDDEDEEIEEKEKPETNFPSPFTNILCGIIFVERR 441 373 374Query: 395 YIAYSLLLMMRHIKSWEPKFKFVNPDYVVGAS-GRNLA-SSDSQGLHKRQTEVLRRFHRN 452 375 Y A L +++ +P+ +++ +++ G G+N + + ++Q EVLR+F + 376Sbjct: 442 YTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEEVLRKFRAH 501 377 378Query: 453 EINCLIATSVLEEGVDVKQCNLVIKFDRPLDMRSYVQSKGRARRAGSRYVITVE------ 506 379 E N LIATS++EEGVD+ +CNLV++FD P + RSYVQSKGRAR S Y++ + 380Sbjct: 502 ETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIMLADTDKIKS 561 381 382Query: 507 -EKD-----------------------------------------------------TAA 512 383 E+D TA 384Sbjct: 562 FEEDLKTYKAIEKILRNKCSKSVDTGETDIDPVMDDDDVFPPYVLRPDDGGPRVTINTAI 621 385 386Query: 513 -----YCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAELLLPINSPIKHAIVLKNPMPNK 567 387 YC++LPSD FT L P + + + T Y + L LPINSP++ +IV PM 388Sbjct: 622 GHINRYCARLPSDPFTHLAPKCRTRELPDG--TFY-STLYLPINSPLRASIV-GPPMSCV 677 389 390Query: 568 KTAQMAVALEACRQLHLEGELDDNLLPKGRESIAKLLEHIDEEPDEYAPGIAAKVGSSKR 627 391 + A+ VAL C +LH GELDD+L+P G+E++ K E +D DE + + GS+KR 392Sbjct: 678 RLAERVVALICCEKLHKIGELDDHLMPVGKETV-KYEEELDLH-DEEETSVPGRPGSTKR 735 393 394Query: 628 KQLYDKKIARALNESFVEADKECFIYAFELERFREAELTLNPKRRKFEDPFNYEYCFGFL 687 395 +Q Y K I L +S+ D+ C++Y + LN +RRK P + CFG L 396Sbjct: 736 RQCYPKAIPECLRDSYPRPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGIL 795 397 398Query: 688 SAKEIPKIPPFPVFLRQGNMKVRLIVAPKKTTVTAAQLQEIQLFHNYLFTQVLQMCKTGN 747 399 +AK IP+IP FPV+ R G + + + + ++ L+ I H Y+F+ +L++ K 400Sbjct: 796 TAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSLQMLELITRLHQYIFSHILRLEKPA- 854 401 402Query: 748 LEFDGTSNAPLNTLIVPLNKRKDDMSYTINMKYVSEVVANMENMPRIPKDEVRRQ--YKF 805 403 LEF T +A ++PLN D + I+ K++ ++ + E IP + ++ + F 404Sbjct: 855 LEFKPT-DADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKS-EARIGIPSTKYTKETPFVF 912 405 406Query: 806 NAEDYKDAIVMPWYRNLEQPVFYYVAEILPEWRPSSKFPDTHFETFNEYFIKKYKLEIYD 865 407 EDY+DA+++P YRN +QP +YVA++ + P SKFP +ETF EY+ KY L++ + 408Sbjct: 913 KLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTN 972 409 410Query: 866 QNQSLLDVDFTSTRLNLLQPRIQNQPRRSRTVSNSSTSNIPQASASDSKESNTSVPHSSQ 925 411 NQ LLDVD TS+RLNLL PR NQ ++ +P +SA K S+ + 412Sbjct: 973 LNQPLLDVDHTSSRLNLLTPRHLNQKGKA----------LPLSSAEKRKAKWESLQN--- 1019 413 414Query: 926 RQILVPELMDIHPISATLWNVIAALPSIFYRVNQLLLTDELRETILVKAFGKEKTKLDDN 985 415 +QILVPEL IHPI A+LW LPSI YR++ LL +ELR +T D 416Sbjct: 1020 KQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRA----------QTASDAG 1069 417 418Query: 986 VEWNSLAYATEYEEKQTIIVKKIQQLRDLNQKSIEDQERETRENDKIDDGEELFNIGVWD 1045 419 V SL Y K I ++ I + END + 420Sbjct: 1070 VGVRSLPADFRYPNLDFGWKKSID-----SKSFISISNSSSAENDNYCKHSTIV------ 1118 421 422Query: 1046 PEEAVRIGVEISSRDDRMDGEDQDTVGLTQGLHDGNISDEDDELPFVMHDYTARLTSNRN 1105 423 PE A G ++R ++ DQ +V L 424Sbjct: 1119 PENAAHQG---ANRTSSLENHDQMSVNCRTLL---------------------------- 1147 425 426Query: 1106 GIGAWSGSESIVPSGWGDWDGPEPDNSPMPFQILGGPGGLNVQALMADVGRVFDPSTASS 1165 427 SES PG L+V+ + AD+ TA + 428Sbjct: 1148 -------SES--------------------------PGKLHVE-VSADL-------TAIN 1166 429 430Query: 1166 SLSQTVQESTVSPPKQLTKEEEQFKKLQNDLLKQAKERLEALEMSEDMEKPRRLEDTVNL 1225 431 LS ++ + L + F Q + L K+ + +P NL 432Sbjct: 1167 GLSYN--QNLANGSYDLANRD--F--CQGNQLNYYKQEIPV--------QPTTSYSIQNL 1212 433 434Query: 1226 EDYGDDQENQEDENTPTNFPKTIDEEIEELSIGARKKQEIDDNAAKTDVLERENCEVLPV 1285 435 Y ENQ P+ DE ++ + K +D NA K+ V+P 436Sbjct: 1213 YSY----ENQ---------PQPSDE----CTLLSNKY--LDGNANKSTSDGSPVMAVMPG 1253 437 438Query: 1286 AINEKSRSFSFEKESKAINGRLIRQRSEEYVSHIDSDIGLGVSPCLLLTALTTSNAADGM 1345 439 + + + GR+ ++S + + S LG +P L+L ALT SNA+DG 440Sbjct: 1254 TTDT----------IQVLKGRMDSEQSPS-IGY--SSRTLGPNPGLILQALTLSNASDGF 1300 441 442Query: 1346 SLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQLIV 1405 443 +LER E +GDSFLK A T YL+ T D HEG+LS+ RSK+VSNCNLYRLGKK G+P +V 444Sbjct: 1301 NLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMV 1360 445 446Query: 1406 ANKFDAHDSWLPPCYIPTCDFKAPNTD--------------------DAEEKDNEIERIL 1445 447 + FD +WLPP Y+ D K+ NTD D EE+D E E ++ 448Sbjct: 1361 VSIFDPPVNWLPPGYVVNQD-KS-NTDKWEKDEMTKDCMLANGKLDEDYEEEDEEEESLM 1418 449 450Query: 1446 ----------DGQVIEEKPENKTGWD-----IGGDVSK------STTDGIETITFPKQAR 1484 451 + +E E+ D G V K STTD PK++ 452Sbjct: 1419 WRAPKEEADYEDDFLEYDQEHIRFIDNMLMGSGAFVKKISLSPFSTTDSAYEWKMPKKSS 1478 453 454Query: 1485 VGN-----------------------------DDI-----SP-------------LPYNL 1497 455 +G+ DD +P + Y+L 456Sbjct: 1479 LGSMPFSSDFEDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDL 1538 457 458Query: 1498 LTQQHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSD-----VP--- 1549 459 T+Q I+DKSIAD VEAL+G +L + G + +GLKV+ +++D P 460Sbjct: 1539 HTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTDREKALCPTRE 1598 461 462Query: 1550 ----------------------SPLLR-----FIDTPT-----NPNASLNFLNNLWQQFQ 1577 463 S +L+ + P +P+A LN+L F+ 464Sbjct: 1599 NFNSQQKNLSVSCAAASVASSRSSVLKDSEYGCLKIPPRCMFDHPDADKT-LNHLISGFE 1657 465 466Query: 1578 FTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGCYQRLEFLGDAVLDYMITRYLFEDSR 1637 467 E+KI YRFK +AYL+QAFTHASY N +T CYQRLEFLGDA+LDY+IT++L+ED R 468Sbjct: 1658 --NFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPR 1715 469 470Query: 1638 QYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYHMIEKFVKLCSERNFDTNF 1697 471 Q+SPGVLTDLRSALVNNTIFASLAVK+++ K+F A+ P L+H+I+ FV+ E+N 472Sbjct: 1716 QHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGM 1775 473 474Query: 1698 NAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDSGRNLDTTWQVIFHMMRGT 1757 475 ++E+ +EE DE +EEDIEVPKAMGDIFES+AGAIY+DSG +L+T WQV + MMR 476Sbjct: 1776 DSELRR--SEE--DEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPL 1831 477 478Query: 1758 IELCCANPPRSPIRELMEFEQSKVRFSKMERILESGKVRVTVEVVNNMRFTGMGRNYRIA 1817 479 IE AN PRSP+REL+E E +FS ER + GKVRVTVEVV +F G+GR+YRIA 480Sbjct: 1832 IEKFSANVPRSPVRELLEMEPETAKFSPAERTYD-GKVRVTVEVVGKGKFKGVGRSYRIA 1890 481 482Query: 1818 KATAAKRALKYLHQIEQQ 1835 483 K+ AA+RAL+ L + Q 484Sbjct: 1891 KSAAARRALRSLKANQPQ 1908 485 486 487>sp|Q8R418.2|DICER_MOUSE RecName: Full=Endoribonuclease Dicer; AltName: 488 Full=Double-strand-specific ribonuclease mDCR-1 489 Length = 1906 490 491 Score = 2120 (751.3 bits), Expect = 1.6e-219, P = 1.6e-219 492 Identities = 698/2050 (34%), Positives = 1005/2050 (49%) 493 Links = (1) 494 495Query: 11 FNPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKRAFFVVE 70 496 + PR YQVELL+ A NTIV L TGSGKTFIAVLL KE Q+ L+ KR F+V 497Sbjct: 32 YTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELAHQIRGDLNPHAKRTVFLVN 91 498 499Query: 71 KVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLIR 130 500 N V QQ + H+ KVG+ + W +KE+ Q +H V+++T L +++ 501Sbjct: 92 SANQVAQQVSAVRTHSDLKVGEYSDLEVNASW-TKERWSQEFTKHQVLIMTCYVALTVLK 150 502 503Query: 131 HAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKVAP 190 504 + YL + D+ +L+FDECH A+ HPYR IM KL + PR+LGLTAS++ K P 505Sbjct: 151 NGYLSLSDINLLVFDECHLAI-LDHPYREIM---KLCESCPSCPRILGLTASILNGKCDP 206 506 507Query: 191 EKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTVIEI 250 508 E+L E+++KLE + S ETA+DLV L +Y ++P E+V+ C F G+ ++ ++ 509Sbjct: 207 EELEEKIQKLERILRSDAETATDLVVLDRYTSQPCEIVVDCGPFTDRS-GL--YERLLME 263 510 511Query: 251 FDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELGKII 310 512 + + F+N + D K L RAV LGPW A + A + +EL K I 513Sbjct: 264 LEAALDFINDCNVAVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYI 323 514 515Query: 311 KSQVLPDKTLRFLNMAKTSMITIKRLLE----P---EMKKI-----KSIEALRPYVPQRV 358 516 K + + +FL T + I L E P ++K + K +E LR Y P 517Sbjct: 324 KHEQ-EELHRKFLLFTDTLLRKIHALCEEYFSPASLDLKYVTPKVMKLLEILRKYKPYER 382 518 519Query: 359 IRLFEILETFNPEFQ---------------KERMKLEKAEH---------LSAIIFVDQR 394 520 + FE +E +N Q +E + EK E L IIFV++R 521Sbjct: 383 -QQFESVEWYNNRNQDNYVSWSDSEDDDDDEEIEEKEKPETNFPSPFTNILCGIIFVERR 441 522 523Query: 395 YIAYSLLLMMRHIKSWEPKFKFVNPDYVVGAS-GRNLA-SSDSQGLHKRQTEVLRRFHRN 452 524 Y A L +++ +P+ +++ +++ G G+N S + ++Q EVLR+F + 525Sbjct: 442 YTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRSKQMEAEFRKQEEVLRKFRAH 501 526 527Query: 453 EINCLIATSVLEEGVDVKQCNLVIKFDRPLDMRSYVQSKGRARRAGSRYVIT-------- 504 528 E N LIATSV+EEGVD+ +CNLV++FD P + RSYVQSKGRAR S YV+ 529Sbjct: 502 ETNLLIATSVVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVMLADTDKIKS 561 530 531Query: 505 ---------------------------------VEEKD-------------------TAA 512 532 V+++D TA 533Sbjct: 562 FEEDLKTYKAIEKILRNKCSKSADGAEADVHAGVDDEDAFPPYVLRPDDGGPRVTINTAI 621 534 535Query: 513 -----YCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAELLLPINSPIKHAIVLKNPMPNK 567 536 YC++LPSD FT L P + + + T Y + L LPINSP++ +IV PM + 537Sbjct: 622 GHINRYCARLPSDPFTHLAPKCRTRELPDG--TFY-STLYLPINSPLRASIV-GPPMDSV 677 538 539Query: 568 KTAQMAVALEACRQLHLEGELDDNLLPKGRESIAKLLEHIDEEPDEYAPGIAAKVGSSKR 627 540 + A+ VAL C +LH GELD++L+P G+E++ K E +D DE + + GS+KR 541Sbjct: 678 RLAERVVALICCEKLHKIGELDEHLMPVGKETV-KYEEELDLH-DEEETSVPGRPGSTKR 735 542 543Query: 628 KQLYDKKIARALNESFVEADKECFIYAFELERFREAELTLNPKRRKFEDPFNYEYCFGFL 687 544 +Q Y K I L ES+ + D+ C++Y + LN +RRK P + CFG L 545Sbjct: 736 RQCYPKAIPECLRESYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGIL 795 546 547Query: 688 SAKEIPKIPPFPVFLRQGNMKVRLIVAPKKTTVTAAQLQEIQLFHNYLFTQVLQMCKTGN 747 548 +AK IP+IP FPV+ R G + + + + T++ L+ I H Y+F+ +L++ K 549Sbjct: 796 TAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSQQMLELITRLHQYIFSHILRLEKPA- 854 550 551Query: 748 LEFDGTSNAPLNTLIVPLNKRKDDMSYTINMKYVSEVVANMENMPRIPKDEVRRQ--YKF 805 552 LEF T A ++PLN D + I+ K++ ++ + E IP + ++ + F 553Sbjct: 855 LEFKPTG-AESAYCVLPLNVVNDSGTLDIDFKFMEDIEKS-EARIGIPSTKYSKETPFVF 912 554 555Query: 806 NAEDYKDAIVMPWYRNLEQPVFYYVAEILPEWRPSSKFPDTHFETFNEYFIKKYKLEIYD 865 556 EDY+DA+++P YRN +QP +YVA++ + P SKFP +ETF EY+ KY L++ + 557Sbjct: 913 KLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTN 972 558 559Query: 866 QNQSLLDVDFTSTRLNLLQPRIQNQPRRSRTVSNSSTSNIPQASASDSKESNTSVPHSSQ 925 560 NQ LLDVD TS+RLNLL PR NQ ++ +P +SA K S+ + 561Sbjct: 973 LNQPLLDVDHTSSRLNLLTPRHLNQKGKA----------LPLSSAEKRKAKWESLQN--- 1019 562 563Query: 926 RQILVPELMDIHPISATLWNVIAALPSIFYRVNQLLLTDELRETILVKAFGKEKTKLDDN 985 564 +QILVPEL IHPI A+LW LPSI YR++ LL +ELR A G L + 565Sbjct: 1020 KQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDA-GVGVRSLPVD 1078 566 567Query: 986 VEWNSLAYATEYEEKQTIIVKKIQQLRDLNQKSIEDQERETRENDKIDDGEELFNIGVWD 1045 568 + +L ++ K++I K + N S+ + + + + + 569Sbjct: 1079 FRYPNL----DFGWKKSIDSKSF--ISTCNS-SLAESDNYCKHSTTVV------------ 1119 570 571Query: 1046 PEEAVRIGVEISSRDDRMDGEDQDTVGLTQGLHDGNISDEDDELPFVMHDYTARLTSNRN 1105 572 PE A G S ++ DQ +V RL 573Sbjct: 1120 PEHAAHQGATRPS----LENHDQMSVNCK------------------------RL----- 1146 574 575Query: 1106 GIGAWSGSESIVPSGWGDWDGPEPDNSPMPFQILGGPGGLNVQALMADVGRVFDPSTASS 1165 576 P SP Q + D+ TA + 577Sbjct: 1147 -----------------------PAESPAKLQ----------SEVSTDL-------TAIN 1166 578 579Query: 1166 SLSQTVQESTVSPPKQLTKEEEQFKKLQNDLLKQAKERLEALEMSEDMEKPRRLEDTVNL 1225 580 LS ++ + L + F Q + L K+ + +P NL 581Sbjct: 1167 GLSYN--KNLANGSYDLVNRD--F--CQGNQLNYFKQEIPV--------QPTTSYPIQNL 1212 582 583Query: 1226 EDYGDDQENQEDENTPTNFPKTIDEEIEELSIGARKKQEIDDNAAKTDVLERENCEVLPV 1285 584 +Y ENQ P+N E LS +D NA + +P 585Sbjct: 1213 YNY----ENQPK---PSN-------ECPLLS-----NTYLDGNANTSTSDGSPAVSTMPA 1253 586 587Query: 1286 AINEKSRSFSFEKESKAINGRLIRQRSEEYVSHIDSDIGLGVSPCLLLTALTTSNAADGM 1345 588 +N KA+ R+ ++S V + S LG +P L+L ALT SNA+DG 589Sbjct: 1254 MMNAV----------KALKDRMDSEQSPS-VGY--SSRTLGPNPGLILQALTLSNASDGF 1300 590 591Query: 1346 SLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQLIV 1405 592 +LER E +GDSFLK A T YL+ T D HEG+LS+ RSK+VSNCNLYRLGKK G+P +V 593Sbjct: 1301 NLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMV 1360 594 595Query: 1406 ANKFDAHDSWLPPCYI----------------------------PTCD------FKAPNT 1431 596 + FD +WLPP Y+ C+ ++AP 597Sbjct: 1361 VSIFDPPVNWLPPGYVVNQDKSNSEKWEKDEMTKDCLLANGKLGEACEEEEDLTWRAPK- 1419 598 599Query: 1432 DDAEEKDNEIE------RILDGQVI---------------------EEKPENK------- 1457 600 ++AE++D+ +E + +D ++ E K K 601Sbjct: 1420 EEAEDEDDFLEYDQEHIQFIDSMLMGSGAFVRKISLSPFSASDSAYEWKMPKKASLGSMP 1479 602 603Query: 1458 ----------TGWDIGG--DVSKSTTDGIETITF--PKQARVGNDD-ISPLPYNLLTQQH 1502 604 + WD D SK+ + + F P + G D + Y+L T+Q 605Sbjct: 1480 FASGLEDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQC 1539 606 607Query: 1503 ISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKV---IQKDQKSDVPSP-------- 1551 608 I+DKSIAD VEAL+G +L + G + +GLKV I++ + P 609Sbjct: 1540 IADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTSREKALDPAQENGSSQ 1599 610 611Query: 1552 ---LLRFIDTPTNPNAS----LNF-------------------LNNLWQQFQFTQLEEKI 1585 612 L P P +S L + LN+L F+ E+KI 613Sbjct: 1600 QKSLSGSCAAPVGPRSSAGKDLEYGCLKIPPRCMFDHPDAEKTLNHLISGFE--TFEKKI 1657 614 615Query: 1586 GYRFKERAYLVQAFTHASYINNRVTGCYQRLEFLGDAVLDYMITRYLFEDSRQYSPGVLT 1645 616 YRFK +AYL+QAFTHASY N +T CYQRLEFLGDA+LDY+IT++L+ED RQ+SPGVLT 617Sbjct: 1658 NYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLT 1717 618 619Query: 1646 DLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYHMIEKFVKLCSERNFDTNFNAEMYMVT 1705 620 DLRSALVNNTIFASLAVK+++ K+F A+ P L+H+I+ FVK E+N ++E+ 621Sbjct: 1718 DLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVKFQLEKNEMQGMDSELRR-- 1775 622 623Query: 1706 TEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDSGRNLDTTWQVIFHMMRGTIELCCANP 1765 624 +EE DE +EEDIEVPKAMGDIFES+AGAIY+DSG +L+ WQV + MM+ IE AN 625Sbjct: 1776 SEE--DEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLEVVWQVYYPMMQPLIEKFSANV 1833 626 627Query: 1766 PRSPIRELMEFEQSKVRFSKMERILESGKVRVTVEVVNNMRFTGMGRNYRIAKATAAKRA 1825 628 PRSP+REL+E E +FS ER + GKVRVTVEVV +F G+GR+YRIAK+ AA+RA 629Sbjct: 1834 PRSPVRELLEMEPETAKFSPAERTYD-GKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRA 1892 630 631Query: 1826 LKYLHQIEQQ 1835 632 L+ L + Q 633Sbjct: 1893 LRSLKANQPQ 1902 634 635 636>sp|P84634.1|DCL4_ARATH RecName: Full=Dicer-like protein 4 637 Length = 1589 638 639 Score = 471 (170.9 bits), Expect = 8.6e-72, Sum P(5) = 8.6e-72 640 Identities = 201/689 (29%), Positives = 323/689 (46%) 641 Links = (1)-4-3-2-5 642 643Query: 14 RDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKRAFFVVEKVN 73 644 R YQVEL KAT++N IV LGTG GKT IAV+L+ E G + +P F+ V 645Sbjct: 125 RRYQVELCKKATEENVIVYLGTGCGKTHIAVMLIYELGHLVLSPKKSV---CIFLAPTVA 181 646 647Query: 74 LVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLIRHAY 133 648 LVEQQA I +FKV +H + S + ++ + + V+V+T Q LL ++H + 649Sbjct: 182 LVEQQAKVIADSVNFKVA-IHCG-GKRIVKSHSEWEREIAANEVLVMTPQILLHNLQHCF 239 650 651Query: 134 LKIEDMCVLIFDECHHALG-SQHPYRSIM-VDYKLLKKDKPVPRVLGLTASLIKAKVAPE 191 652 +K+E + +LIFDECHHA S HPY IM V YK +P R+ G+TAS + K P 653Sbjct: 240 IKMECISLLIFDECHHAQQQSNHPYAEIMKVFYKSESLQRP--RIFGMTASPVVGKDGPP 297 654 655Query: 192 KLMEQLKKLESAMDSVIETASDLVSLSKY-GAKPYEVVIICKDFEIGCLGIPNFDTV-IE 249 656 ++ + S + + SL AK Y V + + G + V + 657Sbjct: 298 --LDSFTYFSGSFQSE-NLSKSINSLENLLNAKVYSV-----ESNVQLDGFVSSPLVKVY 349 658 659Query: 250 IFDETVAFVNTTTEFHPDL--DLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELG 307 660 + ++ + +T + ++ D+ RR L+ A QL V ++ +G 661Sbjct: 350 YYRSALSDASQSTIRYENMLEDIKQRRANVYCLRFLEAAKIQLNS-----DHNVQDEPVG 404 662 663Query: 308 KIIKSQVLPDKTLRFLNMAKTSMIT-IKRLLEPEMKKIKSIEALR-PYVPQRVIRLFEIL 365 664 K KS++ +L+MA ++ + + + + + S+ AL+ P +++++L +IL 665Sbjct: 405 KNPKSKICDT----YLSMAAEALSSGVAK--DENASDLLSLAALKEPLFSRKLVQLIKIL 458 666 667Query: 366 ETFNPEFQKERMKLEKAEHLSAIIFVDQRYIAYSLLLMMRHI---KSWEPKFKFVNPDYV 422 668 F +LE H+ IIFV++ A +L ++ ++ +SW+ D++ 669Sbjct: 459 SVF---------RLEP--HMKCIIFVNRIVTARTLSCILNNLELLRSWKS-------DFL 500 670 671Query: 423 VGASGRNLASSDSQGLHKRQTE-VLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDRP 481 672 VG S S + + +R E +L+RF E+N L+AT V EEG+D++ C LVI++D P 673Sbjct: 501 VGLS------SGLKSMSRRSMETILKRFQSKELNLLVATKVGEEGLDIQTCCLVIRYDLP 554 674 675Query: 482 LDMRSYVQSKGRARRAGSRYVITVE---EKD----------------------------- 509 676 + S++QS+GRAR S Y V+ EK+ 677Sbjct: 555 ETVTSFIQSRGRARMPQSEYAFLVDSGNEKEMDLIENFKVNEDRMNLEITYRSSEETCPR 614 678 679Query: 510 ----------TAA-------------YCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAEL 546 680 T A YCS+LP D F + P Q P++E G T C + 681Sbjct: 615 LDEELYKVHETGACISGGSSISLLYKYCSRLPHDEFFQPKPEFQFKPVDEFGGT-IC-RI 672 682 683Query: 547 LLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELDDNLLPKGRESIAKLLEH 606 684 LP N+PI + + +P+ + A+ L+A +LH G L+D LLP ++ I L 685Sbjct: 673 TLPANAPISE--IESSLLPSTEAAKKDACLKAVHELHNLGVLNDFLLPDSKDEIEDELS- 729 686 687Query: 607 IDEEPDEYAPGIAAKVGSSKRKQLYDKKI 635 688 D+E D I + G S R LY+ ++ 689Sbjct: 730 -DDEFD--FDNIKGE-GCS-RGDLYEMRV 753 690 691 Score = 290 (107.1 bits), Expect = 8.6e-72, Sum P(5) = 8.6e-72 692 Identities = 76/182 (41%), Positives = 99/182 (54%) 693 Links = 1-4-3-(2)-5 694 695Query: 1506 KSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKV-IQKDQKSDVPSPLLRFIDTPTNPNA 1564 696 K+IAD VEAL+G L+ G +K + W+G+ V + Q D R++ T 697Sbjct: 1162 KTIADVVEALVGAFLVDSGFKGAVKFLKWIGVNVDFESLQVQDACIASRRYLPLTTR--- 1218 698 699Query: 1565 SLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGCYQRLEFLGDAVL 1624 700 NNL LE ++ Y+F + LVQAF H SY N GCYQRLEFLGDAVL 701Sbjct: 1219 -----NNL------ETLENQLDYKFLHKGLLVQAFIHPSY-NRHGGGCYQRLEFLGDAVL 1266 702 703Query: 1625 DYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLY-H-MIE 1682 704 DY++T Y F + PG LTDLRS VNN A++AV F K F+ C +Y H +IE 705Sbjct: 1267 DYLMTSYFFTVFPKLKPGQLTDLRSLSVNNEALANVAVSFSL-KRFL-FCESIYLHEVIE 1324 706 707Query: 1683 KF 1684 708 + 709Sbjct: 1325 DY 1326 710 711 Score = 109 (43.4 bits), Expect = 8.6e-72, Sum P(5) = 8.6e-72 712 Identities = 28/59 (47%), Positives = 38/59 (64%) 713 Links = 1-4-(3)-2-5 714 715Query: 1327 VSPCLLLTALTTSNAADGMSLERFETIGDSFLKFATTDYLY--HTLLDQHEGKLSFARS 1383 716 VS +L ALTT + +SLER E +GD+FLKFA + +L+ H LD EG+L+ RS 717Sbjct: 1044 VSGHRVLEALTTEKCHERLSLERLEVLGDAFLKFAVSRHLFLHHDSLD--EGELTRRRS 1100 718 719 Score = 58 (25.5 bits), Expect = 8.6e-72, Sum P(5) = 8.6e-72 720 Identities = 14/42 (33%), Positives = 25/42 (59%) 721 Links = 1-(4)-3-2-5 722 723Query: 931 PEL--MDIHPISATLWNVIAALPSIFYRVNQLLLTDELRETI 970 724 PEL + I +S + + ++ LPSI +R+ LL+ EL+ + 725Sbjct: 993 PELSHLKIKGLSKDIGSSLSLLPSIMHRMENLLVAIELKHVL 1034 726 727 Score = 57 (25.1 bits), Expect = 8.6e-72, Sum P(5) = 8.6e-72 728 Identities = 22/79 (27%), Positives = 33/79 (41%) 729 Links = 1-4-3-2-(5) 730 731Query: 1765 PPRSPIRELMEFEQSKVRFSKMERILESGKVRVTVEVVNN---MRFTGMGRNYRIAKATA 1821 732 P SPI+EL+E QS ++ + G V ++V N + + GRN R A 733Sbjct: 1346 PKISPIKELIELCQSYKWDREISATKKDGAFTVELKVTKNGCCLTVSATGRNKREGTKKA 1405 734 735Query: 1822 AKRALKYLHQIEQQRRQSP 1840 736 A+ + L E P 737Sbjct: 1406 AQLMITNLKAHENITTSHP 1424 738 739 740>sp|Q7S8J7.1|DCL1_NEUCR RecName: Full=Dicer-like protein 1; Includes: RecName: 741 Full=Endoribonuclease dcl-1; Includes: RecName: Full=ATP-dependent 742 helicase dcl-1 743 Length = 1584 744 745 Score = 505 (182.8 bits), Expect = 3.0e-69, Sum P(6) = 3.0e-69 746 Identities = 164/507 (32%), Positives = 269/507 (53%) 747 Links = (1)-4-6-3-2-8 748 749Query: 12 NPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKR--AFFVV 69 750 +PR+YQVEL ++A ++NTI L TGSGKT IA +LL+ ++G R AFF+V 751Sbjct: 121 SPREYQVELFERAKQQNTIAVLDTGSGKTLIAAMLLRWVITGELEDREKGLPRRIAFFLV 180 752 753Query: 70 EKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLI 129 754 +KV LV QQ + + F + ++ G+ G+ +SK + ++++ VVV TA+ L + 755Sbjct: 181 DKVALVFQQHSFLTKNLDFPMEKLCGEMVEGV-ESKAFWKEALEQNEVVVCTAEILSTAL 239 756 757Query: 130 RHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKVA 189 758 H++++++ + +LIFDE HH HPY I+ ++ + ++ + PR+LGLTAS + AKV 759Sbjct: 240 HHSWIRMDQINLLIFDEAHHTK-KDHPYARIIKNFYIDEQLERRPRILGLTASPVDAKVD 298 760 761Query: 190 PEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTVIE 249 762 P + +L E+ + S I TA+D +L KP +++ ++ G P+ +TV+ 763Sbjct: 299 PRRAAAEL---EALLHSQIATAADPAALQHTICKPKTELVV--EY---VRGRPDSETVLN 350 764 765Query: 250 IFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELGKI 309 766 + V F ++P+ TT A + LG W A R Q++ K+ I 767Sbjct: 351 --KQLRKLVGGQELF--------KKPLNF---TTSAASK-LGTWCADRYWQLFFKQ-EDI 395 768 769Query: 310 IKSQVLPDKTLRFLNMAKTSMIT---IKRLLEP-EMKKIKSIE--ALRP-YVPQRVIRLF 362 770 +K + ++ L + +A IT +K++ E E+ + AL P + +VI L 771Sbjct: 396 VKLESRTERDL--MKVAALDEITEKHVKQVREAHELVNAHTFSPAALDPTMLSSKVIMLV 453 772 773Query: 363 EILETFNPEFQKERMKLEKAEHLSAIIFVDQRYIAYSL--LLMMRHIKSWEPKFKFVNPD 420 774 IL +F++ A+ IIFV QR A L LL IKS P + + 775Sbjct: 454 RILRD---QFERG----VGAQR--CIIFVRQRNTAMLLADLLQQPEIKSHIPS---IAAE 501 776 777Query: 421 YVVGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDR 480 778 +VG + +++ ++Q ++R+F EINCL ATSV EEG+D+ CN+VI+FD 779Sbjct: 502 VLVGGGTTGSSYVNAKINFQQQNRIIRKFKLGEINCLFATSVAEEGLDIPDCNIVIRFDL 561 780 781Query: 481 PLDMRSYVQSKGRARRAGSRYVITVEE 507 782 + +QS+GRARR SRY+ +E+ 783Sbjct: 562 YDTLIQCIQSRGRARRPDSRYIQMIEK 588 784 785 Score = 233 (87.1 bits), Expect = 3.0e-69, Sum P(6) = 3.0e-69 786 Identities = 81/263 (30%), Positives = 117/263 (44%) 787 Links = 1-4-6-3-(2)-8 788 789Query: 1500 QQHI-SDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPS--PLLRFI 1556 790 Q+H+ +DKSIAD EALIG LT G M + + KD+K + S 791Sbjct: 1182 QRHVLADKSIADVCEALIGAAYLT-GQEKGSFDMAIKAVTAMVKDKKHRMISYGDYYAVY 1240 792 793Query: 1557 DTPTNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASY--INNRVTGCYQ 1614 794 PT S N Q+ + E++GY+FK L AF H +Y + R+ YQ 795Sbjct: 1241 QKPTWQTESANSA----QRDMAKKFSERMGYKFKHPRLLRAAFQHPTYPSLYERLPS-YQ 1295 796 797Query: 1615 RLEFLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMC 1674 798 RLEFLGDA+ D + YLF P LT+ + A+V+N L+ F K M 799Sbjct: 1296 RLEFLGDALFDMVAVDYLFRKFPAADPQWLTEHKMAMVSNQFLCCLSFHLGFNKCIATMS 1355 800 801Query: 1675 PGLYHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDI----EVPKAMGDIFES 1730 802 P + I ++V E +T + T +E I +PK + D+ E+ 803Sbjct: 1356 PSILKDIAEYVTEIEEA-LETAKQEAINAGKTADEYSRDYWVHITHASRLPKCLSDVVEA 1414 804 805Query: 1731 VAGAIYLDSGRNLDTTWQVIFHM 1753 806 GAI++DS + Q F+M 807Sbjct: 1415 YIGAIFVDSEYDYSVV-QNFFNM 1436 808 809 Score = 109 (43.4 bits), Expect = 3.0e-69, Sum P(6) = 3.0e-69 810 Identities = 49/187 (26%), Positives = 86/187 (45%) 811 Links = 1-4-6-(3)-2-8 812 813Query: 1249 DEEIEELSIGARKKQEIDDNAAKTDVLERENCEVL--PVAINEKSRSFSFEKESKAINGR 1306 814 D+ + E ++ + ++ +DD DV E + C ++ P+ I+ + + + 815Sbjct: 987 DQPVVEAALISTRRDFLDDTLRDEDV-EPQQCFLILEPMRISP----IPADVVAMLLCFP 1041 816 817Query: 1307 LIRQRSEEYVSHIDSD--IGLGVSPCLLLTALTT-SNAAD-----------GM--SLERF 1350 818 I R E + +D+ +GL + P L L A T S+ +D GM + ER 819Sbjct: 1042 SIIHRVESNLVALDACKLLGLDLRPDLALEAFTKDSDNSDEHDAEKENFQTGMGDNYERL 1101 820 821Query: 1351 ETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQLIVANKFD 1410 822 E +GDSFLK ATT +Y + D+ E + R + N NL+ ++G+ + I + F+ 823Sbjct: 1102 EFLGDSFLKMATTIAIYTLIPDKGEFEYHVERMLLICNKNLFNNALEIGLEEYIRSMSFN 1161 824 825Query: 1411 AHDSWLP 1417 826 W P 827Sbjct: 1162 RRQ-WYP 1167 828 829 Score = 69 (29.3 bits), Expect = 3.0e-69, Sum P(6) = 3.0e-69 830 Identities = 28/82 (34%), Positives = 40/82 (48%) 831 Links = 1-(4)-6-3-2-8 832 833Query: 511 AAYCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAELLLPINSPIKHAIVLKNPMPNKKTA 570 834 A + + LP T L P I + G C E+++P SPIK A+ K + +K A 835Sbjct: 659 ANFTATLPHPPETSLSPEYYITTVP-GGFQ--C-EVVMPDASPIKSAVG-KVHL-SKGVA 712 836 837Query: 571 QMAVALEACRQLHLEGELDDNL 592 838 + A A E C L G LD++L 839Sbjct: 713 KCAAAFELCLALLKAGHLDNHL 734 840 841 Score = 65 (27.9 bits), Expect = 1.0e-64, Sum P(6) = 1.0e-64 842 Identities = 21/69 (30%), Positives = 36/69 (52%) 843 Links = 1-4-6-(5)-2-8 844 845Query: 925 QRQILVPELMDIHPISATLWNVIAALPSIFYRV-NQLLLTD-------ELRETILVKAFG 976 846 Q+ L+ E M I PI A + ++ PSI +RV + L+ D +LR + ++AF 847Sbjct: 1015 QQCFLILEPMRISPIPADVVAMLLCFPSIIHRVESNLVALDACKLLGLDLRPDLALEAFT 1074 848 849Query: 977 KEKTKLDDN 985 850 K+ D++ 851Sbjct: 1075 KDSDNSDEH 1083 852 853 Score = 49 (22.3 bits), Expect = 3.0e-69, Sum P(6) = 3.0e-69 854 Identities = 44/220 (20%), Positives = 84/220 (38%) 855 Links = 1-4-(6)-3-2-8 856 857Query: 687 LSAKEIPKIPPFPVFLRQGNM-KVRLIVAPKKTTVTAAQLQEIQLFHNYLFTQVLQMCKT 745 858 LS +P++ FP+F KVR + P ++++ F F V 859Sbjct: 801 LSRSALPEVASFPLFFGTKRFSKVRCVPIPGSVQADDTLVEQLTRFTLKAFMDVFSK--- 857 860 861Query: 746 GNLEFDGTS-NAPLNTLIVPLN-------KRKDDMSYTINMKYVSEVVANMENMPR--IP 795 862 E++ T+ N P + P++ + ++ I+ K ++ V N E +P + 863Sbjct: 858 ---EYEATAVNLPY--FLSPMDGGHGFDFRLAKSPAHLIDRKALAYVSEN-EKVPYTFLE 911 864 865Query: 796 KDEVRRQYKFNAEDYKDAI-VMPWYRNLEQPVFYYVAE--ILPEWRPSSKFPDTH--FET 850 866 D+ Q KF + Y A +R + V + + P R TH 867Sbjct: 912 PDDFF-QDKFVVDPYDGARKFFTHHRRHDMKPTDPVPDGIVAPNHRAWRGLGTTHDILNY 970 868 869Query: 851 FNEYFIKKYKLEIYDQNQSLLDVDFTSTRLNLLQPRIQNQ 890 870 N + K I+ +Q +++ STR + L ++++ 871Sbjct: 971 SNSLWSKSRGFMIFQADQPVVEAALISTRRDFLDDTLRDE 1010 872 873 Score = 45 (20.9 bits), Expect = 4.1e-60, Sum P(4) = 4.1e-60 874 Identities = 25/88 (28%), Positives = 41/88 (46%) 875 Links = 1-(7)-2-8 876 877Query: 535 EENGVTKYCAELLLPIN-SPIKH---AIVLKNPMPNKKTAQMAVALEACRQLHLEGELDD 590 878 +E+ + C +L P+ SPI A++L P + VAL+AC+ L L+ D 879Sbjct: 1009 DEDVEPQQCFLILEPMRISPIPADVVAMLLCFPSIIHRVESNLVALDACKLLGLDLRPDL 1068 880 881Query: 591 NLLPKGRESIAKLLEHIDEEPDEYAPGI 618 882 L ++S EH D E + + G+ 883Sbjct: 1069 ALEAFTKDS-DNSDEH-DAEKENFQTGM 1094 884 885 Score = 40 (19.1 bits), Expect = 3.0e-69, Sum P(6) = 3.0e-69 886 Identities = 10/26 (38%), Positives = 16/26 (61%) 887 Links = 1-4-6-3-2-(8) 888 889Query: 1815 RIAKATAAKRALKYLH--QIEQQRRQ 1838 890 R AK+ AK+A+K L +E+ R + 891Sbjct: 1529 RYAKSAMAKKAIKLLEGMSVEEFRER 1554 892 893 894>sp|A4RKC3.2|DCL1_MAGGR RecName: Full=Dicer-like protein 1; Includes: RecName: 895 Full=Endoribonuclease DCL1; Includes: RecName: Full=ATP-dependent 896 helicase DCL1 897 Length = 1591 898 899 Score = 481 (174.4 bits), Expect = 3.5e-69, Sum P(6) = 3.5e-69 900 Identities = 152/502 (30%), Positives = 238/502 (47%) 901 Links = (1)-4-5-7-3-2 902 903Query: 13 PRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEY-GVQLFAPLDQGGKR-AFFVVE 70 904 PR+YQ+EL ++A +KNTI L TG+GKT IA+LL++ ++L A KR FF+V+ 905Sbjct: 108 PREYQIELFERAKQKNTIAVLDTGTGKTLIAILLIRHIIELELGARWQGREKRITFFLVD 167 906 907Query: 71 KVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLIR 130 908 KV LV QQ HI + F V +HG T LW SKE ++ ++ VVV TA+ L + 909Sbjct: 168 KVALVRQQTDHIRANLDFPVTGLHGDTVRNLWYSKEYFEKLLQEQEVVVCTAEILYRCLH 227 910 911Query: 131 HAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKD-KPVPRVLGLTASLIKAKVA 189 912 +YL I + +++FDE HHA H Y I+ D+ L+++D + PR+ G+TAS I K 913Sbjct: 228 RSYLNISQVSLVVFDEAHHAK-KNHVYARIIKDFYLMEEDCQKRPRIFGMTASPIDTKDT 286 914 915Query: 190 PEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTVIE 249 916 +LES + S I T SD L G++P EV ++ V+ 917Sbjct: 287 CISYERATHELESLLHSEIATISDRDLLKVIGSRPQEVR-------------KSYARVLR 333 918 919Query: 250 IFDETVAFVNTTTEFHPDLDLDPRRPI-KDSLKTTRAVFRQLGPWAAWRTAQV-WEKELG 307 920 E N E L P+ K + + +LG W A + ++ + +E 921Sbjct: 334 --QENTELCNQLRE------LVGNHPLFKQTFDSAEFAVTELGAWCADKLWELCFREEAV 385 922 923Query: 308 KIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVIRLFEILET 367 924 + +V + R + S + E + ++ P + +++E 925Sbjct: 386 STLDGRVEGSRA-RDPDEVGESSHEVSNAREA-LSLVQQWSFSPPEDGSLSTKTHKLIEI 443 926 927Query: 368 FNPEFQKERMKLEKAEHLSAIIFVDQRYIAYSL--LLMMRHIKSWEPKFKFVNPDYVVGA 425 928 F + + I+FV +R A L L I++ P K +++GA 929Sbjct: 444 LAECFSQA----SAGNAIQCIVFVKRRDTAVLLNALCEQAEIRTKIPDLKGA---FLIGA 496 930 931Query: 426 S-GRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDRPLDM 484 932 G N A + + ++Q + + RF EINCL ATS+ EEG+D+ CN+VI+FD 933Sbjct: 497 GRGGNAAFTTT----RQQEQTVSRFRDGEINCLFATSIAEEGLDIPGCNVVIRFDLHGTT 552 934 935Query: 485 RSYVQSKGRARRAGSRYVITVE 506 936 Y+QS+GRAR S ++ E 937Sbjct: 553 IQYIQSRGRARMRNSWFIHMTE 574 938 939 Score = 251 (93.4 bits), Expect = 3.5e-69, Sum P(6) = 3.5e-69 940 Identities = 83/256 (32%), Positives = 125/256 (48%) 941 Links = 1-4-5-7-3-(2) 942 943Query: 1501 QH-ISDKSIADAVEALIGVHLLTL----GPN-----PTLKVMNWMGLKVIQ--KDQKSDV 1548 944 +H + DKSIAD EALIG LT PN + VM +Q D + 945Sbjct: 1166 EHALGDKSIADVCEALIGAAYLTAQAQSSPNFDLAVKAVTVMTHSKTHTMQAWSDYYASY 1225 946 947Query: 1549 PSPLLRFIDTPTNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNR 1608 948 P ++ TP P+ + Q +Q++ K+GYRFK L AF H SY 949Sbjct: 1226 QCP--EWLSTP--PSQT--------QLELCSQIKNKMGYRFKNPRLLRCAFMHPSYPRQY 1273 950 951Query: 1609 VT-GCYQRLEFLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQ 1667 952 YQRLEFLGD++LD + YLF+ P LT+ + A+V+N F +AV F 953Sbjct: 1274 ENIPSYQRLEFLGDSLLDMVCVDYLFKKHPDKDPQWLTEHKMAMVSNQFFGCVAVGLGFH 1333 954 955Query: 1668 KHFIAMCPGLYHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEV---PKAM 1724 956 +H I M P L I ++ +L +++ + ++ + + E D ++ IEV PK + 957Sbjct: 1334 RHLIHMQPALGGSITEWAELVTKKREEAR---QLAVRRGQREEDYARDFWIEVHHPPKCL 1390 958 959Query: 1725 GDIFESVAGAIYLDSG 1740 960 DI E+ GA+++D+G 961Sbjct: 1391 PDILEAYVGALFVDTG 1406 962 963 Score = 99 (39.9 bits), Expect = 3.5e-69, Sum P(6) = 3.5e-69 964 Identities = 25/75 (33%), Positives = 39/75 (52%) 965 Links = 1-4-5-7-(3)-2 966 967Query: 1344 GMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQL 1403 968 G + ER E +GD FLK AT+ LY TL++ E + R ++ N NL + + + 969Sbjct: 1079 GQNYERLEFLGDCFLKMATSIALY-TLVEGDEFEYHVERMLDICNKNLLNWALESNLQEH 1137 970 971Query: 1404 IVANKFDAHDSWLPP 1418 972 I + F+ +W PP 973Sbjct: 1138 IRSKSFNRR-TWYPP 1151 974 975 Score = 70 (29.7 bits), Expect = 3.5e-69, Sum P(6) = 3.5e-69 976 Identities = 20/60 (33%), Positives = 34/60 (56%) 977 Links = 1-(4)-5-7-3-2 978 979Query: 545 ELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELDDNLLPKGRESIAKLL 604 980 E+ LP +SP++ A + +K+ A+ A A C QL+ LDD+L + ++AK+L 981Sbjct: 674 EVYLPASSPLRSA--MGGVYRSKQLAKCAAAYAMCIQLYNSNYLDDHL----KSTLAKVL 727 982 983 Score = 65 (27.9 bits), Expect = 3.5e-69, Sum P(6) = 3.5e-69 984 Identities = 35/168 (20%), Positives = 70/168 (41%) 985 Links = 1-4-(5)-7-3-2 986 987Query: 687 LSAKEIPKIPPFPVFLRQGNMK---VRLIVAPKKTTVTAAQLQEIQLFHNYLFTQVLQMC 743 988 L+ K +P+I FP+F +G+ + VR I + T Q++ I F +F + 989Sbjct: 786 LTRKPLPEIAQFPLFFGKGSSRRSNVRCIPLAHPWSPTTTQVEGICAFTLCIFRDIFSK- 844 990 991Query: 744 KTGNLEFDGTSNAPLNTLIVPLN--KRKDDMSYTINMKYVSE--VVANMENMPRIPKDEV 799 992 + + GT + P + P + D+S +N + + + V R+P 993Sbjct: 845 ---DFQASGT-DMPY--FLAPSTGIEHGTDLSSLVNPERIIDWATVHRTTTTDRVP---- 894 994 995Query: 800 RRQYKFNAED--YKDAIVMPWYRNLEQPVFYYVAEILPEWRPSSKFPD 845 996 Y FN D ++D V + + +++ ++ + +P K P+ 997Sbjct: 895 ---YNFNEPDEFFQDKYVSDPFDGSRK---FFMRKVRRDLKPQDKVPE 936 998 999 Score = 51 (23.0 bits), Expect = 3.9e-66, Sum P(4) = 3.9e-66 1000 Identities = 33/139 (23%), Positives = 58/139 (41%) 1001 Links = 1-(6)-3-2 1002 1003Query: 490 SKGRA-RRAGSRYVITVEEKDTAAYCSKLPSDIF-TRLVPHNQIIPIEENGV------TK 541 1004 SK RA Y +++ +K A + S+ + L P + + E +G T 1005Sbjct: 942 SKWRAVEHTILNYSVSLWKKSRAGHNSRQDQPVVEAELAPLRRNLLDETDGENSTGPQTC 1001 1006 1007Query: 542 YCA-ELLLPINSPIKHAIVLKN-PMPNKKTAQMAVALEACRQLHLEGELDDNLLPKGRES 599 1008 Y E LL P+ ++ P + ++LEAC+ L L+ +D L+ ++S 1009Sbjct: 1002 YLVLETLLISQIPVDTVVMAYTFPAIIYRLENSLISLEACQNLGLDIPIDIALIAMTKDS 1061 1010 1011Query: 600 IAKLLEHIDEEPDEYAPGI 618 1012 +H DE P + G+ 1013Sbjct: 1062 -DNSDDH-DEAPINFQSGM 1078 1014 1015 Score = 40 (19.1 bits), Expect = 3.5e-69, Sum P(6) = 3.5e-69 1016 Identities = 8/26 (30%), Positives = 13/26 (50%) 1017 Links = 1-4-5-(7)-3-2 1018 1019Query: 1231 DQENQED-ENTPTNFPKTIDEEIEEL 1255 1020 D +N +D + P NF + + E L 1021Sbjct: 1060 DSDNSDDHDEAPINFQSGMGQNYERL 1085 1022 1023 1024>sp|Q0CW42.2|DCL1_ASPTN RecName: Full=Dicer-like protein 1; Includes: RecName: 1025 Full=Endoribonuclease dcl1; Includes: RecName: Full=ATP-dependent 1026 helicase dcl1 1027 Length = 1519 1028 1029 Score = 464 (168.4 bits), Expect = 4.8e-65, Sum P(6) = 4.8e-65 1030 Identities = 159/512 (31%), Positives = 242/512 (47%) 1031 Links = (1)-4-5-9-3-2 1032 1033Query: 12 NPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEY-GVQLFAPLDQGGKR-AFFVV 69 1034 NPR+YQ+EL ++A +NTI L TGSGKT IAVLLLK +L + R +FF+V 1035Sbjct: 108 NPREYQIELFERAKVQNTIAVLDTGSGKTLIAVLLLKHVIQTELIDRANGNPPRISFFLV 167 1036 1037Query: 70 EKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLI 129 1038 + V LV QQA + + V G LW+ + + F K + V+V TA+ L + 1039Sbjct: 168 DSVTLVYQQASVLRNNLDQNVAHFFGAMGVDLWNKQTWAEHFEK-NMVIVCTAEILNQCL 226 1040 1041Query: 130 RHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKVA 189 1042 +AY+ ++ + +L+FDE HH HPY I+ D L PR+ G+TAS + K 1043Sbjct: 227 LNAYITMQQINLLVFDEAHHTK-KDHPYARIIRDSYLRVPPSSRPRIFGMTASPVDTK-- 283 1044 1045Query: 190 PEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTVIE 249 1046 ++E + LE+ +DS I T S L L + +P E V I + P F + + 1047Sbjct: 284 -GDVLEAARNLEALLDSKIATTSKLTILRQVVNRPNEEVWIYDKLQ------PTFTSDLY 336 1048 1049Query: 250 IFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELGKI 309 1050 E+ F L+P + R +LG W A R VW L 1051Sbjct: 337 KLMES--------RFGDISHLEPM------FRFARHATSELGTWCADR---VWVSALADD 379 1052 1053Query: 310 IKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVIRLFEILETFN 369 1054 + +V + ++ + T + + + + ++ +IK L P E L + 1055Sbjct: 380 VLPKV--EGSIGGKRQS-TGLGQLPKDVHRDITRIKEASELVESHPPNDPGAPEALSSKV 436 1056 1057Query: 370 PEFQKERMKLEKAE-HLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPDYVVGASGR 428 1058 KE + E + I+F ++RY A L + + P + P ++G 1059Sbjct: 437 RVLWKEISQCFGQETNTKCIVFTEKRYTAKVLFDLFTVLNV--PGLR---PGVLIG---- 487 1060 1061Query: 429 NLASSDSQGLH---KRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDRPLDMR 485 1062 + SSD G++ ++Q + RF EINCL AT+V EEG+D+ CNLV++FD + 1063Sbjct: 488 -VRSSDRIGMNVTFRQQILTMVRFRTGEINCLFATAVAEEGLDIPDCNLVVRFDLYKTLI 546 1064 1065Query: 486 SYVQSKGRARRAGSRYVITVEEKDTAAYCSKL 517 1066 YVQS+GRAR A S Y +E KD A + S L 1067Sbjct: 547 QYVQSRGRARHADSTYASMIE-KDNADHESIL 577 1068 1069 Score = 208 (78.3 bits), Expect = 4.8e-65, Sum P(6) = 4.8e-65 1070 Identities = 91/350 (26%), Positives = 148/350 (42%) 1071 Links = 1-4-5-9-3-(2) 1072 1073Query: 1503 ISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQK--DQKSDVPSPLLRFIDTPT 1560 1074 +++K+IAD EALIG LLT GP MG++ + D + +I + 1075Sbjct: 1163 LAEKTIADVCEALIGAALLTPGPQHRFD----MGVRAVSAVVDSNEHNAASWRDYISLYS 1218 1076 1077Query: 1561 NPNASLNFLNNLWQQFQFTQ-LEEKIGYRFKERAYLVQAFTHASYINN--RVTGCYQRLE 1617 1078 P + + + +EEK+GY F+ L AFTH SY + RV CYQ LE 1079Sbjct: 1219 IPKYQEQAPDG--SEIDLCRRVEEKLGYHFRYPRLLHSAFTHPSYPSAWARVP-CYQSLE 1275 1080 1081Query: 1618 FLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGL 1677 1082 FLGDA+LD + LF P LT+ + A+V+N +LAVK H L 1083Sbjct: 1276 FLGDALLDMVCVEDLFRRFPDRDPQWLTEHKMAMVSNKFLGALAVKLGLHTHLSYFSSAL 1335 1084 1085Query: 1678 YHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKA-MGDIFESVAGAIY 1736 1086 I + + ++ + + +T + PK + D+ E+ GA++ 1087Sbjct: 1336 QSQITHYAEEAQAAASQSDVAVDYWTLTQDP------------PKVCLPDMVEAYLGAVF 1383 1088 1089Query: 1737 LDSG---RNLDTTWQV----IFHMMRGTIELCCANPPRSPIRELMEFEQSKVRFS-KMER 1788 1090 +DS ++ +Q FH M + P + + + E + + K 1091Sbjct: 1384 VDSNFRFEEVEVFFQQHIKPYFHDM-AIYDTFANRHPTTFLHNKLTNEYGCLNYCLKAGE 1442 1092 1093Query: 1789 IL----ESGKVRVTVEVVNNMRFTGMGRNYRIAKATAAKRALKYLHQIEQ 1834 1094 I ++ V V V + + TG+ + R AK A++ AL L I++ 1095Sbjct: 1443 IPGADGDASTVLAAVIVHDTILTTGVASSGRYAKVKASENALTELLHIDR 1492 1096 1097 Score = 94 (38.1 bits), Expect = 4.8e-65, Sum P(6) = 4.8e-65 1098 Identities = 25/74 (33%), Positives = 37/74 (50%) 1099 Links = 1-4-5-9-(3)-2 1100 1101Query: 1344 GMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQL 1403 1102 G + ER E +GD FLK AT+ L++ D +E R + N NL+ K + Q 1103Sbjct: 1068 GKNYERLEFLGDCFLKMATSISLFNQHPDDNEFDYHVNRMCLICNRNLFNSAVKKELYQF 1127 1104 1105Query: 1404 IVANKFDAHDSWLP 1417 1106 I + F + D+W P 1107Sbjct: 1128 IRSRGF-SRDTWYP 1140 1108 1109 Score = 85 (35.0 bits), Expect = 4.8e-65, Sum P(6) = 4.8e-65 1110 Identities = 27/82 (32%), Positives = 38/82 (46%) 1111 Links = 1-(4)-5-9-3-2 1112 1113Query: 511 AAYCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAELLLPINSPIKHAIVLKNPMPNKKTA 570 1114 A Y S L + T ++P+ + Y E++LP SPI+ A + P K TA 1115Sbjct: 639 ARYASSLQYENDTSAQVTYVVLPVND----AYVCEVILPEKSPIRGATGM--PAMKKSTA 692 1116 1117Query: 571 QMAVALEACRQLHLEGELDDNL 592 1118 + A EACR L LD+ L 1119Sbjct: 693 KRYAAFEACRLLRKHRLLDEYL 714 1120 1121 Score = 76 (31.8 bits), Expect = 4.8e-65, Sum P(6) = 4.8e-65 1122 Identities = 50/220 (22%), Positives = 88/220 (40%) 1123 Links = 1-4-(5)-9-3-2 1124 1125Query: 692 IPKIPPFPVFLRQGNMKVRLIVAPKKTTV--TAAQLQEIQLFHNYLFTQVLQMCKTGNLE 749 1126 +P+ P FP+FL + +++ ++ P + +A +L + F +F V + KT + E 1127Sbjct: 788 LPQFPTFPIFLGE-DVETIVLTVPVNMELQPSADELDYMTTFTLRIFRDVFR--KTYDKE 844 1128 1129Query: 750 FDGTSNAPLNTLIVPLNKRKDDMSYTINMKYVSEVVANMENMPRIPKDEVRRQYKFNAED 809 1130 + L + P N+ D +N + +S V +D++ Q E 1131Sbjct: 845 PEKLPYWLLPAISFPCNQEADPRD-VVNWEILSSVHE---------RDDIEYQADMPPEM 894 1132 1133Query: 810 YKDAIVMPWYRNLEQPVFYYVAEILPEWRPSSKFPD-----THFETFNEYFIKKYK---- 860 1134 D V Y + + Y+ + +PSS P H +T Y I K 1135Sbjct: 895 LVDRFV---YDHWDGRYRYFTLAVDENLQPSSPPPSHVARRRHMDTIMNYSISLSKNSRA 951 1136 1137Query: 861 --LEIYDQNQSLLDVDFTSTRLNLLQPRIQNQPRRSRTVS 898 1138 L + NQ +L + R NLL R+ ++ R+ T S 1139Sbjct: 952 KFLSRCNWNQPVLHAELVRLRRNLLD-RMTDKERKLETRS 990 1140 1141 Score = 49 (22.3 bits), Expect = 3.5e-58, Sum P(5) = 3.5e-58 1142 Identities = 20/74 (27%), Positives = 31/74 (41%) 1143 Links = 1-(6)-10-3-2 1144 1145Query: 1028 ENDKIDDGEELFNIGVWDPEEAVRIGVEISSRDDRMDGEDQDTVGLTQGLHDGNISDEDD 1087 1146 E D D E + V D E+ ++ ++ D + G D DT D + E+ 1147Sbjct: 567 EKDNAD--HESILVQVNDAEKIMQSFCQLLPEDRILHGNDDDT--------DAVLDREEW 616 1148 1149Query: 1088 ELPFVMHDYTARLT 1101 1150 E P+ + ARLT 1151Sbjct: 617 EEPYTLPSTAARLT 630 1152 1153 Score = 41 (19.5 bits), Expect = 2.2e-58, Sum P(4) = 2.2e-58 1154 Identities = 8/16 (50%), Positives = 12/16 (75%) 1155 Links = 1-(7)-3-2 1156 1157Query: 574 VALEACRQLHLEGELD 589 1158 + LEAC++L LE L+ 1159Sbjct: 1025 IGLEACKKLGLEISLE 1040 1160 1161 Score = 39 (18.8 bits), Expect = 3.8e-57, Sum P(5) = 3.8e-57 1162 Identities = 15/79 (18%), Positives = 35/79 (44%) 1163 Links = 1-(8)-9-3-2 1164 1165Query: 729 QLFHNYLFTQVLQMCKTGNLEFDGTSNAPLNTLIVPLNKRKDDMSYTINMKYVSEVVANM 788 1166 +L H+ T + + + L+++ ++A + +++P+N D + + S + 1167Sbjct: 628 RLTHHSAITVLARYASS--LQYENDTSAQVTYVVLPVN---DAYVCEVILPEKSPI-RGA 681 1168 1169Query: 789 ENMPRIPKDEVRRQYKFNA 807 1170 MP + K +R F A 1171Sbjct: 682 TGMPAMKKSTAKRYAAFEA 700 1172 1173 Score = 38 (18.4 bits), Expect = 4.8e-65, Sum P(6) = 4.8e-65 1174 Identities = 10/37 (27%), Positives = 18/37 (48%) 1175 Links = 1-4-5-(9)-3-2 1176 1177Query: 926 RQILVPELMDIHPISATLWNVIAALPSIFYRVNQLLL 962 1178 R ++ E + I I A + A P+I R++ L+ 1179Sbjct: 989 RSVICIEPLKISAIPAAIAATCLAFPAIISRLDAYLI 1025 1180 1181 Score = 38 (18.4 bits), Expect = 6.7e-62, Sum P(5) = 6.7e-62 1182 Identities = 9/35 (25%), Positives = 18/35 (51%) 1183 Links = 1-4-(10)-3-2 1184 1185Query: 1241 PTNFPKTIDEEIEELSIGARKKQEIDDNAAKTDVL 1275 1186 PT FP + E++E + + E+ +A + D + 1187Sbjct: 792 PT-FPIFLGEDVETIVLTVPVNMELQPSADELDYM 825 1188 1189 1190>sp|Q1DKI1.2|DCL1_COCIM RecName: Full=Dicer-like protein 1; Includes: RecName: 1191 Full=Endoribonuclease DCL1; Includes: RecName: Full=ATP-dependent 1192 helicase DCL1 1193 Length = 1464 1194 1195 Score = 498 (180.4 bits), Expect = 8.4e-64, Sum P(6) = 8.4e-64 1196 Identities = 159/507 (31%), Positives = 260/507 (51%) 1197 Links = (1)-3-5-8-4-2 1198 1199Query: 12 NPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKR----AFF 67 1200 +PR+YQVEL +KA K N I L TGSGKT IAVLLLK Q +D+ ++ +FF 1201Sbjct: 98 DPREYQVELFEKAKKDNIIAVLDTGSGKTLIAVLLLKHIIEQEL--IDRSAEKPHRVSFF 155 1202 1203Query: 68 VVEKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLD 127 1204 +V+ V LV QQA ++ + + +V + G + LW+ E ++ + ++ V+V TA+ L 1205Sbjct: 156 LVDSVTLVFQQAAVLQNNINQRVDKFCGAMETDLWNG-ETWERHLAKNMVIVCTAEVLYQ 214 1206 1207Query: 128 LIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAK 187 1208 + HA++K+E++ +LIFDE H+A HPY I+ D+ L + P++ G+TAS + AK 1209Sbjct: 215 CLLHAFVKMENINLLIFDEAHNAK-KDHPYARIVKDFYLKDGNAKRPKIFGMTASPVDAK 273 1210 1211Query: 188 VAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTV 247 1212 + +++ + LE+ ++S I TAS+L L + +P E V ++D + 1213Sbjct: 274 M---DVVKAARNLETLLNSQIATASNLSLLRQSVPRPNEEVW-------------SYDRL 317 1214 1215Query: 248 IEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAA-WRTAQVWEKEL 306 1216 + F ET + + F DL R ++ + LG W A W VW L 1217Sbjct: 318 DQPF-ETRLYKELRSRFG-DL-----RALEKLFTFSLKASSNLGAWCADW----VWSYAL 366 1218 1219Query: 307 GKIIKSQVLPDKTLRFLNMAKTSM--ITIKRLLEPE--MKKIKSI-EALRPY-VPQRVIR 360 1220 + + LP R A+T+M + I +++ PE +++I+ E +R + +R 1221Sbjct: 367 TE----ESLPKLEGR---AARTAMGNLPIAKIVRPEAEIQRIREASEIIRSHKFGDPAVR 419 1222 1223Query: 361 LFEILETFNPEFQKERMK-LEKAEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNP 419 1224 E+L E +K E+ I+F +QR+ A L + I + K + P 1225Sbjct: 420 P-ELLSPKVRRLHHELLKYFERHTDTKCIVFTEQRHTARILCDLFSRIGT-----KHLRP 473 1226 1227Query: 420 DYVVGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFD 479 1228 ++G R+ AS ++Q + F + E+NCL ATSV EEG+D+ CNL+++FD 1229Sbjct: 474 GVLIGV--RSDASGGMNISFRQQVLAVVSFRKGEVNCLFATSVAEEGLDIPDCNLIVRFD 531 1230 1231Query: 480 RPLDMRSYVQSKGRARRAGSRYVITVE 506 1232 + Y+QS+GRAR S + VE 1233Sbjct: 532 LASTLTQYIQSRGRARHMNSTFAHLVE 558 1234 1235 Score = 218 (81.8 bits), Expect = 8.4e-64, Sum P(6) = 8.4e-64 1236 Identities = 68/241 (28%), Positives = 108/241 (44%) 1237 Links = 1-3-5-8-4-(2) 1238 1239Query: 1503 ISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVP-SPLLRFIDTPTN 1561 1240 ++DK+IAD EALIG L N + ++ D + + R P 1241Sbjct: 1115 LADKTIADVCEALIGACCLLASKNHRFDIAVKAVTALVSSDDHNVLNWEQYSRLYSIPKY 1174 1242 1243Query: 1562 PNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINN--RVTGCYQRLEFL 1619 1244 A ++ + Q+++K+GY FK L AFTH SY + RV CYQRLEFL 1245Sbjct: 1175 QTAVVDAA----ELDLAAQVKKKLGYDFKYPKLLRSAFTHPSYPSAWARVP-CYQRLEFL 1229 1246 1247Query: 1620 GDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYH 1679 1248 GDA+LD +++ P LT+ + A+V+N S+AV+ H L 1249Sbjct: 1230 GDALLDMACVEHIYHKHPDKDPQWLTEHKMAMVSNKFLGSVAVRLGLHSHLNHFSTSLQS 1289 1250 1251Query: 1680 MIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDS 1739 1252 I +V+ ++ + + +T++ PK + D+ E+ GAI++DS 1253Sbjct: 1290 QITNYVEEIEAAELESGDPPDAWTLTSDP------------PKCLPDMVEAYIGAIFIDS 1337 1254 1255Query: 1740 G 1740 1256 G 1257Sbjct: 1338 G 1338 1258 1259 Score = 75 (31.5 bits), Expect = 8.4e-64, Sum P(6) = 8.4e-64 1260 Identities = 20/52 (38%), Positives = 28/52 (53%) 1261 Links = 1-(3)-5-8-4-2 1262 1263Query: 542 YCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELDDNLL 593 1264 + E++LP SPI+ IV K P K A+ + A E C L G LDD+ + 1265Sbjct: 655 FVCEVVLPEKSPIR-GIVGK-PASKKLIAKQSAAFETCLLLRKHGLLDDHFV 704 1266 1267 Score = 66 (28.3 bits), Expect = 8.4e-64, Sum P(6) = 8.4e-64 1268 Identities = 28/84 (33%), Positives = 40/84 (47%) 1269 Links = 1-3-5-8-(4)-2 1270 1271Query: 1308 IRQRSEEYVSHIDS--DIGLGVSPCLLLTALTT-SNAAD-------------GMSLERFE 1351 1272 I R E Y+ +++ ++ L +SP L L ALT S+ D G + ER E 1273Sbjct: 1005 IISRIESYLIALEACQELDLPISPELALEALTKDSDNTDEHRAQQIHFQRGMGKNYERLE 1064 1274 1275Query: 1352 TIGDSFLKFATTDYLYHTLLDQHE 1375 1276 +GD FLK AT+ L+ D E 1277Sbjct: 1065 FLGDCFLKMATSISLFAMNPDNDE 1088 1278 1279 Score = 55 (24.4 bits), Expect = 8.4e-64, Sum P(6) = 8.4e-64 1280 Identities = 44/218 (20%), Positives = 88/218 (40%) 1281 Links = 1-3-(5)-8-4-2 1282 1283Query: 687 LSAKEIPKIPPFPVFLRQGNMKVRLIVAPKKT--TVTAAQLQEIQLFHNYLFTQVLQMCK 744 1284 L+ +++P P FP++L + +++ +I + + V++ L+ + F +F + 1285Sbjct: 772 LTREKLPHFPEFPLYL-EDDIECDVICSSISSGFQVSSHDLEVLTTFTLRIFQDIFHKVY 830 1286 1287Query: 745 TGNLEFDGTSNAPLN-TLIVPLNKRKDDMSYTINMKYVSEVVANMENMPRIPKDEVRRQY 803 1288 ++ APLN + + + +D + + I +++V +N P IP 1289Sbjct: 831 DRDVGMMTYWLAPLNLSCDISSSASRDLLDWGI-LQFV------FDN-PEIPWSSSN--- 879 1290 1291Query: 804 KFNAEDYKDAIVMPWYRNLEQPVFYYVAEILPEWRPSSKFPDT-----HFETFNEYFIKK 858 1292 +A + + V Y + Y+ I P RPS P + H +Y + 1293Sbjct: 880 --SAAFFANRFV---YDRWDGRYRYFTHGIDPSLRPSDPPPSSMARRRHMGNIMDYCLSL 934 1294 1295Query: 859 YK------LEIYDQNQSLLDVDFTSTRLNLLQPRIQNQ 890 1296 +K LE D Q ++ + R NLL R + 1297Sbjct: 935 FKNARKKFLENCDWTQPVIKAEIIQLRRNLLDKRTNKE 972 1298 1299 Score = 39 (18.8 bits), Expect = 4.1e-60, Sum P(4) = 4.1e-60 1300 Identities = 12/49 (24%), Positives = 24/49 (48%) 1301 Links = 1-(6)-4-2 1302 1303Query: 957 VNQLLLTDELRETILVKAFGKEKTKLDDNVEWNSLAYATEYEEKQTIIV 1005 1304 V+ L +D R++ V+ G + T V A + +YE++ + +V 1305Sbjct: 596 VDALYESDRNRKSYTVQTTGAKLTYSSSLVVLAHFANSLQYEKETSTVV 644 1306 1307 Score = 39 (18.8 bits), Expect = 2.0e-58, Sum P(3) = 2.0e-58 1308 Identities = 7/11 (63%), Positives = 10/11 (90%) 1309 Links = 1-(7)-2 1310 1311Query: 574 VALEACRQLHL 584 1312 +ALEAC++L L 1313Sbjct: 1014 IALEACQELDL 1024 1314 1315 Score = 37 (18.1 bits), Expect = 8.4e-64, Sum P(6) = 8.4e-64 1316 Identities = 9/20 (45%), Positives = 11/20 (55%) 1317 Links = 1-3-5-(8)-4-2 1318 1319Query: 965 ELRETILVKAFGKEKTKLDD 984 1320 +LR +L K KEK K D 1321Sbjct: 959 QLRRNLLDKRTNKEKIKEGD 978 1322 1323 1324>sp|A2RAF3.2|DCL1_ASPNC RecName: Full=Dicer-like protein 1; Includes: RecName: 1325 Full=Endoribonuclease dcl1; Includes: RecName: Full=ATP-dependent 1326 helicase dcl1 1327 Length = 1525 1328 1329 Score = 466 (169.1 bits), Expect = 5.3e-62, Sum P(5) = 5.3e-62 1330 Identities = 154/501 (30%), Positives = 233/501 (46%) 1331 Links = (1)-4-5-3-2 1332 1333Query: 12 NPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKE-YGVQLFAPLDQGGKR-AFFVV 69 1334 +PR+YQ+EL ++A +NTI L TGSGKT IAVLLLK +L ++ R AFF+V 1335Sbjct: 116 DPREYQLELFERAKVQNTIAVLDTGSGKTLIAVLLLKHTLEKELNDRMEGKPHRIAFFLV 175 1336 1337Query: 70 EKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLI 129 1338 + V L QQA + + VG G + LW SK DQ +++ V+V TA+ L + 1339Sbjct: 176 DSVTLAYQQAAVLRNNLDQSVGHFFGAMGTDLW-SKSVWDQHFQKNMVIVCTAEILNQCL 234 1340 1341Query: 130 RHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKVA 189 1342 ++Y+K+ + +LIFDE HH HPY I+ D L + PR+ G+TAS I K 1343Sbjct: 235 LNSYIKMSQINILIFDEAHHTK-KDHPYARIIRDSYLEEVYSKRPRIFGMTASPIDTK-- 291 1344 1345Query: 190 PEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTVIE 249 1346 ++++ +LE +DS I T S++ L + +P E V +F+ + + 1347Sbjct: 292 -GDIVDEATRLEKLLDSRIATTSNMSLLRQVARRPVERVW-------------SFNKLEQ 337 1348 1349Query: 250 IFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELGKI 309 1350 F T + + F D+ ++ + +LG W + R W + L 1351Sbjct: 338 PF-ATSLYKHLEDRFG-DMAC-----LEGIFRFAWQASSELGRWCSDRA---WARALA-- 385 1352 1353Query: 310 IKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVIRLFEILETFN 369 1354 VLP A + T + E K+I I V E + 1355Sbjct: 386 --DDVLPKLEGSVRKTANSE--TSSNVPESAYKEILRITEASEIVKSYAFSSPETFGQLS 441 1356 1357Query: 370 PEFQKERMKLEK----AEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPDYVVGA 425 1358 P+ Q R +L + I+F +RY A L + + + F+ P ++G 1359Sbjct: 442 PKVQVLREELARYFGRQTETKCIVFTQKRYTALILAELFQTLN-----IPFLRPGVLIGV 496 1360 1361Query: 426 SGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDRPLDMR 485 1362 +LA + ++Q L +F EINCL ATSV EEG+D+ CNLV++FD + 1363Sbjct: 497 RSGDLAGMNIT--FRQQFISLVKFRTGEINCLFATSVAEEGLDIPDCNLVVRFDLYQTLI 554 1364 1365Query: 486 SYVQSKGRARRAGSRYVITVE 506 1366 YVQS+GRAR S Y VE 1367Sbjct: 555 QYVQSRGRARHFNSTYASMVE 575 1368 1369 Score = 220 (82.5 bits), Expect = 5.3e-62, Sum P(5) = 5.3e-62 1370 Identities = 67/244 (27%), Positives = 112/244 (45%) 1371 Links = 1-4-5-3-(2) 1372 1373Query: 1503 ISDKSIADAVEALIGVHLLTLGPNPTLKV-MNWMGLKVIQKDQKSDVPSPLLRFIDTPTN 1561 1374 +++K+IAD EALIG LL+ GP+ + + + V K++ + F P 1375Sbjct: 1171 LAEKTIADVCEALIGAALLSGGPDHRFDMAVKAVTTLVNSPSHKAERWKDYISFYTIPKY 1230 1376 1377Query: 1562 PNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRV-TGCYQRLEFLG 1620 1378 + + + + ++EEK+ YRF+ L AFTH SY + CYQRLEFLG 1379Sbjct: 1231 QRRAADGA----ELYLSRKIEEKLSYRFRYPTLLGSAFTHPSYPSAWAKVPCYQRLEFLG 1286 1380 1381Query: 1621 DAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYHM 1680 1382 D+++D + LF P LT+ + A+V+N +LAVK H L 1383Sbjct: 1287 DSLIDMVCVEDLFARFPDRDPQWLTEHKMAMVSNKFLGALAVKLGLHTHLKYFSAPLQSQ 1346 1384 1385Query: 1681 IEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDSG 1740 1386 I ++ + ++ + + VT + PK + D+ E+ GA+++DS 1387Sbjct: 1347 ITQYAEEIQTAEGESEGAVDYWTVTKDP------------PKCLPDMVEAYVGAVFVDSD 1394 1388 1389Query: 1741 RNLD 1744 1390 N + 1391Sbjct: 1395 FNFE 1398 1392 1393 Score = 81 (33.6 bits), Expect = 5.3e-62, Sum P(5) = 5.3e-62 1394 Identities = 24/74 (32%), Positives = 33/74 (44%) 1395 Links = 1-4-5-(3)-2 1396 1397Query: 1344 GMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQL 1403 1398 G + ER E +GD FLK AT+ L+ D E R + N NL+ I + 1399Sbjct: 1076 GRNYERLEFLGDCFLKMATSIALFTQNPDDDEFDYHVNRMCLICNKNLFNAAVDKEIYKY 1135 1400 1401Query: 1404 IVANKFDAHDSWLP 1417 1402 I + F H +W P 1403Sbjct: 1136 IRSRGFSRH-TWYP 1148 1404 1405 Score = 71 (30.1 bits), Expect = 5.3e-62, Sum P(5) = 5.3e-62 1406 Identities = 32/122 (26%), Positives = 52/122 (42%) 1407 Links = 1-(4)-5-3-2 1408 1409Query: 474 LVIKFDRPLD---MRSYVQSKGRARRAGSRYVITVEEKDTAAYCSKLPSDI-FTRLVPHN 529 1410 L+ FD LD + R + G++ A Y S L + F+ V + 1411Sbjct: 606 LLYGFDHDLDTVLQKDEGNRTFRIKSTGAKLTYHSATAILARYASSLQYEKEFSAQVTY- 664 1412 1413Query: 530 QIIPIEENGVTKYCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELD 589 1414 ++PI NG + E++LP SPI+ + +P K A+ + A + C L LD 1415Sbjct: 665 VVLPI--NGA--FVCEVILPEKSPIRG--LTGSPAMKKSIAKRSAAFDTCLLLRKNKLLD 718 1416 1417Query: 590 DN 591 1418 D+ 1419Sbjct: 719 DH 720 1420 1421 Score = 52 (23.4 bits), Expect = 5.3e-62, Sum P(5) = 5.3e-62 1422 Identities = 12/52 (23%), Positives = 27/52 (51%) 1423 Links = 1-4-(5)-3-2 1424 1425Query: 690 KEIPKIPPFPVFLRQGNMKVRLIVAP--KKTTVTAAQLQEIQLFHNYLFTQV 739 1426 + +P P FP+FL +++ +I P K+ ++ ++ + +F +F V 1427Sbjct: 793 ERLPHFPEFPIFL-DDDVETTIITTPLEKQLLLSEKEVDALTVFTLRVFRDV 843 1428 1429 1430>sp|Q09884.1|DCR1_SCHPO RecName: Full=Protein Dicer; AltName: Full=Cell cycle 1431 control protein dcr1; AltName: Full=RNA interference pathway 1432 protein dcr1; Includes: RecName: Full=Endoribonuclease dcr1; 1433 Includes: RecName: Full=ATP-dependent helicase dcr1 1434 Length = 1374 1435 1436 Score = 415 (151.1 bits), Expect = 7.7e-61, Sum P(4) = 7.7e-61 1437 Identities = 147/509 (28%), Positives = 247/509 (48%) 1438 Links = (1)-4-3-2 1439 1440Query: 14 RDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKE-YGVQLFAPLD--QGGKRAFFVVE 70 1441 R YQ ++ + A+K+NT++ + TG+GKT +AV L+K+ Q+ + K + F+V 1442Sbjct: 13 RKYQQDVYNIASKQNTLLVMRTGAGKTLLAVKLIKQKLEEQILIQESNLEHKKISVFLVN 72 1443 1444Query: 71 KVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLIR 130 1445 KV LV QQA +I KVG +G+ S + S++ + +++V+VITA + 1446Sbjct: 73 KVPLVFQQAEYIRSQLPAKVGMFYGELSIEM--SEQLLTNIILKYNVIVITADLFYLFLA 130 1447 1448Query: 131 HAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYK------LLKKDKPVPRVLGLTASLI 184 1449 +L I D+ ++IFDECHHA+G+ Y IM D+ L KK +PR+ G+TAS 1450Sbjct: 131 RGFLSINDLNLIIFDECHHAIGND-AYARIMNDFYHRAKAVLSKKHFTLPRIFGMTASPF 189 1451 1452Query: 185 KAKVAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNF 244 1453 K L +L + E DS S+ L+ Y P E ++ + L +P 1454Sbjct: 190 TGKKG--NLYHRLYQWEQLFDSKAHVVSEN-ELADYFCLPEESYVMYSNK----LVVPPS 242 1455 1456Query: 245 DTVIEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEK 304 1457 D++I+ +ET L + I ++KT A +G W QVW 1458Sbjct: 243 DSIIKKCEET---------------LQGCKLISRAVKTALAETIDMGLWFG---EQVW-L 283 1459 1460Query: 305 ELGKIIKSQVLPDKTLRFLNMAKTSMITIKRL-LEPEMKKIKSIEALRPYVPQRVIRLFE 363 1461 L ++++ L K L ++ + I RL + E K P +P +F+ 1462Sbjct: 284 YLVDFVETKRLKKKALG-KQLSDDEELAIDRLKIFVEDWKNNKYSDNGPRIP-----VFD 337 1463 1464Query: 364 ILETFNPEFQK-ERMKL--EKAEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPD 420 1465 + + F+ E +K K++ + +IFV+++ A++L L M+ + P + 1466Sbjct: 338 STDVTDKVFKLLELLKATYRKSDSVRTVIFVERKATAFTLSLFMKTLNL--PN---IRAH 392 1467 1468Query: 421 YVVGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDR 480 1469 +G + + +RQ + L +F + N LIAT+V EEG+DV CNLVI+F+ 1470Sbjct: 393 SFIGHGPSD--QGEFSMTFRRQKDTLHKFKTGKYNVLIATAVAEEGIDVPSCNLVIRFNI 450 1471 1472Query: 481 PLDMRSYVQSKGRARRAGSRYVITVEEKD 509 1473 + YVQS+GRAR S+++I + ++ 1474Sbjct: 451 CRTVTQYVQSRGRARAMASKFLIFLNTEE 479 1475 1476 Score = 224 (83.9 bits), Expect = 7.7e-61, Sum P(4) = 7.7e-61 1477 Identities = 81/254 (31%), Positives = 123/254 (48%) 1478 Links = 1-4-3-(2) 1479 1480Query: 1501 QHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPSPLLRFIDTPT 1560 1481 Q +S K IAD VEA IG LL G + LK+ + + ++ + + + D T 1482Sbjct: 1015 QKLSVKRIADMVEASIGACLLDSGLDSALKICKSLSVGLLDISNWDEWNN----YFDLNT 1070 1483 1484Query: 1561 NPNASLNFLNNLWQQFQFTQ-LEEKIGYRFKERAYLVQAFTHASYINNR-VTGCYQRLEF 1618 1485 ++ L N+ QF ++ +EE IGY FK + L AF H S ++ + + YQ+LEF 1486Sbjct: 1071 YADS----LRNV--QFPYSSYIEETIGYSFKNKKLLHLAFIHPSMMSQQGIYENYQQLEF 1124 1487 1488Query: 1619 LGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHF----IAMC 1674 1489 LGDAVLDY+I +YL++ + G LTD +S V N + + K+ AMC 1490Sbjct: 1125 LGDAVLDYIIVQYLYKKYPNATSGELTDYKSFYVCNKSLSYIGFVLNLHKYIQHESAAMC 1184 1491 1492Query: 1675 PGLYH---MIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESV 1731 1493 ++ +IE F + SE N + EID PK + D E++ 1494Sbjct: 1185 DAIFEYQELIEAFRETASE-------NPWFWF-----EIDS--------PKFISDTLEAM 1224 1495 1496Query: 1732 AGAIYLDSGRNLDT 1745 1497 AI+LDSG +L + 1498Sbjct: 1225 ICAIFLDSGFSLQS 1238 1499 1500 Score = 118 (46.6 bits), Expect = 7.7e-61, Sum P(4) = 7.7e-61 1501 Identities = 34/136 (25%), Positives = 61/136 (44%) 1502 Links = 1-4-(3)-2 1503 1504Query: 1282 VLPVAINEKSRSFSFEKESKAINGRLIRQRSEEYVSHIDSDIGLGVSPCLLLTALTTSNA 1341 1505 +LPV+ + K+ + I L+ + ++ H D + + C ALT++ + 1506Sbjct: 871 ILPVSRHLKNSALLIPSILYHIENLLV---ASSFIEHFRLDCKIDTA-C---QALTSAES 923 1507 1508Query: 1342 ADGMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIP 1401 1509 +R E GD FLK + ++ D E +L F R K +SNCNLY++ +P 1510Sbjct: 924 QLNFDYDRLEFYGDCFLKLGASITVFLKFPDTQEYQLHFNRKKIISNCNLYKVAIDCELP 983 1511 1512Query: 1402 QLIVANKFDAHDSWLP 1417 1513 + ++ + W P 1514Sbjct: 984 KYALSTPLEIRH-WCP 998 1515 1516 Score = 73 (30.8 bits), Expect = 7.7e-61, Sum P(4) = 7.7e-61 1517 Identities = 32/104 (30%), Positives = 43/104 (41%) 1518 Links = 1-(4)-3-2 1519 1520Query: 513 YCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAELLLPINSPIKHAIVLKNPMPNKKTAQM 572 1521 +C+ L D++TR P P YC E+ LP K +P + + A+ 1522Sbjct: 544 FCNTLSRDVYTRYYPTFTAQPCLSGW---YCFEVELP--KACKVPAAQGSPAKSIRKAKQ 598 1523 1524Query: 573 AVALEACRQLHLEGELDDNLLPKG-RESIAKL--LEHIDEEPDE 613 1525 A C L G +D +L P R IA L LE DE DE 1526Sbjct: 599 NAAFIMCLDLIRMGLIDKHLKPLDFRRKIADLETLEE-DELKDE 641 1527 1528 Score = 66 (28.3 bits), Expect = 1.9e-55, Sum P(4) = 1.9e-55 1529 Identities = 18/51 (35%), Positives = 25/51 (49%) 1530 Links = 1-4-(5)-2 1531 1532Query: 919 SVPHSSQ-RQILVPELMDIHPISATLWNVIAALPSIFYRVNQLLLTDELRE 968 1533 S+P S Q R + +L I P+S L N +PSI Y + LL+ E 1534Sbjct: 854 SIPKSQQVRSFYINDLY-ILPVSRHLKNSALLIPSILYHIENLLVASSFIE 903 1535 1536 Score = 57 (25.1 bits), Expect = 4.2e-52, Sum P(3) = 4.2e-52 1537 Identities = 21/72 (29%), Positives = 29/72 (40%) 1538 Links = 1-(6)-2 1539 1540Query: 1324 GLGVSPCLLLTALTTSNAADG--MSLERFETIGDSFLKFATTD-YLYHTLLDQHEGKLSF 1380 1541 G+ V C L+ S R + FL F T+ L H + E L F 1542Sbjct: 436 GIDVPSCNLVIRFNICRTVTQYVQSRGRARAMASKFLIFLNTEELLIHERILHEEKNLKF 495 1543 1544Query: 1381 ARSKEVSNCNLY 1392 1545 A S E+SN N++ 1546Sbjct: 496 ALS-ELSNSNIF 506 1547 1548 Score = 56 (24.8 bits), Expect = 4.5e-59, Sum P(4) = 4.5e-59 1549 Identities = 19/66 (28%), Positives = 36/66 (54%) 1550 Links = 1-(7)-3-2 1551 1552Query: 499 SRYVITVEEKDTA--AYCSKLPSDIFTRLVPHN-QIIPIEENGVTKYCAEL-LLPINSPI 554 1553 S ++I ++KD A A C KLP + L + + IP + + Y +L +LP++ + 1554Sbjct: 819 SEFMIPAKKKDKAPSALCKKLPLRLNYSLWGNRAKSIPKSQQVRSFYINDLYILPVSRHL 878 1555 1556Query: 555 KHAIVL 560 1557 K++ +L 1558Sbjct: 879 KNSALL 884 1559 1560 1561>sp|A1CBC9.2|DCL1_ASPCL RecName: Full=Dicer-like protein 1; Includes: RecName: 1562 Full=Endoribonuclease dcl1; Includes: RecName: Full=ATP-dependent 1563 helicase dcl1 1564 Length = 1534 1565 1566 Score = 428 (155.7 bits), Expect = 1.2e-60, Sum P(6) = 1.2e-60 1567 Identities = 151/514 (29%), Positives = 241/514 (46%) 1568 Links = (1)-4-5-7-3-2 1569 1570Query: 12 NPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKR---AFFV 68 1571 +PR+YQ+EL ++A +NTI L TGSGKT IAVLLL+ +Q GK +FF+ 1572Sbjct: 122 DPREYQIELFERAKAQNTIAVLDTGSGKTLIAVLLLRHV-LQNELNDRANGKPHRVSFFL 180 1573 1574Query: 69 VEKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDL 128 1575 V+ V L QQA + + V G + LWD ++ ++ ++++ V+V TA+ L 1576Sbjct: 181 VDSVTLAYQQAAVLRNNIDQNVAHFFGAMGTDLWD-RQVWEEHLQQNMVIVCTAEILNQC 239 1577 1578Query: 129 IRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPV-PRVLGLTASLIKAK 187 1579 + ++++++ + +LIFDE HH HPY I+ D K P PR+ G+TAS I K 1580Sbjct: 240 LLNSHVRMNQINLLIFDEAHHTK-KDHPYARIIRD-SYFKASPPQRPRIFGMTASPIDTK 297 1581 1582Query: 188 VAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTV 247 1583 ++ +LE+ +DS I T S + L + ++P E V + L P F T 1584Sbjct: 298 ---GDIIAAATRLETLLDSRIATTSKITLLRQVVSRPIEKV-----WAYDRLESP-FKTN 348 1585 1586Query: 248 IEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELG 307 1587 + E F N + ++ + +LG W + R W L 1588Sbjct: 349 LHKLMEN-RFGNV-------------KALEGVFRFAWYASSELGRWCSDRA---WLYALA 391 1589 1590Query: 308 KIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVIRLFEILET 367 1591 VLP +A+++ +R + K+I I+ V E 1592Sbjct: 392 ----DDVLPKLEGHVNKLAESTAAATER--DMAFKEITLIKEASNIVKAHTFNDPEFPGE 445 1593 1594Query: 368 FNPEFQKERMKLEK----AEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPDYVV 423 1595 +P+ + + +L K A IIF +RY A +L + + P + P ++ 1596Sbjct: 446 LSPKVRLLQTELSKHFSHAPETKCIIFTQKRYTAKTLHELFTILSI--PHLR---PGVLI 500 1597 1598Query: 424 GASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDRPLD 483 1599 G ++ + ++Q L +F + EINCL ATSV EEG+D+ CNLV++FD 1600Sbjct: 501 GVRSGDIGGMNIT--FRQQFLALVKFRKGEINCLFATSVAEEGLDIPDCNLVVRFDLYHT 558 1601 1602Query: 484 MRSYVQSKGRARRAGSRYVITVEEKDTAAYCSKL 517 1603 + YVQS+GRAR S Y VE KD + + ++L 1604Sbjct: 559 LIQYVQSRGRARHYHSTYASMVE-KDNSDHEARL 591 1605 1606 Score = 244 (91.0 bits), Expect = 1.2e-60, Sum P(6) = 1.2e-60 1607 Identities = 85/261 (32%), Positives = 122/261 (46%) 1608 Links = 1-4-5-7-3-(2) 1609 1610Query: 1497 LLTQ-QH-ISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQK--DQKSDVPSPL 1552 1611 +L+Q +H + +K+IAD EALIG LL+ GP MG+K + D S S 1612Sbjct: 1170 MLSQAKHALGEKTIADVCEALIGACLLSGGPEHRFD----MGVKAVSVFVDSPSHAVSRW 1225 1613 1614Query: 1553 LRFIDTPTNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINN---RV 1609 1615 +I PN + Q+EEK+GY F+ L A TH S + RV 1616Sbjct: 1226 KEYIGLYKPPNYQVRKAEGAETNLAL-QVEEKLGYHFRYPRLLCSAVTHPSTPSTWYFRV 1284 1617 1618Query: 1610 TGCYQRLEFLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKH 1669 1619 CYQRLEFLGD++LD + LF P LT+ + A+V+N +LAVK F KH 1620Sbjct: 1285 P-CYQRLEFLGDSLLDMVCVEDLFHRFPDRDPQWLTEHKMAMVSNKFLGALAVKLGFHKH 1343 1621 1622Query: 1670 FIAMCPGLYHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFE 1729 1623 A L I +V+ ++ A Y V ++ PK + D+ E 1624Sbjct: 1344 IKAFSNPLQAQITYYVEEIETAEAESE-GAVDYWVVAKDP-----------PKCLPDMVE 1391 1625 1626Query: 1730 SVAGAIYLDSGRNLDTTWQVI 1750 1627 + GAI++DS D +++VI 1628Sbjct: 1392 AYLGAIFVDS----DFSFEVI 1408 1629 1630 Score = 93 (37.8 bits), Expect = 1.2e-60, Sum P(6) = 1.2e-60 1631 Identities = 26/74 (35%), Positives = 34/74 (45%) 1632 Links = 1-4-5-7-(3)-2 1633 1634Query: 1344 GMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQL 1403 1635 G + ER E +GD FLK AT+ L+ D E R + N NL+ KK I + 1636Sbjct: 1083 GKNYERLEFLGDCFLKMATSIALFTQNPDDDEFDYHVNRMCLICNKNLFNTAKKRQIYRY 1142 1637 1638Query: 1404 IVANKFDAHDSWLP 1417 1639 I + F H W P 1640Sbjct: 1143 IRSRSFSRH-VWYP 1155 1641 1642 Score = 66 (28.3 bits), Expect = 1.2e-60, Sum P(6) = 1.2e-60 1643 Identities = 31/113 (27%), Positives = 48/113 (42%) 1644 Links = 1-(4)-5-7-3-2 1645 1646Query: 483 DMRSYVQ-SKGR----ARRAGSRYVITVEEKDTAAYCSKLPSDIFTRLVPHNQIIPIEEN 537 1647 D+ S +Q +GR + G+R A Y S L + T P + ++ 1648Sbjct: 620 DLDSLLQHEEGRRTFTVKSTGARLTYHSAIAILARYASSLQYEKET--TPQATYV-VQSV 676 1649 1650Query: 538 GVTKYCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELDD 590 1651 G T C E++LP SPI+ + +P K A+ + A + C L LDD 1652Sbjct: 677 GNTYVC-EVILPEKSPIRG--LTGSPAIRKSIAKQSAAFDTCLLLRRHKLLDD 726 1653 1654 Score = 50 (22.7 bits), Expect = 1.2e-60, Sum P(6) = 1.2e-60 1655 Identities = 12/55 (21%), Positives = 31/55 (56%) 1656 Links = 1-4-(5)-7-3-2 1657 1658Query: 687 LSAKEIPKIPPFPVFLRQGNMKVRLIVAPKKT--TVTAAQLQEIQLFHNYLFTQV 739 1659 L+ +++P P FP++L + +++ +++ T ++A +L+ + F +F V 1660Sbjct: 797 LTREKLPDFPAFPIYLDE-DIETKVVPRSLDTGMELSAEELRALTTFTLRIFRDV 850 1661 1662 Score = 45 (20.9 bits), Expect = 4.1e-54, Sum P(3) = 4.1e-54 1663 Identities = 39/168 (23%), Positives = 66/168 (39%) 1664 Links = 1-(6)-2 1665 1666Query: 1232 QENQEDENTPTNFPKTIDEEIEELSIGARKKQEID-----DNAAKTDVLERENCEVL--- 1283 1667 +E +E E T NF +T+ E+ + G ++D + +T ++ + 1668Sbjct: 592 REVREAEKTMQNFCETLPED--RILHG--NDHDLDSLLQHEEGRRTFTVKSTGARLTYHS 647 1669 1670Query: 1284 PVAINEK-SRSFSFEKESKAINGRLIRQRSEEYVSHI----DSDI-GLGVSPCLLLTALT 1337 1671 +AI + + S +EKE+ +++ YV + S I GL SP + + 1672Sbjct: 648 AIAILARYASSLQYEKETTPQATYVVQSVGNTYVCEVILPEKSPIRGLTGSPAIRKSIAK 707 1673 1674Query: 1338 TSNAADGMSLERFETIGDSFLKFATTDYLYHTLLD-QHEGKLSFARSK 1384 1675 S A D L R + D F K +YH L KL+ K 1676Sbjct: 708 QSAAFDTCLLLRRHKLLDDFFKS-----IYHKRLPAMRNAKLAITSKK 750 1677 1678 Score = 44 (20.5 bits), Expect = 1.2e-60, Sum P(6) = 1.2e-60 1679 Identities = 17/61 (27%), Positives = 30/61 (49%) 1680 Links = 1-4-5-(7)-3-2 1681 1682Query: 932 ELMDIHPISATLWNVIAALPSIFYRVNQLLLT----DELRETILVKAFGKEK-TKLDDNV 986 1683 E + I I ++ + A P+I R++ L++ DEL + ++ + E TK DN 1684Sbjct: 1010 EPLKISAIPPSIASTCLAFPAIITRLDSYLISIEACDEL-DLVIRSDYALEAVTKDSDNT 1068 1685 1686Query: 987 E 987 1687 E 1688Sbjct: 1069 E 1069 1689 1690 Score = 39 (18.8 bits), Expect = 6.9e-58, Sum P(4) = 6.9e-58 1691 Identities = 19/76 (25%), Positives = 31/76 (40%) 1692 Links = 1-(8)-3-2 1693 1694Query: 933 LMDIHPISATLWNVIAALPS--IFYR----VNQLLLTDELRETILVKAFGKEKTKLDDNV 986 1695 L ++ T+ N LP I + ++ LL +E R T VK+ G T 1696Sbjct: 591 LREVREAEKTMQNFCETLPEDRILHGNDHDLDSLLQHEEGRRTFTVKSTGARLTYHSAIA 650 1697 1698Query: 987 EWNSLAYATEYEEKQT 1002 1699 A + +YE++ T 1700Sbjct: 651 ILARYASSLQYEKETT 666 1701 1702 1703>sp|A1DE13.1|DCL1_NEOFI RecName: Full=Dicer-like protein 1; Includes: RecName: 1704 Full=Endoribonuclease dcl1; Includes: RecName: Full=ATP-dependent 1705 helicase dcl1 1706 Length = 1538 1707 1708 Score = 457 (165.9 bits), Expect = 1.6e-60, Sum P(6) = 1.6e-60 1709 Identities = 157/517 (30%), Positives = 237/517 (45%) 1710 Links = (1)-4-6-5-3-2 1711 1712Query: 12 NPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQ--GGKR---AF 66 1713 +PR+YQ+EL ++A +NTI L TGSGKT IAVLLL+ + LD GK +F 1714Sbjct: 126 DPREYQIELFERAKTQNTIAVLDTGSGKTLIAVLLLRH---TILNELDNRANGKPHRVSF 182 1715 1716Query: 67 FVVEKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLL 126 1717 F+V+ V L QQA + + V G + LWD K D+ ++R+ V+V TA+ L 1718Sbjct: 183 FLVDSVTLAYQQAAVLRNNIDQNVAHFFGAMGTDLWD-KRTWDEHLQRNMVIVCTAEILN 241 1719 1720Query: 127 DLIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKA 186 1721 + ++Y+K++ + +LIFDE HHA HPY I+ D + PRV G+TAS I 1722Sbjct: 242 QCLLNSYVKMDQINLLIFDEAHHAK-KDHPYARIIRDSYFKAQPSQRPRVFGMTASPIDT 300 1723 1724Query: 187 KVAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDT 246 1725 K + E +LE+ +DS I T S + L + ++P E V + L P 1726Sbjct: 301 K---GDITEAATRLETLLDSRIATTSKITLLREVVSRPIEKV-----WAYNRLESPFATE 352 1727 1728Query: 247 VIEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKEL 306 1729 + ++ D + ++ + +LG W + R W L 1730Sbjct: 353 LYKLMDTRYGNIKV---------------LEGVYRFAWHASSELGKWCSDRA---WWHAL 394 1731 1732Query: 307 GKIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVIRLFEILE 366 1733 VLP + +++ + + K I I V E+ 1734Sbjct: 395 A----DDVLPKLEGNISKLVESNTLNAEH--GAVFKDIIRIREASETVKNYSFADPELPG 448 1735 1736Query: 367 TFNPEFQKERMKLEKAEHLS------AIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPD 420 1737 +P+ Q RM+L K H S I+F +RY A L + + P + P 1738Sbjct: 449 ELSPKVQLLRMELSK--HFSDTTGTKCIVFTQKRYTAKILNELFTVLNI--PHLR---PG 501 1739 1740Query: 421 YVVGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDR 480 1741 ++G ++ + ++Q L +F EINCL ATSV EEG+D+ CNLV++FD 1742Sbjct: 502 VLIGVRPGDIGGMNVT--FRQQFLALVKFRTGEINCLFATSVAEEGLDIPDCNLVVRFDL 559 1743 1744Query: 481 PLDMRSYVQSKGRARRAGSRYVITVEEKDTAAYCSKL 517 1745 + YVQS+GRAR S Y I VE KD A + +L 1746Sbjct: 560 YRTLIQYVQSRGRARHCTSTYAIMVE-KDNAEHEGRL 595 1747 1748 Score = 210 (79.0 bits), Expect = 1.6e-60, Sum P(6) = 1.6e-60 1749 Identities = 74/248 (29%), Positives = 111/248 (44%) 1750 Links = 1-4-6-5-3-(2) 1751 1752Query: 1497 LLTQ-QH-ISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPSPLLR 1554 1753 LL++ +H + +K+IAD EALIG LL+ GP + ++ D S S 1754Sbjct: 1174 LLSEGKHALGEKTIADVCEALIGASLLSGGPENRFDMATKAVTALV--DSPSHRVSCWKE 1231 1755 1756Query: 1555 FIDTPTNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINN---RVTG 1611 1757 +I T P +EE++GY F L A TH S + RV 1758Sbjct: 1232 YITLYTMPKYQTEKPRGSEDDLA-RHVEEELGYHFTYPRLLASAITHPSLPSTWGYRVP- 1289 1759 1760Query: 1612 CYQRLEFLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFI 1671 1761 CYQRLEFLGD++LD + LF P LT+ + A+V+N +L+VK F + + 1762Sbjct: 1290 CYQRLEFLGDSLLDMVCVEDLFRRFPDRDPQWLTEHKMAMVSNKFLGALSVKLGFHRRIM 1349 1763 1764Query: 1672 AMCPGLYHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESV 1731 1765 A L I +V+ ++ A Y V ++ PK + D+ E+ 1766Sbjct: 1350 AFSNPLQAQITHYVEEIESAQAESR-GAVDYWVVAKDP-----------PKCLPDMVEAY 1397 1767 1768Query: 1732 AGAIYLDS 1739 1769 GAI++DS 1770Sbjct: 1398 LGAIFVDS 1405 1771 1772 Score = 87 (35.7 bits), Expect = 1.6e-60, Sum P(6) = 1.6e-60 1773 Identities = 26/74 (35%), Positives = 33/74 (44%) 1774 Links = 1-4-6-5-(3)-2 1775 1776Query: 1344 GMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQL 1403 1777 G + ER E +GD FLK AT+ LY D E R + N NL+ K I + 1778Sbjct: 1087 GKNYERLEFLGDCFLKMATSIALYTQNPDDDEFDYHVNRMCLICNKNLFNTAIKKQIYRY 1146 1779 1780Query: 1404 IVANKFDAHDSWLP 1417 1781 I + F H W P 1782Sbjct: 1147 IRSRGFSRH-IWYP 1159 1783 1784 Score = 65 (27.9 bits), Expect = 1.6e-60, Sum P(6) = 1.6e-60 1785 Identities = 24/80 (30%), Positives = 36/80 (45%) 1786 Links = 1-(4)-6-5-3-2 1787 1788Query: 511 AAYCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAELLLPINSPIKHAIVLKNPMPNKKTA 570 1789 A Y S L + T VP Q+ + + Y E++LP SPI+ + +P K A 1790Sbjct: 657 ARYASSLQYEKET--VP--QVTYVVGHVSNAYVCEVILPEKSPIRG--LTGSPAIRKAVA 710 1791 1792Query: 571 QMAVALEACRQLHLEGELDD 590 1793 + + A + C L LDD 1794Sbjct: 711 KQSAAFDTCLLLRKHRLLDD 730 1795 1796 Score = 52 (23.4 bits), Expect = 1.6e-60, Sum P(6) = 1.6e-60 1797 Identities = 35/136 (25%), Positives = 48/136 (35%) 1798 Links = 1-4-6-(5)-3-2 1799 1800Query: 1108 GAWSGSESIVPSGWGDWDGPE--PDNSPMPFQILGGPGGLNVQALMADV--GRVFDPSTA 1163 1801 G SG+ P W DWD +N +PF P L V + D GR F T 1802Sbjct: 878 GPGSGTN---PRDWTDWDTVSFVHNNDEIPFTRDLNPDSL-VNRFIFDNWDGR-FRYFTV 932 1803 1804Query: 1164 SSSLSQTVQESTVSPPKQLTKEEEQFKKLQNDLLKQAKERLEALEMSEDMEKPRRLEDTV 1223 1805 + ++ T+Q S PP + N L +K D +P + V 1806Sbjct: 933 A--VADTLQPSDPPPPS--VPRRRHMNNIMNYTLSLSKNSRARFFSGCDWNQPVLQAELV 988 1807 1808Query: 1224 NLE-DYGDDQENQEDE 1238 1809 L + D QE E 1810Sbjct: 989 RLRRNLLDKMTTQEKE 1004 1811 1812 Score = 51 (23.0 bits), Expect = 1.6e-60, Sum P(6) = 1.6e-60 1813 Identities = 11/55 (20%), Positives = 31/55 (56%) 1814 Links = 1-4-(6)-5-3-2 1815 1816Query: 687 LSAKEIPKIPPFPVFLRQGNMKVRLIVAPKK--TTVTAAQLQEIQLFHNYLFTQV 739 1817 L+ +++P+ P F ++L + +++ +++ P K ++ +LQ + F +F + 1818Sbjct: 801 LTREKLPEFPAFSIYLDE-DVETKVLSYPLKHGLQISVDELQSLTTFTLRIFRDI 854 1819 1820 Score = 46 (21.3 bits), Expect = 5.2e-60, Sum P(6) = 5.2e-60 1821 Identities = 16/48 (33%), Positives = 24/48 (50%) 1822 Links = 1-4-(7)-5-3-2 1823 1824Query: 824 QPVFYYVAEILPEWRPSSKFPDTHFETFNEYFIKKYKLEI-YDQNQSL 870 1825 +P+ E LPE+ S + D ET + K+ L+I D+ QSL 1826Sbjct: 796 RPILLLTREKLPEFPAFSIYLDEDVETKVLSYPLKHGLQISVDELQSL 843 1827 1828 Score = 39 (18.8 bits), Expect = 7.3e-57, Sum P(4) = 7.3e-57 1829 Identities = 17/46 (36%), Positives = 22/46 (47%) 1830 Links = 1-(8)-3-2 1831 1832Query: 543 CAELLLPIN-SPIKHAIV---LKNPMPNKKTAQMAVALEACRQLHL 584 1833 CAE P+ S I +IV L P + +ALEAC +L L 1834Sbjct: 1012 CAE---PLRISAIPTSIVSTCLAFPAIISRLDSYLIALEACDELEL 1054 1835 1836 1837>sp|Q2VF19.1|DCL1_CRYPA RecName: Full=Dicer-like protein 1; Includes: RecName: 1838 Full=Endoribonuclease DCL-1; Includes: RecName: Full=ATP-dependent 1839 helicase DCL-1 1840 Length = 1548 1841 1842 Score = 465 (168.7 bits), Expect = 4.2e-60, Sum P(4) = 4.2e-60 1843 Identities = 146/501 (29%), Positives = 246/501 (49%) 1844 Links = (1)-4-3-2 1845 1846Query: 12 NPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKR--AFFVV 69 1847 +PRDYQ+EL ++A ++NTI L TGSGKT IA LLL Q +G R AFF+V 1848Sbjct: 98 SPRDYQMELFERAKQQNTIAVLDTGSGKTLIAALLLDHTVNQELEDRAKGLPRRIAFFLV 157 1849 1850Query: 70 EKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLI 129 1851 EKV L QQ +E + + V G++ W +K + + H V+V TA+ L + 1852Sbjct: 158 EKVALAFQQHAVLECNLAHSVAVFSGESIKNTW-TKGFWETQLADHEVIVCTAEILNQCL 216 1853 1854Query: 130 RHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPV--PRVLGLTASLIKAK 187 1855 ++AY++I+ + +L+FDE HH HPY I+ DY KD+ + PR+ G+TAS + A 1856Sbjct: 217 QYAYIRIDQINLLVFDEAHHTK-KNHPYARIIKDYYASGKDRGLRLPRIFGMTASPVDAL 275 1857 1858Query: 188 VAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTV 247 1859 + + + +LE + S I T +D +L + +P + +I ++ + 1860Sbjct: 276 I---DVRQAAIELEGLLHSRIATTADPDALRRAVGRPKKEIIY------------KYNPL 320 1861 1862Query: 248 IEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELG 307 1863 ++ + F + P L + + + + A R+LG W R Q++ ++ 1864Sbjct: 321 VKPIQTMLTF-----KLRP-L-IANNKQFSKAFAFSEAAARELGTWFVDRMWQLFLED-E 372 1865 1866Query: 308 KIIKSQVLPDKTLRFLNMAKTSMITIKR-LLEPEMKKIKSIEALRPYVPQRVIRLFEILE 366 1867 +++K + +++L +MA ++ R + + I+S E +P P + + L 1868Sbjct: 373 ELLKLEAKTERSLS-KDMAAPEVVEKHRNAVRSARELIRSHEFPKPE-PGLLSSKLKTLS 430 1869 1870Query: 367 TFNPEFQKERMKLEKAEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPDYVVGA- 425 1871 E+ + + I+FV++R+ A L+ +S + P VG+ 1872Sbjct: 431 KLLEEYFTD-------SSIRCIVFVERRWTAK---LLTDFFESHAAEI----PGLKVGSL 476 1873 1874Query: 426 SGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDRPLDMR 485 1875 G N SQ + Q + F + NC+ ATSV EEG+D+ CNL+I+FD M 1876Sbjct: 477 MGANAEGGSSQTSFREQIRTILSFKKGNTNCIFATSVAEEGLDIPDCNLIIRFDICKTMI 536 1877 1878Query: 486 SYVQSKGRARRAGSRYVITVE 506 1879 Y+QS+GRAR+A S Y+ +E 1880Sbjct: 537 QYIQSRGRARQADSTYIHLIE 557 1881 1882 Score = 204 (76.9 bits), Expect = 4.2e-60, Sum P(4) = 4.2e-60 1883 Identities = 72/260 (27%), Positives = 111/260 (42%) 1884 Links = 1-4-3-(2) 1885 1886Query: 1498 LTQQHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPSPLLRFID 1557 1887 + + ++DKSIAD EALIG +T + + +++ Q P+ ++ D 1888Sbjct: 1171 MDEHRLADKSIADVCEALIGAAYMTTRKHDDYDLAVRAVTRLVNHKQH-----PMTKWDD 1225 1889 1890Query: 1558 ---TPTNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHAS--YINNRVTGC 1612 1891 P N + ++ E GY+FK L AF H S Y+ ++V 1892Sbjct: 1226 YHAAYVMPGWQ-TMPANAAELDMAQKIHEATGYQFKHPRVLRSAFRHPSRPYVFDKVPH- 1283 1893 1894Query: 1613 YQRLEFLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIA 1672 1895 YQRLEFLGDA+ D YLF + P LT+ + A+V+N LAV F K + 1896Sbjct: 1284 YQRLEFLGDALFDMACVDYLFHIAPDEGPQWLTEHKMAMVSNQFLGCLAVSLGFHKFILH 1343 1897 1898Query: 1673 MCPGLYHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVA 1732 1899 + I ++V +E AE + E + PK + D+ E+ 1900Sbjct: 1344 HHASIGSQIHEYVTEITEARRAAEDAAEAAGKPRSAYSRDYWVEAPQPPKCIPDVLEAYV 1403 1901 1902Query: 1733 GAIYLDSGRNLDTTWQVIFH 1752 1903 GAI++DS + Q FH 1904Sbjct: 1404 GAIFVDSKYDYSVVQQ-FFH 1422 1905 1906 Score = 90 (36.7 bits), Expect = 4.2e-60, Sum P(4) = 4.2e-60 1907 Identities = 24/76 (31%), Positives = 39/76 (51%) 1908 Links = 1-4-(3)-2 1909 1910Query: 1344 GMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKK--LGIP 1401 1911 G + ER E +GDSFLK ATT ++ + ++ E R + N NL+ + K L + 1912Sbjct: 1080 GANYERLELLGDSFLKMATTIAVFTLIPNKDEFDYHCERMVMICNQNLFGVAKSDDLKLH 1139 1913 1914Query: 1402 QLIVANKFDAHDSWLP 1417 1915 + I + F+ +W P 1916Sbjct: 1140 EYIRSKSFE-RGTWYP 1154 1917 1918 Score = 65 (27.9 bits), Expect = 4.2e-60, Sum P(4) = 4.2e-60 1919 Identities = 28/102 (27%), Positives = 48/102 (47%) 1920 Links = 1-(4)-3-2 1921 1922Query: 529 NQIIPIEENGVTKYCAELLLPIN-SPIKHAIV-LKNPMPN--KKTAQMAVALEACR--QL 582 1923 N + I E +C +L P+ SP+ +V + +P+ + Q +AL+ACR QL 1924Sbjct: 981 NFLADINETSKNPFCYFVLEPMRISPLPVDVVAMAYLLPSIIHRIEQNLIALDACRLLQL 1040 1925 1926Query: 583 HLEGELDDNLLPKGRESIAKLLEHIDE----EPDEYAPGIAA 620 1927 + +L L K ++ + E +D EP + PG+ A 1928Sbjct: 1041 DIHPDLALEALTKDSDNQGED-ERMDSIQAFEPVNFQPGMGA 1081 1929 1930 Score = 64 (27.6 bits), Expect = 7.1e-60, Sum P(5) = 7.1e-60 1931 Identities = 18/54 (33%), Positives = 28/54 (51%) 1932 Links = 1-(5)-6-3-2 1933 1934Query: 542 YCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELDDNLLPK 595 1935 + E+++P SP+ AI K+ A+ + A E C QL + LDD+L K 1936Sbjct: 660 FICEVMMPPLSPVTSAI--GKVYSTKQVAKCSAAFELCFQLIQKKFLDDHLRSK 711 1937 1938 Score = 47 (21.6 bits), Expect = 7.1e-60, Sum P(5) = 7.1e-60 1939 Identities = 14/39 (35%), Positives = 20/39 (51%) 1940 Links = 1-5-(6)-3-2 1941 1942Query: 930 VPELMDIHPISATLWNVIAALPSIFYRVNQ-LLLTDELR 967 1943 V E M I P+ + + LPSI +R+ Q L+ D R 1944Sbjct: 998 VLEPMRISPLPVDVVAMAYLLPSIIHRIEQNLIALDACR 1036 1945 1946 1947>sp|Q0UI93.2|DCL1_PHANO RecName: Full=Dicer-like protein 1; Includes: RecName: 1948 Full=Endoribonuclease DCL1; Includes: RecName: Full=ATP-dependent 1949 helicase DCL1 1950 Length = 1522 1951 1952 Score = 490 (177.5 bits), Expect = 3.8e-59, Sum P(5) = 3.8e-59 1953 Identities = 162/507 (31%), Positives = 253/507 (49%) 1954 Links = (1)-4-5-3-2 1955 1956Query: 12 NPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQG--GKRAFFVV 69 1957 NPRDYQ+EL +A +NTI L TG+GKT IA LLL+ + +G K AFF+V 1958Sbjct: 68 NPRDYQMELFLRAKMQNTIAVLDTGTGKTHIATLLLRHVLEEELENRAKGCAHKMAFFLV 127 1959 1960Query: 70 EKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLI 129 1961 + VNLV QQA + V + G L+ K+ D+ + V+V TAQ L+D + 1962Sbjct: 128 DSVNLVFQQANVLRCGLDQGVEGISGAMGQSLFQ-KQTWDKLFAVNMVIVCTAQVLVDCM 186 1963 1964Query: 130 RHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPV-PRVLGLTASLIKAK- 187 1965 H+++ I M +LIFDE HHA S HPY +M DY + D PR+ +TAS + K 1966Sbjct: 187 MHSFMSISRMNLLIFDEAHHAK-SNHPYARVMKDYYAHELDTSKRPRIFAMTASPVDVKG 245 1967 1968Query: 188 VAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTV 247 1969 + E + E ++LE+ + S I T SD +P E V + + + 1970Sbjct: 246 QSAEHVREAARELETLLHSRIATTSDSALARNSITRPEEEVAV-------------YTRL 292 1971 1972Query: 248 IEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAA---WRTAQVWEK 304 1973 F ET ++ D+ P R + T + +LG WA+ W A E+ 1974Sbjct: 293 RNEF-ETPLHQKVKAKYG---DVAPFRKL---FITAKLHASELGRWASDMYWSFAFADEQ 345 1975 1976Query: 305 ELGKIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVI--RLF 362 1977 I+ ++ +++ R + A+ + RL E ++ E P + ++ + ++ 1978Sbjct: 346 SRKLQIREELKYNRSKRDWSAAELDA-QMARLKEATAF-VQQYEIGAPTLSEQDLSSKVM 403 1979 1980Query: 363 EILETFNPEFQKERMKLEKAEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPDYV 422 1981 ++ N + ER L + I+FV++R+ A L L+ HI P ++ D + 1982Sbjct: 404 KLQYWLNLYY--ERTTLARC-----IVFVEKRHTAQLLKLIFDHIGG--PN---LHCDVL 451 1983 1984Query: 423 VGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDRPL 482 1985 VG + R A ++ L + Q L++F R E+NCL ATSV EEG+D+ QCNLV++FD 1986Sbjct: 452 VGINNR--AGEENVSL-RSQILTLQKFRRGELNCLFATSVAEEGLDIPQCNLVVRFDLYR 508 1987 1988Query: 483 DMRSYVQSKGRARRAGSRYVITVEEKD 509 1989 M YVQS+GRAR S+Y+ +E ++ 1990Sbjct: 509 TMIGYVQSRGRARHRNSKYLHMLEAEN 535 1991 1992 Score = 183 (69.5 bits), Expect = 3.8e-59, Sum P(5) = 3.8e-59 1993 Identities = 86/348 (24%), Positives = 140/348 (40%) 1994 Links = 1-4-5-3-(2) 1995 1996Query: 1502 HISDKSIADAVEALIGVHLLTLGPNPTLKVMNW-MGLKVIQKDQKSD--VPSPLLRFIDT 1558 1997 ++ DKS+AD EA IG + +W +K ++ SD + + 1998Sbjct: 1144 NLGDKSVADVCEAFIGAAFMQHHKGGQWTPNDWDEAVKAVKLFANSDDHLMEKWTDYYAA 1203 1999 2000Query: 1559 PTNPNASLNFLNNLWQQFQFT-QLEEKIGYRFKERAYLVQAFTHAS--YINNRVTGCYQR 1615 2001 T P Q ++E K YRF+ L AF H S ++ + YQR 2002Sbjct: 1204 YTKPKYQT--AGATATQLDLAHKIEMKHPYRFRYPRLLRSAFIHPSQPFMWENIPS-YQR 1260 2003 2004Query: 1616 LEFLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCP 1675 2005 LEFLGD++LD +LF P LT+ ++ +V+N ++ VK + H 2006Sbjct: 1261 LEFLGDSLLDMAFIMHLFYKYPDKDPQWLTEHKTPMVSNKFLGAVCVKLGWHTHMKQNTA 1320 2007 2008Query: 1676 GLYHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAI 1735 2009 L I +V E + N A Y V+ E PK + D+ E+ AI 2010Sbjct: 1321 ILSSQIRDYVYEVEEAEREAN-GAVDYWVSVSEP-----------PKCLADVIEAFVAAI 1368 2011 2012Query: 1736 YLDSGRNLDTTWQVI-FH-------MMRGTIELCCANPPRSPIRELME--FEQSKVRFSK 1785 2013 ++DS + + + H M E +N P + + L+ F S+ R 2014Sbjct: 1369 FVDSEFDFNVVQKFFDLHLKPFFLDMTLDAYENFASNHPTTRLSRLLSINFGCSEWRMGA 1428 2015 2016Query: 1786 ME-RILESGK---VRVTVEVVNNMRFTGMGRNYRIAKATAAKRALKYL 1829 2017 +E L GK + V + + + F +G++ R A+ A+ AL+ L 2018Sbjct: 1429 LETETLIPGKGKAIAAMVMIHDKVHFHSLGQSGRYARVRASHAALEKL 1476 2019 2020 Score = 83 (34.3 bits), Expect = 3.8e-59, Sum P(5) = 3.8e-59 2021 Identities = 39/128 (30%), Positives = 59/128 (46%) 2022 Links = 1-4-5-(3)-2 2023 2024Query: 1308 IRQRSEEYVSHIDS-DI-GLGVSPCLLLTALTTS------------NAADGM--SLERFE 1351 2025 I R E Y+ +D+ D+ L VSP L L ALT N GM + ER E 2026Sbjct: 995 IIHRFESYLIALDACDVLDLKVSPALALEALTKDSDNSEEHGEEKINFKSGMGPNYERLE 1054 2027 2028Query: 1352 TIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYR--LGKKLGIPQLIVANKF 1409 2029 +GD FLK AT+ ++ +++E + R + N NL +GKK + + + + F 2030Sbjct: 1055 FLGDCFLKVATSLSVFVQQPEENEFEFHVRRMLMLCNQNLMETAVGKKK-LYKYVRTDAF 1113 2031 2032Query: 1410 DAHDSWLP 1417 2033 + W P 2034Sbjct: 1114 SRRN-WYP 1120 2035 2036 Score = 59 (25.8 bits), Expect = 3.8e-59, Sum P(5) = 3.8e-59 2037 Identities = 25/115 (21%), Positives = 56/115 (48%) 2038 Links = 1-(4)-5-3-2 2039 2040Query: 535 EENGVTKYCAELLLPINSPIKHAIVLKNPMPNKKT-AQMAVALEACRQLHLEGELDDNLL 593 2041 + NG + E++LP + PI I + + ++KT A+ + A + C +L + L++ LL 2042Sbjct: 638 QRNG---FVCEVILPEHCPI---ISMVGQVYSRKTIAKCSAAFKMCIELRRKDHLNEFLL 691 2043 2044Query: 594 PKGRESIAKLLEHIDEEPDEYAPGIAAKVGSSKRKQLYDKKIARALNESFVEADK 648 2045 P + + + + ++ A + + KQ D + +L+ + ++AD+ 2046Sbjct: 692 PTISKYLPAMRNALLAVSEKKKGNYAMVIKPTFWKQDRDT-VPESLHLTIIDADR 745 2047 2048 Score = 46 (21.3 bits), Expect = 3.8e-59, Sum P(5) = 3.8e-59 2049 Identities = 40/219 (18%), Positives = 97/219 (44%) 2050 Links = 1-4-(5)-3-2 2051 2052Query: 687 LSAKEIPKIPPFPVFL---RQGNMKVRLIVAPKKTTVTAAQLQEIQLFHNYLFTQVLQMC 743 2053 L+ + P++P FP++L R N+ + + P ++T L+ F +F + 2054Sbjct: 757 LTRRPFPQLPSFPIYLTDCRPSNIVSQSLHIP--ISLTPELLEMFTRFTLRIFEDIYNKV 814 2055 2056Query: 744 KTGNLEFDGTSNAPLNTLIVPLNKRKDDMSYTINMKYVSEVVANMENMPRIPKDEVRRQY 803 2057 ++D + ++ ++P+ + + ++ +M EV+ +M+ + ++ + + 2058Sbjct: 815 ----YDYDVSK---MSYWMLPVIEHR--VASVRSMSNPQEVL-DMDQIRKVYNEPF---W 861 2059 2060Query: 804 KFNAEDYKDAIVMPWYRN-LEQPVFYYVAEILPEWRPSSKFPDTHFETFNEYFIKKYKLE 862 2061 K++ + D ++ ++ + + YY + P +P P + N F+K L+ 2062Sbjct: 862 KWSPQSRTDDLIDRYFVDPMNGGRRYYSDRLAPHLKPQDPVP-ANVPRQNHKFMKNI-LD 919 2063 2064Query: 863 IYDQNQSLLDVDFTSTRLNLLQPRIQNQ--PRRSRTVSN 899 2065 D ++ + D T R + QP +Q + P R ++N 2066Sbjct: 920 FSD-SKWMKSRDIT--RWHQDQPVLQVEKIPFRRNHLAN 955 2067 2068 Score = 42 (19.8 bits), Expect = 9.7e-59, Sum P(5) = 9.7e-59 2069 Identities = 14/53 (26%), Positives = 28/53 (52%) 2070 Links = 1-4-(6)-3-2 2071 2072Query: 979 KTKLD-DNVEWNSLAYATEYEEKQTII-VKKIQQLRDLNQKSIEDQERETREN 1029 2073 K LD + +W T + + Q ++ V+KI R+ + ++ED+E++ N 2074Sbjct: 915 KNILDFSDSKWMKSRDITRWHQDQPVLQVEKIPFRRN-HLANVEDKEKKELAN 966 2075 2076 2077>sp|Q4WVE3.3|DCL1_ASPFU RecName: Full=Dicer-like protein 1; Includes: RecName: 2078 Full=Endoribonuclease dcl1; Includes: RecName: Full=ATP-dependent 2079 helicase dcl1 2080 Length = 1537 2081 2082 Score = 466 (169.1 bits), Expect = 4.8e-59, Sum P(6) = 4.8e-59 2083 Identities = 160/515 (31%), Positives = 241/515 (46%) 2084 Links = (1)-4-5-7-3-2 2085 2086Query: 12 NPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQ--GGKR---AF 66 2087 +PR+YQ+EL ++A +NTI L TGSGKT IAVLLL+ + LD GK +F 2088Sbjct: 125 DPREYQIELFERAKTQNTIAVLDTGSGKTLIAVLLLRH---TILNELDDRANGKTHRVSF 181 2089 2090Query: 67 FVVEKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLL 126 2091 F+V+ V L QQA + + V G + LWD K D+ ++R+ V+V TA+ L 2092Sbjct: 182 FLVDSVTLAYQQAAVLRNNIDQNVAHFFGAMGTDLWD-KRTWDKHLQRNMVIVCTAEILN 240 2093 2094Query: 127 DLIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKA 186 2095 + ++Y++++ + +LIFDE HHA HPY I+ D + PRV G+TAS I 2096Sbjct: 241 QCLLNSYVRMDQINLLIFDEAHHAK-KDHPYARIIRDSYFKAQPSQRPRVFGMTASPIDT 299 2097 2098Query: 187 KVAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDT 246 2099 K + E +LE+ +DS I T S + L + ++P E V E P F T 2100Sbjct: 300 K---GDITEAATRLETFLDSRIATTSKITLLREVVSRPIEKVWAYNRLE------PPFAT 350 2101 2102Query: 247 VIEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKEL 306 2103 E ++T + ++ + ++ + +LG W + R W L 2104Sbjct: 351 ------ELYKLMDTR---YGNIKV-----LEGVYRFAWNASSELGKWCSDRA---WWHAL 393 2105 2106Query: 307 GKIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVIRLFEILE 366 2107 VLP + +++ T+K K I I V E+ 2108Sbjct: 394 A----DDVLPKLEGNINKLIESN--TMKAEHGAVFKDIIRIREASETVKNYFFTDPELPG 447 2109 2110Query: 367 TFNPEFQKERMKLEK----AEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPDYV 422 2111 +P+ Q+ RM+L K I+F +RY A L + + P + P + 2112Sbjct: 448 ELSPKVQRLRMELSKHFNDTTGTKCIVFTQKRYTAKILNELFTVLNI--PNLR---PGVL 502 2113 2114Query: 423 VGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDRPL 482 2115 +G ++ + ++Q L +F EINCL ATSV EEG+D+ CNLVI+FD 2116Sbjct: 503 IGVRPGDIGGMNIT--FRQQFLALVKFRTGEINCLFATSVAEEGLDIPDCNLVIRFDLYR 560 2117 2118Query: 483 DMRSYVQSKGRARRAGSRYVITVEEKDTAAYCSKL 517 2119 + YVQS+GRAR S Y I VE KD A + +L 2120Sbjct: 561 TLIQYVQSRGRARHCTSTYAIMVE-KDNAEHEGRL 594 2121 2122 Score = 205 (77.2 bits), Expect = 4.8e-59, Sum P(6) = 4.8e-59 2123 Identities = 75/250 (30%), Positives = 111/250 (44%) 2124 Links = 1-4-5-7-3-(2) 2125 2126Query: 1497 LLTQ-QH-ISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQK--DQKSDVPSPL 1552 2127 LL++ +H + +K+IAD EALIG LL+ GP M K + D S S 2128Sbjct: 1173 LLSEGKHALGEKTIADVCEALIGASLLSGGPEHRFD----MATKAVSALVDSPSHRVSCW 1228 2129 2130Query: 1553 LRFIDTPTNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINN---RV 1609 2131 +I T P +EE++GY F L A TH S + RV 2132Sbjct: 1229 KEYITLYTLPKYQTEKHRGSEDDLA-RHVEEELGYHFTYPRLLASAITHPSLPSTWGYRV 1287 2133 2134Query: 1610 TGCYQRLEFLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKH 1669 2135 CYQRLEFLGD++LD + LF P L++ + A+V+N +L+VK F + 2136Sbjct: 1288 P-CYQRLEFLGDSLLDMVCVEDLFRRFPDRDPQWLSEHKMAMVSNKFLGALSVKLGFHRR 1346 2137 2138Query: 1670 FIAMCPGLYHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFE 1729 2139 +A L I +V+ ++ A Y V ++ PK + D+ E 2140Sbjct: 1347 IMAFSNPLQAQITHYVEEIETAQAESQ-GAVDYWVVAKDP-----------PKCLPDMVE 1394 2141 2142Query: 1730 SVAGAIYLDS 1739 2143 + GAI++DS 2144Sbjct: 1395 AYLGAIFVDS 1404 2145 2146 Score = 79 (32.9 bits), Expect = 4.8e-59, Sum P(6) = 4.8e-59 2147 Identities = 24/74 (32%), Positives = 33/74 (44%) 2148 Links = 1-4-5-7-(3)-2 2149 2150Query: 1344 GMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQL 1403 2151 G + ER E +GD FLK AT+ L+ + E R + N NL+ K I + 2152Sbjct: 1086 GKNYERLEFLGDCFLKMATSIALFSQNPNDDEFDYHVNRMCLICNKNLFNTAIKKQIYRY 1145 2153 2154Query: 1404 IVANKFDAHDSWLP 1417 2155 I + F H W P 2156Sbjct: 1146 IRSRGFSRH-IWYP 1158 2157 2158 Score = 65 (27.9 bits), Expect = 4.8e-59, Sum P(6) = 4.8e-59 2159 Identities = 30/113 (26%), Positives = 48/113 (42%) 2160 Links = 1-(4)-5-7-3-2 2161 2162Query: 483 DMRSYVQSK-GR----ARRAGSRYVITVEEKDTAAYCSKLPSDIFTRLVPH-NQIIPIEE 536 2163 D+ S++Q + GR + G++ A Y S L + T VP ++ I 2164Sbjct: 623 DLDSFLQEEEGRRTFTVKSTGAKLTYHSAIAILARYASSLQYEKET--VPQVTYVVTIAS 680 2165 2166Query: 537 NGVTKYCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELD 589 2167 N Y E++LP SPI+ + +P K A+ + A + C L LD 2168Sbjct: 681 NA---YVCEVILPEKSPIRG--LTGSPAMRKAVAKRSAAFDTCLLLRKNRLLD 728 2169 2170 Score = 52 (23.4 bits), Expect = 4.8e-59, Sum P(6) = 4.8e-59 2171 Identities = 11/55 (20%), Positives = 32/55 (58%) 2172 Links = 1-4-(5)-7-3-2 2173 2174Query: 687 LSAKEIPKIPPFPVFLRQGNMKVRLIVAPKK--TTVTAAQLQEIQLFHNYLFTQV 739 2175 L+ +++P+ P F ++L + +++ +++ P K ++ +LQ + +F +F + 2176Sbjct: 800 LTREKLPEFPAFSIYLDE-DVETKVLSYPLKHGLQISVDKLQSLTVFTLRIFRDI 853 2177 2178 Score = 45 (20.9 bits), Expect = 2.5e-58, Sum P(6) = 2.5e-58 2179 Identities = 16/48 (33%), Positives = 24/48 (50%) 2180 Links = 1-4-(6)-7-3-2 2181 2182Query: 824 QPVFYYVAEILPEWRPSSKFPDTHFETFNEYFIKKYKLEI-YDQNQSL 870 2183 +P+ E LPE+ S + D ET + K+ L+I D+ QSL 2184Sbjct: 795 RPILLLTREKLPEFPAFSIYLDEDVETKVLSYPLKHGLQISVDKLQSL 842 2185 2186 Score = 40 (19.1 bits), Expect = 4.8e-59, Sum P(6) = 4.8e-59 2187 Identities = 10/32 (31%), Positives = 16/32 (50%) 2188 Links = 1-4-5-(7)-3-2 2189 2190Query: 865 DQNQSLLDVDFTSTRLNLLQPRIQNQPRRSRT 896 2191 D NQ +L + R NLL ++ Q + +T 2192Sbjct: 976 DWNQPVLQAELVRLRRNLLD-KMTTQEKEMQT 1006 2193 2194 Score = 39 (18.8 bits), Expect = 1.7e-56, Sum P(4) = 1.7e-56 2195 Identities = 14/43 (32%), Positives = 19/43 (44%) 2196 Links = 1-(8)-3-2 2197 2198Query: 543 CAE-LLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHL 584 2199 CAE L + P + L P + +ALEAC +L L 2200Sbjct: 1011 CAEPLRISALPPSIVSTCLAFPAIISRLDSYLIALEACDELEL 1053 2201 2202 2203>sp|Q2U6C4.2|DCL1_ASPOR RecName: Full=Dicer-like protein 1; Includes: RecName: 2204 Full=Endoribonuclease dcl1; Includes: RecName: Full=ATP-dependent 2205 helicase dcl1 2206 Length = 1523 2207 2208 Score = 474 (171.9 bits), Expect = 8.5e-58, Sum P(4) = 8.5e-58 2209 Identities = 196/684 (28%), Positives = 307/684 (44%) 2210 Links = (1)-4-3-2 2211 2212Query: 12 NPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQG-GKR---AFF 67 2213 +PR+YQVEL ++A +NTI L TGSGKT IAVLLLK +Q +D+ GK +FF 2214Sbjct: 115 DPREYQVELFERAKSQNTIAVLDTGSGKTLIAVLLLKHI-IQNEL-IDRANGKPPRISFF 172 2215 2216Query: 68 VVEKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLD 127 2217 +V+ V L QQA + + V Q G + LW SK+ D + + V+V TA+ L 2218Sbjct: 173 LVDSVTLAFQQAAVLRNNLDQNVAQFFGAMGTDLW-SKQTWDHQFENNMVIVCTAEILNQ 231 2219 2220Query: 128 LIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPV-PRVLGLTASLIKA 186 2221 + ++Y++++ + +LIFDE HH HPY I+ + LK D PR+ G+TAS I 2222Sbjct: 232 CLLNSYIRMDQINLLIFDEAHHTK-KDHPYARIIRE-SYLKADPTKRPRIFGMTASPIDT 289 2223 2224Query: 187 KVAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDT 246 2225 K ++E KLE +DS I T S L + +P E + +E L P F T 2226Sbjct: 290 K---GDIIESATKLEVLLDSKIATTSKPNLLREVVRRPIE-----ESWEYDKLD-PPFAT 340 2227 2228Query: 247 VIEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKEL 306 2229 +++ A F D+ +P+ + T +LGP A R W L 2230Sbjct: 341 --KLYQILQA------RFG---DISSLQPV---FRFTLQASSELGPCCADRA---WAYAL 383 2231 2232Query: 307 GKIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVIRLFEILE 366 2233 VLP L N+ K + + + +K+I I+ V + 2234Sbjct: 384 A----DDVLPK--LEG-NVRKLAQSISSPIPQCALKEISRIQEASDIVKNHSFNSPNVPG 436 2235 2236Query: 367 TFNPEFQKERMKLEKA-EH---LSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPDYV 422 2237 +P+ Q R KL K EH I+F +RY A L + ++ ++ P + 2238Sbjct: 437 ELSPKVQLLRQKLIKYFEHPTKTKCIVFTQKRYTAKMLFDLFSTLE-----IPYLRPGVL 491 2239 2240Query: 423 VGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDRPL 482 2241 +G ++ + ++Q L +F EINCL ATSV EEG+D+ CNLV++FD 2242Sbjct: 492 IGVRSGDIVGMNVS--FRQQFLALVKFRSGEINCLFATSVAEEGLDIPDCNLVVRFDLYN 549 2243 2244Query: 483 DMRSYVQSKGRARRAGSRYVITVEE--KDTAAY------CSKLPSDIFTRLVPHNQIIPI 534 2245 + YVQS+GRAR + S Y +E D AA KL F +P ++I+ 2246Sbjct: 550 TLIQYVQSRGRARHSSSTYASMIERYNADHAARLVEVREAEKLMQS-FCETLPEDRIL-- 606 2247 2248Query: 535 EENGVTKYCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEA--CRQLHLEGELDDN- 591 2249 +G+ +L K +++ K T A+A+ A L E E 2250Sbjct: 607 --HGIDSEIDSILQ--GEEEKRTFIIR-ATGAKLTYHSALAILARYASSLQYEKETSAQA 661 2251 2252Query: 592 ---LLPKGRESIAKLLEHIDEEPDEYAPGI-AAKVGSSKRKQLYDKKIARALNESFVEAD 647 2253 +LP+ + +++ ++ P G+ A+K ++K+ +D + L + + D 2254Sbjct: 662 TYVVLPQNNSFVCEVILP-EKSPVRGLTGVPASKKSAAKQSAAFDTCVL--LRKHKLLDD 718 2255 2256Query: 648 KECFIYAFELERFREAELTLNPKR 671 2257 +Y L R A L + R 2258Sbjct: 719 HFNSVYHRRLPAMRNARLAITSSR 742 2259 2260 Score = 204 (76.9 bits), Expect = 8.5e-58, Sum P(4) = 8.5e-58 2261 Identities = 95/348 (27%), Positives = 153/348 (43%) 2262 Links = 1-4-3-(2) 2263 2264Query: 1503 ISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPS-PLLRFIDTPTN 1561 2265 + +K++AD EALIG LL+ G + M +K + D P+ L + D ++ 2266Sbjct: 1169 LREKTVADVCEALIGASLLSGGLHNQFD----MAVKAVTA--VVDSPNHKALCWADYTSS 1222 2267 2268Query: 1562 ---PNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRV-TGCYQRLE 1617 2269 P + ++ ++EEK+GYRFK L AFTH SY + CYQRLE 2270Sbjct: 1223 YMLPKYQTQSPDG-YELDLGRKVEEKLGYRFKYPRLLHSAFTHPSYPSTWAKVPCYQRLE 1281 2271 2272Query: 1618 FLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGL 1677 2273 FLGD++LD + LF P LT+ + A+V+N +LAVK H L 2274Sbjct: 1282 FLGDSLLDMVCVDDLFYRYPDKDPQWLTEHKMAMVSNKFLGALAVKLGLHTHLRHFSNPL 1341 2275 2276Query: 1678 YHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYL 1737 2277 I + + ++ + ++VT + PK + D+ E+ GA ++ 2278Sbjct: 1342 QSQITHYAEEIQAAENESQGAVDYWLVTKDP------------PKCLPDMVEAYLGAAFV 1389 2279 2280Query: 1738 DSG---RNLDTTWQ----VIFHMMRGTIELCCANP-PRSPIRELMEFEQSKVRFS-KMER 1788 2281 DS R ++ +Q FH M TI AN P + ++ + E + K 2282Sbjct: 1390 DSDFQFRVVEDFFQRHVKSYFHDM--TIYDTFANKHPTTFLQNRLTNEYGCTNYCLKAGE 1447 2283 2284Query: 1789 I--LESGKVRVTVEVVNN--MRFTGMGRNYRIAKATAAKRALKYLHQI 1832 2285 I ++ G V V V+ + + G + R AK A+++AL L + 2286Sbjct: 1448 IPVVDGGTVSVLAAVIVHEVVIAEGTASSGRYAKVKASEKALSVLENM 1495 2287 2288 Score = 84 (34.6 bits), Expect = 8.5e-58, Sum P(4) = 8.5e-58 2289 Identities = 24/74 (32%), Positives = 33/74 (44%) 2290 Links = 1-4-(3)-2 2291 2292Query: 1344 GMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQL 1403 2293 G + ER E +GD FLK AT+ L+ D E R + N NL+ K + Q 2294Sbjct: 1074 GKNYERLEFLGDCFLKMATSISLFVQNPDDDEFDFHVNRMCLICNKNLFNTALKKELYQY 1133 2295 2296Query: 1404 IVANKFDAHDSWLP 1417 2297 + F H +W P 2298Sbjct: 1134 TRSRGFSRH-TWYP 1146 2299 2300 Score = 39 (18.8 bits), Expect = 8.5e-58, Sum P(4) = 8.5e-58 2301 Identities = 10/50 (20%), Positives = 22/50 (44%) 2302 Links = 1-(4)-3-2 2303 2304Query: 687 LSAKEIPKIPPFPVFLRQGNMKVRLIVAPKKTTVTAAQLQEIQLFHNYLF 736 2305 L+ + +P P F +FL +++ ++V QE++ + F 2306Sbjct: 789 LTRERLPDFPSFTIFL-DDDIET-IVVTESVEEALHISSQELEYLSTFTF 836 2307 2308 2309>sp|Q2UNX5.1|DCL2_ASPOR RecName: Full=Dicer-like protein 2; Includes: RecName: 2310 Full=Endoribonuclease dcl2; Includes: RecName: Full=ATP-dependent 2311 helicase dcl2 2312 Length = 1377 2313 2314 Score = 396 (144.5 bits), Expect = 1.0e-53, Sum P(5) = 1.0e-53 2315 Identities = 144/525 (27%), Positives = 243/525 (46%) 2316 Links = (1)-5-3-2-4 2317 2318Query: 11 FNPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKR--AFFV 68 2319 + PR YQ E+ + + K+N IV + TG+GKT IA+L + L+ GG R +F+ 2320Sbjct: 14 YKPRQYQYEMFEASLKENIIVAMDTGTGKTQIALLRIAHQ-------LEGGGPRKLTWFL 66 2321 2322Query: 69 VEKVNLVEQQAIHIEVHT-SFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLD 127 2323 V L QQ I H + + + G W S+ D+ +K VVV T L + 2324Sbjct: 67 TPTVALCLQQYEVIRSHLPAVRACTITGLDKVERWKSQYIWDELLKDKQVVVSTHAVLFE 126 2325 2326Query: 128 LIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDY--KLLKKD--KPVPRVLGLTAS- 182 2327 + H +++I + +LIFDE HH + +HP IM+D+ L+K VP +LGLTAS 2328Sbjct: 127 ALTHGFVRISQLGLLIFDEAHHCM-RRHPANMIMLDFYHPTLRKHGRDSVPCILGLTASP 185 2329 2330Query: 183 LIKAKVAPEKLMEQLKKLESAMDSVIETAS-DLVSLSKYGAKPYEVVIICKDFEIGCLG- 240 2331 ++++K +++K LES +DS+ +T L+ Y +P + IICK + G G 2332Sbjct: 186 VVRSK------SQEMKTLESNLDSICKTPQVHKQELTTYAHRPELLPIICKAIDEGPGGR 239 2333 2334Query: 241 ----------IPNFDTVIEIFDETVAFVNTTTEFHPDLDLDP--RRPIKDSLKTTRAVFR 288 2335 + D + + + +N + E+ + IK + +R +F 2336Sbjct: 240 ALQALEHAWDTADIDGDPDAIPQNGSLLNGSGEYKALMVRKTLCNEQIKRFVDRSRHIFA 299 2337 2338Query: 289 QLGPWAAWRTAQVWEKELGKIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIE 348 2339 +LG WAA ++L I+ Q L T+ + + + + L + + 2340Sbjct: 300 ELGEWAADYYICTSVEQLRTTIRDQSL---TMDWEDEERAYLSNFLSKLPVAEVQANLAD 356 2341 2342Query: 349 ALRPYVPQRVIRLFEILETFN-PEFQKERMKLEKAEHLSAIIFVDQRYIAYSLLLMMRHI 407 2343 + ++ L L+ F+ PEF S +IFV QR + S+L + + 2344Sbjct: 357 PNNFTMSPKLAALINFLDKFDDPEF-------------SGLIFVKQR-VTVSVLARLLSL 402 2345 2346Query: 408 KSWEPKFKFVNPDYV---VGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLE 464 2347 + + +F YV VG+ +++ K+Q + F N ++ TSVLE 2348Sbjct: 403 HP-QTRDRFRCAAYVGMSVGSCRQDMVGDWHNA--KKQRGTMDDFRSGRKNLIVTTSVLE 459 2349 2350Query: 465 EGVDVKQCNLVIKFDRPLDMRSYVQSKGRARRAGSRYVITVEEKD 509 2351 EG+DV C +V+ FD+P +++S++Q +GRAR+ S Y I D 2352Sbjct: 460 EGIDVTACRVVVCFDKPANLKSFIQRRGRARQQKSTYAIMFSTAD 504 2353 2354 Score = 196 (74.1 bits), Expect = 1.0e-53, Sum P(5) = 1.0e-53 2355 Identities = 52/169 (30%), Positives = 88/169 (52%) 2356 Links = 1-5-3-(2)-4 2357 2358Query: 1500 QQHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPSPLLRFIDTP 1559 2359 ++ +S K +AD +EALIG L G + ++ L + + Q D+PS + T 2360Sbjct: 1028 KRQMSAKVLADVIEALIGAAYLD-GGHSKAQICTHCFLPEVNR-QPLDIPSLI-----TQ 1080 2361 2362Query: 1560 TNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGCYQRLEFL 1619 2363 T + + + L+ +GY FK L++A TH S +++ T YQRLEFL 2364Sbjct: 1081 TEHGRTARHIID-------GDLQRHLGYTFKNEDLLIEALTHPSCQHDQTTQSYQRLEFL 1133 2365 2366Query: 1620 GDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQK 1668 2367 GDA+LD +I +F+ S + SPG +T ++ A+VN + ++F ++ 2368Sbjct: 1134 GDAILDMVIVPIIFQYSNKISPGDMTLIKHAVVNANLLGFFCMEFSIEQ 1182 2369 2370 Score = 99 (39.9 bits), Expect = 1.0e-53, Sum P(5) = 1.0e-53 2371 Identities = 36/155 (23%), Positives = 64/155 (41%) 2372 Links = 1-5-(3)-2-4 2373 2374Query: 1264 EIDDNAAKTDVLERENCEVLPVAINEKSRSFSFEKESKAINGRLIRQRSEEYVSHIDSDI 1323 2375 E + +AK ++ E+C V + ++ + LI R + I D+ 2376Sbjct: 867 ESEHGSAKVHMVAAESCTVDKLPVSTAIFGLFIPHIVDRLESTLIANR---LCATILCDV 923 2377 2378Query: 1324 GLGVSPCLLLTALTTSNAADGMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARS 1383 2379 G ++ TA+ +A + +R+E +GDS LK+ + L+ L+ EG L+ R+ 2380Sbjct: 924 GFADIQHVI-TAIMAPSAQGVTNYQRYEFLGDSILKYIVSCQLFFQNLNWPEGFLTEGRT 982 2381 2382Query: 1384 KEVSNCNLYRLGKKLGIPQLIVANKFDAHDSWLPP 1418 2383 V N L R G+ I+ W+ P 2384Sbjct: 983 TIVQNPRLTRAALDAGLDSFIITKALTPR-RWIAP 1016 2385 2386 Score = 65 (27.9 bits), Expect = 1.0e-53, Sum P(5) = 1.0e-53 2387 Identities = 14/22 (63%), Positives = 16/22 (72%) 2388 Links = 1-5-3-2-(4) 2389 2390Query: 1722 KAMGDIFESVAGAIYLDSGRNL 1743 2391 K DI ESV GAIY+DSG +L 2392Sbjct: 1257 KFFSDIVESVLGAIYVDSGGDL 1278 2393 2394 Score = 54 (24.1 bits), Expect = 1.0e-53, Sum P(5) = 1.0e-53 2395 Identities = 29/111 (26%), Positives = 52/111 (46%) 2396 Links = 1-(5)-3-2-4 2397 2398Query: 502 VITVEEKDTAAY--CSKLPSDIFTRLVPHNQIIPIEEN--GVTKYCAELLLP--INSPIK 555 2399 VIT + T Y C+ LP + R V + E++ G+ K ++LP ++ ++ 2400Sbjct: 555 VITPDSVVTHLYHFCAVLPEE---RYVDNRPEFSFEKDRQGLIK--GTVILPSCVHPKVR 609 2401 2402Query: 556 HAIVLKNPMPNKKTAQMAVALEACRQLHLEGELDDNLLPKGRESIAKLLEH 606 2403 I K +++ A A +A R L+ G L+D+LLP + + +H 2404Sbjct: 610 R-IQGKLWWKSERAAVKETAFQAYRALYEFGLLNDHLLPLTKNPEMRPTDH 659 2405 2406 Score = 41 (19.5 bits), Expect = 2.2e-52, Sum P(5) = 2.2e-52 2407 Identities = 10/30 (33%), Positives = 14/30 (46%) 2408 Links = 1-(6)-3-2-4 2409 2410Query: 828 YYVAEILPEWRPSSKFPDTHFETFNEYFIK 857 2411 Y+ +LPE R P+ FE + IK 2412Sbjct: 566 YHFCAVLPEERYVDNRPEFSFEKDRQGLIK 595 2413 2414 2415>sp|Q4WA22.2|DCL2_ASPFU RecName: Full=Dicer-like protein 2; Includes: RecName: 2416 Full=Endoribonuclease dcl2; Includes: RecName: Full=ATP-dependent 2417 helicase dcl2 2418 Length = 1388 2419 2420 Score = 369 (135.0 bits), Expect = 1.7e-51, Sum P(5) = 1.7e-51 2421 Identities = 156/536 (29%), Positives = 255/536 (47%) 2422 Links = (1)-5-3-2-4 2423 2424Query: 7 DLQCFNPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKRAF 66 2425 D + PR+YQ+E+L+ + K+N IV + TGSGKT IAVL +K + + +P K + 2426Sbjct: 10 DASPYQPRNYQLEMLEASMKENIIVAMDTGSGKTHIAVLRIKAE-LDICSP----DKVVW 64 2427 2428Query: 67 FVVEKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGL-----WDSKEQCDQFMKRHHVVVIT 121 2429 F+ V L QQ H EV S + V +T +GL W + D + + V+V T 2430Sbjct: 65 FLAPTVALCIQQ--H-EVIAS-NLPAVRTRTLTGLDKVELWTDQSIWDAVLNGYRVIVST 120 2431 2432Query: 122 AQCLLDLIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDY--KLLKKDKP--VPRVL 177 2433 L D + H ++K+ + +LIFDE HH +H IM D+ L K P VPR++ 2434Sbjct: 121 HAVLADALSHGFVKMSQLALLIFDEAHHCT-RRHAANKIMQDFYHPTLTKSGPAAVPRIM 179 2435 2436Query: 178 GLTASLIKAKVAPEKLMEQLKKLESAMDSVIETAS-DLVSLSKYGAKPY--EVVIICKD- 233 2437 GLTAS + E LM +ES +D+V T L K+ +P+ ++ D 2438Sbjct: 180 GLTASPVVRSNHQELLM-----VESNLDAVCRTPRLHRQELLKFTHRPHLQQIWYTPTDP 234 2439 2440Query: 234 --FEIGCLGIPNFDTVIEIFD-ETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFR-Q 289 2441 F L + E D ++ + P LD R +K +L T + R Q 2442Sbjct: 235 AGFRSASLTLGALYHAWENLDIGDDPYIQRLRK-SP---LDDRA-LKKALLTGKTYCREQ 289 2443 2444Query: 290 LGPWAAWRTAQVWEKELGKIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEA 349 2445 L + R+ ++E ELG+ + + + + S ++ E +K ++ 2446Sbjct: 290 LRRFVD-RSRHIFE-ELGEWAAEYYIYASIKQLRDRVRDSYMSGDW---DEAEKAYLVDF 344 2447 2448Query: 350 LRPYVPQRVIRLFEILET----FNPEFQKERMKLEKAEH--LSAIIFVDQRYIAYSLLLM 403 2449 L +P I F + + +P+F+ L+ ++ S +IFV QR + S + 2450Sbjct: 345 LSK-IPTSDIH-FALNDPDGFRISPKFESLLNFLDSSDQREFSGLIFVKQR-VTVSAMTS 401 2451 2452Query: 404 MRHIKSWEPKFKFVNPDYVVGASGRNLASSDSQG--LHKR-QTEVLRRFHRNEINCLIAT 460 2453 + + + + +F YV G S + AS D G L+ + Q + L F N +IAT 2454Sbjct: 402 LLSVHPYTRE-RFRCAAYV-GWSNSS-ASKDILGDLLNMQLQRDTLDDFRSGRKNLIIAT 458 2455 2456Query: 461 SVLEEGVDVKQCNLVIKFDRPLDMRSYVQSKGRARRAGSRYVITVEEKDTAAYCSK 516 2457 VLEEG+D+ C++V+ +D+P +++S++Q +GRARR S + I DT+A S+ 2458Sbjct: 459 DVLEEGIDLSACSVVVCYDKPPNLKSFIQRRGRARRKQSTFAIMFPTDDTSADVSR 514 2459 2460 Score = 178 (67.7 bits), Expect = 1.7e-51, Sum P(5) = 1.7e-51 2461 Identities = 54/165 (32%), Positives = 86/165 (52%) 2462 Links = 1-5-3-(2)-4 2463 2464Query: 1500 QQHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPSPLLRFIDTP 1559 2465 ++ +S K +AD VEALIG + G + T + I++ +P L +DT 2466Sbjct: 1035 KRQMSTKVLADVVEALIGAAYVD-GGHSTAQAC-------IRRF----LPEINLHAVDTR 1082 2467 2468Query: 1560 TNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGCYQRLEFL 1619 2469 T A+ + + +L++ IGY F++ + LV+A TH S + T YQRLE+L 2470Sbjct: 1083 T---AARSVAPESARHMMNDRLKDHIGYTFEDESLLVEALTHPSCDYDSTTQSYQRLEYL 1139 2471 2472Query: 1620 GDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKF 1664 2473 GDAVLD +I +F Q G +T ++ A+VN + A L ++F 2474Sbjct: 1140 GDAVLDMVIVSAIFNHRIQRPQGDMTKIKHAVVNANLLAFLCMEF 1184 2475 2476 Score = 116 (45.9 bits), Expect = 1.7e-51, Sum P(5) = 1.7e-51 2477 Identities = 45/158 (28%), Positives = 69/158 (43%) 2478 Links = 1-5-(3)-2-4 2479 2480Query: 1263 QEIDDNAAKTDVLERENCEV--LPVAINEKSRSFSFEKESKAINGRLIRQRSEEYVSHID 1320 2481 + I D+AAK ++ E C + LP + S E I LI R + + 2482Sbjct: 873 EAIPDSAAKNPIVAAEACTIDRLPFTMAIFGLFISAIVEQLEIE--LIATRLRDTILR-- 928 2483 2484Query: 1321 SDIGLGVSPCLLLTALTTSNAADGMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSF 1380 2485 D+ S ++TA++T A + +R+E +GDS LKF+ + L+ + HEG LS 2486Sbjct: 929 -DVSFK-STDHIITAISTPLAHRLTNYQRYEFLGDSILKFSVSCQLFFQHPNWHEGYLSE 986 2487 2488Query: 1381 ARSKEVSNCNLYRLGKKLGIPQLIVANKFDAHDSWLPP 1418 2489 R V N L + G+ IV + A W P 2490Sbjct: 987 GRDMIVQNPRLAKAALDTGLDAYIVTKRL-ASRKWSAP 1023 2491 2492 Score = 74 (31.1 bits), Expect = 1.7e-51, Sum P(5) = 1.7e-51 2493 Identities = 35/126 (27%), Positives = 61/126 (48%) 2494 Links = 1-5-3-2-(4) 2495 2496Query: 1718 IEVPKAMGDIFESVAGAIYLDSGRNLDT----TWQV-IFHMMRGTIELCC-ANPPRSPIR 1771 2497 + K DI ESV GAI++DSG NL Q+ + +R ++ PRS ++ 2498Sbjct: 1259 LNADKFFSDIIESVLGAIFVDSGGNLAPCEVFVEQIGLMAYLRRILDHGIDVRHPRSVVQ 1318 2499 2500Query: 1772 ELMEFEQSKVRFSKMERI-LESG--KVRVTVEVVNNMRFTGMG-RNYRIAKATAAKRALK 1827 2501 +L + + ++F ++R+ E G + +V++ F G A+ TAA A+K 2502Sbjct: 1319 QLAK---TNIQFV-LQRVPTEEGGASYQCSVQMEQAELFVVTGCLTAEEAEVTAAVEAIK 1374 2503 2504Query: 1828 YLHQIE 1833 2505 +L + E 2506Sbjct: 1375 FLTRDE 1380 2507 2508 Score = 53 (23.7 bits), Expect = 1.7e-51, Sum P(5) = 1.7e-51 2509 Identities = 30/145 (20%), Positives = 61/145 (42%) 2510 Links = 1-(5)-3-2-4 2511 2512Query: 513 YCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAELLLP--INSPIKHAIVLKNPMPNKKTA 570 2513 +C+ LP + + P E+G+ K ++LP ++ ++ + ++ A 2514Sbjct: 571 FCAVLPPQPYVDMRPVFSF-ETNEDGLLK--GTVILPSCVHPKVRRTEG-RRWWRTERAA 626 2515 2516Query: 571 QMAVALEACRQLHLEGELDDNLLPKGRESIAKL-----LEHIDEEPDEYAPGIAAKVGSS 625 2517 A +A + L+ G ++D+LLP ++ K + I E ++Y P I S 2518Sbjct: 627 MKETAFQAYKSLYEFGLVNDHLLPLTKKPELKTHDLGSMPSILETSEQYDPWIEWAYSWS 686 2519 2520Query: 626 KRKQLYDKKIARALNESFVEADKEC 650 2521 ++ +I +NE D+ C 2522Sbjct: 687 S-PDIHQSRIVVKMNEG--RGDELC 708 2523 2524 2525Parameters: 2526 links 2527 postsw 2528 -i cele_dcr1.fa 2529 -i cele_dcr1.fa 2530 wordmask=seg+xnu 2531 -d /data/databases/BLAST/swissprot 2532 -o celedcr1-vs-swissprot.BLASTP 2533 E=1e-50 2534 2535 ctxfactor=1.00 2536 2537 Query ----- As Used ----- ----- Computed ---- 2538 Frame MatID Matrix name Lambda K H Lambda K H 2539 +0 0 BLOSUM62 0.318 0.134 0.390 same same same 2540 Q=9,R=2 0.244 0.0300 0.180 n/a n/a n/a 2541 2542 Query 2543 Frame MatID Length Eff.Length E S W T X E2 S2 2544 +0 0 1845 1845 9.0e-51 566 3 11 22 0.41 34 2545 40 0.45 37 2546 2547 2548Statistics: 2549 2550 Database: /data/databases/BLAST/swissprot 2551 Title: swissprot 2552 Posted: 9:42:51 AM PST Dec 14, 2008 2553 Created: 9:42:51 AM PST Dec 14, 2008 2554 Format: XDF-1 2555 # of letters in database: 132,868,552 2556 # of sequences in database: 353,658 2557 # of database sequences satisfying E: 19 2558 No. of states in DFA: 634 (134 KB) 2559 Total size of DFA: 1250 KB (2395 KB) 2560 Time to generate neighborhood: 0.00u 0.00s 0.00t Elapsed: 00:00:00 2561 No. of threads or processors used: 4 2562 Search cpu time: 109.05u 0.35s 109.40t Elapsed: 00:00:27 2563 Total cpu time: 109.26u 0.35s 109.61t Elapsed: 00:00:27 2564 Start: Sun Dec 14 09:52:50 2008 End: Sun Dec 14 09:53:17 2008 2565