1# hmmscan :: search sequence(s) against a profile database 2# HMMER 3.0 (March 2010); http://hmmer.org/ 3# Copyright (C) 2010 Howard Hughes Medical Institute. 4# Freely distributed under the GNU General Public License (GPLv3). 5# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 6# query sequence file: ../nrpspks.fa 7# target HMM database: /data/uni/antismash2/antismash/specific_modules/nrpspks/nrpspksdomains.hmm 8# model-specific thresholding: TC cutoffs 9# number of worker threads: 2 10# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 11 12Query: bpsA [L=3165] 13Scores for complete sequence (score includes all domains): 14 --- full sequence --- --- best 1 domain --- -#dom- 15 E-value score bias E-value score bias exp N Model Description 16 ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 17 0 1080.2 1.3 4e-111 362.7 0.0 3.3 3 AMP-binding AMP-binding enzyme 18 6.6e-248 811.3 29.9 1.3e-133 436.1 3.5 3.3 3 Cglyc 19 2.5e-218 714.1 0.0 2.7e-107 349.6 0.0 3.3 3 Condensation_DCL 20 2.8e-168 552.4 119.2 1.7e-143 470.4 30.9 4.4 3 Epimerization 21 2e-135 441.8 0.0 3.7e-59 191.5 0.0 3.5 3 Condensation_LCL 22 1.7e-110 360.3 2.5 7.7e-49 157.9 0.2 3.2 3 Condensation_Starter 23 2e-92 300.9 0.0 5.4e-47 151.8 0.0 3.2 2 Condensation_Dual 24 1.3e-81 265.3 81.7 8.1e-23 70.6 9.9 8.9 6 CAL_domain 25 9.6e-65 206.1 3.3 2.8e-22 70.0 0.1 3.7 3 PCP 26 4.5e-62 201.4 0.0 3.1e-26 83.7 0.1 3.5 3 Heterocyclization 27 6.2e-38 121.7 38.4 4.5e-21 66.4 5.5 3.9 2 CXglyc 28 8.5e-27 84.6 5.1 2.2e-10 32.0 0.1 3.9 3 ACP 29 2.4e-12 37.2 0.1 4.1e-08 23.6 0.0 2.4 1 NRPS-COM_Nterm 30 4.4e-11 33.6 10.2 1.7e-06 19.1 1.2 2.9 0 NRPS-COM_Cterm 31 32 33Domain annotation for each model (and alignments): 34>> AMP-binding AMP-binding enzyme 35 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 36 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 37 1 ! 360.7 0.1 6.3e-111 1.7e-110 1 418 [] 36 428 .. 36 428 .. 0.96 38 2 ! 362.7 0.0 1.5e-111 4e-111 1 418 [] 1059 1449 .. 1059 1449 .. 0.96 39 3 ! 354.4 0.0 5.1e-109 1.4e-108 1 418 [] 2564 2970 .. 2564 2970 .. 0.96 40 41 Alignments for each domain: 42 == domain 1 score: 360.7 bits; conditional E-value: 6.3e-111 43 EHHHHHHHHHHHHHHHHH----TT-EEEEE-SSSHHHHHHHHHHHHTT-EEEE--TTS-HHHHHHHHHHCTESEEEEESBCHCCHHHHHHHHHCHHEC CS 44 AMP-binding 1 TYreldervnrlaagLrklGvkpgdrVaillpnspewviaflaclkaGavyvpvyptlpaerlayilndseakvlitddelltklkeaaskelakeal 98 45 TYr+lder+ rla L ++G+++gdrVa+++++s+++v+a+la++kaGa+yvpv++ +pa r+a++++ds ak++++++++ ++++ +++ + 46 bpsA 36 TYRQLDERAGRLAGRLASRGIRRGDRVAVVMDRSADLVVALLAVWKAGAAYVPVDAGYPAPRVAFMVADSAAKLVVCSAASRGAVPAGVESLEP---- 129 47 9*************************************************************************************99888764.... PP 48 49 CETTCCEESECCCCCCEHCHHHHGTSTSS-CCCSBTTTSEEEEEEE-------EEEEEEHHHHHHHHHHHHHHHTTTTT.EEEEES-TTSTHHHCCCH CS 50 AMP-binding 99 iivrsepaesvgeeellleleslkkasteppkvplkpddlayiiyTSGtTGkPKgVmlthrnllalvagiakrvglkpddrvlsllplafdgsvleil 196 51 + +++++++ p++ ++p d+ay++yTSG+TG+PKgV ++++ ++ l++ +++ ++ ++ +vl+ +p+afd+s++e++ 52 bpsA 130 -------------------AAAAEEGASDAPAATVRPGDPAYVMYTSGSTGTPKGVTISQGCVAELTMDAGWAMEPGE--AVLMHSPHAFDASLFELW 206 53 ...................67888888888999999***********************************9999944..6***************** PP 54 55 HHHTTT-EEEEESSCCTCSHHHHHHHHHHTT-SEEEE-HHHHHHHHHHHHCCCTTTTT--EEEE-----THHHHHHHHHHCTTSEEEEEE--GGGSSE CS 56 AMP-binding 197 gplllGatlvlvspedlkdpalllddiekykvtvlalvptllelllkapekkkldlsslrlilsggeplspellrrlreafggipivngYGltEttvi 294 57 +pl++G+++vl++p + d+++l + ++ +vt ++l+ l++++++++ +++ r +l+gg+ +++++++r+r a +++++ n+YG+tE+t++ 58 bpsA 207 MPLASGVRVVLAEPGSV-DARRL-REAAAAGVTRVYLTAGSLRAVAEEAP---ESFAEFREVLTGGDVVPAHAVERVRTAAPRARFRNMYGPTEATMC 299 59 ****************6.66665.666689*******************8...9******************************************** PP 60 61 SEEEECGHHH..-SSC---EBSTTTEEEEEBSTT-BEE-S----EEEESTTS--B-TT-HHHHHHHEEESTT-....EEE---EEEE-TT--EEEEEG CS 62 AMP-binding 295 vtvslpgdee..tkpgsiGrplpgveikivdeegkevppgevGEllirgpsvakGYlkdpeltaeafvedgwk....lyrTGDlgridedGyleiiGR 386 63 +t++l+ + + +++iGrpl+g +++++d ++v+pg+vG l+++g+ +a+GY+++ +ltae+fv+d+ + +y TGDl+ +++dG+l + GR 64 bpsA 300 ATWHLLQPGDvvGPVVPIGRPLTGRRVQVLDASLRPVGPGVVGDLYLSGA-LAEGYFNRAALTAERFVADPSApgqrMYWTGDLAQWTADGELVFAGR 396 65 *********999*************************************5.9********************************************** PP 66 67 GGCEEEB---EEEHHHHHHHHHTSTTEEEEEE CS 68 AMP-binding 387 kkdqvkirGeriepgeiEsvllehpgvaeaaV 418 69 ++dqvkirG+riepgeiE++l++ p+v++a+V 70 bpsA 397 ADDQVKIRGFRIEPGEIEAALIAQPDVHDAVV 428 71 ******************************98 PP 72 73 == domain 2 score: 362.7 bits; conditional E-value: 1.5e-111 74 EHHHHHHHHHHHHHHHHH----TT-EEEEE-SSSHHHHHHHHHHHHTT-EEEE--TTS-HHHHHHHHHHCTESEEEEESBCHCCHHHHHHHHHCHH CS 75 AMP-binding 1 TYreldervnrlaagLrklGvkpgdrVaillpnspewviaflaclkaGavyvpvyptlpaerlayilndseakvlitddelltklkeaaskelake 96 76 +Y++l+er+ ++aa+Lr++Gv+ +drV++++ +s++w + +l++l aG+++vpv+p +paer ++i++ +++ ++++ + +++++ +++l++ 77 bpsA 1059 SYADLWERSLKFAAVLRAHGVRSEDRVGLVVGRSAWWTVGMLGVLLAGGTFVPVDPAYPAERKEWIFRSANPMLVVCAGATRGAVPAEFADRLVV- 1153 78 7**************************************************************************************99999865. PP 79 80 ECCETTCCEESECCCCCCEHCHHHHGTSTSS-CCCSBTTTSEEEEEEE-------EEEEEEHHHHHHHHHHHHHHHTTTTT.EEEEES-TTSTHHH CS 81 AMP-binding 97 aliivrsepaesvgeeellleleslkkasteppkvplkpddlayiiyTSGtTGkPKgVmlthrnllalvagiakrvglkpddrvlsllplafdgsv 192 82 +e +++a ++ + ++p++ ay+iyTSG+TG+PKgV++th++l +l+ ++++r+g++p++rvl++++l fd v 83 bpsA 1154 --------------------IDEVDPAAGSAGDLPRVDPRSAAYVIYTSGSTGTPKGVVVTHAGLGNLALAHIDRFGVSPSSRVLQFAALGFDTIV 1229 84 ....................355555555555555557********************************************************** PP 85 86 CCCHHHHTTT-EEEEESSCCTCSHHHHHHHHHHTT-SEEEE-HHHHHHHHHHHHCCCTTTTT--EEEE-----THHHHHHHHHHCTTSEEEEEE-- CS 87 AMP-binding 193 leilgplllGatlvlvspedlkdpalllddiekykvtvlalvptllelllkapekkkldlsslrlilsggeplspellrrlreafggipivngYGl 288 88 e++++ll+Gatlv+++++dl+ a + d++e+ +t++ ++p++l + p s++ +++ +ge ++p l++rl + +++n+YG+ 89 bpsA 1230 SEVMMALLSGATLVVPPERDLPPRASFTDALERWDITHVKAPPSVLGTADVLP-------STVETVVAAGELCPPGLVDRLSAD---RRMINAYGP 1315 90 ***********************************************999888.......8*********************95...57******* PP 91 92 GGGSSESEEEECGHHH-SSC---EBSTTTEEEEEBSTT-BEE-S----EEEESTTS--B-TT-HHHHHHHEEESTT-....EEE---EEEE-TT-- CS 93 AMP-binding 289 tEttvivtvslpgdeetkpgsiGrplpgveikivdeegkevppgevGEllirgpsvakGYlkdpeltaeafvedgwk....lyrTGDlgridedGy 380 94 tEtt+++t+s p + ++p++ G+p+pgv+ +++d +++ppg++GEl+++g +va+GYl++ +ltae+fv+d++ +yrTGDl++++e+G+ 95 bpsA 1316 TETTICATMSMPLSPGQHPIPFGKPVPGVRGYLLDSFLRPLPPGVTGELYLAGIGVARGYLGRSALTAERFVADPFVpgerMYRTGDLAYWTEQGE 1411 96 ************************************************************************************************ PP 97 98 EEEEEGGGCEEEB---EEEHHHHHHHHHTSTTEEEEEE CS 99 AMP-binding 381 leiiGRkkdqvkirGeriepgeiEsvllehpgvaeaaV 418 100 l GR++dqvkirG+r+ep eiE +l++ p v +aaV 101 bpsA 1412 LVSAGRADDQVKIRGFRVEPREIEFALSGYPRVTQAAV 1449 102 *************************************9 PP 103 104 == domain 3 score: 354.4 bits; conditional E-value: 5.1e-109 105 EHHHHHHHHHHHHHHHHH----TT-EEEEE-SSSHHHHHHHHHHHHTT-EEEE--TTS-HHHHHHHHHHCTESEEEEESBCHCCHHHHHHHHHCHH CS 106 AMP-binding 1 TYreldervnrlaagLrklGvkpgdrVaillpnspewviaflaclkaGavyvpvyptlpaerlayilndseakvlitddelltklkeaaskelake 96 107 TY+eld+r+n+la++L ++G++p+ Va+llp+s+e+v+a+la+ k+G++++p++p +pa+r+a++l+d++++++it++ l ++ + + + + 108 bpsA 2564 TYAELDARANQLARWLIDQGAGPEGLVAVLLPRSLELVVALLAVTKTGGAWLPIDPGYPADRIAFMLDDAGPALVITTAVLSASPIGDVLAARSRT 2659 109 9*********************************************************************************99999888888776 PP 110 111 ECCETTCCEESECCCCCCEHCHHHHGTSTSS-CCCSBTTTSEEEEEEE-------EEEEEEHHHHHHHHHHHHHHHTTTTT.EEEEES-TTSTHHH CS 112 AMP-binding 97 aliivrsepaesvgeeellleleslkkasteppkvplkpddlayiiyTSGtTGkPKgVmlthrnllalvagiakrvglkpddrvlsllplafdgsv 192 113 ++ + ++ + +l + ++ ++ ++++ l+p+++ay+iyTSG+TG+PK+V++thrnl++++ +++++++ + r+++ +++afd+ v 114 bpsA 2660 VVLD--------EPAAAGQLAGRDRAPVTDTDRARALDPRHPAYLIYTSGSTGRPKAVVVTHRNLTNYLLHCGRMYPGLRG-RSVLHSSIAFDLTV 2746 115 6555........5667788999999999999999999*****************************************999.************** PP 116 117 CCCHHHHTTT-EEEEESSCCTCSHHHHHHHHHHTT-SEEEE-HHHHHHHHHHHHCCCTTTTT--EEEE-----THHHHHHHHHHCTTSEEEEEE-- CS 118 AMP-binding 193 leilgplllGatlvlvspedlkdpalllddiekykvtvlalvptllelllkapekkkldlsslrlilsggeplspellrrlreafggipivngYGl 288 119 +++++pl++G+ +++ ed l +e+ +l ++p++l +l a +l+gge+l+++++ ++r++ ++i++vn YG+ 120 bpsA 2747 TATFTPLIVGGEIHVGALED------LIGVVEAAPSIFLKATPSHLLTLDTASR----GSAGSGDLLLGGEQLPADTVVQWRRKYPNIVVVNEYGP 2832 121 ***************99555......8999999999999999999999999995....55666779****************************** PP 122 123 GGGSSESEEEECGHHH....-SSC---EBSTTTEEEEEBSTT-BEE-S----EEEESTTS--B-TT-HHHHHHHEEESTT-....EEE---EEEE- CS 124 AMP-binding 289 tEttvivtvslpgdee....tkpgsiGrplpgveikivdeegkevppgevGEllirgpsvakGYlkdpeltaeafvedgwk....lyrTGDlgrid 376 125 tE+tv+++ +++++ + +++iG+pl+++++ ++d + ++vppg+vGEl+++g+++a+GYl++ lta +fv+d+++ +yrTGDl+ ++ 126 bpsA 2833 TEATVGCVEYRLEPGQecppGGVVPIGTPLANMRAFVLDSWLRLVPPGAVGELYVAGAGLARGYLGRAGLTATRFVADPFGsgerMYRTGDLVQWN 2928 127 ************99999******************************************************************************* PP 128 129 TT--EEEEEGGGCEEEB---EEEHHHHHHHHHTSTTEEEEEE CS 130 AMP-binding 377 edGyleiiGRkkdqvkirGeriepgeiEsvllehpgvaeaaV 418 131 +dG+l + GR++dqvk+rG+riepgeiE++l + + v +a+V 132 bpsA 2929 PDGQLVFAGRVDDQVKVRGFRIEPGEIEAALVAQESVGQAVV 2970 133 ****************************************98 PP 134 135>> Cglyc 136 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 137 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 138 1 ! 436.1 3.5 4.7e-134 1.3e-133 2 299 .] 601 893 .. 600 893 .. 0.98 139 2 ! 35.4 5.4 5.3e-12 1.4e-11 39 297 .. 1638 1904 .. 1626 1906 .. 0.80 140 3 ! 351.5 1.2 2.8e-108 7.5e-108 1 298 [. 2087 2381 .. 2087 2382 .. 0.98 141 142 Alignments for each domain: 143 == domain 1 score: 436.1 bits; conditional E-value: 4.7e-134 144 Cglyc 2 edvWPLsPlqeGllfhaaldeegpdvYqvqrileldgpldaarlraaWeallarhaaLrasfrrlksgetvqvvarevelpWrevDlselpedeaeaeverlaa 105 145 e++WPL+PlqeGllf+++ld++g+d+Yqvq ilel+gp+da rlraaW+a+++rh++Lr sf+rl+sg+tvq+v+++v+ pWr+vDl+++ +++a+v++l+a 146 bpsA 601 EEIWPLAPLQEGLLFESILDDQGSDIYQVQVILELNGPVDAPRLRAAWDAVVRRHPELRLSFHRLASGKTVQAVHGDVTPPWRVVDLTGA--GDVDAAVAALVA 702 147 89***************************************************************************************9..99********** PP 148 149 Cglyc 106 eeraerfdlakaPllrllLvrlgedrhrlvvtshhilvDGWslpiileelaalYaaggdaselpaaasyrdylaWlsrqdkeaaraaWraelagldeptlvapa 209 150 ee+++rf+la+aPl+rl+Lvr+++dr+rl++++hhilvDGWs+++il++++++Y+ag+ ++e++ a++rdylaWl+rqd++aaraaWraelagldep+l+a++ 151 bpsA 703 EEQQQRFELATAPLVRLVLVRIAADRYRLLFVIHHILVDGWSVAVILNDVSEAYEAGEPVPEQRGGATFRDYLAWLDRQDDDAARAAWRAELAGLDEPALIATS 806 152 ******************************************************************************************************76 PP 153 154 Cglyc 210 daarapaepeevvlelseeltrrlvelarehgltlntvvqgaWalvLarLagrtdvvfGatvagrPaelpgvesmvGlllntvPvrvrLd 299 155 +++e+++++++l+++l++rl+ +arehglt +tvv++aWa+vLarL++rtdvvfG++va+rP+el+g+esm+Gll+++vPvrv Ld 156 bpsA 807 G---VETEYDYRATHLTPALHTRLLGFAREHGLTPSTVVHAAWAMVLARLTRRTDVVFGTMVATRPPELAGIESMPGLLMTAVPVRVPLD 893 157 6...5667999*****************************************************************************97 PP 158 159 == domain 2 score: 35.4 bits; conditional E-value: 5.3e-12 160 Cglyc 39 pldaarlraaWeallarhaaLrasfrrlksgetvqvva.revelpWrevDlselpedeaeaeverlaaeeraerfdlakaPllrllLvrlgedrh.rlvvts 138 161 l ++ l a + a+++ h++Lra ++g+ + v + ++v++ ++ + + +e+ + aa+ +r+d ++ + + + v g+d+ rlvv+ 162 bpsA 1638 DLTEKALAAGFAAVVDTHDMLRARVVADEGGRRLVVGErGSVDVAGAVTRIRAD--GRSLDEAVADAARAAVTRLDPSAGVMAQAVWVDAGPDQVgRLVVVA 1737 163 466788999********************9998766541568888777777544..55555555567788899******************988559***** PP 164 165 Cglyc 139 hhilvDGWslpiileelaalYaa...ggdaselpaaasyrdy...l.aWlsrqdkeaaraaWraelagldeptlvapadaarapaepeevvlelseeltrrl 233 166 hh+ vDG s i+l++l+a+ +a g + p as++ + l W ++ aaW+a l d+p+ ++++ + a+ + ++ +++ t +l 167 bpsA 1738 HHLSVDGVSWRILLSDLQAACEAavaGREPVLEPVGASFKRWaglLaEWAVSAERAGELAAWKAILGPGDRPAGAQATS-RAAEGAVRSRSWVVPKVETAAL 1838 168 ******************9988722133344456789***98333224777888888899************9887544.4455555667777777788888 PP 169 170 Cglyc 234 velar.ehgltlntvvqgaWalvLarLagrtdvvfGatvagr.PaelpgvesmvGlllntvPvrvr 297 171 + a +n v+ + a +ar g + v+ gr P + +++ + vG + ++ Pvr 172 bpsA 1839 AGRAPvAFHCGVNEVLLAGLAGAVARWRGGDAVLVDVESHGRhPVDGTDLSRTVGWFTSAHPVRLD 1904 173 87775255788999999999****************999999799*******************75 PP 174 175 == domain 3 score: 351.5 bits; conditional E-value: 2.8e-108 176 Cglyc 1 ledvWPLsPlqeGllfhaaldeegpdvYqvqrileldgpldaarlraaWeallarhaaLrasfrrlksgetvqvvarevelpWrevDlselpedeaeaever 102 177 l++v PLsPlq+Gl fha + +g+dvY++q +lel gpld+ lr++ +all+rha+Lra+fr+ ++g++ qvv + v++p + vD++e ++++ae+++ 178 bpsA 2087 LAEVLPLSPLQHGLAFHAGYAGDGVDVYTAQAVLELAGPLDVPLLRKSVRALLDRHANLRAGFRHGADGTAYQVVPGAVAVPVTLVDVTES--ADPAAEAAA 2186 179 579**************************************************************************************99..88999999* PP 180 181 Cglyc 103 laaeeraerfdlakaPllrllLvrlgedrhrlvvtshhilvDGWslpiileelaalYaaggdaselpaaasyrdylaWlsrqdkeaaraaWraelagldept 204 182 +aa era+ f+la++Pllr+++v lg+drhrlv+t hhil+DGWs+p++l+el++lY +g + ++l++++ yrdylaW+ d+eaa +aWr+ lagl ept 183 bpsA 2187 VAAAERARPFELARPPLLRVMVVVLGPDRHRLVLTNHHILLDGWSTPLLLDELLTLYRNGAAPAALAPVTPYRDYLAWVRETDREAATEAWRDALAGLPEPT 2288 184 ****************************************************************************************************** PP 185 186 Cglyc 205 lvapadaarapaepeevvlelseeltrrlvelarehgltlntvvqgaWalvLarLagrtdvvfGatvagrPaelpgvesmvGlllntvPvrvrL 298 187 lva+ + + pe+ ++l+e+++++l + are g+t++tv+q++W +vLa L+gr+dvvfG++v+grPaelpg+e+mvGl++ntvPvrvr+ 188 bpsA 2289 LVAADRPV-PVEVPEQIWTTLDETFAQALGARARECGVTVSTVLQAVWGMVLAALTGRDDVVFGSVVSGRPAELPGIETMVGLFINTVPVRVRM 2381 189 ***65555.55789******************************************************************************97 PP 190 191>> Condensation_DCL 192 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 193 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 194 1 ! 306.5 0.0 1.3e-94 3.5e-94 1 299 [. 601 892 .. 601 893 .. 0.95 195 2 ! 54.2 0.0 9.1e-18 2.4e-17 28 299 .. 1629 1905 .. 1618 1906 .. 0.86 196 3 ! 349.6 0.0 1e-107 2.7e-107 2 299 .. 2089 2381 .. 2088 2382 .. 0.98 197 198 Alignments for each domain: 199 == domain 1 score: 306.5 bits; conditional E-value: 1.3e-94 200 Condensation_DCL 1 edvypLsplQeGllfhallde.eadvYvvqlvlelegeldverlraaaqalvdrheiLrtaFveeeleepvqvvlkevelelreldlselaee 92 201 e+++pL+plQeGllf ++ld+ ++d Y vq++lel+g++d+ rlraa++a+v+rh+ Lr +F++ +++++vq v+ +v+ ++r++dl++ + 202 bpsA 601 EEIWPLAPLQEGLLFESILDDqGSDIYQVQVILELNGPVDAPRLRAAWDAVVRRHPELRLSFHRLASGKTVQAVHGDVTPPWRVVDLTGAGDV 693 203 68*****************9989******************************************************************8886 PP 204 205 Condensation_DCL 93 eqeeelealaaedrergFdlarapllrltlirlaeeryrlvltnHhillDGWslplllkellelYqalaegepaalpaa.rpYrdYiawlarq 184 206 + +++ al ae+++++F+la+apl+rl+l+r a++ryrl++ Hhil+DGWs++++l+++ e Y ++gep+ ++ +++rdY+awl+rq 207 bpsA 694 D--AAVAALVAEEQQQRFELATAPLVRLVLVRIAADRYRLLFVIHHILVDGWSVAVILNDVSEAY---EAGEPVPEQRGgATFRDYLAWLDRQ 781 208 6..**************************************************************...556655554545************* PP 209 210 Condensation_DCL 185 dkeaaeaaWreeLagleeptllaeakkeeeeeaepeeleveldeeateaLeelarsqgvTlntlvqaawallLsrltgrddvvFGatvsgRpa 277 211 d++aa+aaWr+eLagl+ep l+a + e+e + ++l+ + +++L +ar++g+T +t+v+aawa++L+rlt+r+dvvFG+ v+ Rp+ 212 bpsA 782 DDDAARAAWRAELAGLDEPALIATSGVETE----YDYRATHLTPALHTRLLGFAREHGLTPSTVVHAAWAMVLARLTRRTDVVFGTMVATRPP 870 213 **********************99998774....666778899************************************************** PP 214 215 Condensation_DCL 278 elpgvesmvGlfiNtvPvrvrl 299 216 el+g+esm Gl++ vPvrv l 217 bpsA 871 ELAGIESMPGLLMTAVPVRVPL 892 218 *******************976 PP 219 220 == domain 2 score: 54.2 bits; conditional E-value: 9.1e-18 221 Condensation_DCL 28 vqlvlelegeldverlraaaqalvdrheiLrtaFveeeleepvqvvlkevelelreldlselaeeeqeeelealaaedrergFdlarapll 118 222 + +v+ + l ++l+a ++a+vd h++Lr+ v +e + + vv ++ ++++ ++ +a+ ++ +e+ a aa+ ++ d+++ ++ 223 bpsA 1629 QWMVVGTPSDLTEKALAAGFAAVVDTHDMLRARVVADEGG-RRLVVGERGSVDVAGAVTRIRADGRSLDEAVADAARAAVTRLDPSAGVMA 1718 224 5566777788999*********************996655.56699999999998877777767666666666667777889********* PP 225 226 Condensation_DCL 119 rltlirlaeery.rlvltnHhillDGWslplllkellelYqalaegepaalpaa.rpYrdYiawlarq....dkeaaeaaWreeLagleep 203 227 + + + + +++ rlv+ +Hh+ +DG s +ll++l + +a+ +g+++ l+++ ++++ + + la+ +++ aaW++ L ++p 228 bpsA 1719 QAVWVDAGPDQVgRLVVVAHHLSVDGVSWRILLSDLQAACEAAVAGREPVLEPVgASFKRWAGLLAEWavsaERAGELAAWKAILGPGDRP 1809 229 *******9987659*************************************9999******988877622226666778************ PP 230 231 Condensation_DCL 204 tllaeakkeeeeeaepeeleveldeeateaLeelar.sqgvTlntlvqaawallLsrltgrddvvFGatvsgR.paelpgvesmvGlfiNt 292 232 + +++++ e ++++ + +++ +t+aL+ a + + +n ++ a a ++r g d v+ + gR p++ ++ ++vG f 233 bpsA 1810 AGAQATSRAA--EGAVRSRSWVVPKVETAALAGRAPvAFHCGVNEVLLAGLAGAVARWRGGDAVLVDVESHGRhPVDGTDLSRTVGWFTSA 1898 234 9988777776..68899999999********988862679*************************99999999567888899********* PP 235 236 Condensation_DCL 293 vPvrvrl 299 237 Pvr+++ 238 bpsA 1899 HPVRLDV 1905 239 ****876 PP 240 241 == domain 3 score: 349.6 bits; conditional E-value: 1e-107 242 Condensation_DCL 2 dvypLsplQeGllfhallde.eadvYvvqlvlelegeldverlraaaqalvdrheiLrtaFveeeleepvqvvlkevelelreldlselae 91 243 +v+pLsplQ+Gl fha ++ + dvY+ q+vlel+g+ldv +lr++++al+drh++Lr++F + ++++ qvv+ v+++++ +d++e a+ 244 bpsA 2089 EVLPLSPLQHGLAFHAGYAGdGVDVYTAQAVLELAGPLDVPLLRKSVRALLDRHANLRAGFRHGADGTAYQVVPGAVAVPVTLVDVTESAD 2179 245 79****************9989******************************************************************877 PP 246 247 Condensation_DCL 92 eeqeeelealaaedrergFdlarapllrltlirlaeeryrlvltnHhillDGWslplllkellelYqalaegepaalpaarpYrdYiawla 182 248 + +e+ a+aa++r+r F+lar+pllr++++ l+ +r+rlvltnHhillDGWs+plll+ell+lY +++ paal +++pYrdY+aw++ 249 bpsA 2180 PA--AEAAAVAAAERARPFELARPPLLRVMVVVLGPDRHRLVLTNHHILLDGWSTPLLLDELLTLY--RNGAAPAALAPVTPYRDYLAWVR 2266 250 76..9999**********************************************************..99999****************** PP 251 252 Condensation_DCL 183 rqdkeaaeaaWreeLagleeptllaeakkeeeeeaepeeleveldeeateaLeelarsqgvTlntlvqaawallLsrltgrddvvFGatvs 273 253 + d+eaa++aWr++Lagl eptl+a +++ + pe++ ++lde+ +aL + ar++gvT++t++qa+w+++L++ltgrddvvFG++vs 254 bpsA 2267 ETDREAATEAWRDALAGLPEPTLVAADRPVP--VEVPEQIWTTLDETFAQALGARARECGVTVSTVLQAVWGMVLAALTGRDDVVFGSVVS 2355 255 **************************99988..59******************************************************** PP 256 257 Condensation_DCL 274 gRpaelpgvesmvGlfiNtvPvrvrl 299 258 gRpaelpg+e+mvGlfiNtvPvrvr+ 259 bpsA 2356 GRPAELPGIETMVGLFINTVPVRVRM 2381 260 ************************98 PP 261 262>> Epimerization 263 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 264 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 265 1 ! 57.4 16.7 4.3e-19 1.1e-18 28 178 .. 631 773 .. 631 802 .. 0.80 266 2 ! 470.4 30.9 6.4e-144 1.7e-143 1 317 [] 1606 1906 .. 1606 1906 .. 0.99 267 3 ! 41.6 18.3 2.7e-14 7e-14 29 214 .. 2119 2294 .. 2118 2316 .. 0.87 268 269 Alignments for each domain: 270 == domain 1 score: 57.4 bits; conditional E-value: 4.3e-19 271 Epimerization 28 vlLevpagldedaLraALqaLldhHDALRlRf.reedggwrqrnvperGavdeaaflLevvdlsggdd.ldaaieaaaneaQasLDlaaGpLlrAv 121 272 v Le+ ++d+ +LraA a++++H+ LRl f r + g+ +q + +G v ++ +vvdl+g+ d ++a+++ a e Q+++ la+ pL+r+v 273 bpsA 631 VILELNGPVDAPRLRAAWDAVVRRHPELRLSFhRLASGKTVQAV---HGDVT---PPWRVVDLTGAGDvDAAVAALVAEEQQQRFELATAPLVRLV 720 274 67999999**********************************88...55555...*************6666666678899*************** PP 275 276 Epimerization 122 lfd.agdgdpgrLlLviHHLVVDGVSWRILLEDLaaAYeQaaaGqaiaLppKTtSfrr 178 277 l++ a+d rLl+viHH VDG S ++L D AYe+ G+++ + fr+ 278 bpsA 721 LVRiAADRY--RLLFVIHHILVDGWSVAVILNDVSEAYEA---GEPVPEQRGGATFRD 773 279 ***655555..*************8888888888888885...666555555555555 PP 280 281 == domain 2 score: 470.4 bits; conditional E-value: 6.4e-144 282 Epimerization 1 tGevpLTPIQrWFfeqdggerhHfNQsvlLevpagldedaLraALqaLldhHDALRlRfreedggwrqrnvperGavdeaaflLevvdlsggdd 94 283 +G+v++TP++ ++ dg + + f+Q++++ +p++l+e+aL+a+++a++d+HD+LR+R++ ++gg r+++ +erG+vd +a+++++++++g + 284 bpsA 1606 VGDVAWTPVMWMLG--DGVAGPAFAQWMVVGTPSDLTEKALAAGFAAVVDTHDMLRARVVADEGGRRLVV-GERGSVD-VAGAVTRIRADGRS- 1694 285 7*************..6************************************************9****.*******.**************. PP 286 287 Epimerization 95 ldaaieaaaneaQasLDlaaGpLlrAvlfdagdgdpgrLlLviHHLVVDGVSWRILLEDLaaAYeQaaaGqaiaLppKTtSfrrWAerLaeyAq 188 288 ld+a+++aa++a+++LD++aG++ +Av++dag++++grL++v+HHL VDGVSWRILL DL+aA+e+a+aG++++L+p++ Sf+rWA +Lae+A 289 bpsA 1695 LDEAVADAARAAVTRLDPSAGVMAQAVWVDAGPDQVGRLVVVAHHLSVDGVSWRILLSDLQAACEAAVAGREPVLEPVGASFKRWAGLLAEWAV 1788 290 ********************************************************************************************** PP 291 292 Epimerization 189 seallaEldYWrevlagpdppLPadrpdgdkaddtagtartvsvtLsaeeTraLLtevpaAYhTgvNDvLLtALalAlarWtGgrGggdaavlv 282 293 s ++++El+ W+++l+++d+p +a + + +g++r++s+++++ eT+aL +++p A+h+gvN+vLL++La+A+arW+Gg+ avlv 294 bpsA 1789 SAERAGELAAWKAILGPGDRPAGAQATSR----AAEGAVRSRSWVVPKVETAALAGRAPVAFHCGVNEVLLAGLAGAVARWRGGD-----AVLV 1873 295 ************************99999....****************************************************.....**** PP 296 297 Epimerization 283 dLEGHGReEelfdglDlSRTVGWFTSiYPVrLdla 317 298 d+E+HGR +++dg DlSRTVGWFTS +PVrLd+a 299 bpsA 1874 DVESHGR--HPVDGTDLSRTVGWFTSAHPVRLDVA 1906 300 *******..************************96 PP 301 302 == domain 3 score: 41.6 bits; conditional E-value: 2.7e-14 303 Epimerization 29 lLevpagldedaLraALqaLldhHDALRlRfreedgg.wrqrnvperGavdeaaflLevvdlsggddldaaieaaaneaQas.LDlaaGpLlrA 120 304 +Le+ +ld+ Lr+ +aLld+H LR+ fr+ ++g q++ +Gav+ ++++ vd+++ +d++a ++a a++ +a+ + la+ pLlr+ 305 bpsA 2119 VLELAGPLDVPLLRKSVRALLDRHANLRAGFRHGADGtAYQVV---PGAVA---VPVTLVDVTESADPAAEAAAVAAAERARpFELARPPLLRV 2206 306 89*****************************9999999*****...*****...***********99666666666666666799********* PP 307 308 Epimerization 121 vlfdagdgdpgrLlLviHHLVVDGVSWRILLEDLaaAYeQaaaGqaiaLppKTtSfrrWAerLaeyAqseallaEldYWrevlagpdpp..LPa 212 309 + +g+++ +rL+L+ HH DG S LL+ L ++Y+ +G a+a ++ t++r++ + e +++a + Wr +lag +p + a 310 bpsA 2207 MVVVLGPDR-HRLVLTNHHILLDGWSTPLLLDELLTLYR---NGAAPAALAPVTPYRDYLAWVRET----DREAATEAWRDALAGLPEPtlVAA 2292 311 *********.*****************************...9***99999999999975555555....677777889999998777644455 PP 312 313 Epimerization 213 dr 214 314 dr 315 bpsA 2293 DR 2294 316 55 PP 317 318>> Condensation_LCL 319 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 320 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 321 1 ! 178.3 0.0 1.4e-55 3.6e-55 3 295 .. 603 892 .. 601 893 .. 0.90 322 2 ! 68.0 0.0 5.8e-22 1.5e-21 33 295 .. 1634 1905 .. 1615 1906 .. 0.81 323 3 ! 191.5 0.0 1.4e-59 3.7e-59 2 295 .. 2089 2381 .. 2088 2382 .. 0.92 324 325 Alignments for each domain: 326 == domain 1 score: 178.3 bits; conditional E-value: 1.4e-55 327 Condensation_LCL 3 rlplSfaQqrlwflnqle.pesaayniplalrltgeldvealeaAladlvaRheiLRtvf.peedgepvqvvlpaaelelevedls.....ea 88 328 +pl++ Q+ l f + l+ + s+ y+++++l+l+g++d+ +l+aA++++v+Rh LR +f + g++vq v+ +++++++v+dl+ +a 329 bpsA 603 IWPLAPLQEGLLFESILDdQGSDIYQVQVILELNGPVDAPRLRAAWDAVVRRHPELRLSFhRLASGKTVQAVHGDVTPPWRVVDLTgagdvDA 695 330 58999***********98366888************************************66789999************************* PP 331 332 Condensation_LCL 89 eleelveeeaarpFdLekepllrvrllrlaeeehvLllvvHHiiaDgwSlgvllrelaalYaarlagqapelaplpvqYaDYalwqrelleee 181 333 ++++lv+ee +++F+L+++pl+r+ l+r+a++++ Ll+v+HHi +DgwS++v+l++++++Y+a g+ + + +++DY +w + + 334 bpsA 696 AVAALVAEEQQQRFELATAPLVRLVLVRIAADRYRLLFVIHHILVDGWSVAVILNDVSEAYEA---GEPVPEQRGGATFRDYLAWLDR----Q 781 335 *************************************************************54...7777778888********9875....4 PP 336 337 Condensation_LCL 182 elarqlaYWreqLaglpelleLptdrprpavqsyrGarvefeldaelsaklkelarehgvtlFmvllaalavlLsrlsgqeDivvGtpvagRt 274 338 + ++ +a Wr++Lagl e L + + + +yr+ +l ++l+++l +arehg t+ +v++aa+a++L+rl++++D+v Gt va R 339 bpsA 782 DDDAARAAWRAELAGLDEPA-LIATSGVETEYDYRA----THLTPALHTRLLGFAREHGLTPSTVVHAAWAMVLARLTRRTDVVFGTMVATRP 869 340 45666677********8875.666666677777775....78899***********************************************6 PP 341 342 Condensation_LCL 275 ..raeledliGfFvNtlvlrtel 295 343 a +e++ G+ + +++r+ l 344 bpsA 870 peLAGIESMPGLLMTAVPVRVPL 892 345 22578999999999999999865 PP 346 347 == domain 2 score: 68.0 bits; conditional E-value: 5.8e-22 348 Condensation_LCL 33 rltgeldvealeaAladlvaRheiLRtvfpeedgepvqvvlpa..aelelevedls......eaeleelveeeaarpFdLekepllrvrll 115 349 +l ++al+a +a++v+ h++LR + + ++g + vv ++ ++++ +v++++ ++++++++ ++a ++ d +++++ ++ + 350 bpsA 1634 GTPSDLTEKALAAGFAAVVDTHDMLRARVVADEGGRRLVVGERgsVDVAGAVTRIRadgrslDEAVADAA-RAAVTRLDPSAGVMAQAVWV 1723 351 55678999**********************************9665555555555588887555555554.888999************** PP 352 353 Condensation_LCL 116 rlaee.ehvLllvvHHiiaDgwSlgvllrelaalYaarlagqapelaplpvqYaDYalwqrelleeeelarqlaYWreqLaglpelleLpt 205 354 ++ L++v+HH +Dg+S+++ll++l+a+ +a++ag++p l+p+ +++ +a e++ + e a +la W++ L 355 bpsA 1724 DAGPDqVGRLVVVAHHLSVDGVSWRILLSDLQAACEAAVAGREPVLEPVGASFKRWAGLLAEWAVSAERAGELAAWKAILGPG-------- 1806 356 998761578***********************************************************************854........ PP 357 358 Condensation_LCL 206 drprpavqsyrGarvefeldaelsaklkela......rehgvtlFmvllaalavlLsrlsgqeDivvGtpvagRtr...aeledliGfFvN 287 359 drp a+++ r+a+ +++ + + k+++ a + ++ + vlla la ++r g + ++v + gR+ ++l++++G F 360 bpsA 1807 DRPAGAQATSRAAEGAVRSRSWVVPKVETAAlagrapVAFHCGVNEVLLAGLAGAVARWRGGDAVLVDVESHGRHPvdgTDLSRTVGWFTS 1897 361 5666666666555555555555555554433000001344566778****************************85222789999*****9 PP 362 363 Condensation_LCL 288 tlvlrtel 295 364 ++r+++ 365 bpsA 1898 AHPVRLDV 1905 366 99999987 PP 367 368 == domain 3 score: 191.5 bits; conditional E-value: 1.4e-59 369 Condensation_LCL 2 erlplSfaQqrlwflnqlepes.aayniplalrltgeldvealeaAladlvaRheiLRtvf.peedgepvqvvlpaaelelevedls.... 86 370 e lplS+ Q+ l f + ++++ ++y +++l+l g+ldv l++++++l++Rh LR f + dg+++qvv a++++++ +d++ 371 bpsA 2089 EVLPLSPLQHGLAFHAGYAGDGvDVYTAQAVLELAGPLDVPLLRKSVRALLDRHANLRAGFrHGADGTAYQVVPGAVAVPVTLVDVTesad 2179 372 568**************998762679***********************************77899999******************9999 PP 373 374 Condensation_LCL 87 .eaeleelveeeaarpFdLekepllrvrllrlaeeehvLllvvHHiiaDgwSlgvllrelaalYaarlagqapelaplpvqYaDYalwqre 176 375 +ae+++++++e arpF+L++ pllrv ++ l +++h L+l+ HHi DgwS+ +ll+el +lY ++g+ap+ + Y+DY +w re 376 bpsA 2180 pAAEAAAVAAAERARPFELARPPLLRVMVVVLGPDRHRLVLTNHHILLDGWSTPLLLDELLTLY---RNGAAPAALAPVTPYRDYLAWVRE 2267 377 9999999*********************************************************...44555555545559********96 PP 378 379 Condensation_LCL 177 lleeeelarqlaYWreqLaglpelleLptdrprpavqsyrGarvefeldaelsaklkelarehgvtlFmvllaalavlLsrlsgqeDivvG 267 380 + + ++ + Wr++Laglpe + + +drp p + +++ +ld++++++l + are gvt+ +vl+a++ ++L+ l+g++D+v G 381 bpsA 2268 T----DREAATEAWRDALAGLPEPTLVAADRPVPVEVP---EQIWTTLDETFAQALGARARECGVTVSTVLQAVWGMVLAALTGRDDVVFG 2351 382 4....55666677*******************998876...679*********************************************** PP 383 384 Condensation_LCL 268 tpvagRtr..aeledliGfFvNtlvlrtel 295 385 + v+gR + +e ++G+F+Nt+++r+++ 386 bpsA 2352 SVVSGRPAelPGIETMVGLFINTVPVRVRM 2381 387 ******863369***************986 PP 388 389>> Condensation_Starter 390 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 391 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 392 1 ! 157.9 0.2 2.9e-49 7.7e-49 4 299 .. 604 892 .. 601 893 .. 0.91 393 2 ! 47.2 0.1 1.5e-15 4e-15 37 299 .. 1638 1905 .. 1629 1906 .. 0.87 394 3 ! 153.7 0.0 5.3e-48 1.4e-47 3 299 .. 2090 2381 .. 2088 2382 .. 0.92 395 396 Alignments for each domain: 397 == domain 1 score: 157.9 bits; conditional E-value: 2.9e-49 398 Condensation_Starter 4 lpLtaaQrgiWlaqqldpd.spvynigeyveikgeldlelLeeAirqvvaeadalrvrl.veeegepvqavaeelpveleviDlsaeed 90 399 pL + Q+g+ + ld++ s +y++ ++e++g++d+++L++A vv+++ lr+++ + g+ vqav +++ +++v+Dl+++ d 400 bpsA 604 WPLAPLQEGLLFESILDDQgSDIYQVQVILELNGPVDAPRLRAAWDAVVRRHPELRLSFhRLASGKTVQAVHGDVTPPWRVVDLTGAGD 692 401 59999**********9875378*************************************888999************************ PP 402 403 Condensation_Starter 91 peaaaeawmradlarpldldgdpLfrfallrlgeeryywyqrvHHiilDGfgfalltrriaeiYtalaageaapeapfgslsdllaeeq 179 404 +aa+ a++ ++ ++ ++l++ pL+r +l+r++ +ry +++ +HHi++DG+++a++++ ++e+Y+a + ++pe++ g + 405 bpsA 693 VDAAVAALVAEEQQQRFELATAPLVRLVLVRIAADRYRLLFVIHHILVDGWSVAVILNDVSEAYEAGE---PVPEQRGGA---TFRDYL 775 406 ****************************************************************9855...766666553...334455 PP 407 408 Condensation_Starter 180 aYraSerfakDrayWleklaalpepvslseraapakeasasalrrsaelpaallerlkelaeasgisvaelliAalaaylsrltgeddv 268 409 a+ + ++ +ra W+++la+l ep++++ ++ +++ r ++l++al+ rl +a+++g++ ++++ Aa a+ l+rlt + dv 410 bpsA 776 AWLDRQDDDAARAAWRAELAGLDEPALIA--TSG---VETEYDYRATHLTPALHTRLLGFAREHGLTPSTVVHAAWAMVLARLTRRTDV 859 411 56666777889999**************5..444...6788999999****************************************** PP 412 413 Condensation_Starter 269 vlglpvmnRlgsaa..krtpGmvanvlPLrlsv 299 414 v+g++v+ R + a ++pG ++ +P+r+ + 415 bpsA 860 VFGTMVATRPPELAgiESMPGLLMTAVPVRVPL 892 416 *********876543389************976 PP 417 418 == domain 2 score: 47.2 bits; conditional E-value: 1.5e-15 419 Condensation_Starter 37 eldlelLeeAirqvvaeadalrvrlveeegepvqavaeelpvelev..iDlsaeedpeaaaeawmradlarpldldgdpLfrfallr 121 420 +l +++L++ ++ vv+++d lr+r+v +eg+ + v e v+++ + ++a+ ++a a +++ + ld ++ + + + + 421 bpsA 1638 DLTEKALAAGFAAVVDTHDMLRARVVADEGGRRLVVGERGSVDVAGavTRIRADGRSLDEAVADAARAAVTRLDPSAGVMAQAVWVD 1724 422 567899999*****************************9998887622556666666678888888888888999999********* PP 423 424 Condensation_Starter 122 lgeery.ywyqrvHHiilDGfgfalltrriaeiYtalaagea.apeapfgslsdllaeeqaYraSerfakDrayWleklaalpepvs 206 425 g++++ +++ +HH+ +DG++ +l+ ++++ +a +ag++ + e +s+++ + ++++ S++ a a W++ l p+ 426 bpsA 1725 AGPDQVgRLVVVAHHLSVDGVSWRILLSDLQAACEAAVAGREpVLEPVGASFKRWAGLLAEWAVSAERAGELAAWKAILGPGDRPAG 1811 427 **8887358899****************************98466777889***************************999999888 PP 428 429 Condensation_Starter 207 lseraapakeasasalrrsaelpaallerlk.elaeasgisvaelliAalaaylsrltgeddvvlglpvmnRl...gsaakrtpGmv 289 430 ++ +++ a+ + +rs+ +p+ ++++l ++ a ++v+e+l+A la ++r+ g d v++++ ++R+ g+ rt+G + 431 bpsA 1812 AQATSRA---AEGAVRSRSWVVPKVETAALAgRAPVAFHCGVNEVLLAGLAGAVARWRGGDAVLVDVESHGRHpvdGTDLSRTVGWF 1895 432 7655555...7778888888888877777751566799**********************************966678899****** PP 433 434 Condensation_Starter 290 anvlPLrlsv 299 435 ++ P+rl+v 436 bpsA 1896 TSAHPVRLDV 1905 437 *******998 PP 438 439 == domain 3 score: 153.7 bits; conditional E-value: 5.3e-48 440 Condensation_Starter 3 rlpLtaaQrgiWl.aqqldpdspvynigeyveikgeldlelLeeAirqvvaeadalrvrl.veeegepvqavaeelpveleviDlsa 87 441 lpL++ Q+g+ + a + vy+ +++e+ g+ld++lL++++r +++++ lr+ + +++g+++q v ++ v+++++D+++ 442 bpsA 2090 VLPLSPLQHGLAFhAGYAGDGVDVYTAQAVLELAGPLDVPLLRKSVRALLDRHANLRAGFrHGADGTAYQVVPGAVAVPVTLVDVTE 2176 443 79********96615557777899*************************************************************** PP 444 445 Condensation_Starter 88 eedpeaaaeawmradlarpldldgdpLfrfallrlgeeryywyqrvHHiilDGfgfalltrriaeiYtalaageaapeapfgslsdl 174 446 ++dp+a+a a+ a+ arp++l++ pL r+ ++ lg++r+ ++ + HHi+lDG+++ ll+ ++ ++Y++ a ++a+ ap +++ d+ 447 bpsA 2177 SADPAAEAAAVAAAERARPFELARPPLLRVMVVVLGPDRHRLVLTNHHILLDGWSTPLLLDELLTLYRNGA--APAALAPVTPYRDY 2261 448 *********************************************************************99..66678888888888 PP 449 450 Condensation_Starter 175 laeeqaYraSerfakDrayWleklaalpepvslseraapakeasasalrrsaelpaallerlkelaeasgisvaelliAalaaylsr 261 451 la ++ ++ + + + W++ la+lpep++++++++ + + + +++++l+++ +++l + a+++g++v+++l A+ + l+ 452 bpsA 2262 LAWVRETDR----EAATEAWRDALAGLPEPTLVAADRPV---PVEVPEQIWTTLDETFAQALGARARECGVTVSTVLQAVWGMVLAA 2341 453 887765544....344445**************886666...899999*************************************** PP 454 455 Condensation_Starter 262 ltgeddvvlglpvmnRlgsa..akrtpGmvanvlPLrlsv 299 456 ltg+ddvv+g v++R + +++G ++n++P+r+++ 457 bpsA 2342 LTGRDDVVFGSVVSGRPAELpgIETMVGLFINTVPVRVRM 2381 458 ****************987522789************997 PP 459 460>> Condensation_Dual 461 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 462 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 463 1 ! 133.9 0.0 5.8e-42 1.5e-41 2 296 .] 602 893 .. 601 893 .. 0.89 464 2 ! 151.8 0.0 2.1e-47 5.4e-47 2 295 .. 2089 2381 .. 2088 2382 .. 0.91 465 466 Alignments for each domain: 467 == domain 1 score: 133.9 bits; conditional E-value: 5.8e-42 468 Condensation_Dual 2 diYpLapLqeGilfHhllaeeg.DpYllqallafasrerldaflaalqqvidRhdiLrtavlWegleepvqvvwrqaeleveeleldsadge 92 469 +i+pLapLqeG+lf +l ++g D Y +q+ l+++ + aa ++v+ Rh Lr +++ + vq v+ ++ + + ++l+ a + 470 bpsA 602 EIWPLAPLQEGLLFESILDDQGsDIYQVQVILELNGPVDAPRLRAAWDAVVRRHPELRLSFHRLASGKTVQAVHGDVTPPWRVVDLTGAGD- 692 471 8***************9988754***********************************************************999998866. PP 472 473 Condensation_Dual 93 vaeqlea.rfdprrarldlsqapllrlvvaedaaegrllllllfHHlilDhttlevlseEvqallq.gqe.ealpapvpyRnfvaqarlgvs 181 474 v + ++a + +++r++l+ apl+rlv+++ a +r+ ll +HH+++D +++v+ ++v+ + g+ + + +R+++a + ++ 475 bpsA 693 VDAAVAAlVAEEQQQRFELATAPLVRLVLVRI-AADRYRLLFVIHHILVDGWSVAVILNDVSEAYEaGEPvPEQRGGATFRDYLAWLDR-QD 782 476 777666615678899*************9998.8899999*******************99765541443134455789******9955.56 PP 477 478 Condensation_Dual 182 eaeheafFrekLadvdeptlpfglaevqgdgseieearraleaeLsqrlreqarrlgvsaasllHlawaqvlartsgredvvFGtvllGRlq 273 479 +++++a +r++La +dep l ++g ++e + +++l+++L++rl ar+ g+ +++++H awa+vlar++ r+dvvFGt++ R 480 bpsA 783 DDAARAAWRAELAGLDEPAL----IATSGVETEYDYRATHLTPALHTRLLGFAREHGLTPSTVVHAAWAMVLARLTRRTDVVFGTMVATRPP 870 481 66777788**********75....677888888999999***************************************************** PP 482 483 Condensation_Dual 274 ggegadralGlfintLPlrldld 296 484 +g +++ Gl++ +P+r+ ld 485 bpsA 871 ELAGIESMPGLLMTAVPVRVPLD 893 486 *******************9875 PP 487 488 == domain 2 score: 151.8 bits; conditional E-value: 2.1e-47 489 Condensation_Dual 2 diYpLapLqeGilfHhllaeeg.DpYllqallafasrerldaflaalqqvidRhdiLrtavlWegleepvqvvwrqaeleveeleldsad 90 490 ++ pL+pLq+G+ fH +a++g D Y qa+l++a + +++++++dRh Lr+++ ++ qvv + ++v+ ++++++ 491 bpsA 2089 EVLPLSPLQHGLAFHAGYAGDGvDVYTAQAVLELAGPLDVPLLRKSVRALLDRHANLRAGFRHGADGTAYQVVPGAVAVPVTLVDVTESA 2178 492 678*************9999877****************************************9999*********************** PP 493 494 Condensation_Dual 91 gevaeqlearfdprrarldlsqapllrlvvaedaaegrllllllfHHlilDhttlevlseEvqallqgqe..ealpapvpyRnfvaqarl 178 495 ++ ae + + r++ ++l++ pllr++v+ +r l+l+ HH++lD + +l +E+ +l ++ + +al++ +pyR+++a +r 496 bpsA 2179 DPAAEAAAVAAAERARPFELARPPLLRVMVVVL-GPDRHRLVLTNHHILLDGWSTPLLLDELLTLYRNGAapAALAPVTPYRDYLAWVRE 2267 497 **9999999999***************999887.6778888899*****************98877664412689999**********77 PP 498 499 Condensation_Dual 179 gvseaeheafFrekLadvdeptlpfglaevqgdgseieearraleaeLsqrlreqarrlgvsaasllHlawaqvlartsgredvvFGtvl 268 500 + ea+ ++ +r+ La + eptl + v + e++ ++l+++ +q+l ++ar+ gv ++++l w++vla ++gr+dvvFG+v+ 501 bpsA 2268 TDREAA-TEAWRDALAGLPEPTLVAADRPVPV--EVPEQIWTTLDETFAQALGARARECGVTVSTVLQAVWGMVLAALTGRDDVVFGSVV 2354 502 665555.5557************876665555..5556999************************************************* PP 503 504 Condensation_Dual 269 lGRlqggegadralGlfintLPlrldl 295 505 +GR + g ++++Glfint+P+r+++ 506 bpsA 2355 SGRPAELPGIETMVGLFINTVPVRVRM 2381 507 ************************987 PP 508 509>> CAL_domain 510 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 511 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 512 1 ! 70.6 9.9 3.1e-23 8.1e-23 1 157 [. 36 171 .. 36 172 .. 0.88 513 2 ! 39.0 6.1 1.1e-13 2.8e-13 243 465 .] 246 428 .. 246 428 .. 0.88 514 3 ! 35.0 0.1 1.7e-12 4.4e-12 104 180 .. 1141 1218 .. 1125 1223 .. 0.82 515 4 ! 40.6 1.4 3.6e-14 9.5e-14 291 465 .] 1309 1449 .. 1283 1449 .. 0.93 516 5 ! 58.9 5.9 1e-19 2.8e-19 1 160 [. 2564 2716 .. 2564 2734 .. 0.89 517 6 ! 43.0 0.8 6.6e-15 1.7e-14 368 457 .. 2876 2964 .. 2875 2970 .. 0.89 518 519 Alignments for each domain: 520 == domain 1 score: 70.6 bits; conditional E-value: 3.1e-23 521 CAL_domain 1 syaeLerrarrlAGhLqdlGlkpGdrVvillgnrvefVeayLAclrAgaVAVPlnpdsadaelahllrdsGiravltdaAhaavLdkvrrtapalalvd 99 522 +y++L++ra+rlAG L+ +G+++GdrV++ + V+a+LA+ Aga VP++ + + +a + +ds + +v+ +a+ + 523 bpsA 36 TYRQLDERAGRLAGRLASRGIRRGDRVAVVMDRSADLVVALLAVWKAGAAYVPVDAGYPAPRVAFMVADSAAKLVVC---------------SAASRG- 118 524 8**************************************************************************44...............444455. PP 525 526 CAL_domain 100 ahaagrelagfasyeelatpe...salpArDDPvlglDelAwmlYTSGsTGrPKGVlsthr 157 527 +++ag+ s+e++a e s +pA++ + ++A+ +YTSGsTG+PKGV +++ 528 bpsA 119 -----AVPAGVESLEPAAAAEegaSDAPAATV---RPGDPAYVMYTSGSTGTPKGVTISQG 171 529 .....669999999988865322255555554...8********************99997 PP 530 531 == domain 2 score: 39.0 bits; conditional E-value: 1.1e-13 532 CAL_domain 243 ldavkeeerpdfdlssLrvalvGGepvrAsLlreFeerFavfglkrsplldtYGltETsgsitvnkkgeqfrpleldrdaLnlgkrapaGarveglell 341 533 l+av ee ++ + + r l GG +v+A ++++ ++ a+ r + + YG tE++ +t ++g +++ 534 bpsA 246 LRAVAEE--APESFAEFREVLTGGDVVPAHAVERVRTA-AP----RARFRNMYGPTEATMCATWH---------------------L----LQPG-DVV 311 535 5788888..88888888999999999999999998654.78....88899999999999999999.....................3....4788.888 PP 536 537 CAL_domain 342 sCAsFvEvGlpvpgltLRiVDPetgadvppGeeGEiWvkGPnvmrGYLhnqPeataqaLrsilhtddDG......WyRTGDLGrr.aeaGnltvTGRiK 433 538 + v +G p g + + D ++ + v pG +G ++ +G +++ GY +n+ + ta+ ++ D+ y TGDL+ a+ G+l+ GR + 539 bpsA 312 GP--VVPIGRPLTGRRVQVLD-ASLRPVGPGVVGDLYLSG-ALAEGY-FNRAALTAERFVA------DPsapgqrMYWTGDLAQWtAD-GELVFAGRAD 398 540 88..8999*************.******************.9*****.********99998......55334444799*****86266.********** PP 541 542 CAL_domain 434 elIirgGeNiHPheiEasiVaravpgvadaaV 465 543 + + ++G i P+eiEa +++a p+v da+V 544 bpsA 399 DQVKIRGFRIEPGEIEA--ALIAQPDVHDAVV 428 545 *****************..***********98 PP 546 547 == domain 3 score: 35.0 bits; conditional E-value: 1.7e-12 548 CAL_domain 104 grelagfas.yeelatpesalpArDD.PvlglDelAwmlYTSGsTGrPKGVlsthrNcLwsnaaCivpalgldedDrvL 180 549 g+++a fa+ + + + +++a++ + D P ++ +A+ YTSGsTG+PKGV++th L a + + g+++ +rvL 550 bpsA 1141 GAVPAEFADrLVVIDEVDPAAGSAGDlPRVDPRSAAYVIYTSGSTGTPKGVVVTHAG-LGNLALAHIDRFGVSPSSRVL 1218 551 5566666654566777888888766646778999*********************98.999999999999999999998 PP 552 553 == domain 4 score: 40.6 bits; conditional E-value: 3.6e-14 554 CAL_domain 291 lldtYGltETsgsitvnkkgeqfrpleldrdaLnlgkrapaGarveglellsCAsFvEvGlpvpgltLRiVDPetgadvppGeeGEiWvkGPnvmrG 387 555 ++++YG tET+ +t++ p +++ + G+pvpg+ + D + +ppG GE++ G +v+rG 556 bpsA 1309 MINAYGPTETTICATMS---------------------MPLSPGQHP---IPF------GKPVPGVRGYLLD-SFLRPLPPGVTGELYLAGIGVARG 1374 557 59***************.....................*******99...555......*************.99999******************* PP 558 559 CAL_domain 388 YLhnqPeataqaLrsilhtddDGW......yRTGDLGrraeaGnltvTGRiKelIirgGeNiHPheiEasiVaravpgvadaaV 465 560 Y ++ + ta+ ++ D++ yRTGDL+ e G+l+ GR ++ + ++G + P+eiE ++ p v aaV 561 bpsA 1375 Y-LGRSALTAERFVA------DPFvpgermYRTGDLAYWTEQGELVSAGRADDQVKIRGFRVEPREIEF--ALSGYPRVTQAAV 1449 562 *.9*******99998......9997777778**************************************..******9999998 PP 563 564 == domain 5 score: 58.9 bits; conditional E-value: 1e-19 565 CAL_domain 1 syaeLerrarrlAGhLqdlGlkpGdrVvillgnrvefVeayLAclrAgaVAVPlnpdsadaelahllrdsGiravlt.daAhaavLdkvrrtapala 96 566 +yaeL++ra +lA L d G p V++ll+ e V+a+LA+ g P++p+ + a +l+d+G +v+t + +a +v ++++ 567 bpsA 2564 TYAELDARANQLARWLIDQGAGPEGLVAVLLPRSLELVVALLAVTKTGGAWLPIDPGYPADRIAFMLDDAGPALVITtAVLSASPIGDVLAARSRTV 2660 568 8**********************************************************************77776515689999999999998655 PP 569 570 CAL_domain 97 lvdahaagrelag.fasyeelatpesalpArDDPvlglDelAwmlYTSGsTGrPKGVlsthrNcL 160 571 ++ +++ ag +a +++++++ ++ + l++ +A++ YTSGsTGrPK V++thrN L 572 bpsA 2661 VL----DEPAAAGqLAGRDRAPVTDTDRA--RA--LDPRHPAYLIYTSGSTGRPKAVVVTHRN-L 2716 573 55....67777764666789999999999..45..****************************.8 PP 574 575 == domain 6 score: 43.0 bits; conditional E-value: 6.6e-15 576 CAL_domain 368 dvppGeeGEiWvkGPnvmrGYLhnqPeataqaLrsilhtddDGW......yRTGDLGrraeaGnltvTGRiKelIirgGeNiHPheiEasiVarav 457 577 +vppG++GE++v G +++rGY ++ ta ++ D++ yRTGDL G l+ GR+++ + ++G i P+eiEa++Va+++ 578 bpsA 2876 LVPPGAVGELYVAGAGLARGY-LGRAGLTATRFVA------DPFgsgermYRTGDLVQWNPDGQLVFAGRVDDQVKVRGFRIEPGEIEAALVAQES 2964 579 79*******************.9*******99998......665555555*******99877***************************8888875 PP 580 581>> PCP 582 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 583 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 584 1 ! 66.0 0.0 1.9e-21 5.1e-21 1 66 [. 505 569 .. 505 571 .. 0.97 585 2 ! 68.6 0.1 2.9e-22 7.7e-22 1 69 [. 1525 1592 .. 1525 1593 .. 0.96 586 3 ! 70.0 0.1 1.1e-22 2.8e-22 1 68 [. 3053 3119 .. 3053 3121 .. 0.97 587 588 Alignments for each domain: 589 == domain 1 score: 66.0 bits; conditional E-value: 1.9e-21 590 PCP 1 EteLaeiwaevLgverVgidDdFFelGGhSLlatrliarirqelgvelsvkdLfaaptvaalaall 66 591 E+ L+ ++aevLgv r g+dD FFelGG+S+ a+rl+ar + +g+ ++++++f++pt a laa++ 592 bpsA 505 ERVLCGLFAEVLGVARAGVDDGFFELGGDSIGAMRLAARAAK-AGLLVTPAQIFEEPTPARLAAVA 569 593 889**************************************9.********************986 PP 594 595 == domain 2 score: 68.6 bits; conditional E-value: 2.9e-22 596 PCP 1 EteLaeiwaevLgverVgidDdFFelGGhSLlatrliarirqelgvelsvkdLfaaptvaalaallsed 69 597 E+ L+e++a vLg+ rVg+dD+FFelGG+S+l+++l+ar r+ g++ + +d+f+ +t + +a+l++e+ 598 bpsA 1525 ERVLCELFAGVLGLARVGVDDSFFELGGDSILSMQLAARARR-SGLTFTAADVFDGKTPERIAQLAAES 1592 599 899***************************************.********************998875 PP 600 601 == domain 3 score: 70.0 bits; conditional E-value: 1.1e-22 602 PCP 1 EteLaeiwaevLgverVgidDdFFelGGhSLlatrliarirqelgvelsvkdLfaaptvaalaallse 68 603 E+ L++++aevLg+er g+dD+FFelGG+S+l++rl+ar ++ g++ +++f+++t a +aa++++ 604 bpsA 3053 ERLLCALFAEVLGLERAGADDSFFELGGDSILSMRLAARAHR-EGMSFGAREVFEQRTPAGIAAIVER 3119 605 889***************************************.9********************9986 PP 606 607>> Heterocyclization 608 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 609 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 610 1 ! 83.7 0.1 1.2e-26 3.1e-26 40 278 .. 639 871 .. 629 880 .. 0.88 611 2 ! 37.0 0.0 1.9e-12 5.1e-12 38 294 .. 1637 1900 .. 1618 1906 .. 0.73 612 3 ! 76.1 0.0 2.4e-24 6.3e-24 39 298 .. 2125 2380 .. 2089 2382 .. 0.86 613 614 Alignments for each domain: 615 == domain 1 score: 83.7 bits; conditional E-value: 1.2e-26 616 Heterocyclization 40 ldlarleaaiealiarHpMLrvvvledGeQrilpavp...kkkievhDlrevkadevearlaalRerlshqvldvergelfeleltllpegk 128 617 +d+ rl+aa+ a+++rHp Lr++++ + ++++av+ + +v Dl a v+a++aal ++ ++q+ +++ +l+ l l++++ ++ 618 bpsA 639 VDAPRLRAAWDAVVRRHPELRLSFHRLASGKTVQAVHgdvTPPWRVVDLTG--AGDVDAAVAALVAEEQQQRFELATAPLVRLVLVRIAADR 728 619 7999*********************9998888888876556778999*988..5567899******************************** PP 620 621 Heterocyclization 129 trlhlslDllvaDaaSfrlLlaeLaalye.geeleaaplevsFrdyllaeraqreaarerdrayWqarlpeLpaaPeLPlakepekleeprf 219 622 rl + + +++D +S+ ++l++ +++ye ge ++++ ++Frdyl+ ++q++ a+ ra W a l+ L ++P+L + e+ + 623 bpsA 729 YRLLFVIHHILVDGWSVAVILNDVSEAYEaGEPVPEQRGGATFRDYLAWLDRQDDDAA---RAAWRAELAGL-DEPALIATSGVET----EY 812 624 ***************************97356788999999*******9998887665...899********.5788877666555....77 PP 625 626 Heterocyclization 220 trrrhsldpeewqalkaraaeagvtpsmvllaafaevlarwsessrflLnltlfnrqpl 278 627 r+++l+p+ +l +a+e+g+tps+v+ aa+a vlar ++++ +++ + r+p 628 bpsA 813 DYRATHLTPALHTRLLGFAREHGLTPSTVVHAAWAMVLARLTRRTDVVFGTMVATRPPE 871 629 8888999***********************************99999887777766665 PP 630 631 == domain 2 score: 37.0 bits; conditional E-value: 1.9e-12 632 Heterocyclization 38 edldlarleaaiealiarHpMLrvvvled..GeQrilpavpkkki..evhDlrevkadevearlaalRerlshqvldvergelf.elelt 122 633 +dl+ ++l a a++ H+MLr++v +d G+ ++ + + + +v+ +r+ + ea +a R++ + +ld+ g + ++ + 634 bpsA 1637 SDLTEKALAAGFAAVVDTHDMLRARVVADegGRRLVVGERGSVDVagAVTRIRADGRSLDEAVADAARAAVT--RLDPSAGVMAqAVWVD 1724 635 689999******************998774344445555554444114666676666655555555555544..4555555444156677 PP 636 637 Heterocyclization 123 llpegktrlhlslDllvaDaaSfrlLlaeLaalyege....eleaaplevsFrdy..llaeraqreaarerdrayWqarlpeLpaaPeLP 206 638 p++ rl + l +D S r+Ll++L+a+ e + e ++p+ +sF + llae a +++++ + a W a + ++ + P 639 bpsA 1725 AGPDQVGRLVVVAHHLSVDGVSWRILLSDLQAACEAAvagrEPVLEPVGASFKRWagLLAEWAVSAERA-GELAAWKA----ILGPGDRP 1809 640 79****************************98765443333888999999**98633555555555555.44455655....55666778 PP 641 642 Heterocyclization 207 lakepekleeprftrrrhs.ldpeewqalkaraa.eagvtpsmvllaafaevlarwsessrflLnltlfnrqplh.pdvdklvgDFtsll 293 643 +++++ +++ +r r + +++ e +al+ ra + + + vlla a +arw + +++l+ + r+p++ +d+ ++vg Fts 644 bpsA 1810 AGAQATSRAAEGAVRSRSWvVPKVETAALAGRAPvAFHCGVNEVLLAGLAGAVARWRGGDAVLVDVESHGRHPVDgTDLSRTVGWFTSAH 1899 645 87666666666666666661566789999999853789***********************************98579*********976 PP 646 647 Heterocyclization 294 l 294 648 649 bpsA 1900 P 1900 650 5 PP 651 652 == domain 3 score: 76.1 bits; conditional E-value: 2.4e-24 653 Heterocyclization 39 dldlarleaaiealiarHpMLrvvvl..edGe.QrilpavpkkkievhDlrevkadevearlaalRerlshqvldvergelfeleltllp 125 654 ld+ l++ ++al+ rH Lr+ ++ +dG+ +++p + + ++ D+ e+++ ++ + aa+ ++ + +++r +l+ + +++l 655 bpsA 2125 PLDVPLLRKSVRALLDRHANLRAGFRhgADGTaYQVVPGAVAVPVTLVDVTESADPAA--EAAAVAAAERARPFELARPPLLRVMVVVLG 2212 656 589999******************9833477635888999999*******99666654..56777788888999999************* PP 657 658 Heterocyclization 126 egktrlhlslDllvaDaaSfrlLlaeLaalyegeeleaaplev.sFrdyllaeraqreaarerdrayWqarlpeLpaaPeLPlakepekl 214 659 +++rl l +++D +S lLl+eL +ly++ +++aa v +rdyl+ r+++++a + + W + l+ Lp+ P+L a p + 660 bpsA 2213 PDRHRLVLTNHHILLDGWSTPLLLDELLTLYRNGAAPAALAPVtPYRDYLAWVRETDREA---ATEAWRDALAGLPE-PTLVAADRPVPV 2298 661 **********************************99998888879*****9988776655...5777********95.999999999886 PP 662 663 Heterocyclization 215 eeprftrrrhsldpeewqalkaraaeagvtpsmvllaafaevlarwsessrflLnltlfnrqplhpdvdklvgDFtsllllevd 298 664 e p ++ +++ld++ qal ara+e gvt+s+vl a++ vla+ ++++ +++ + r++ p ++ +vg F + + + v+ 665 bpsA 2299 EVP--EQIWTTLDETFAQALGARARECGVTVSTVLQAVWGMVLAALTGRDDVVFGSVVSGRPAELPGIETMVGLFINTVPVRVR 2380 666 655..679*****************************************************************99988766665 PP 667 668>> CXglyc 669 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 670 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 671 1 ! 66.4 5.5 1.7e-21 4.5e-21 27 300 .. 627 890 .. 606 893 .. 0.84 672 2 ! 64.4 4.5 6.7e-21 1.8e-20 18 300 .. 2104 2379 .. 2088 2382 .. 0.84 673 674 Alignments for each domain: 675 == domain 1 score: 66.4 bits; conditional E-value: 1.7e-21 676 CXglyc 27 lhvsvalrlrGrldvpaleaalgdvaarheilrttfp....G.daqsvhqhv.hdaaaveltpveateedlpgllaerresvfdltrevpwrcdlfalsdkeh 123 677 v v l l+G +d p l aa v rh lr +f G + q+vh v + v+lt + + +l+ae +++ f+l+ r l +++ + + 678 bpsA 627 YQVQVILELNGPVDAPRLRAAWDAVVRRHPELRLSFHrlasGkTVQAVHGDVtPPWRVVDLTGAGDVDAAVAALVAEEQQQRFELATAPLVRLVLVRIAADRY 729 679 457899*****************************96332232457888888445566899999999999****************99999************ PP 680 681 CXglyc 124 vlalkvhriladddsldvflrdlaaayGarraGrvperaplalqfadyalwerrllegerekdslindqiafwrdnlagideetvlpfdrersavpsrraGtv 226 682 l + +h il d s+ v+l d++ ay a vpe+ a f dy w r + d+ a wr +lag+de + + + r 683 bpsA 730 RLLFVIHHILVDGWSVAVILNDVSEAYEAGE--PVPEQRGGA-TFRDYLAWLDRQ-----DDDA----ARAAWRAELAGLDEPALIATSGVETEYDYR----- 815 684 ***************************9964..699988755.7*******7663.....3332....2357**********9998877665555444..... PP 685 686 CXglyc 227 alrldaepharlteavepaGadalqlvhaalalllarlGagedvviGttl.prdedlidlepliGpfarplalrt 300 687 a +l + h+rl+ + G ++vhaa a++larl +dvv Gt++ r +l +e++ G + ++++r 688 bpsA 816 ATHLTPALHTRLLGFAREHGLTPSTVVHAAWAMVLARLTRRTDVVFGTMVaTRPPELAGIESMPGLLMTAVPVRV 890 689 56788999****************************************87358999**********999999996 PP 690 691 == domain 2 score: 64.4 bits; conditional E-value: 6.7e-21 692 CXglyc 18 arpgeetaglhvsva.lrlrGrldvpaleaalgdvaarheilrttfp.Gdaqsvhqhvhdaaaveltpveateedlpg.....llaerresvfdltrevpw 111 693 a +++ +++++ a l l G ldvp l +++ + +rh lr+ f G + +q v+ a av +t+v++te p+ + a r++ f+l+r 694 bpsA 2104 AGYAGDGVDVYTAQAvLELAGPLDVPLLRKSVRALLDRHANLRAGFRhGADGTAYQVVPGAVAVPVTLVDVTESADPAaeaaaVAAAERARPFELARPPLL 2204 695 555677777777755389****************************736667899******************9888622221445678899********* PP 696 697 CXglyc 112 rcdlfalsdkehvlalkvhriladddsldvflrdlaaayGarraGrvper.aplalqfadyalwerrllegerekdslindqiafwrdnlagideetvlpf 211 698 r + l + h l l+ h il d s+ ++l +l + y r+G +p ap+ + dy w r+ +re+ + wrd+lag++e t + 699 bpsA 2205 RVMVVVLGPDRHRLVLTNHHILLDGWSTPLLLDELLTLY---RNGAAPAAlAPV-TPYRDYLAWVRE---TDREAA------TEAWRDALAGLPEPTLVAA 2292 700 ***********************************9999...99***9862555.589******764...444443......356**************** PP 701 702 CXglyc 212 drersavpsrraGtvalrldaepharlteavepaGadalqlvhaalalllarlGagedvviGttlp.rdedlidlepliGpfarplalrt 300 703 dr+ ++ + ld l + + G + ++++a ++la l +dvv G+++ r +l +e+++G f ++++r 704 bpsA 2293 DRPVPV---EVPEQIWTTLDETFAQALGARARECGVTVSTVLQAVWGMVLAALTGRDDVVFGSVVSgRPAELPGIETMVGLFINTVPVRV 2379 705 **9766...44455667789888788999999******************************98854999999***********999996 PP 706 707>> ACP 708 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 709 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 710 1 ! 29.4 0.1 5.4e-10 1.4e-09 3 67 .. 507 567 .. 505 569 .. 0.89 711 2 ! 32.0 0.1 8.4e-11 2.2e-10 2 67 .. 1526 1587 .. 1525 1592 .. 0.94 712 3 ! 23.2 0.1 4.7e-08 1.2e-07 2 69 .. 3054 3117 .. 3053 3120 .. 0.93 713 714 Alignments for each domain: 715 == domain 1 score: 29.4 bits; conditional E-value: 5.4e-10 716 ACP 3 lvreevaavlglasasdvdpdraFkdlGvDSltaveLrnrLeaatGlrLpatlvfdhptpraLae 67 717 +++ a+vlg+ + +d+ F++lG DS+ a++L r ++a Gl ++++++f+ ptp++La+ 718 bpsA 507 VLCGLFAEVLGV-ARAG--VDDGFFELGGDSIGAMRLAARAAKA-GLLVTPAQIFEEPTPARLAA 567 719 6778889*****.5555..599******************8877.******************97 PP 720 721 == domain 2 score: 32.0 bits; conditional E-value: 8.4e-11 722 ACP 2 alvreevaavlglasasdvdpdraFkdlGvDSltaveLrnrLeaatGlrLpatlvfdhptpraLae 67 723 ++++e a vlgl v +d++F++lG DS+ +++L r ++ Gl+++a+ vfd +tp+++a+ 724 bpsA 1526 RVLCELFAGVLGL---ARVGVDDSFFELGGDSILSMQLAARARRS-GLTFTAADVFDGKTPERIAQ 1587 725 689999*******...99***********************8776.*****************997 PP 726 727 == domain 3 score: 23.2 bits; conditional E-value: 4.7e-08 728 ACP 2 alvreevaavlglasasdvdpdraFkdlGvDSltaveLrnrLeaatGlrLpatlvfdhptpraLaehL 69 729 +l+++ a+vlgl + +d++F++lG DS+ +++L r +++ G+++ a vf+ tp+ +a+ + 730 bpsA 3054 RLLCALFAEVLGL---ERAGADDSFFELGGDSILSMRLAARAHRE-GMSFGAREVFEQRTPAGIAAIV 3117 731 6899999******...88889********************9999.****************999876 PP 732 733>> NRPS-COM_Nterm 734 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 735 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 736 1 ! 23.6 0.0 1.6e-08 4.1e-08 11 31 .. 601 621 .. 600 623 .. 0.92 737 738 Alignments for each domain: 739 == domain 1 score: 23.6 bits; conditional E-value: 1.6e-08 740 NRPS-COM_Nterm 11 edIYpLSPMQeGMLFHsLldp 31 741 e I+pL+P+QeG+LF s+ld 742 bpsA 601 EEIWPLAPLQEGLLFESILDD 621 743 78****************986 PP 744 745>> NRPS-COM_Cterm 746 [No individual domains that satisfy reporting thresholds (although complete target did)] 747 748 749 750Internal pipeline statistics summary: 751------------------------------------- 752Query sequence(s): 1 (3165 residues) 753Target model(s): 37 (9277 nodes) 754Passed MSV filter: 17 (0.459459); expected 0.7 (0.02) 755Passed bias filter: 16 (0.432432); expected 0.7 (0.02) 756Passed Vit filter: 15 (0.405405); expected 0.0 (0.001) 757Passed Fwd filter: 14 (0.378378); expected 0.0 (1e-05) 758Initial search space (Z): 37 [actual number of targets] 759Domain search space (domZ): 14 [number of targets reported over threshold] 760# CPU time: 0.17u 0.00s 00:00:00.17 Elapsed: 00:00:00.17 761# Mc/sec: 172.72 762// 763Query: bpsB [L=4077] 764Scores for complete sequence (score includes all domains): 765 --- full sequence --- --- best 1 domain --- -#dom- 766 E-value score bias E-value score bias exp N Model Description 767 ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 768 0 1441.4 36.7 2.4e-149 487.7 0.7 5.7 5 Cglyc 769 0 1154.9 0.0 1.8e-113 369.9 0.0 5.3 5 Condensation_DCL 770 0 1082.9 9.3 5.8e-116 378.6 0.1 3.3 3 AMP-binding AMP-binding enzyme 771 3.3e-282 929.2 176.5 1.4e-131 430.9 26.9 5.8 5 Epimerization 772 7.2e-210 686.2 0.0 3.3e-61 198.2 0.0 5.3 5 Condensation_LCL 773 4.6e-152 496.7 0.0 8.3e-48 154.5 0.0 5.5 4 Condensation_Dual 774 1.1e-149 488.9 0.1 4.5e-44 142.2 0.0 5.7 5 Condensation_Starter 775 2.7e-89 290.8 0.0 4.3e-27 86.5 0.0 5.6 4 Heterocyclization 776 2e-82 268.0 78.7 3.3e-25 78.5 8.8 7.7 6 CAL_domain 777 8.3e-66 209.5 1.5 1.2e-22 71.2 0.0 4.1 3 PCP 778 1.1e-50 163.6 52.7 7.6e-20 62.3 3.0 5.8 3 CXglyc 779 7.3e-33 104.0 2.7 4.4e-13 40.7 0.0 4.1 3 ACP 780 2.8e-28 88.2 0.0 7e-11 32.5 0.0 3.4 3 NRPS-COM_Nterm 781 4.2e-11 33.7 0.4 6.6e-06 17.3 0.0 3.2 0 NRPS-COM_Cterm 782 783 784Domain annotation for each model (and alignments): 785>> Cglyc 786 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 787 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 788 1 ! 487.7 0.7 9.1e-150 2.4e-149 1 298 [. 6 301 .. 6 302 .. 0.99 789 2 ! 20.9 0.4 1.3e-07 3.5e-07 106 298 .. 1132 1332 .. 1051 1333 .. 0.62 790 3 ! 465.2 1.9 6.4e-143 1.7e-142 1 299 [] 1507 1801 .. 1507 1801 .. 0.99 791 4 ! 23.3 1.3 2.5e-08 6.5e-08 40 207 .. 2575 2748 .. 2559 2840 .. 0.71 792 5 ! 466.4 0.5 2.9e-143 7.8e-143 2 298 .. 3020 3315 .. 3019 3316 .. 0.99 793 794 Alignments for each domain: 795 == domain 1 score: 487.7 bits; conditional E-value: 9.1e-150 796 Cglyc 1 ledvWPLsPlqeGllfhaaldeegpdvYqvqrileldgpldaarlraaWeallarhaaLrasfrrlksgetvqvvarevelpWrevDlselpedeaeaeverla 104 797 +e++WPLsPlq Gllfha++d egpdvY +++il+l gp+daa lraaWe+llarha Lra+fr++ksgetvq++ar+velpWrevDls+l d++e++v++la 798 bpsB 6 IEEIWPLSPLQAGLLFHAVYDGEGPDVYIGHWILDLAGPVDAAGLRAAWETLLARHAPLRACFRQRKSGETVQIIARQVELPWREVDLSHL--DDPEEAVRELA 107 799 68*****************************************************************************************..99********* PP 800 801 Cglyc 105 aeeraerfdlakaPllrllLvrlgedrhrlvvtshhilvDGWslpiileelaalYaaggdaselpaaasyrdylaWlsrqdkeaaraaWraelagldeptlvap 208 802 +++r++rfdla+aPllrl+L+rlg+d hrlvvt+hh ++DGWslpi+++el+ lY aggdas+lp+++syr+ylaWlsrqdke+a +aW ael+g++eptlv+p 803 bpsB 108 EQDRTTRFDLAQAPLLRLTLIRLGADAHRLVVTCHHTIMDGWSLPIVIDELSVLYPAGGDASALPDVPSYREYLAWLSRQDKERALSAWTAELSGAEEPTLVVP 211 804 ******************************************************************************************************** PP 805 806 Cglyc 209 adaarapaepeevvlelseeltrrlvelarehgltlntvvqgaWalvLarLagrtdvvfGatvagrPaelpgvesmvGlllntvPvrvrL 298 807 ad++rapaepe+v ++l+e+ltr+l+elar+hgltlntvvqgaWalvLa+Lagr dvvfGa+v++rP++lpgve mvGl+lntvPvrvrL 808 bpsB 212 ADPGRAPAEPESVEAHLPEHLTRSLAELARRHGLTLNTVVQGAWALVLAQLAGRPDVVFGAAVSARPPDLPGVEGMVGLFLNTVPVRVRL 301 809 *****************************************************************************************9 PP 810 811 == domain 2 score: 20.9 bits; conditional E-value: 1.3e-07 812 Cglyc 106 eeraerfdlakaPllrllLvrlgedr.hrlvvtshhilvDGWslpiileelaalYa...aggdaselpaaasyrdylaWls.rqdkeaar...aaWraelag 199 813 + + +d ++ + r++ + g+++ rl ++ hh+ vD s i+l +l a+Y+ +gg+ + p+++syr++ l r e++ + W+a ++g 814 bpsB 1132 RTATGTLDPSAGIMARVVWIDAGDAEpGRLAFVAHHLSVDAVSWGILLPDLRAAYDeviSGGTPALEPPVTSYRQWARRLTaRALSESTVaelEKWAAVVEG 1233 815 34455688888889999999998865379**************************84446899999999*****9887775144444443001344444444 PP 816 817 Cglyc 200 ldeptlvapadaarapaepeevvlelseeltrrlvelar.ehgltlntvvqgaWalvLarLagrtdvv.fGatvagr.PaelpgvesmvGlllntvPvrvrL 298 818 + p+d+++ + + ++ ++ls + r+lv++ ++ v+ + a +ar+ g + gr a+ ++ + vG + ++ Pvr +L 819 bpsB 1234 A---EPALPQDTGQHTGQSHSWSTSLSGTEVRDLVTVLPgAFHCGIQDVLLAGLAGAVARVRGSGAALlVDVEGHGReAADGEDLLRTVGWFTSVHPVRLEL 1332 820 4...34456677777777777777777777777766533033444444444444445555544433220222333441234555556677777777777665 PP 821 822 == domain 3 score: 465.2 bits; conditional E-value: 6.4e-143 823 Cglyc 1 ledvWPLsPlqeGllfhaaldeegpdvYqvqrileldgpldaarlraaWeallarhaaLrasfrrlksgetvqvvarevelpWrevDlselpedeaeaever 102 824 l+d+WPLsPlqeG+lf++a+de+g+dvYq+qril+ldgpld+ rlraaW+++larha+Lr++f++l sg+tvqvv+re+++pWr++Dls+l+++ea+aever 825 bpsB 1507 LTDIWPLSPLQEGMLFERAFDEDGVDVYQTQRILDLDGPLDEPRLRAAWNQVLARHASLRTGFHQLGSGATVQVVVREADIPWRVADLSHLDAAEAAAEVER 1608 826 68**************************************************************************************************** PP 827 828 Cglyc 103 laaeeraerfdlakaPllrllLvrlgedrhrlvvtshhilvDGWslpiileelaalYaaggdaselpaaasyrdylaWlsrqdkeaaraaWraelagldept 204 829 l+ae++ +rfd++++PllrllL+rlg+d+hrlvvtshh+l+DGWs+p+++ e+++ Ya+g +++++++sy+dylaWlsrqd ea+r+aWraelag+dept 830 bpsB 1609 LLAEDQGRRFDVTRPPLLRLLLIRLGADEHRLVVTSHHVLLDGWSTPLVVGEMSDGYAGG---RSSSKPPSYQDYLAWLSRQDAEATRSAWRAELAGADEPT 1707 831 **********************************************************99...778899********************************* PP 832 833 Cglyc 205 lvapadaarapaepeevvlelseeltrrlvelarehgltlntvvqgaWalvLarLagrtdvvfGatvagrPaelpgvesmvGlllntvPvrvrLd 299 834 lv+ ada+++ ++p+e++ +l+e +tr+l+ +ar+hglt++t+v gaWalvLarLagrtdvvfG++v+grPa++p+ve+mvG+++ntvP rvrLd 835 bpsB 1708 LVD-ADAGKTLVMPDEHAEWLPEPATRALAGFARGHGLTVSTIVLGAWALVLARLAGRTDVVFGSVVSGRPADVPDVERMVGMFINTVPARVRLD 1801 836 **9.999**************************************************************************************98 PP 837 838 == domain 4 score: 23.3 bits; conditional E-value: 2.5e-08 839 Cglyc 40 ldaarlraaWeallarhaaLrasfrrlksgetvqvvarevelpWrev.DlselpedeaeaeverlaaeeraerfdlakaPllrllLvrlgedrh.rlvvtsh 139 840 l ++ l a a+++ h++Lr + ++ e vva++ +++ + e+ d ae++ a+++a r+d + l+r + v g+ r rlvv+ h 841 bpsB 2575 LSVTALVAGLGAVIDTHDMLRSRIVESEGVEPRLVVAGRGTVDAAALvERVEA-GDGDLAEIADRCAHDTAARLDPVAGVLVRAVWVDAGPGRAgRLVVAAH 2675 842 556778889999****************9999999999888876543033333.455678888888999*********************977449****** PP 843 844 Cglyc 140 hilvDGWslpiileelaalYa...aggdaselpaaasyrdylaWlsrqdkeaa..raaWraelagldeptlva 207 845 h++vD s +l +l+a+ + agg+ + p+ +s+r + l+ + ++ a+W + l+g+++ 846 bpsB 2676 HLVVDVVSWRTLLPDLQAACEavvAGGQPALDPPDVSFRRWSRTLDGEAAIRTgeLAVWTEILDGAQSRLGEL 2748 847 *************9999876522269999999999****9888887766544422578999999987654333 PP 848 849 == domain 5 score: 466.4 bits; conditional E-value: 2.9e-143 850 Cglyc 2 edvWPLsPlqeGllfhaaldeegpdvYqvqrileldgpldaarlraaWeallarhaaLrasfrrlksgetvqvvarevelpWrevDlselpedeaeaeverl 103 851 d+WPLsPlqeGllfhaa d++gpdvY+++r+l++dgpld+ar+ra+W+ ll+rh+aLrasf++l+sge+vqv+ar+v +Wre+Dls+lpe+ea ae++rl 852 bpsB 3020 LDIWPLSPLQEGLLFHAA-DDRGPDVYASMRTLAIDGPLDVARFRASWTVLLDRHPALRASFHQLESGEAVQVIARDVPPDWRETDLSGLPESEALAEFDRL 3120 853 69***************9.*********************************************************************************** PP 854 855 Cglyc 104 aaeeraerfdlakaPllrllLvrlgedrhrlvvtshhilvDGWslpiileelaalYaaggdaselpaaasyrdylaWlsrqdkeaaraaWraelagldeptl 205 856 aa+ +aerfdl+kaP lrl+Lvrlg++r+rl++tshhi++DGWslp+il +++++Y+aggd ++lpaa+syrd+laW++rqdk aa +aWr+elaglde+t+ 857 bpsB 3121 AARMHAERFDLTKAPQLRLHLVRLGDRRYRLIFTSHHIVADGWSLPLILVDVLTAYEAGGDGRTLPAATSYRDFLAWVDRQDKGAAGQAWRTELAGLDEATH 3222 858 ****************************************************************************************************** PP 859 860 Cglyc 206 vapadaarapaepeevvlelseeltrrlvelarehgltlntvvqgaWalvLarLagrtdvvfGatvagrPaelpgvesmvGlllntvPvrvrL 298 861 v+p + +p epe+v++el++e+++rlve++r+hg+t nt++qg+Wal+LarLagr+dvvfGa+vagrP+e+pgves+vGl++n++Pvr+rL 862 bpsB 3223 VVPPGSIITPLEPERVAFELDDETSKRLVEFTRRHGVTANTLFQGVWALHLARLAGRNDVVFGAAVAGRPPEIPGVESAVGLFMNMLPVRARL 3315 863 ********************************************************************************************9 PP 864 865>> Condensation_DCL 866 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 867 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 868 1 ! 369.9 0.0 6.7e-114 1.8e-113 1 299 [. 7 301 .. 7 302 .. 0.99 869 2 ! 36.5 0.0 2.3e-12 6.2e-12 36 236 .. 1068 1266 .. 1046 1333 .. 0.72 870 3 ! 352.0 0.0 1.9e-108 4.9e-108 2 300 .] 1509 1801 .. 1508 1801 .. 0.97 871 4 ! 49.0 0.0 3.6e-16 9.5e-16 31 297 .. 2568 2838 .. 2544 2841 .. 0.80 872 5 ! 340.8 0.0 4.8e-105 1.3e-104 2 299 .. 3021 3315 .. 3020 3316 .. 0.99 873 874 Alignments for each domain: 875 == domain 1 score: 369.9 bits; conditional E-value: 6.7e-114 876 Condensation_DCL 1 edvypLsplQeGllfhallde.eadvYvvqlvlelegeldverlraaaqalvdrheiLrtaFveeeleepvqvvlkevelelreldlselaee 92 877 e+++pLsplQ Gllfha++d + dvY+ +l+l+g++d++ lraa+++l++rh+ Lr++F +++++e+vq+++++vel++re+dls+l++ 878 bpsB 7 EEIWPLSPLQAGLLFHAVYDGeGPDVYIGHWILDLAGPVDAAGLRAAWETLLARHAPLRACFRQRKSGETVQIIARQVELPWREVDLSHLDDP 99 879 68******************999*******************************************************************998 PP 880 881 Condensation_DCL 93 eqeeelealaaedrergFdlarapllrltlirlaeeryrlvltnHhillDGWslplllkellelYqalaegepaalpaarpYrdYiawlarqd 185 882 e e++++la++dr+++Fdla+apllrltlirl+++ +rlv+t Hh ++DGWslp++++el lY a+g+++alp +++Yr+Y+awl+rqd 883 bpsB 100 E--EAVRELAEQDRTTRFDLAQAPLLRLTLIRLGADAHRLVVTCHHTIMDGWSLPIVIDELSVLY--PAGGDASALPDVPSYREYLAWLSRQD 188 884 7..9*************************************************************..99************************ PP 885 886 Condensation_DCL 186 keaaeaaWreeLagleeptllaeakkeeeeeaepeeleveldeeateaLeelarsqgvTlntlvqaawallLsrltgrddvvFGatvsgRpae 278 887 ke+a +aW++eL+g+eeptl+ +a++ ++ +aepe++e++l+e+ t++L+elar++g+Tlnt+vq+awal+L++l+gr dvvFGa+vs Rp++ 888 bpsB 189 KERALSAWTAELSGAEEPTLVVPADPGRA-PAEPESVEAHLPEHLTRSLAELARRHGLTLNTVVQGAWALVLAQLAGRPDVVFGAAVSARPPD 280 889 **************************998.*************************************************************** PP 890 891 Condensation_DCL 279 lpgvesmvGlfiNtvPvrvrl 299 892 lpgve mvGlf+NtvPvrvrl 893 bpsB 281 LPGVEGMVGLFLNTVPVRVRL 301 894 *******************98 PP 895 896 == domain 2 score: 36.5 bits; conditional E-value: 2.3e-12 897 Condensation_DCL 36 geldverlraaaqalvdrheiLrtaFveeeleepvqvvlkevelelreldlselaeeeqeeelealaaedrergFdlarapllrltlirla 126 898 +++++l a+qa++d h+ Lr+ + + +v+++ +++ l ++ a + +e+ + + + + + d+++ ++ r++ i + 899 bpsB 1068 AGVNPDALVSALQAVLDAHDLLRARVE----PDGRLIVPERGAVAAAGLLTRVAAGTGGLDEIAEREVRTATGTLDPSAGIMARVVWIDAG 1154 900 3499********************994....4677899**99999999988888887766777777777777889**************99 PP 901 902 Condensation_DCL 127 eer.yrlvltnHhillDGWslplllkellelYqalaegepaalpaa.rpYrdYiawlarqdkeaae....aaWreeLagleeptllaeakk 211 903 +++ rl + +Hh+ +D+ s +ll +l + Y+++ +g ++al+++ ++Yr++ + l+++ ++++ + W++ +g+e +l++++ 904 bpsB 1155 DAEpGRLAFVAHHLSVDAVSWGILLPDLRAAYDEVISGGTPALEPPvTSYRQWARRLTARALSESTvaelEKWAAVVEGAEP--ALPQDTG 1243 905 876279**************************999999999986555************98877761111556666666652..2333333 PP 906 907 Condensation_DCL 212 eeeeeaepeeleveldeeateaLee 236 908 ++ + ++++++++l+ +++++L + 909 bpsB 1244 QH--TGQSHSWSTSLSGTEVRDLVT 1266 910 33..567777777777777776654 PP 911 912 == domain 3 score: 352.0 bits; conditional E-value: 1.9e-108 913 Condensation_DCL 2 dvypLsplQeGllfhallde.eadvYvvqlvlelegeldverlraaaqalvdrheiLrtaFveeeleepvqvvlkevelelreldlselae 91 914 d++pLsplQeG+lf +de + dvY +q +l+l+g+ld rlraa++++++rh+ Lrt+F++ ++ +vqvv++e+++++r+ dls+l++ 915 bpsB 1509 DIWPLSPLQEGMLFERAFDEdGVDVYQTQRILDLDGPLDEPRLRAAWNQVLARHASLRTGFHQLGSGATVQVVVREADIPWRVADLSHLDA 1599 916 9*****************9999********************************************************************* PP 917 918 Condensation_DCL 92 eeqeeelealaaedrergFdlarapllrltlirlaeeryrlvltnHhillDGWslplllkellelYqalaegepaalpaarpYrdYiawla 182 919 +e+++e+e+l+aed+ r+Fd++r+pllrl lirl+++++rlv+t+Hh+llDGWs+pl++ e+ + Y a+g+ ++ ++++Y+dY+awl+ 920 bpsB 1600 AEAAAEVERLLAEDQGRRFDVTRPPLLRLLLIRLGADEHRLVVTSHHVLLDGWSTPLVVGEMSDGY---AGGRSSS--KPPSYQDYLAWLS 1685 921 ******************************************************************...6666654..6789********* PP 922 923 Condensation_DCL 183 rqdkeaaeaaWreeLagleeptllaeakkeeeeeaepeeleveldeeateaLeelarsqgvTlntlvqaawallLsrltgrddvvFGatvs 273 924 rqd+ea+++aWr+eLag++eptl+ ++ ++ +p e+ l+e at+aL+ +ar +g+T++t+v +awal+L+rl+gr+dvvFG++vs 925 bpsB 1686 RQDAEATRSAWRAELAGADEPTLVDADAGKT--LVMPDEHAEWLPEPATRALAGFARGHGLTVSTIVLGAWALVLARLAGRTDVVFGSVVS 1774 926 ************************9888777..599******************************************************* PP 927 928 Condensation_DCL 274 gRpaelpgvesmvGlfiNtvPvrvrld 300 929 gRpa++p+ve+mvG+fiNtvP rvrld 930 bpsB 1775 GRPADVPDVERMVGMFINTVPARVRLD 1801 931 ************************986 PP 932 933 == domain 4 score: 49.0 bits; conditional E-value: 3.6e-16 934 Condensation_DCL 31 vlelegeldverlraaaqalvdrheiLrtaFveeeleepvqvvlkevelelreldlselaeeeqeeelealaaedrergFdlarapllrlt 121 935 +++ + l v++l a + a++d h++Lr+ +ve+e ep+ vv+ + +++ l + +a + + +e+ + +a+d +++ d+ + +l+r + 936 bpsB 2568 SVAAPRDLSVTALVAGLGAVIDTHDMLRSRIVESEGVEPRLVVAGRGTVDAAALVERVEAGDGDLAEIADRCAHDTAARLDPVAGVLVRAV 2658 937 56666789999***************************************999988888888889************************** PP 938 939 Condensation_DCL 122 lirlaeery.rlvltnHhillDGWslplllkellelYqalaegepaalpaa.rpYrdYiawlarqdk..eaaeaaWreeLagleeptllae 208 940 + + r rlv+ +Hh+++D s ll +l + +a+ +g ++al+++ ++r + ++l+ + + + a+W+e L+g++++ l e 941 bpsB 2659 WVDAGPGRAgRLVVAAHHLVVDVVSWRTLLPDLQAACEAVVAGGQPALDPPdVSFRRWSRTLDGEAAirTGELAVWTEILDGAQSR--LGE 2747 942 ****9876549**************************999999999996666**********9887511556789*******9854..444 PP 943 944 Condensation_DCL 209 akkeeeeeaepeeleveldeeate.aLeelarsqgvTlntlvqaawallLsrltgrddvvFGatvsgRpa.elpgvesmvGlfiNtvPvrv 297 945 ++++++ ++ ++ + ++++e+ +e+++ + + + ++ a a ++ g + vv + gR++ + +++G f P+r+ 946 bpsB 2748 LDPRRDTVSTAGRRSWTVPREHAGvLVEQVTSAFHCGVHEVLLATLAGAVAGWRGGTAVVVDVEGHGRQPlGELDLSRTLGWFTDVHPLRL 2838 947 4444444455555555665555440456777788888888888888888888888888887777777765222245566677766666665 PP 948 949 == domain 5 score: 340.8 bits; conditional E-value: 4.8e-105 950 Condensation_DCL 2 dvypLsplQeGllfhalldeeadvYvvqlvlelegeldverlraaaqalvdrheiLrtaFveeeleepvqvvlkevelelreldlselaee 92 951 d++pLsplQeGllfha d++ dvY+ +l+++g+ldv+r+ra+++ l+drh++Lr++F++ e++e vqv++++v ++re+dls+l+e+ 952 bpsB 3021 DIWPLSPLQEGLLFHAADDRGPDVYASMRTLAIDGPLDVARFRASWTVLLDRHPALRASFHQLESGEAVQVIARDVPPDWRETDLSGLPES 3111 953 8****************************************************************************************** PP 954 955 Condensation_DCL 93 eqeeelealaaedrergFdlarapllrltlirlaeeryrlvltnHhillDGWslplllkellelYqalaegepaalpaarpYrdYiawlar 183 956 e+ +e+++laa+ ++++Fdl++ap lrl+l+rl+++ryrl++t+Hhi+ DGWslpl+l ++l+ Y a+g+ +lpaa++Yrd++aw++r 957 bpsB 3112 EALAEFDRLAARMHAERFDLTKAPQLRLHLVRLGDRRYRLIFTSHHIVADGWSLPLILVDVLTAY--EAGGDGRTLPAATSYRDFLAWVDR 3200 958 *****************************************************************..77788888**************** PP 959 960 Condensation_DCL 184 qdkeaaeaaWreeLagleeptllaeakkeeeeeaepeeleveldeeateaLeelarsqgvTlntlvqaawallLsrltgrddvvFGatvsg 274 961 qdk aa +aWr+eLagl+e+t++ + + + + epe++ +eld e++++L e++r++gvT ntl+q++wal L+rl+gr+dvvFGa+v+g 962 bpsB 3201 QDKGAAGQAWRTELAGLDEATHVVPPGSIIT-PLEPERVAFELDDETSKRLVEFTRRHGVTANTLFQGVWALHLARLAGRNDVVFGAAVAG 3290 963 *************************999998.*********************************************************** PP 964 965 Condensation_DCL 275 RpaelpgvesmvGlfiNtvPvrvrl 299 966 Rp+e+pgves vGlf+N +Pvr+rl 967 bpsB 3291 RPPEIPGVESAVGLFMNMLPVRARL 3315 968 **********************997 PP 969 970>> AMP-binding AMP-binding enzyme 971 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 972 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 973 1 ! 378.6 0.1 2.2e-116 5.8e-116 1 418 [] 482 879 .. 482 879 .. 0.96 974 2 ! 349.7 0.5 1.3e-107 3.5e-107 1 418 [] 1981 2375 .. 1981 2375 .. 0.98 975 3 ! 359.2 0.1 1.7e-110 4.5e-110 1 418 [] 3498 3887 .. 3498 3887 .. 0.98 976 977 Alignments for each domain: 978 == domain 1 score: 378.6 bits; conditional E-value: 2.2e-116 979 EHHHHHHHHHHHHHHHHH----TT-EEEEE-SSSHHHHHHHHHHHHTT-EEEE--TTS-HHHHHHHHHHCTESEEEEESBCHCCHHHHHHHHHCHHEC CS 980 AMP-binding 1 TYreldervnrlaagLrklGvkpgdrVaillpnspewviaflaclkaGavyvpvyptlpaerlayilndseakvlitddelltklkeaaskelakeal 98 981 +Y+el+er++rla +L +Gv++gdrVa++l++sp++++++la++kaGa+yvpv+p +p er +++l+ds+++++++ ++ +++++ + ++ 982 bpsB 482 SYGELAERAERLAGYLNGRGVRRGDRVAVVLDRSPDLIATLLAVWKAGAAYVPVDPAYPVERRKFMLADSGPAAVVCAEAYRAAVPDTCPEPIVL--- 576 983 7*****************************************************************************************99975... PP 984 985 CETTCCEESECCCCCCEHCHHHHGTSTSS-CCCSBTTTSEEEEEEE-------EEEEEEHHHHHHHHHHHHHHHTTTTT.EEEEES-TTSTHHHCCCH CS 986 AMP-binding 99 iivrsepaesvgeeellleleslkkasteppkvplkpddlayiiyTSGtTGkPKgVmlthrnllalvagiakrvglkpddrvlsllplafdgsvleil 196 987 ++ + + a++++ ++ +++ddlay++yTSG+TG+PKgV ++h+n++al+ ++rvg +d+vl+ +++afd s++e++ 988 bpsB 577 ----------------DDPRTRQAVAESPRLSAGTSADDLAYVMYTSGSTGTPKGVAVSHGNVAALAGEPGWRVGP--GDAVLLHASHAFDISLFEMW 656 989 ................5667778888888888888*********************************99999998..669***************** PP 990 991 HHHTTT-EEEEESSCCTCSHHHHHHHHHHTT-SEEEE-HHHHHHHHHHHHCCCTTTTT--EEEE-----THHHHHHHHHHCTTSEEEEEE--GGGSSE CS 992 AMP-binding 197 gplllGatlvlvspedlkdpalllddiekykvtvlalvptllelllkapekkkldlsslrlilsggeplspellrrlreafggipivngYGltEttvi 294 993 +pll+Ga++vl+ p d a+l + + +vt +l+ ++++l+++ + + lr +l+gg++++ ++++r+r +++++++ ++YG+tE+t++ 994 bpsB 657 VPLLSGARVVLAGPGAV-DGAAL-AAYVAGGVTAAHLTAGAFRVLADESP---EAVAGLREVLTGGDAVPLAAVERVRGRVRNVRVRHLYGPTEATLC 749 995 ****************6.55555.555589*******************8...9******************************************** PP 996 997 SEEEECGHHH..-SSC---EBSTTTEEEEEBSTT-BEE-S----EEEESTTS--B-TT-HHHHHHHEEESTT-....EEE---EEEE-TT--EEEEEG CS 998 AMP-binding 295 vtvslpgdee..tkpgsiGrplpgveikivdeegkevppgevGEllirgpsvakGYlkdpeltaeafvedgwk....lyrTGDlgridedGyleiiGR 386 999 +t+ l+++ + ++ +iGrpl+g +++++d ++vppg+ GEl+++g++va+GY +p+ltae+fv+d+ + +yrTGDl++++e+G l + GR 1000 bpsB 750 ATWWLLEPGDetGSVLPIGRPLAGRRVHVLDAFLRPVPPGVAGELYVAGAGVAQGYSSRPALTAERFVADPSGsgarMYRTGDLAYWTEQGALAFAGR 847 1001 ****999998889************************************************************************************* PP 1002 1003 GGCEEEB---EEEHHHHHHHHHTSTTEEEEEE CS 1004 AMP-binding 387 kkdqvkirGeriepgeiEsvllehpgvaeaaV 418 1005 ++dqvkirG+r+epgeiE vl+++pgv +a+V 1006 bpsB 848 ADDQVKIRGYRVEPGEIEVVLAGLPGVGQAVV 879 1007 ******************************98 PP 1008 1009 == domain 2 score: 349.7 bits; conditional E-value: 1.3e-107 1010 EHHHHHHHHHHHHHHHHH----TT-EEEEE-SSSHHHHHHHHHHHHTT-EEEE--TTS-HHHHHHHHHHCTESEEEEESBCHCCHHHHHHHHHCHH CS 1011 AMP-binding 1 TYreldervnrlaagLrklGvkpgdrVaillpnspewviaflaclkaGavyvpvyptlpaerlayilndseakvlitddelltklkeaaskelake 96 1012 +Y++ld++++rla +L Gv++gdrV++++++++++++a+l+++kaGa+ vpv+ ++paer++++l+d++a+v+++ ++ +++++ + ++ 1013 bpsB 1981 SYADLDRESDRLAGHLAGIGVGRGDRVGVVMTRGADLFVALLGVWKAGAAQVPVNVDYPAERIERMLADVGASVAVCVEATRKAVPDGVEPVVV-- 2074 1014 7*************************************************************************************99988875.. PP 1015 1016 ECCETTCCEESECCCCCCEHCHHHHGTSTSS-CCCSBTTTSEEEEEEE-------EEEEEEHHHHHHHHHHHHHHHTTTTT.EEEEES-TTSTHHH CS 1017 AMP-binding 97 aliivrsepaesvgeeellleleslkkasteppkvplkpddlayiiyTSGtTGkPKgVmlthrnllalvagiakrvglkpddrvlsllplafdgsv 192 1018 +l +++ +e p+v + ++d+ay++yTSG+TG PK+V + h++++al++ ++ g +d vl+ +++afd+s+ 1019 bpsB 2075 --------------------DLPVIGGVRPEAPPVTVGAHDVAYVMYTSGSTGVPKAVAVPHGSVAALASDPGWSQGP--GDCVLLHASHAFDASL 2148 1020 ....................6899********************************************9999888887..668************* PP 1021 1022 CCCHHHHTTT-EEEEESSCCTCSHHHHHHHHHHTT-SEEEE-HHHHHHHHHHHHCCCTTTTT--EEEE-----THHHHHHHHHHCTTSEEEEEE-- CS 1023 AMP-binding 193 leilgplllGatlvlvspedlkdpalllddiekykvtvlalvptllelllkapekkkldlsslrlilsggeplspellrrlreafggipivngYGl 288 1024 +ei++pl++Ga++ +++p + d+++l +++++ +vt+++l+ ++++++++ + ++ lr il+gg++++ + + r+r+a++++++ ++YG+ 1025 bpsB 2149 VEIWVPLVSGARVLVAEPGT-VDAERLREAVSR-GVTTVHLTAGAFRAVAEESP---DSFIGLREILTGGDAVPLASVVRMRQACPDVRVRQLYGP 2239 1026 ********************.699999999976.*******************8...8************************************** PP 1027 1028 GGGSSESEEEECGHHH..-SSC---EBSTTTEEEEEBSTT-BEE-S----EEEESTTS--B-TT-HHHHHHHEEESTT-....EEE---EEEE-TT CS 1029 AMP-binding 289 tEttvivtvslpgdee..tkpgsiGrplpgveikivdeegkevppgevGEllirgpsvakGYlkdpeltaeafvedgwk....lyrTGDlgrided 378 1030 tE t+++t+ +++ + + +iGrpl+g +++++d ++v+p+++GEl+++g+++a GYl++ ++t e+fv++++ +yrTGDl+r++++ 1031 bpsB 2240 TEITLCATWLVLEPGAatGDVLPIGRPLAGRQAYVLDAFLQPVAPNVTGELYLAGAGLAHGYLGNTAATSERFVANPFSgggrMYRTGDLARWTDQ 2335 1032 **********999999999***************************************************************************** PP 1033 1034 --EEEEEGGGCEEEB---EEEHHHHHHHHHTSTTEEEEEE CS 1035 AMP-binding 379 GyleiiGRkkdqvkirGeriepgeiEsvllehpgvaeaaV 418 1036 G+l + GR++ qvkirG+r+epge+E +l e+p va+a+V 1037 bpsB 2336 GELVFAGRADSQVKIRGYRVEPGEVEVALTEVPHVAQAVV 2375 1038 **************************************98 PP 1039 1040 == domain 3 score: 359.2 bits; conditional E-value: 1.7e-110 1041 EHHHHHHHHHHHHHHHHH----TT-EEEEE-SSSHHHHHHHHHHHHTT-EEEE--TTS-HHHHHHHHHHCTESEEEEESBCHCCHHHHHHHHHCHH CS 1042 AMP-binding 1 TYreldervnrlaagLrklGvkpgdrVaillpnspewviaflaclkaGavyvpvyptlpaerlayilndseakvlitddelltklkeaaskelake 96 1043 T++ l +v+ la+ L Gv+++ rV++l+++s+e+ ++++a+ aG+v+vpv+p++p+er++++l++s + v+++++ ++++++ + ++ 1044 bpsB 3498 TFGGLLGEVEALARLLVGAGVRREHRVGVLVERSAELAVTMMAVSFAGGVFVPVDPDYPRERVEFMLANSAPGVMVCTKTTRAAVPAEFAGTVL-- 3591 1045 66778889*******************************************************************************9999985.. PP 1046 1047 ECCETTCCEESECCCCCCEHCHHHHGTSTSS-CCCSBTTTSEEEEEEE-------EEEEEEHHHHHHHHHHHHHHHTTTTT.EEEEES-TTSTHHH CS 1048 AMP-binding 97 aliivrsepaesvgeeellleleslkkasteppkvplkpddlayiiyTSGtTGkPKgVmlthrnllalvagiakrvglkpddrvlsllplafdgsv 192 1049 l++l++a+++ + +p+ p+d ay+iyTSG+TG PKgV++th +l++l ++++r+ ++ ++rvl+l++ fd+ v 1050 bpsB 3592 --------------------VLDELPAADPDVELPPVAPEDAAYVIYTSGSTGVPKGVLVTHSGLANLGYAHIERMAVTSSSRVLQLSATGFDAIV 3667 1051 ....................5899************************************************************************ PP 1052 1053 CCCHHHHTTT-EEEEESSCCTCSHHHHHHHHHHTT-SEEEE-HHHHHHHHHHHHCCCTTTTT--EEEE-----THHHHHHHHHHCTTSEEEEEE-- CS 1054 AMP-binding 193 leilgplllGatlvlvspedlkdpalllddiekykvtvlalvptllelllkapekkkldlsslrlilsggeplspellrrlreafggipivngYGl 288 1055 e++++ll+Gatlvl++ + + +l ++i++ ++t+l++ p++l + p +lr++l+gge+l+p+l++r+ g +++++YG+ 1056 bpsB 3668 SELYMALLAGATLVLPDAASMPPRVTLGEAIRRAGITHLTVSPSVLASEDDLP-------DTLRTVLTGGEALPPALVDRWSP---GRRVIQAYGP 3753 1057 ********************99999999*************************.......59********************6...679******* PP 1058 1059 GGGSSESEEEECGHHH-SSC---EBSTTTEEEEEBSTT-BEE-S----EEEESTTS--B-TT-HHHHHHHEEESTT-....EEE---EEEE-TT-- CS 1060 AMP-binding 289 tEttvivtvslpgdeetkpgsiGrplpgveikivdeegkevppgevGEllirgpsvakGYlkdpeltaeafvedgwk....lyrTGDlgridedGy 380 1061 tEtt+++t+s p + ++ G p+++v+ +++d ++vppg+vGEl+i+g ++a+GYl++p ltae+fv+ +++ +yr+GDl r++ +G+ 1062 bpsB 3754 TETTICSTMSAPLSPGHDQVPLGGPIHNVRHYVLDAFLQPVPPGVVGELYITGVGLARGYLGRPGLTAERFVASPFApgerMYRSGDLFRWTREGQ 3849 1063 ************************************************************************************************ PP 1064 1065 EEEEEGGGCEEEB---EEEHHHHHHHHHTSTTEEEEEE CS 1066 AMP-binding 381 leiiGRkkdqvkirGeriepgeiEsvllehpgvaeaaV 418 1067 l + GR++ qvk+rG+r+ep+eiE+vl+ehp v ++aV 1068 bpsB 3850 LLFAGRVDAQVKVRGYRVEPAEIEAVLAEHPWVGQVAV 3887 1069 ************************************98 PP 1070 1071>> Epimerization 1072 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1073 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1074 1 ! 44.0 16.3 4.8e-15 1.3e-14 31 242 .. 40 236 .. 38 238 .. 0.90 1075 2 ! 430.9 26.9 5.4e-132 1.4e-131 1 316 [. 1037 1332 .. 1037 1333 .. 0.99 1076 3 ! 30.8 13.9 4.8e-11 1.3e-10 30 140 .. 1540 1647 .. 1538 1651 .. 0.82 1077 4 ! 420.9 33.7 5.8e-129 1.5e-128 1 316 [. 2538 2840 .. 2538 2841 .. 0.97 1078 5 ! 26.8 9.3 7.6e-10 2e-09 30 178 .. 3051 3193 .. 3049 3194 .. 0.86 1079 1080 Alignments for each domain: 1081 == domain 1 score: 44.0 bits; conditional E-value: 4.8e-15 1082 Epimerization 31 evpagldedaLraALqaLldhHDALRlRf.reedggwrqrnvperGavdeaaflLevvdlsggddldaaieaaan.eaQasLDlaaGpLlrAvlfd 124 1083 + ++d++ LraA + Ll++H LR++f +++ g+ +q++ + v+ + ++vdls +dd+++a++++a + +++Dla+ pLlr+ l + 1084 bpsB 40 DLAGPVDAAGLRAAWETLLARHAPLRACFrQRKSGETVQII---ARQVE---LPWREVDLSHLDDPEEAVRELAEqDRTTRFDLAQAPLLRLTLIR 129 1085 567789***********************************...55555...799999*******888888888615678**************** PP 1086 1087 Epimerization 125 agdgdpgrLlLviHHLVVDGVSWRILLEDLaaAYeQaaaGqaiaLppKTtSfrrWAerLaeyAqseallaEldYWrevlagpdppLPadrpdgdka 220 1088 +g++ +rL+++ HH + DG S I ++ L +Y + G +++ p S+r++ + L+++ +++ l W++ l+g+++p + ++d+ 1089 bpsB 130 LGADA-HRLVVTCHHTIMDGWSLPIVIDELSVLYPA---GGDASALPDVPSYREYLAWLSRQ--DKE--RALSAWTAELSGAEEPTLVVPADP--- 214 1090 *****.*****************************6...55555555556************..544..79**************99999999... PP 1091 1092 Epimerization 221 ddtagtartvsvtLsaeeTraL 242 1093 ++ + ++v+ L++ Tr L 1094 bpsB 215 GRAPAEPESVEAHLPEHLTRSL 236 1095 9******************977 PP 1096 1097 == domain 2 score: 430.9 bits; conditional E-value: 5.4e-132 1098 Epimerization 1 tGevpLTPIQrWFfeqdggerhHfNQsvlLevpagldedaLraALqaLldhHDALRlRfreedggwrqrnvperGavdeaaflLevvdlsggdd 94 1099 +Ge+p+TP++r+++ d++ r++f+Q +++ +pag+++daL+ ALqa+ld HD LR+R+ e++g r+++ perGav+ aa+lL++v +++g 1100 bpsB 1037 VGEIPWTPVMRALG--DDAMRPGFAQVRVVVTPAGVNPDALVSALQAVLDAHDLLRARV--EPDG-RLIV-PERGAVA-AAGLLTRVAAGTGG- 1122 1101 7*************..6******************************************..9999.4555.*******.**************. PP 1102 1103 Epimerization 95 ldaaieaaaneaQasLDlaaGpLlrAvlfdagdgdpgrLlLviHHLVVDGVSWRILLEDLaaAYeQaaaGqaiaLppKTtSfrrWAerLaeyAq 188 1104 ld+++e++++ a + LD++aG + r+v+ dagd+ pgrL +v+HHL VD+VSW ILL+DL+aAY + +G ++aL+p+ tS+r+WA+rL+++A 1105 bpsB 1123 LDEIAEREVRTATGTLDPSAGIMARVVWIDAGDAEPGRLAFVAHHLSVDAVSWGILLPDLRAAYDEVISGGTPALEPPVTSYRQWARRLTARAL 1216 1106 ********************************************************************************************** PP 1107 1108 Epimerization 189 seallaEldYWrevlagpdppLPadrpdgdkaddtagtartvsvtLsaeeTraLLtevpaAYhTgvNDvLLtALalAlarWtGgrGggdaavlv 282 1109 se+ +aEl+ W++v++g++p+LP+d ++ g+++++s++Ls +e r L+t p A+h+g++DvLL++La+A+ar +G + aa+lv 1110 bpsB 1217 SESTVAELEKWAAVVEGAEPALPQDTGQH------TGQSHSWSTSLSGTEVRDLVTVLPGAFHCGIQDVLLAGLAGAVARVRGSG----AALLV 1300 1111 *****************************......**************************************************....***** PP 1112 1113 Epimerization 283 dLEGHGReEelfdglDlSRTVGWFTSiYPVrLdl 316 1114 d+EGHGR e++dg Dl RTVGWFTS++PVrL+l 1115 bpsB 1301 DVEGHGR--EAADGEDLLRTVGWFTSVHPVRLEL 1332 1116 *******..***********************98 PP 1117 1118 == domain 3 score: 30.8 bits; conditional E-value: 4.8e-11 1119 Epimerization 30 LevpagldedaLraALqaLldhHDALRlRf.reedggwrqrnvperGavdeaaflLevvdlsggdd..ldaaieaaaneaQ.asLDlaaGpLlr 119 1120 L + +lde +LraA +++l++H LR f + g +q++v+e+ ++ +v+dls +d+ +a +e++++e Q +++D + pLlr 1121 bpsB 1540 LDLDGPLDEPRLRAAWNQVLARHASLRTGFhQLGSGATVQVVVREADIPW------RVADLSHLDAaeAAAEVERLLAEDQgRRFDVTRPPLLR 1627 1122 566779************************99999999998856666666......5555555555556677777666666378********** PP 1123 1124 Epimerization 120 AvlfdagdgdpgrLlLviHHL 140 1125 + l ++g++ +rL+++ HH 1126 bpsB 1628 LLLIRLGADE-HRLVVTSHHV 1647 1127 **********.*********6 PP 1128 1129 == domain 4 score: 420.9 bits; conditional E-value: 5.8e-129 1130 Epimerization 1 tGevpLTPIQrWFfeq..dggerhHfNQsvlLevpagldedaLraALqaLldhHDALRlRfreedgg.wrqrnvperGavdeaaflLevvdlsg 91 1131 +Gevp+TP++r+++e+ g +r+ +Q+v +++p +l+++aL+a+L+a++d+HD+LR+R +e +g +r+++ ++rG+vd aa+l+e+v++++ 1132 bpsB 2538 VGEVPWTPVVRALLERdpAGLTRGAMAQWVSVAAPRDLSVTALVAGLGAVIDTHDMLRSRIVESEGVePRLVV-AGRGTVD-AAALVERVEAGD 2629 1133 7***************555******************************************777776799999.*******.************ PP 1134 1135 Epimerization 92 gddldaaieaaaneaQasLDlaaGpLlrAvlfdagdgdpgrLlLviHHLVVDGVSWRILLEDLaaAYeQaaaGqaiaLppKTtSfrrWAerLae 185 1136 gd l+++++++a + +a+LD+ aG+L+rAv++dag+g++grL++++HHLVVD VSWR LL+DL+aA+e+++aG ++aL+p+ SfrrW+++L 1137 bpsB 2630 GD-LAEIADRCAHDTAARLDPVAGVLVRAVWVDAGPGRAGRLVVAAHHLVVDVVSWRTLLPDLQAACEAVVAGGQPALDPPDVSFRRWSRTLDG 2722 1138 **.******************************************************************************************9 PP 1139 1140 Epimerization 186 yAqseallaEldYWrevlagpdppLPadrpdgdkaddtagtartvsvtLsaeeTraLLtevpaAYhTgvNDvLLtALalAlarWtGgrGggdaa 279 1141 +A+ + +El+ W+e+l+g+ +L+ +p + dt++ta+++s+t+++e + +L+ +v +A+h+gv++vLL++La+A+a W+Gg+ a 1142 bpsB 2723 EAAI--RTGELAVWTEILDGAQSRLGELDPRR----DTVSTAGRRSWTVPREHAGVLVEQVTSAFHCGVHEVLLATLAGAVAGWRGGT-----A 2805 1143 9885..**************************....****************************************************.....* PP 1144 1145 Epimerization 280 vlvdLEGHGReEelfdglDlSRTVGWFTSiYPVrLdl 316 1146 v+vd+EGHGR ++l + lDlSRT GWFT ++P+rLd+ 1147 bpsB 2806 VVVDVEGHGR-QPLGE-LDLSRTLGWFTDVHPLRLDV 2840 1148 **********.66666.*******************8 PP 1149 1150 == domain 5 score: 26.8 bits; conditional E-value: 7.6e-10 1151 Epimerization 30 LevpagldedaLraALqaLldhHDALRlRf.reedggwrqrnvperGavdeaaflLevvdlsggddldaaieaaaneaQa.....sLDlaaGpL 117 1152 L+ +ld+++ ra Lld+H+ALR+ f + e g+ +q++ a d + ++ ++ dlsg+ ++ + a++++++a ++Dl + p 1153 bpsB 3051 LAIDGPLDVARFRASWTVLLDRHPALRASFhQLESGEAVQVI-----ARD-VPPDWRETDLSGL--PESEALAEFDRLAArmhaeRFDLTKAPQ 3136 1154 677789************************************.....777.77899999*****..666666666666662222457******* PP 1155 1156 Epimerization 118 lrAvlfdagdgdpgrLlLviHHLVVDGVSWRILLEDLaaAYeQaaaGqaiaLppKTtSfrr 178 1157 lr+ l+++gd + rL ++ HH V DG S +L D +AYe+ G + + p tS+r+ 1158 bpsB 3137 LRLHLVRLGDRR-YRLIFTSHHIVADGWSLPLILVDVLTAYEA---GGDGRTLPAATSYRD 3193 1159 ************.**************9999999999999996...777777888888886 PP 1160 1161>> Condensation_LCL 1162 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1163 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1164 1 ! 198.2 0.0 1.2e-61 3.3e-61 3 295 .. 9 301 .. 7 302 .. 0.93 1165 2 ! 53.2 0.0 1.8e-17 4.8e-17 38 295 .. 1070 1332 .. 1061 1333 .. 0.79 1166 3 ! 187.3 0.0 2.6e-58 6.9e-58 4 296 .] 1511 1801 .. 1508 1801 .. 0.92 1167 4 ! 61.3 0.0 6e-20 1.6e-19 37 295 .. 2574 2840 .. 2565 2841 .. 0.85 1168 5 ! 179.3 0.0 6.9e-56 1.8e-55 4 295 .. 3023 3315 .. 3021 3316 .. 0.92 1169 1170 Alignments for each domain: 1171 == domain 1 score: 198.2 bits; conditional E-value: 1.2e-61 1172 Condensation_LCL 3 rlplSfaQqrlwflnqlepesaa.yniplalrltgeldvealeaAladlvaRheiLRtvf.peedgepvqvvlpaaelelevedls.....ea 88 1173 +plS+ Q l f + +++e + y +l l g++d++ l+aA+++l+aRh LR +f +++ ge+vq ++ ++el+++++dls e+ 1174 bpsB 9 IWPLSPLQAGLLFHAVYDGEGPDvYIGHWILDLAGPVDAAGLRAAWETLLARHAPLRACFrQRKSGETVQIIARQVELPWREVDLShlddpEE 101 1175 58****************998762677889******************************77788999************************* PP 1176 1177 Condensation_LCL 89 eleelveeeaarpFdLekepllrvrllrlaeeehvLllvvHHiiaDgwSlgvllrelaalYaarlagqapelaplpvqYaDYalwqrelleee 181 1178 +++el+e++ +++FdL+++pllr++l+rl ++ h L++++HH i+DgwSl + ++el+ lY + g+a++l+++p +Y++Y +w + ++ 1179 bpsB 102 AVRELAEQDRTTRFDLAQAPLLRLTLIRLGADAHRLVVTCHHTIMDGWSLPIVIDELSVLY--PAGGDASALPDVP-SYREYLAWLS----RQ 187 1180 *************************************************************..6699********9.9******877....56 PP 1181 1182 Condensation_LCL 182 elarqlaYWreqLagl.pelleLptdrprpavqsyrGarvefeldaelsaklkelarehgvtlFmvllaalavlLsrlsgqeDivvGtpvagR 273 1183 + +r l+ W+++L+g+ +++l +p+d r + + ++ve +l+++l+++l+elar+hg tl +v++ a+a++L++l+g+ D+v G+ v+ R 1184 bpsB 188 DKERALSAWTAELSGAeEPTLVVPADPGRAPAE---PESVEAHLPEHLTRSLAELARRHGLTLNTVVQGAWALVLAQLAGRPDVVFGAAVSAR 277 1185 77899999******9956778899998887765...478****************************************************** PP 1186 1187 Condensation_LCL 274 t..raeledliGfFvNtlvlrtel 295 1188 + +e+++G+F+Nt+++r++l 1189 bpsB 278 PpdLPGVEGMVGLFLNTVPVRVRL 301 1190 622589***************987 PP 1191 1192 == domain 2 score: 53.2 bits; conditional E-value: 1.8e-17 1193 Condensation_LCL 38 ldvealeaAladlvaRheiLRtvfpeedgepvqvvlpa.aele.levedls....eaeleelveeeaarpFdLekepllrvrllrlae.ee 121 1194 ++ +al +Al+++++ h+ LR + e dg+ + + a a++ l+ ++ + +e++e+ + a+ + d +++++ rv + + e 1195 bpsB 1070 VNPDALVSALQAVLDAHDLLRARV-EPDGRLIVPERGAvAAAGlLTRVA-AgtggLDEIAEREVRTATGTLDPSAGIMARVVWIDAGDaEP 1158 1196 67899******************9.666665332222222222133333.24466556666666777789**************9988346 PP 1197 1198 Condensation_LCL 122 hvLllvvHHiiaDgwSlgvllrelaalYaarlagqapelaplpvqYaDYalwqrelleeeelarqlaYWreqLaglpelleLptdrprpav 212 1199 L++v+HH +D +S+g+ll +l a+Y++ +g +p+l+p +Y+++a + + +e++ ++l+ W + +g+++ +Lp d ++ 1200 bpsB 1159 GRLAFVAHHLSVDAVSWGILLPDLRAAYDEVISGGTPALEPPVTSYRQWARRLTARALSESTVAELEKWAAVVEGAEP--ALPQDTGQHTG 1247 1201 89*************************************************99999999999999***********98..58***999999 PP 1202 1203 Condensation_LCL 213 qsyrGarvefeld.aelsaklkelarehgvtlFmvllaalavlLsrlsgq.eDivvGtpvagRtraeledl...iGfFvNtlvlrtel 295 1204 qs++ + +l+ e+++ ++ l + ++ vlla la ++r+ g+ + ++v + gR+ a+ edl +G F ++r+el 1205 bpsB 1248 QSHS---WSTSLSgTEVRDLVTVLPGAFHCGIQDVLLAGLAGAVARVRGSgAALLVDVEGHGREAADGEDLlrtVGWFTSVHPVRLEL 1332 1206 9885...555555145555666667788999999999999999999987636788999999999887776534478888888888776 PP 1207 1208 == domain 3 score: 187.3 bits; conditional E-value: 2.6e-58 1209 Condensation_LCL 4 lplSfaQqrlwflnqlepes.aayniplalrltgeldvealeaAladlvaRheiLRtvf.peedgepvqvvlpaaelelevedls...... 86 1210 +plS+ Q+ + f ++++ ++y+ + +l l+g+ld+ +l+aA+++++aRh +LRt f + g +vqvv +a+++++v dls 1211 bpsB 1511 WPLSPLQEGMLFERAFDEDGvDVYQTQRILDLDGPLDEPRLRAAWNQVLARHASLRTGFhQLGSGATVQVVVREADIPWRVADLShldaae 1601 1212 89**************98762679***********************************55577888***********************9 PP 1213 1214 Condensation_LCL 87 .eaeleelveeeaarpFdLekepllrvrllrlaeeehvLllvvHHiiaDgwSlgvllrelaalYaarlagqapelaplpvqYaDYalwqre 176 1215 +ae+e+l++e+ r+Fd+++ pllr+ l+rl ++eh L+++ HH+ DgwS+ + + e+++ Y ag +++ + p +Y+DY +w + 1216 bpsB 1602 aAAEVERLLAEDQGRRFDVTRPPLLRLLLIRLGADEHRLVVTSHHVLLDGWSTPLVVGEMSDGY----AGGRSSSK--PPSYQDYLAWLS- 1685 1217 999*************************************************************....33333333..458*****9876. PP 1218 1219 Condensation_LCL 177 lleeeelarqlaYWreqLaglpelleLptdrprpavqsyrGarvefeldaelsaklkelarehgvtlFmvllaalavlLsrlsgqeDivvG 267 1220 ++++++ ++ Wr++Lag+ e + + +d + v ++++ l++ +++l+ +ar hg t+ +++l a+a++L+rl+g++D+v G 1221 bpsB 1686 ---RQDAEATRSAWRAELAGADEPTLVDADAGKTLVMP---DEHAEWLPEPATRALAGFARGHGLTVSTIVLGAWALVLARLAGRTDVVFG 1770 1222 ...6788999999**********999999998888776...678999******************************************** PP 1223 1224 Condensation_LCL 268 tpvagRtr..aeledliGfFvNtlvlrteld 296 1225 + v+gR +++e+++G+F+Nt++ r++ld 1226 bpsB 1771 SVVSGRPAdvPDVERMVGMFINTVPARVRLD 1801 1227 ******763379***************9975 PP 1228 1229 == domain 4 score: 61.3 bits; conditional E-value: 6e-20 1230 Condensation_LCL 37 eldvealeaAladlvaRheiLRtvfpeedgep.vqvvlpa..aelelevedls.....eaeleelveeeaarpFdLekepllrvrllrlae 119 1231 +l v+al a l ++++ h++LR++++e++g + vv+ + ++++ ve+++ ae+++++++++a++ d +++l+r+ + + 1232 bpsB 2574 DLSVTALVAGLGAVIDTHDMLRSRIVESEGVEpRLVVAGRgtVDAAALVERVEagdgdLAEIADRCAHDTAARLDPVAGVLVRAVWVDAGP 2664 1233 68899********************8888865277777777766666666666778888999999999*******************9988 PP 1234 1235 Condensation_LCL 120 .eehvLllvvHHiiaDgwSlgvllrelaalYaarlagqapelaplpvqYaDYalwqrelle.eeelarqlaYWreqLaglpelleLptdrp 208 1236 + L++ +HH ++D +S++ ll +l+a+ +a +ag +p+l p +v+++ + +r+l + + + +la W+e L+g++++ L p 1237 bpsB 2665 gRAGRLVVAAHHLVVDVVSWRTLLPDLQAACEAVVAGGQPALDPPDVSFRRW---SRTLDGeAAIRTGELAVWTEILDGAQSR--LGELDP 2750 1238 46789*****************************************998765...555555244566799**********876..556678 PP 1239 1240 Condensation_LCL 209 rpavqsyrGarvefeldaelsaklkelarehgvtlFmvllaalavlLsrlsgqeDivvGtpvagRt...raeledliGfFvNtlvlrtel 295 1241 r+ + s++G+r ++ ++++ + ++ ++ vlla la ++ g + +vv + gR+ + +l++++G F +lr+++ 1242 bpsB 2751 RRDTVSTAGRRSWTVPREHAGVLVEQVTSAFHCGVHEVLLATLAGAVAGWRGGTAVVVDVEGHGRQplgELDLSRTLGWFTDVHPLRLDV 2840 1243 9999999997765555555566778999999**********************************64447899**************987 PP 1244 1245 == domain 5 score: 179.3 bits; conditional E-value: 6.9e-56 1246 Condensation_LCL 4 lplSfaQqrlwflnqlepesaayniplalrltgeldvealeaAladlvaRheiLRtvf.peedgepvqvvlpaaelelevedls....... 86 1247 +plS+ Q+ l f + ++ ++y +l ++g+ldv++++a+++ l++Rh +LR +f + e ge+vqv++ +++++++++dls 1248 bpsB 3023 WPLSPLQEGLLFHAADDRGPDVYASMRTLAIDGPLDVARFRASWTVLLDRHPALRASFhQLESGEAVQVIARDVPPDWRETDLSglpesea 3113 1249 79********************************************************66789999*********************9998 PP 1250 1251 Condensation_LCL 87 eaeleelveeeaarpFdLekepllrvrllrlaeeehvLllvvHHiiaDgwSlgvllrelaalYaarlagqapelaplpvqYaDYalwqrel 177 1252 ae+++l+++ a++FdL+k+p lr++l+rl ++++ L+++ HHi+aDgwSl ++l ++ ++Y+a g++ +l+ + +Y+D+ +w ++ 1253 bpsB 3114 LAEFDRLAARMHAERFDLTKAPQLRLHLVRLGDRRYRLIFTSHHIVADGWSLPLILVDVLTAYEA--GGDGRTLP-AATSYRDFLAWVDRQ 3201 1254 8899999*9******************************************************66..56666666.667********9864 PP 1255 1256 Condensation_LCL 178 leeeelarqlaYWreqLaglpelleLptdrprpavqsyrGarvefeldaelsaklkelarehgvtlFmvllaalavlLsrlsgqeDivvGt 268 1257 + + + Wr++Lagl e +++ p + + +rv+feld+e+s++l e+ r+hgvt ++++ ++a+ L+rl+g++D+v G+ 1258 bpsB 3202 DK----GAAGQAWRTELAGLDEATHVV--PPGSIITPLEPERVAFELDDETSKRLVEFTRRHGVTANTLFQGVWALHLARLAGRNDVVFGA 3286 1259 33....344445********9988664..577788889999************************************************** PP 1260 1261 Condensation_LCL 269 pvagRtr..aeledliGfFvNtlvlrtel 295 1262 vagR + +e+ +G+F+N l++r++l 1263 bpsB 3287 AVAGRPPeiPGVESAVGLFMNMLPVRARL 3315 1264 *****752279***************986 PP 1265 1266>> Condensation_Dual 1267 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1268 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1269 1 ! 154.1 0.0 4e-48 1.1e-47 2 295 .. 8 301 .. 7 302 .. 0.91 1270 2 ! 154.5 0.0 3.1e-48 8.3e-48 2 296 .] 1509 1801 .. 1508 1801 .. 0.88 1271 3 ! 22.3 0.0 5.8e-08 1.5e-07 40 171 .. 2577 2715 .. 2564 2841 .. 0.83 1272 4 ! 148.2 0.0 2.5e-46 6.7e-46 2 295 .. 3021 3315 .. 3020 3316 .. 0.89 1273 1274 Alignments for each domain: 1275 == domain 1 score: 154.1 bits; conditional E-value: 4e-48 1276 Condensation_Dual 2 diYpLapLqeGilfHhllaeeg.DpYllqallafasrerldaflaalqqvidRhdiLrtavlWegleepvqvvwrqaeleveeleldsadge 92 1277 +i+pL+pLq G+lfH ++ +eg D Y+ + l +a aa +++++Rh Lr+ + + e vq++ rq+el+ +e++l++ d++ 1278 bpsB 8 EIWPLSPLQAGLLFHAVYDGEGpDVYIGHWILDLAGPVDAAGLRAAWETLLARHAPLRACFRQRKSGETVQIIARQVELPWREVDLSHLDDP 99 1279 8*****************99987********************************************************************9 PP 1280 1281 Condensation_Dual 93 vaeqlearfdprrarldlsqapllrlvvaedaaegrllllllfHHlilDhttlevlseEvqall..qgqeealpapvpyRnfvaqarlgvse 182 1282 ++ e + + r++r+dl+qapllrl++ + + l+++ HH i+D +l ++++E++ l g+++alp +yR+++a ++ +e 1283 bpsB 100 EEAVRELAEQDRTTRFDLAQAPLLRLTLIRLG-ADAHRLVVTCHHTIMDGWSLPIVIDELSVLYpaGGDASALPDVPSYREYLAWLSRQDKE 190 1284 7777777778899**************99984.5556677899*****************98852268999*************99666555 PP 1285 1286 Condensation_Dual 183 aeheafFrekLadvdeptlpfglaevqgdgseieearraleaeLsqrlreqarrlgvsaasllHlawaqvlartsgredvvFGtvllGRlqg 274 1287 ++ + ++++L+ +eptl + e e+++ +l+++L+++l e arr g+ + +++ awa vla+++gr dvvFG+ ++ R 1288 bpsB 191 RAL-SAWTAELSGAEEPTLVVPADP-GRAPAEPESVEAHLPEHLTRSLAELARRHGLTLNTVVQGAWALVLAQLAGRPDVVFGAAVSARPPD 280 1289 555.556999*********987655.555566699999****************************************************** PP 1290 1291 Condensation_Dual 275 gegadralGlfintLPlrldl 295 1292 g++ ++Glf+nt+P+r++l 1293 bpsB 281 LPGVEGMVGLFLNTVPVRVRL 301 1294 *******************97 PP 1295 1296 == domain 2 score: 154.5 bits; conditional E-value: 3.1e-48 1297 Condensation_Dual 2 diYpLapLqeGilfHhllaeeg.DpYllqallafasrerldaflaalqqvidRhdiLrtavlWegleepvqvvwrqaeleveeleldsad 90 1298 di+pL+pLqeG+lf + + e+g D Y +q l ++ + aa +qv++Rh Lrt+++ g + vqvv r+a+++ + +l++ d 1299 bpsB 1509 DIWPLSPLQEGMLFERAFDEDGvDVYQTQRILDLDGPLDEPRLRAAWNQVLARHASLRTGFHQLGSGATVQVVVREADIPWRVADLSHLD 1598 1300 9****************999877*************999999************************************987766665544 PP 1301 1302 Condensation_Dual 91 ..gevaeqlearfdprrarldlsqapllrlvvaedaaegrllllllfHHlilDhttlevlseEvqallqgqeealpapvpyRnfvaqarl 178 1303 ++ ae + + + +r+d+++ pllrl + + ++ l+++ HH++lD + +++ E++ +g +++ ++p +y +++a 1304 bpsB 1599 aaEAAAEVERLLAEDQGRRFDVTRPPLLRLLLIRL-GADEHRLVVTSHHVLLDGWSTPLVVGEMSDGYAGGRSS-SKPPSYQDYLAWLS- 1685 1305 104444444555678889************99998.55666778899*******************99998776.77889******995. PP 1306 1307 Condensation_Dual 179 gvseaeheafFrekLadvdeptlpfglaevqgdgseieearraleaeLsqrlreqarrlgvsaasllHlawaqvlartsgredvvFGtvl 268 1308 ++++++ ++ +r++La deptl a++ + +e+++ l++ +++l ar g+ +++++ awa vlar++gr+dvvFG+v+ 1309 bpsB 1686 RQDAEATRSAWRAELAGADEPTLVD--ADAGKTLVMPDEHAEWLPEPATRALAGFARGHGLTVSTIVLGAWALVLARLAGRTDVVFGSVV 1773 1310 55666677778***********853..3444444555789999*********************************************** PP 1311 1312 Condensation_Dual 269 lGRlqggegadralGlfintLPlrldld 296 1313 +GR + +++r++G+fint+P r++ld 1314 bpsB 1774 SGRPADVPDVERMVGMFINTVPARVRLD 1801 1315 *************************986 PP 1316 1317 == domain 3 score: 22.3 bits; conditional E-value: 5.8e-08 1318 Condensation_Dual 40 ldaflaalqqvidRhdiLrtavlWegleepvqvvwrqaeleveel..eldsadgevaeqlearfdprrarldlsqapllrlvvaedaaeg 127 1319 ++a +a l +vid hd+Lr+ ++ + ep vv + +++ +l ++++ dg++ae ++ + +arld l+r+v++ 1320 bpsB 2577 VTALVAGLGAVIDTHDMLRSRIVESEGVEPRLVVAGRGTVDAAALveRVEAGDGDLAEIADRCAHDTAARLDPVAGVLVRAVWVDAGPGR 2666 1321 6788999****************999999******99999988763356788899999999999999*************9999887777 PP 1322 1323 Condensation_Dual 128 rllllllfHHlilDhttlevlseEvqa....llqgqeealpap.vpyRn 171 1324 l++ HHl++D ++ ++l ++qa +++g + al +p v++R 1325 bpsB 2667 AGRLVVAAHHLVVDVVSWRTLLPDLQAaceaVVAGGQPALDPPdVSFRR 2715 1326 7789999**********99988777761111455556666443267775 PP 1327 1328 == domain 4 score: 148.2 bits; conditional E-value: 2.5e-46 1329 Condensation_Dual 2 diYpLapLqeGilfHhllaeegDpYllqallafasrerldaflaalqqvidRhdiLrtavlWegleepvqvvwrqaeleveeleld..sa 89 1330 di+pL+pLqeG+lfH + D Y +la++ + +f a+ ++dRh Lr++++ + e+vqv+ r ++ + +e++l+ ++ 1331 bpsB 3021 DIWPLSPLQEGLLFHAADDRGPDVYASMRTLAIDGPLDVARFRASWTVLLDRHPALRASFHQLESGEAVQVIARDVPPDWRETDLSglPE 3110 1332 9****************************************************************************9999888763345 PP 1333 1334 Condensation_Dual 90 dgevae..qlearfdprrarldlsqapllrlvvaedaaegrllllllfHHlilDhttlevlseEvq.allq.gqeealpapvpyRnfvaq 175 1335 ++++ae +l+ar++ ++r+dl++ap lrl++++ + r+ l+ + HH++ D +l ++ +v a+ + g+ ++lpa+++yR+f+a 1336 bpsB 3111 SEALAEfdRLAARMH--AERFDLTKAPQLRLHLVRL-GDRRYRLIFTSHHIVADGWSLPLILVDVLtAYEAgGDGRTLPAATSYRDFLAW 3197 1337 555554115555555..689************9998.889999***************9998887515544367899************* PP 1338 1339 Condensation_Dual 176 arlgvseaeheafFrekLadvdeptlpfglaevqgdgseieearraleaeLsqrlreqarrlgvsaasllHlawaqvlartsgredvvFG 265 1340 + ++ + a+ +a +r +La +de t+ ++ + e e ++ +l+ e s+rl e +rr gv a +l+ wa lar++gr+dvvFG 1341 bpsB 3198 VDRQDKGAAGQA-WRTELAGLDEATHVVPPGSIITPL-EPERVAFELDDETSKRLVEFTRRHGVTANTLFQGVWALHLARLAGRNDVVFG 3285 1342 *77776666666.6899********988877776654.4588999********************************************* PP 1343 1344 Condensation_Dual 266 tvllGRlqggegadralGlfintLPlrldl 295 1345 + + GR + g+++a+Glf+n LP+r +l 1346 bpsB 3286 AAVAGRPPEIPGVESAVGLFMNMLPVRARL 3315 1347 ***************************876 PP 1348 1349>> Condensation_Starter 1350 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1351 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1352 1 ! 141.3 0.0 3.2e-44 8.5e-44 4 299 .. 10 301 .. 7 302 .. 0.91 1353 2 ! 33.1 0.0 2.9e-11 7.8e-11 38 299 .. 1070 1332 .. 1061 1333 .. 0.75 1354 3 ! 142.2 0.0 1.7e-44 4.5e-44 4 299 .. 1511 1800 .. 1508 1801 .. 0.89 1355 4 ! 34.9 0.0 8.1e-12 2.1e-11 38 299 .. 2575 2840 .. 2563 2841 .. 0.81 1356 5 ! 129.9 0.0 9.4e-41 2.5e-40 5 299 .. 3024 3315 .. 3021 3316 .. 0.92 1357 1358 Alignments for each domain: 1359 == domain 1 score: 141.3 bits; conditional E-value: 3.2e-44 1360 Condensation_Starter 4 lpLtaaQrgiWlaqqldpdspvynige.yveikgeldlelLeeAirqvvaeadalrvrl.veeegepvqavaeelpveleviDlsaeed 90 1361 pL++ Q+g+ + d + p ig+ ++++ g++d++ L++A + ++a++ lr+ + + ge vq +a++++ +++ +Dls+ +d 1362 bpsB 10 WPLSPLQAGLLFHAVYDGEGPDVYIGHwILDLAGPVDAAGLRAAWETLLARHAPLRACFrQRKSGETVQIIARQVELPWREVDLSHLDD 98 1363 69*****************999999984689****************************9999************************** PP 1364 1365 Condensation_Starter 91 peaaaeawmradlarpldldgdpLfrfallrlgeeryywyqrvHHiilDGfgfalltrriaeiYtalaageaapeapfgslsdllaeeq 179 1366 pe+a++++ ++d + +dl++ pL r l+rlg + + +++++HH i+DG+++ +++ +++ +Y a + +a +s+ ++la 1367 bpsB 99 PEEAVRELAEQDRTTRFDLAQAPLLRLTLIRLGADAHRLVVTCHHTIMDGWSLPIVIDELSVLYPAGGDASA--LPDVPSYREYLAWL- 184 1368 *****************************************************************9986665..44567888777654. PP 1369 1370 Condensation_Starter 180 aYraSerfakDrayWleklaalpepvslseraapakeasasalrrsaelpaallerlkelaeasgisvaelliAalaaylsrltgeddv 268 1371 ++ +++ W+++l++++ep+++ + + +a a++ +++a+lp+ l+++l ela+++g+++++++ a a+ l++l+g+ dv 1372 bpsB 185 ---SRQDKERALSAWTAELSGAEEPTLVVPADPG--RAPAEPESVEAHLPEHLTRSLAELARRHGLTLNTVVQGAWALVLAQLAGRPDV 268 1373 ...44555777777*************9875554..4899999********************************************** PP 1374 1375 Condensation_Starter 269 vlglpvmnRlgs..aakrtpGmvanvlPLrlsv 299 1376 v+g v++R ++G ++n++P+r+++ 1377 bpsB 269 VFGAAVSARPPDlpGVEGMVGLFLNTVPVRVRL 301 1378 *********976225789************986 PP 1379 1380 == domain 2 score: 33.1 bits; conditional E-value: 2.9e-11 1381 Condensation_Starter 38 ldlelLeeAirqvvaeadalrvrlveeegepvq.avaeelpveleviDlsaeedpeaaaeawmradlarpldldgdpLfrfallrlg 123 1382 ++ ++L +A++ v++ +d lr+r+ ++ v + a ++ l + + a + +++ + +++ +ld ++ + r++ + g 1383 bpsB 1070 VNPDALVSALQAVLDAHDLLRARVEPDGRLIVPeRGAVAAAGLL--TRVAAGTGGLDEIAEREVRTATGTLDPSAGIMARVVWIDAG 1154 1384 66666666666666667766666643333322201111111111..22222223333333333444555677777788888888888 PP 1385 1386 Condensation_Starter 124 eery.ywyqrvHHiilDGfgfalltrriaeiYtalaagea.apeapfgslsdllaeeqaYraSerfakDrayWleklaalpepvsls 208 1387 +++ + + +HH+ +D+++ +l+ + ++Y + +g + a e p +s+ + + +a + Se + W++ ++++++++ + 1388 bpsB 1155 DAEPgRLAFVAHHLSVDAVSWGILLPDLRAAYDEVISGGTpALEPPVTSYRQWARRLTARALSESTVAELEKWAAVVEGAEPALPQ- 1240 1389 7664258899************************9987653889999******************************999986555. PP 1390 1391 Condensation_Starter 209 eraapakeasasalrrsaelpaallerlkela.easgisvaelliAalaaylsrltged.dvvlglpvmnRl...gsaakrtpGmva 290 1392 ++++ + +++++s++l+ ++++ l ++ a ++++++l+A la ++r+ g+ +++++ ++R g+ +rt+G ++ 1393 bpsB 1241 -DTGQ---HTGQSHSWSTSLSGTEVRDLVTVLpGAFHCGIQDVLLAGLAGAVARVRGSGaALLVDVEGHGREaadGEDLLRTVGWFT 1323 1394 .6777...78999************99998762689**********************978999*******822245789******* PP 1395 1396 Condensation_Starter 291 nvlPLrlsv 299 1397 +v P+rl++ 1398 bpsB 1324 SVHPVRLEL 1332 1399 ******975 PP 1400 1401 == domain 3 score: 142.2 bits; conditional E-value: 1.7e-44 1402 Condensation_Starter 4 lpLtaaQrgiWlaqqldpds.pvynigeyveikgeldlelLeeAirqvvaeadalrvrl.veeegepvqavaeelpveleviDlsae 88 1403 pL++ Q+g+ + ++d+d vy++ +++++g+ld+++L++A +qv+a++ +lr+ + g vq v++e++++++v Dls+ 1404 bpsB 1511 WPLSPLQEGMLFERAFDEDGvDVYQTQRILDLDGPLDEPRLRAAWNQVLARHASLRTGFhQLGSGATVQVVVREADIPWRVADLSHL 1597 1405 59**************998538*************************************656677889*****************86 PP 1406 1407 Condensation_Starter 89 e..dpeaaaeawmradlarpldldgdpLfrfallrlgeeryywyqrvHHiilDGfgfalltrriaeiYtalaageaapeapfgslsd 173 1408 + +++a++e+++ +d r +d+++ pL r l+rlg +++ ++++ HH++lDG+++ l++ + ++ Y ++ ++ p+ s++d 1409 bpsB 1598 DaaEAAAEVERLLAEDQGRRFDVTRPPLLRLLLIRLGADEHRLVVTSHHVLLDGWSTPLVVGEMSDGYAGGRSSSK-PP----SYQD 1679 1410 6226668889**********************************************************98885444.44....4555 PP 1411 1412 Condensation_Starter 174 llaeeqaYraSerfakDrayWleklaalpepvslseraapakeasasalrrsaelpaallerlkelaeasgisvaelliAalaayls 260 1413 +la ++ + r W+++la++ ep+++ ++a++ + + ++ +lp+ +++l +a+ +g++v+++++ a a+ l+ 1414 bpsB 1680 YLAWL----SRQDAEATRSAWRAELAGADEPTLVDADAGK---TLVMPDEHAEWLPEPATRALAGFARGHGLTVSTIVLGAWALVLA 1759 1415 54433....22334455666**************999888...999999999*********************************** PP 1416 1417 Condensation_Starter 261 rltgeddvvlglpvmnRlgs..aakrtpGmvanvlPLrlsv 299 1418 rl+g+ dvv+g v++R r++Gm++n++P r+++ 1419 bpsB 1760 RLAGRTDVVFGSVVSGRPADvpDVERMVGMFINTVPARVRL 1800 1420 *****************98622689************9987 PP 1421 1422 == domain 4 score: 34.9 bits; conditional E-value: 8.1e-12 1423 Condensation_Starter 38 ldlelLeeAirqvvaeadalrvrlveeeg.epvqavaeelpvelev.iDlsaeedpe.aaaeawmradlarpldldgdpLfrfallr 121 1424 l +++L + + v++++d lr r+ve eg ep+ va +v+ + ++ ++ d + a++ d+a+ ld ++ L+r + + 1425 bpsB 2575 LSVTALVAGLGAVIDTHDMLRSRIVESEGvEPRLVVAGRGTVDAAAlVERVEAGDGDlAEIADRCAHDTAARLDPVAGVLVRAVWVD 2661 1426 667888999999************665553899999999999987745555555443488999999999999999999********* PP 1427 1428 Condensation_Starter 122 lgeery.ywyqrvHHiilDGfgfalltrriaeiYtalaagea....apeapfgslsdllaeeqaYraSerfakDrayWleklaalpe 203 1429 g+ r +++ +HH+++D ++ +l+ ++++ +a +ag + +p+ f + s+ l+ e+a r a W+e l++++ 1430 bpsB 2662 AGPGRAgRLVVAAHHLVVDVVSWRTLLPDLQAACEAVVAGGQpaldPPDVSFRRWSRTLDGEAAIRT-----GELAVWTEILDGAQS 2743 1431 **999735899***************************99873222344445555666666666654.....56799*****99997 PP 1432 1433 Condensation_Starter 204 pvslseraapakeasasalrrsaelpaallerl.kelaeasgisvaelliAalaaylsrltgeddvvlglpvmnRl...gsaakrtp 286 1434 + p++++ +a rrs+++p++ + l +++ +a ++v+e+l+A la ++ + g vv+++ ++R+ + rt+ 1435 bpsB 2744 RLGE---LDPRRDTVSTAGRRSWTVPREHAGVLvEQVTSAFHCGVHEVLLATLAGAVAGWRGGTAVVVDVEGHGRQplgELDLSRTL 2827 1436 5544...444344899999*********99988367899************************************8332345569** PP 1437 1438 Condensation_Starter 287 GmvanvlPLrlsv 299 1439 G ++ v PLrl+v 1440 bpsB 2828 GWFTDVHPLRLDV 2840 1441 **********998 PP 1442 1443 == domain 5 score: 129.9 bits; conditional E-value: 9.4e-41 1444 Condensation_Starter 5 pLtaaQrgiWlaqqldpdspvynigeyveikgeldlelLeeAirqvvaeadalrvrl.veeegepvqavaeelpveleviDlsaeed 90 1445 pL++ Q+g+ + + d vy ++i+g+ld+++++++ + +++++ alr+++ e ge+vq +a+++p +++ +Dls+ ++ 1446 bpsB 3024 PLSPLQEGLLFHAADDRGPDVYASMRTLAIDGPLDVARFRASWTVLLDRHPALRASFhQLESGEAVQVIARDVPPDWRETDLSGLPE 3110 1447 9********************************************************88899*********************9887 PP 1448 1449 Condensation_Starter 91 pe..aaaeawmradlarpldldgdpLfrfallrlgeeryywyqrvHHiilDGfgfalltrriaeiYtalaageaapeapfgslsdll 175 1450 e a+ ++ + a+ +dl++ p r l+rlg++ry ++++ HHi++DG+++ l++ + ++Y+a +g++ p+ ++s+ d+l 1451 bpsB 3111 SEalAEFDRLAARMHAERFDLTKAPQLRLHLVRLGDRRYRLIFTSHHIVADGWSLPLILVDVLTAYEAGGDGRTLPA--ATSYRDFL 3195 1452 7733666799**************************************************************99655..58999999 PP 1453 1454 Condensation_Starter 176 aeeqaYraSerfakDrayWleklaalpepvslseraapake.asasalrrsaelpaallerlkelaeasgisvaelliAalaaylsr 261 1455 a + ++ + + + W+ +la+l e++ + +p++ + ++ r+ el++++ +rl e+ +++g+++++l+ + a++l+r 1456 bpsB 3196 AWVDRQDKGA----AGQAWRTELAGLDEATHV---VPPGSIiTPLEPERVAFELDDETSKRLVEFTRRHGVTANTLFQGVWALHLAR 3275 1457 8776655554....5666**********8877...5666777********************************************* PP 1458 1459 Condensation_Starter 262 ltgeddvvlglpvmnRlgs..aakrtpGmvanvlPLrlsv 299 1460 l+g++dvv+g v++R + +++G ++n+lP+r ++ 1461 bpsB 3276 LAGRNDVVFGAAVAGRPPEipGVESAVGLFMNMLPVRARL 3315 1462 ****************876226899************875 PP 1463 1464>> Heterocyclization 1465 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1466 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1467 1 ! 77.7 0.0 8e-25 2.1e-24 39 295 .. 44 297 .. 10 302 .. 0.87 1468 2 ! 86.5 0.0 1.6e-27 4.3e-27 6 292 .. 1512 1793 .. 1508 1800 .. 0.86 1469 3 ! 27.7 0.0 1.4e-09 3.6e-09 38 299 .. 2573 2840 .. 2558 2841 .. 0.80 1470 4 ! 72.5 0.0 3e-23 7.9e-23 40 295 .. 3057 3311 .. 3050 3316 .. 0.90 1471 1472 Alignments for each domain: 1473 == domain 1 score: 77.7 bits; conditional E-value: 8e-25 1474 Heterocyclization 39 dldlarleaaiealiarHpMLrvvvle..dG.eQrilpavpkkkievhDlrevkadevearlaalRerlshqvldvergelfeleltllpeg 127 1475 +d+a l+aa+e+l+arH Lr+ +++ G + +i++++ + + Dl++ ++ e+++++l e+ + d+++ +l+ l+l++l + 1476 bpsB 44 PVDAAGLRAAWETLLARHAPLRACFRQrkSGeTVQIIARQVELPWREVDLSHLDDP--EEAVRELAEQDRTTRFDLAQAPLLRLTLIRLGAD 133 1477 58999********************7522341345666666777888999997766..57999***************************** PP 1478 1479 Heterocyclization 128 ktrlhlslDllvaDaaSfrlLlaeLaalyege.eleaaplevsFrdyllaeraqreaarerdrayWqarlpeLpaaPeLPlakepekleepr 218 1480 +rl + +++D +S+ + ++eL+ ly ++ a p s+r+yl+ ++q+++++ + W+a l+ +++P+L + ++p + + ++ 1481 bpsB 134 AHRLVVTCHHTIMDGWSLPIVIDELSVLYPAGgDASALPDVPSYREYLAWLSRQDKERA---LSAWTAELSG-AEEPTLVVPADPGR-APAE 220 1482 *****************************7662555555555*******9999887766...5669**9998.799****9999999.7777 PP 1483 1484 Heterocyclization 219 ftrrrhsldpeewqalkaraaeagvtpsmvllaafaevlarwsessrflLnltlfnrqplhpdvdklvgDFtsllll 295 1485 + +++l+++ + l++ a+++g+t+ +v+ a+a vla+ ++++ +++ + r+p p v+ +vg F + + + 1486 bpsB 221 PESVEAHLPEHLTRSLAELARRHGLTLNTVVQGAWALVLAQLAGRPDVVFGAAVSARPPDLPGVEGMVGLFLNTVPV 297 1487 8889999**************************************************************99887655 PP 1488 1489 == domain 2 score: 86.5 bits; conditional E-value: 1.6e-27 1490 Heterocyclization 6 pLtdvQaAylvGReaeqelGgvachlYvEf..dgedldlarleaaiealiarHpMLrvvvledGeQ...rilpavpkkkievhDlrevka 90 1491 pL+++Q+ +l R + +gv + + + ld rl+aa+++++arH Lr+ +++ G +++ + ++ +v+Dl++ +a 1492 bpsB 1512 PLSPLQEGMLFERA--FDEDGVDVYQTQRIldLDGPLDEPRLRAAWNQVLARHASLRTGFHQLGSGatvQVVVREADIPWRVADLSHLDA 1599 1493 67777777777653..4556666666666532234599**********************998765111455555688899********* PP 1494 1495 Heterocyclization 91 devearlaalRerlshqvldvergelfeleltllpegktrlhlslDllvaDaaSfrlLlaeLaalyegeeleaaplevsFrdyllaeraq 180 1496 +e++a++++l ++ + ++ dv+r +l+ l l++l +++rl + +++D +S l + e+++ y+g + +p + + dyl+ ++q 1497 bpsB 1600 AEAAAEVERLLAEDQGRRFDVTRPPLLRLLLIRLGADEHRLVVTSHHVLLDGWSTPLVVGEMSDGYAGGRSSSKPPS--YQDYLAWLSRQ 1687 1498 *********************************************************************99999987..78888888887 PP 1499 1500 Heterocyclization 181 reaarerdrayWqarlpeLpaaPeLPlakepekleeprftrrrhsldpeewqalkaraaeagvtpsmvllaafaevlarwsessrflLnl 270 1501 +++a r+ W a l+ +++P+L a + ++l p + +l++ + +al+ +a+ +g+t+s+++l a+a vlar ++++ +++ 1502 bpsB 1688 DAEAT---RSAWRAELAG-ADEPTLVDADAGKTLVMP--DEHAEWLPEPATRALAGFARGHGLTVSTIVLGAWALVLARLAGRTDVVFGS 1771 1503 77666...777**99998.789999777777775555..67899********************************************** PP 1504 1505 Heterocyclization 271 tlfnrqplhpdvdklvgDFtsl 292 1506 + r++ pdv+++vg F + 1507 bpsB 1772 VVSGRPADVPDVERMVGMFINT 1793 1508 *****************99775 PP 1509 1510 == domain 3 score: 27.7 bits; conditional E-value: 1.4e-09 1511 Heterocyclization 38 edldlarleaaiealiarHpMLrvvv.ledGeQrilpavpkkkievhDlrevkadevearlaalRerlshqv...ldvergelf.elelt 122 1512 +dl++++l a + a+i H+MLr ++ +++G l + +++ + l e + ++ + +la++ +r +h + ld+ g l+ ++ + 1513 bpsB 2573 RDLSVTALVAGLGAVIDTHDMLRSRIvESEGVEPRLVVAGRGTVDAAALVE-RVEAGDGDLAEIADRCAHDTaarLDPVAGVLVrAVWVD 2661 1514 5788999999999**********9752679999999999999999999988.66778999****99999976111344444444134455 PP 1515 1516 Heterocyclization 123 llpegktrlhlslDllvaDaaSfrlLlaeLaalyege....eleaaplevsFrdyllaeraqreaarerdrayWqarlpeLpaaPeLPla 208 1517 p+ rl + lv+D+ S r+Ll +L+a+ e + + p +vsFr+ + + ++a r+ + a W++ l+ + +L 1518 bpsB 2662 AGPGRAGRLVVAAHHLVVDVVSWRTLLPDLQAACEAVvaggQPALDPPDVSFRRWSRTLDG-EAAIRTGELAVWTEILDGA--QSRLGEL 2748 1519 5889999***********************98766544444999999******87555444.4455578899****99974..5566544 PP 1520 1521 Heterocyclization 209 kepekleeprftrrrhsldpeewqal.karaaeagvtpsmvllaafaevlarwsessrflLnltlfnrqpl.hpdvdklvgDFtslllle 296 1522 +p + + + rr+ ++++e+ l ++ +++ + + vlla a +a w + +++++ + rqpl + d+ +++g Ft + l 1523 bpsB 2749 -DPRRDTVSTAGRRSWTVPREHAGVLvEQVTSAFHCGVHEVLLATLAGAVAGWRGGTAVVVDVEGHGRQPLgELDLSRTLGWFTDVHPLR 2837 1524 .556667777888888888888887725667899************************************9567***********98887 PP 1525 1526 Heterocyclization 297 vdl 299 1527 +d+ 1528 bpsB 2838 LDV 2840 1529 775 PP 1530 1531 == domain 4 score: 72.5 bits; conditional E-value: 3e-23 1532 Heterocyclization 40 ldlarleaaiealiarHpMLrvvvle....dGeQrilpavpkkkievhDlrevkadevearlaalRerlshqvldvergelfeleltllp 125 1533 ld+ar++a ++ l+ rHp Lr+++++ ++ Q i +vp+ + +Dl+ ++e+ a++++l +r++ ++ d+++ + + l+l++l 1534 bpsB 3057 LDVARFRASWTVLLDRHPALRASFHQlesgEAVQVIARDVPP-DWRETDLSGLPESEALAEFDRLAARMHAERFDLTKAPQLRLHLVRLG 3145 1535 89**********************854443566777777765.67899****************************************** PP 1536 1537 Heterocyclization 126 egktrlhlslDllvaDaaSfrlLlaeLaalye.geeleaaplevsFrdyllaeraqreaarerdrayWqarlpeLpaaPeLPlakepekl 214 1538 + + rl + +vaD +S+ l+l + ++ye g + ++ p + s+rd+l+ ++q++ a+ + W l+ L +a + + + + + 1539 bpsB 3146 DRRYRLIFTSHHIVADGWSLPLILVDVLTAYEaGGDGRTLPAATSYRDFLAWVDRQDKGAA---GQAWRTELAGLDEATH--VVPPGSII 3230 1540 ********************998888776665166999999999*******9999988777...5569*******99976..56777788 PP 1541 1542 Heterocyclization 215 eeprftrrrhsldpeewqalkaraaeagvtpsmvllaafaevlarwsessrflLnltlfnrqplhpdvdklvgDFtsllll 295 1543 + + +r +++ld e++++l ++++++gvt +++ ++a lar ++++ +++ + r+p p v++ vg F ++l + 1544 bpsB 3231 TPLEPERVAFELDDETSKRLVEFTRRHGVTANTLFQGVWALHLARLAGRNDVVFGAAVAGRPPEIPGVESAVGLFMNMLPV 3311 1545 99999**********************************************************************998765 PP 1546 1547>> CAL_domain 1548 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1549 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1550 1 ! 78.5 8.8 1.2e-25 3.3e-25 1 211 [. 482 671 .. 482 681 .. 0.86 1551 2 ! 46.1 3.0 7.9e-16 2.1e-15 369 465 .] 786 879 .. 767 879 .. 0.92 1552 3 ! 60.8 5.7 2.8e-20 7.3e-20 1 158 [. 1981 2118 .. 1981 2129 .. 0.91 1553 4 ! 41.5 1.6 1.8e-14 4.9e-14 370 465 .] 2283 2375 .. 2281 2375 .. 0.93 1554 5 ! 38.1 0.1 1.9e-13 5.1e-13 116 180 .. 3598 3656 .. 3575 3657 .. 0.84 1555 6 ! 32.2 4.3 1.2e-11 3.3e-11 258 460 .. 3722 3882 .. 3714 3887 .. 0.87 1556 1557 Alignments for each domain: 1558 == domain 1 score: 78.5 bits; conditional E-value: 1.2e-25 1559 CAL_domain 1 syaeLerrarrlAGhLqdlGlkpGdrVvillgnrvefVeayLAclrAgaVAVPlnpdsadaelahllrdsGiravltdaAhaavLdkvrrtapalalvd 99 1560 sy+eL++ra rlAG+L ++G+++GdrV++ l + ++ +LA+ Aga VP++p + +l+dsG av+ +++ + 1561 bpsB 482 SYGELAERAERLAGYLNGRGVRRGDRVAVVLDRSPDLIATLLAVWKAGAAYVPVDPAYPVERRKFMLADSGPAAVV---------------CAEAYRA- 564 1562 8*******************************************************9999999999*********4...............4444454. PP 1563 1564 CAL_domain 100 ahaagrelagfasyee...latpesalpArDDPvlglDelAwmlYTSGsTGrPKGVlsthrNcLwsnaaCivpalgldedDrvLwwlPLfHslGLiacl 195 1565 a+ +++ ++ ++ +++ a+ es++ ++D+lA+ +YTSGsTG+PKGV ++h+N +a ++ p +++ + D vL ++ + + +L + 1566 bpsB 565 AV-PDTCPEPIVLDDPrtrQAVAESPRL---SAGTSADDLAYVMYTSGSTGTPKGVAVSHGN---VAALAGEPGWRVGPGDAVLLHASHAFDISL-FEM 655 1567 33.5666666666665111455555554...43469**************************...9999***************99999999999.778 PP 1568 1569 CAL_domain 196 LaptavGAtvrlmpge 211 1570 +p+++GA v+l+++ 1571 bpsB 656 WVPLLSGARVVLAGPG 671 1572 9999999999998885 PP 1573 1574 == domain 2 score: 46.1 bits; conditional E-value: 7.9e-16 1575 CAL_domain 369 vppGeeGEiWvkGPnvmrGYLhnqPeataqaLrsilhtddDG....WyRTGDLGrraeaGnltvTGRiKelIirgGeNiHPheiEasiVaravpgvada 463 1576 vppG GE++v G +v++GY +P+ ta+ ++ d +G yRTGDL+ e G l+ GR ++ + ++G + P+eiE V+ +pgv a 1577 bpsB 786 VPPGVAGELYVAGAGVAQGY-SSRPALTAERFVA----DPSGsgarMYRTGDLAYWTEQGALAFAGRADDQVKIRGYRVEPGEIEV--VLAGLPGVGQA 877 1578 9*******************.9999999999996....333333458***************************************..********999 PP 1579 1580 CAL_domain 464 aV 465 1581 +V 1582 bpsB 878 VV 879 1583 98 PP 1584 1585 == domain 3 score: 60.8 bits; conditional E-value: 2.8e-20 1586 CAL_domain 1 syaeLerrarrlAGhLqdlGlkpGdrVvillgnrvefVeayLAclrAgaVAVPlnpdsadaelahllrdsGiravltdaAhaavLdkvrrtapalal 97 1587 sya+L+r+ rlAGhL+++G+ +GdrV + + + +a+L++ Aga VP+n d + +l+d G+ + + +A r++ p 1588 bpsB 1981 SYADLDRESDRLAGHLAGIGVGRGDRVGVVMTRGADLFVALLGVWKAGAAQVPVNVDYPAERIERMLADVGASVAVCVEAT-------RKAVP---- 2066 1589 8*************************************************************************9655555.......44444.... PP 1590 1591 CAL_domain 98 vdahaagrelagfasyeelatpesalpArDDPvlglDelAwmlYTSGsTGrPKGVlsthrN 158 1592 + +++ ++++ + +++ + +p+ + g+ ++A+ +YTSGsTG PK V + h++ 1593 bpsB 2067 ------DGVEPVVVDLPVIGGVRPEAPPVTV---GAHDVAYVMYTSGSTGVPKAVAVPHGS 2118 1594 ......55566689*************6665...*******************99999998 PP 1595 1596 == domain 4 score: 41.5 bits; conditional E-value: 1.8e-14 1597 CAL_domain 370 ppGeeGEiWvkGPnvmrGYLhnqPeataqaLrsilhtddDGWyRTGDLGrraeaGnltvTGRiKelIirgGeNiHPheiEasiVaravpgvadaaV 465 1598 +p GE++ G +++ GY ++++at + ++ + + yRTGDL+r + G+l+ GR + + ++G + P+e+E ++++vp va a+V 1599 bpsB 2283 APNVTGELYLAGAGLAHGY-LGNTAATSERFVANPFSGGGRMYRTGDLARWTDQGELVFAGRADSQVKIRGYRVEPGEVEV--ALTEVPHVAQAVV 2375 1600 56667**************.99***99999998777888889***************************************..***********98 PP 1601 1602 == domain 5 score: 38.1 bits; conditional E-value: 1.9e-13 1603 CAL_domain 116 latpesalpArDDPvlglDelAwmlYTSGsTGrPKGVlsthrNcLwsnaaCivpalgldedDrvL 180 1604 +a+p+ lp Pv+ + ++A+ YTSGsTG PKGVl+th L ++ + +++++ +rvL 1605 bpsB 3598 AADPDVELP----PVA-PEDAAYVIYTSGSTGVPKGVLVTHSG-LANLGYAHIERMAVTSSSRVL 3656 1606 345555566....665.99*********************976.********************8 PP 1607 1608 == domain 6 score: 32.2 bits; conditional E-value: 1.2e-11 1609 CAL_domain 258 sLrvalvGGepvrAsLlreFeerFavfglkrsplldtYGltETsgsitvnkkgeqfrpleldrdaLnlgkrapaGarveglellsCAsFvEvGlpvp 354 1610 +Lr l GGe +++ L+++ v + +YG tET+ +t++ ap ++ ++ + G p+ 1611 bpsB 3722 TLRTVLTGGEALPPALVDRWSPGRRV--------IQAYGPTETTICSTMS---------------------APLSPGHDQ---V------PLGGPIH 3780 1612 57888888888888888877765555........99**************.....................*********...4......45***** PP 1613 1614 CAL_domain 355 gltLRiVDPetgadvppGeeGEiWvkGPnvmrGYLhnqPeataqaLrsilhtddDGW......yRTGDLGrraeaGnltvTGRiKelIirgGeNiHP 445 1615 + + D + vppG +GE+++ G +++rGY ++P ta+ ++ +++ yR GDL r G l GR++ + ++G + P 1616 bpsB 3781 NVRHYVLD-AFLQPVPPGVVGELYITGVGLARGY-LGRPGLTAERFVA------SPFapgermYRSGDLFRWTREGQLLFAGRVDAQVKVRGYRVEP 3869 1617 **999***.99999********************.9*******97777......554444444******997555********************** PP 1618 1619 CAL_domain 446 heiEasiVaravpgv 460 1620 +eiEa V+ ++p v 1621 bpsB 3870 AEIEA--VLAEHPWV 3882 1622 *****..*****966 PP 1623 1624>> PCP 1625 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1626 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1627 1 ! 71.2 0.0 4.5e-23 1.2e-22 1 69 [. 958 1025 .. 958 1026 .. 0.97 1628 2 ! 67.4 0.0 6.8e-22 1.8e-21 1 69 [. 2459 2526 .. 2459 2527 .. 0.96 1629 3 ! 67.5 0.0 6.7e-22 1.8e-21 1 68 [. 3975 4041 .. 3975 4043 .. 0.97 1630 1631 Alignments for each domain: 1632 == domain 1 score: 71.2 bits; conditional E-value: 4.5e-23 1633 PCP 1 EteLaeiwaevLgverVgidDdFFelGGhSLlatrliarirqelgvelsvkdLfaaptvaalaallsed 69 1634 E+ L+ ++a+vLg+++Vg+dD+FFelGG+S+ +++++ar r+ g +l+++ +f+++t + laal++e+ 1635 bpsB 958 ERVLCGVFADVLGLDHVGVDDSFFELGGDSISSMQVAARARR-EGISLTPRLVFEHRTPERLAALAQEA 1025 1636 889***************************************.9********************99875 PP 1637 1638 == domain 2 score: 67.4 bits; conditional E-value: 6.8e-22 1639 PCP 1 EteLaeiwaevLgverVgidDdFFelGGhSLlatrliarirqelgvelsvkdLfaaptvaalaallsed 69 1640 E+ L+ ++ae+Lg+erVg+dD FFelGG+S+l++rl+ar r+ + k++f+++t a +aa+++++ 1641 bpsB 2459 ERVLCGLFAEILGLERVGADDGFFELGGDSILSMRLAARARR-ENFVFGAKQVFEQKTPAGIAAVAERG 2526 1642 889***************************************.9999*****************99875 PP 1643 1644 == domain 3 score: 67.5 bits; conditional E-value: 6.7e-22 1645 PCP 1 EteLaeiwaevLgverVgidDdFFelGGhSLlatrliarirqelgvelsvkdLfaaptvaalaallse 68 1646 E++L++++a+vLg+++Vg dD+FFelGG+S+ +++l+ar r g+el++ ++f+++t + la +++e 1647 bpsB 3975 EARLCALFADVLGLDQVGPDDSFFELGGDSITSMQLSARARP-TGLELTPWQVFDEKTPERLAVIVQE 4041 1648 789***************************************.********************99986 PP 1649 1650>> CXglyc 1651 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1652 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1653 1 ! 47.1 2.4 1.2e-15 3.3e-15 32 300 .. 38 299 .. 11 302 .. 0.83 1654 2 ! 58.4 3.4 4.5e-19 1.2e-18 21 300 .. 1527 1798 .. 1512 1801 .. 0.83 1655 3 ! 62.3 3.0 2.9e-20 7.6e-20 19 302 .. 3036 3315 .. 3024 3316 .. 0.86 1656 1657 Alignments for each domain: 1658 == domain 1 score: 47.1 bits; conditional E-value: 1.2e-15 1659 CXglyc 32 alrlrGrldvpaleaalgdvaarheilrttfp....Gda.qsvhqhv.hdaaaveltpveateedlpgllaerresvfdltrevpwrcdlfalsdkehvlalk 128 1660 l l G +d + l aa + arh lr+ f G++ q + ++v +v+l+ ++ ee + l + r++ fdl++ r +l++l + h l ++ 1661 bpsB 38 ILDLAGPVDAAGLRAAWETLLARHAPLRACFRqrksGETvQIIARQVeLPWREVDLSHLDDPEEAVRELAEQDRTTRFDLAQAPLLRLTLIRLGADAHRLVVT 140 1662 58899**************************722113221333445523456899****************************99****************** PP 1663 1664 CXglyc 129 vhriladddsldvflrdlaaayGarraGrvperaplalqfadyalwerrllegerekdslindqiafwrdnlagideet.vlpfdrersavpsrraGtvalrl 230 1665 h + d sl +++ +l+ y a + + p + +y w r +++e+ ++ w +l+g++e t v+p d r+ +v +l 1666 bpsB 141 CHHTIMDGWSLPIVIDELSVLYPAGGDASA---LPDVPSYREYLAWLSR---QDKER------ALSAWTAELSGAEEPTlVVPADPGRAPA---EPESVEAHL 228 1667 **********************99766555...455557999*99*766...33332......4678********9965389***998643...456899999 PP 1668 1669 CXglyc 231 daepharlteavepaGadalqlvhaalalllarlGagedvviGttl.prdedlidlepliGpfarplalrt 300 1670 + l+e + G ++v+ a al+la+l dvv G+++ r dl +e+++G f ++++r 1671 bpsB 229 PEHLTRSLAELARRHGLTLNTVVQGAWALVLAQLAGRPDVVFGAAVsARPPDLPGVEGMVGLFLNTVPVRV 299 1672 9999999************************************98736999***************99997 PP 1673 1674 == domain 2 score: 58.4 bits; conditional E-value: 4.5e-19 1675 CXglyc 21 geetaglhv.svalrlrGrldvpaleaalgdvaarheilrttfp..Gdaqsvhqhvhdaa....aveltpveatee..dlpgllaerresvfdltrevpwr 112 1676 +e++ ++++ l l G ld p l aa ++v arh lrt f G++ +v v++a +l+ ++a+e ++ llae + + fd+tr r 1677 bpsB 1527 DEDGVDVYQtQRILDLDGPLDEPRLRAAWNQVLARHASLRTGFHqlGSGATVQVVVREADipwrVADLSHLDAAEAaaEVERLLAEDQGRRFDVTRPPLLR 1627 1678 5555555441456899***************************655999999999999962222468999999985337899******************* PP 1679 1680 CXglyc 113 cdlfalsdkehvlalkvhriladddsldvflrdlaaayGarraGrvperaplalqfadyalwerrllegerekdslindqiafwrdnlagideetvlpfdr 213 1681 l++l +eh l ++ h +l d s+ +++ +++ y r + p + dy w r +++++ + wr +lag+de t + d 1682 bpsB 1628 LLLIRLGADEHRLVVTSHHVLLDGWSTPLVVGEMSDGYAGGR---SSSKPP---SYQDYLAWLSR-----QDAEA----TRSAWRAELAGADEPTLVDADA 1713 1683 **************************************8644...444445...588*****876.....33332....3457*****************9 PP 1684 1685 CXglyc 214 ersav.psrraGtvalrldaepharlteavepaGadalqlvhaalalllarlGagedvviGttlp.rdedlidlepliGpfarplalrt 300 1686 ++ v p a l + l+ + G + ++v a al+larl +dvv G+++ r d+ d+e ++G f +++ r 1687 bpsB 1714 GKTLVmPDEHAEW----LPEPATRALAGFARGHGLTVSTIVLGAWALVLARLAGRTDVVFGSVVSgRPADVPDVERMVGMFINTVPARV 1798 1688 9886516666654....44455556888999******************************98754999************99998876 PP 1689 1690 == domain 3 score: 62.3 bits; conditional E-value: 2.9e-20 1691 CXglyc 19 rpgeetaglhvsv.alrlrGrldvpaleaalgdvaarheilrttf....pGdaqsv.hqhv.hdaaaveltpveatee..dlpgllaerresvfdltrevp 110 1692 ++ + +++ s+ +l + G ldv+ + a+ + +rh lr++f G+a v + v +d + +l+ ++ +e ++ l a+ +++ fdlt+ 1693 bpsB 3036 AADDRGPDVYASMrTLAIDGPLDVARFRASWTVLLDRHPALRASFhqleSGEAVQViARDVpPDWRETDLSGLPESEAlaEFDRLAARMHAERFDLTKAPQ 3136 1694 45556666777764799****************************444447775551556778999999*9999888433777888889999********* PP 1695 1696 CXglyc 111 wrcdlfalsdkehvlalkvhriladddsldvflrdlaaayGarraGrvperaplalqfadyalwerrllegerekdslindqiafwrdnlagideetvlpf 211 1697 r +l +l d+ + l ++ h i+ad sl ++l d+ +ay a +Gr+ p a + d+ w r +k++ + wr +lag+de t + 1698 bpsB 3137 LRLHLVRLGDRRYRLIFTSHHIVADGWSLPLILVDVLTAYEAGGDGRT---LPAATSYRDFLAWVDRQ-----DKGAA----GQAWRTELAGLDEATHVV- 3224 1699 **********************************************97...69999********8764.....44332....246**********98643. PP 1700 1701 CXglyc 212 drersavpsrraGtvalrldaepharlteavepaGadalqlvhaalalllarlGagedvviGttlp.rdedlidlepliGpfarplalrtdl 302 1702 + s+++ va+ ld e+ rl+e + G a +l + al larl +dvv G+++ r ++ +e+ +G f l++r+ l 1703 bpsB 3225 -PPGSIITPLEPERVAFELDDETSKRLVEFTRRHGVTANTLFQGVWALHLARLAGRNDVVFGAAVAgRPPEIPGVESAVGLFMNMLPVRARL 3315 1704 .3778888889999************************************************987538888889**************9865 PP 1705 1706>> ACP 1707 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1708 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1709 1 ! 40.4 0.1 2.1e-13 5.5e-13 3 67 .. 960 1020 .. 958 1025 .. 0.93 1710 2 ! 20.5 0.0 3.2e-07 8.5e-07 3 67 .. 2461 2521 .. 2459 2524 .. 0.92 1711 3 ! 40.7 0.0 1.7e-13 4.4e-13 3 70 .. 3977 4040 .. 3975 4043 .. 0.91 1712 1713 Alignments for each domain: 1714 == domain 1 score: 40.4 bits; conditional E-value: 2.1e-13 1715 ACP 3 lvreevaavlglasasdvdpdraFkdlGvDSltaveLrnrLeaatGlrLpatlvfdhptpraLae 67 1716 +++ a+vlgl + v +d++F++lG DS+ ++++ r +++ G++L++ lvf+h tp++La+ 1717 bpsB 960 VLCGVFADVLGL---DHVGVDDSFFELGGDSISSMQVAARARRE-GISLTPRLVFEHRTPERLAA 1020 1718 6677789*****...*************************9999.******************97 PP 1719 1720 == domain 2 score: 20.5 bits; conditional E-value: 3.2e-07 1721 ACP 3 lvreevaavlglasasdvdpdraFkdlGvDSltaveLrnrLeaatGlrLpatlvfdhptpraLae 67 1722 +++ a+ lgl + v +d+ F++lG DS+ +++L r +++ ++ + a +vf+ +tp+ +a+ 1723 bpsB 2461 VLCGLFAEILGL---ERVGADDGFFELGGDSILSMRLAARARRE-NFVFGAKQVFEQKTPAGIAA 2521 1724 67778899****...*************************9999.***************98775 PP 1725 1726 == domain 3 score: 40.7 bits; conditional E-value: 1.7e-13 1727 ACP 3 lvreevaavlglasasdvdpdraFkdlGvDSltaveLrnrLeaatGlrLpatlvfdhptpraLaehLl 70 1728 +++ a+vlgl ++v pd++F++lG DS+t+++L+ r + tGl+L++ +vfd +tp++La ++ 1729 bpsB 3977 RLCALFADVLGL---DQVGPDDSFFELGGDSITSMQLSARA-RPTGLELTPWQVFDEKTPERLAVIVQ 4040 1730 678899******...*************************5.567******************97766 PP 1731 1732>> NRPS-COM_Nterm 1733 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1734 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1735 1 ! 32.5 0.0 2.7e-11 7e-11 6 32 .. 2 28 .. 1 29 [. 0.91 1736 2 ! 25.0 0.0 5.8e-09 1.5e-08 11 26 .. 1508 1523 .. 1503 1529 .. 0.89 1737 3 ! 26.5 0.0 2e-09 5.2e-09 12 27 .. 3021 3036 .. 3019 3041 .. 0.92 1738 1739 Alignments for each domain: 1740 == domain 1 score: 32.5 bits; conditional E-value: 2.7e-11 1741 NRPS-COM_Nterm 6 kkknIedIYpLSPMQeGMLFHsLldpe 32 1742 +++ Ie I+pLSP+Q G+LFH+ +d e 1743 bpsB 2 SQSRIEEIWPLSPLQAGLLFHAVYDGE 28 1744 7899********************965 PP 1745 1746 == domain 2 score: 25.0 bits; conditional E-value: 5.8e-09 1747 NRPS-COM_Nterm 11 edIYpLSPMQeGMLFH 26 1748 dI+pLSP+QeGMLF 1749 bpsB 1508 TDIWPLSPLQEGMLFE 1523 1750 69*************6 PP 1751 1752 == domain 3 score: 26.5 bits; conditional E-value: 2e-09 1753 NRPS-COM_Nterm 12 dIYpLSPMQeGMLFHs 27 1754 dI+pLSP+QeG+LFH+ 1755 bpsB 3021 DIWPLSPLQEGLLFHA 3036 1756 9**************8 PP 1757 1758>> NRPS-COM_Cterm 1759 [No individual domains that satisfy reporting thresholds (although complete target did)] 1760 1761 1762 1763Internal pipeline statistics summary: 1764------------------------------------- 1765Query sequence(s): 1 (4077 residues) 1766Target model(s): 37 (9277 nodes) 1767Passed MSV filter: 18 (0.486486); expected 0.7 (0.02) 1768Passed bias filter: 15 (0.405405); expected 0.7 (0.02) 1769Passed Vit filter: 14 (0.378378); expected 0.0 (0.001) 1770Passed Fwd filter: 14 (0.378378); expected 0.0 (1e-05) 1771Initial search space (Z): 37 [actual number of targets] 1772Domain search space (domZ): 14 [number of targets reported over threshold] 1773# CPU time: 0.19u 0.00s 00:00:00.19 Elapsed: 00:00:00.20 1774# Mc/sec: 189.11 1775// 1776Query: bpsC [L=1858] 1777Scores for complete sequence (score includes all domains): 1778 --- full sequence --- --- best 1 domain --- -#dom- 1779 E-value score bias E-value score bias exp N Model Description 1780 ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 1781 4.2e-188 614.8 29.7 1e-178 584.0 8.0 3.1 2 CXglyc 1782 6.9e-170 555.2 8.3 1.6e-147 481.7 1.7 2.5 2 Cglyc 1783 3.1e-147 480.7 0.0 2.5e-110 359.5 0.0 2.2 2 Condensation_DCL 1784 5.8e-133 433.7 0.0 5.9e-76 246.6 0.0 2.6 2 Condensation_LCL 1785 1.2e-113 371.0 0.4 5.2e-109 355.7 0.2 2.4 1 AMP-binding AMP-binding enzyme 1786 1.1e-73 239.4 0.0 3.9e-44 142.4 0.0 2.4 2 Condensation_Starter 1787 2.2e-62 202.3 0.0 1.3e-48 157.1 0.0 2.4 2 Condensation_Dual 1788 2.5e-44 143.1 0.1 1.8e-25 81.2 0.0 2.2 2 Heterocyclization 1789 6.7e-40 129.2 0.1 2.1e-39 127.5 0.1 2.0 1 Thioesterase Thioesterase domain 1790 3.8e-24 76.0 0.2 1.8e-23 73.8 0.0 2.3 1 PCP 1791 2.3e-23 72.4 26.1 1.6e-20 63.0 3.4 3.7 1 CAL_domain 1792 1e-21 67.5 38.8 1.3e-18 57.2 17.0 2.9 1 Epimerization 1793 1e-14 45.9 0.1 4.1e-14 44.0 0.0 2.2 1 ACP 1794 6e-13 39.1 0.0 9.9e-13 38.4 0.0 1.3 1 NRPS-COM_Nterm 1795 1796 1797Domain annotation for each model (and alignments): 1798>> CXglyc 1799 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1800 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1801 1 ! 38.8 4.3 4.1e-13 1.1e-12 31 301 .. 45 309 .. 18 311 .. 0.79 1802 2 ! 584.0 8.0 3.8e-179 1e-178 1 303 [] 1048 1350 .. 1048 1350 .. 1.00 1803 1804 Alignments for each domain: 1805 == domain 1 score: 38.8 bits; conditional E-value: 4.1e-13 1806 CXglyc 31 valrlrGrldvpaleaalgdvaarheilrttfp..Gdaqsvhqhvhdaa....avelt..pveateedlpgllaerresvfdltrevpwrcdlfalsdkehvl 125 1807 + G ld l a+ + + +rh lr+ f aq v ++a + +l+ p +++e ++ l a+ ++ + + + +l++l + h l 1808 bpsC 45 TVYGIDGPLDPGLLRASWQALVDRHAALRACFRyvSGAQMVQVIAREAEvpwrETDLSglPDDIAEGEVDRLAADEVAERLRIEAAPLMKLHLIRLGPDRHRL 147 1809 3456899************************972244555544445554211134554224568899999999999999999988888999************ PP 1810 1811 CXglyc 126 alkvhriladddsldvflrdlaaayGarraGrvperaplalqfadyalwerrllegerekdslindqiafwrdnlagideetvlpfdrersavpsrraGtval 228 1812 ++h +l d s+ ++ r+laa y a p ++ + dy w r ++k+ a wr +lag+d t + + vp t + 1813 bpsC 148 VHTLHHVLVDGWSMPILHRELAAIYAAG---GDASGLPPTVSYRDYLAWLGR-----QDKEVA----RAAWRAELAGLDTPTTVAAPDPAR-VPDIH--TAVV 235 1814 *************************984...445567889*********654.....444432....357*********998877654433.56554..5567 PP 1815 1816 CXglyc 229 rldaepharlteavepaGadalqlvhaalalllarlGagedvviG.ttlprdedlidlepliGpfarplalrtd 301 1817 l ae l++ + ++v+ a a++la+l +dvv G t+ r dl +e+++G + +l++r 1818 bpsC 236 ELPAELTDGLAQFARGHDLTLNTVVQGAWAVVLAQLAGRDDVVFGaTASGRPADLPGVEAMVGQLLNTLPVRVR 309 1819 889999999******999**************************9445679*******************9975 PP 1820 1821 == domain 2 score: 584.0 bits; conditional E-value: 3.8e-179 1822 CXglyc 1 rpdrvpltarqlrawllarpgeetaglhvsvalrlrGrldvpaleaalgdvaarheilrttfpGdaqsvhqhvhdaaaveltpveateedlpgllaerres 101 1823 rpdrvp+tarqlrawlla+pg+etaglh+svalrl+Gr+dvpal+aalgdvaarheilrttfpGdaqsvhqhvhda+aveltpv +teedlpgllaerr+ 1824 bpsC 1048 RPDRVPVTARQLRAWLLADPGGETAGLHTSVALRLHGRVDVPALAAALGDVAARHEILRTTFPGDAQSVHQHVHDALAVELTPVGVTEEDLPGLLAERRDL 1148 1825 9**************************************************************************************************** PP 1826 1827 CXglyc 102 vfdltrevpwrcdlfalsdkehvlalkvhriladddsldvflrdlaaayGarraGrvperaplalqfadyalwerrllegerekdslindqiafwrdnlag 202 1828 +fdltr+vpwrcdlfalsd+ehvl+l+vhriladddsldvf+rdlaaayGarr+Grvperaplalqfadyalwe+rll++e+e +slin+q+afwrdnlag 1829 bpsC 1149 LFDLTRDVPWRCDLFALSDNEHVLHLQVHRILADDDSLDVFFRDLAAAYGARREGRVPERAPLALQFADYALWEQRLLTDENEPGSLINEQVAFWRDNLAG 1249 1830 ***************************************************************************************************** PP 1831 1832 CXglyc 203 ideetvlpfdrersavpsrraGtvalrldaepharlteavepaGadalqlvhaalalllarlGagedvviGttlprdedlidlepliGpfarplalrtdls 303 1833 +d+etvlpfdr+r+avpsrraGtvalrl+a+pharltea+ep Gad+l++vhaala+lla+lGag+dvviGt+lprde+l+dlep+iGpf+r+lalrtd+s 1834 bpsC 1250 LDGETVLPFDRPRPAVPSRRAGTVALRLEAGPHARLTEAAEPPGADTLEMVHAALAMLLAKLGAGHDVVIGTALPRDEELFDLEPMIGPFTRALALRTDVS 1350 1835 ***************************************************************************************************97 PP 1836 1837>> Cglyc 1838 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1839 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1840 1 ! 481.7 1.7 6.2e-148 1.6e-147 1 299 [] 14 311 .. 14 311 .. 0.99 1841 2 ! 76.3 0.2 1.8e-24 4.7e-24 31 296 .. 1077 1347 .. 1069 1350 .. 0.81 1842 1843 Alignments for each domain: 1844 == domain 1 score: 481.7 bits; conditional E-value: 6.2e-148 1845 Cglyc 1 ledvWPLsPlqeGllfhaaldeegpdvYqvqrileldgpldaarlraaWeallarhaaLrasfrrlksgetvqvvarevelpWrevDlselpedeaeaeverla 104 1846 +edvWPLsPlqeG+l+h+ald++gpd+Y+vq+++ +dgpld lra+W+al++rhaaLra+fr+++++++vqv+are+e+pWre+Dls+lp+d ae ev+rla 1847 bpsC 14 VEDVWPLSPLQEGMLYHTALDDDGPDTYTVQTVYGIDGPLDPGLLRASWQALVDRHAALRACFRYVSGAQMVQVIAREAEVPWRETDLSGLPDDIAEGEVDRLA 117 1848 69****************************************************************************************************** PP 1849 1850 Cglyc 105 aeeraerfdlakaPllrllLvrlgedrhrlvvtshhilvDGWslpiileelaalYaaggdaselpaaasyrdylaWlsrqdkeaaraaWraelagldeptlvap 208 1851 a+e aer+++++aPl++l+L+rlg+drhrlv+t hh+lvDGWs+pi+++elaa+Yaaggdas+lp+++syrdylaWl+rqdke araaWraelagld+pt+va+ 1852 bpsC 118 ADEVAERLRIEAAPLMKLHLIRLGPDRHRLVHTLHHVLVDGWSMPILHRELAAIYAAGGDASGLPPTVSYRDYLAWLGRQDKEVARAAWRAELAGLDTPTTVAA 221 1853 ******************************************************************************************************** PP 1854 1855 Cglyc 209 adaarapaepeevvlelseeltrrlvelarehgltlntvvqgaWalvLarLagrtdvvfGatvagrPaelpgvesmvGlllntvPvrvrLd 299 1856 d+ar+p++ +++v+el++elt+ l+++ar+h+ltlntvvqgaWa+vLa+Lagr+dvvfGat++grPa+lpgve+mvG llnt+PvrvrLd 1857 bpsC 222 PDPARVPDI-HTAVVELPAELTDGLAQFARGHDLTLNTVVQGAWAVVLAQLAGRDDVVFGATASGRPADLPGVEAMVGQLLNTLPVRVRLD 311 1858 *******99.8999****************************************************************************8 PP 1859 1860 == domain 2 score: 76.3 bits; conditional E-value: 1.8e-24 1861 Cglyc 31 qrileldgpldaarlraaWeallarhaaLrasfrrlksgetvqvvarevelpWrevDlselpedeaeaeverlaaeeraerfdlakaPllrllLvrlgedrh 132 1862 l+l+g++d+ l aa + arh+ Lr++f ++ ++ q v++ + v+l+ + +e+++ l+ae r+ fdl++ r L l++++h 1863 bpsC 1077 SVALRLHGRVDVPALAAALGDVAARHEILRTTFPGDAQ-SVHQHVHDALA-----VELTPV--GVTEEDLPGLLAERRDLLFDLTRDVPWRCDLFALSDNEH 1170 1864 56789****************************75432.23355555554.....455555..667779999****************************** PP 1865 1866 Cglyc 133 rlvvtshhilvDGWslpiileelaalYaa..ggda.selpaaasyrdylaWlsr..qdke.......aaraaWraelagldeptlvapad..aarapaepee 220 1867 l + +h il+D sl + +++laa+Y a +g++ ++ p a + dy W +r d++ a Wr++lagld t++ +a + + + 1868 bpsC 1171 VLHLQVHRILADDDSLDVFFRDLAAAYGArrEGRVpERAPLALQFADYALWEQRllTDENepgslinEQVAFWRDNLAGLDGETVLPFDRprPAVPSRRAGT 1272 1869 ***************************98332334144566789*******999443443122222134578***********9876554114444556778 PP 1870 1871 Cglyc 221 vvlelseeltrrlvelarehgltlntvvqgaWalvLarLagrtdvvfGatvagrPaelpgvesmvGlllntvPvrv 296 1872 v+l+l++ + rl+e a g +v++a a++La+L +dvv G++ r el ++e m+G + ++ r 1873 bpsC 1273 VALRLEAGPHARLTEAAEPPGADTLEMVHAALAMLLAKLGAGHDVVIGTAL-PRDEELFDLEPMIGPFTRALALRT 1347 1874 89999999**************9999**********************987.69**************99998886 PP 1875 1876>> Condensation_DCL 1877 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1878 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1879 1 ! 359.5 0.0 9.5e-111 2.5e-110 1 300 [] 15 311 .. 15 311 .. 0.98 1880 2 ! 119.1 0.0 1.6e-37 4.3e-37 29 299 .. 1077 1349 .. 1064 1350 .. 0.90 1881 1882 Alignments for each domain: 1883 == domain 1 score: 359.5 bits; conditional E-value: 9.5e-111 1884 Condensation_DCL 1 edvypLsplQeGllfhallde.eadvYvvqlvlelegeldverlraaaqalvdrheiLrtaFveeeleepvqvvlkevelelreldlselaee 92 1885 edv+pLsplQeG+l+h+ ld+ + d+Y+vq+v+ ++g+ld+ +lra++qalvdrh++Lr++F + ++vqv+++e+e+++re+dls+l+++ 1886 bpsC 15 EDVWPLSPLQEGMLYHTALDDdGPDTYTVQTVYGIDGPLDPGLLRASWQALVDRHAALRACFRYVSGAQMVQVIAREAEVPWRETDLSGLPDD 107 1887 79*****************9999********************************************************************** PP 1888 1889 Condensation_DCL 93 eqeeelealaaedrergFdlarapllrltlirlaeeryrlvltnHhillDGWslplllkellelYqalaegepaalpaarpYrdYiawlarqd 185 1890 +e e+++laa++ +++ +++apl++l+lirl+ +r+rlv t Hh+l+DGWs+p+l +el ++Y +a+g+++ lp++ +YrdY+awl rqd 1891 bpsC 108 IAEGEVDRLAADEVAERLRIEAAPLMKLHLIRLGPDRHRLVHTLHHVLVDGWSMPILHRELAAIY--AAGGDASGLPPTVSYRDYLAWLGRQD 198 1892 *****************************************************************..99************************ PP 1893 1894 Condensation_DCL 186 keaaeaaWreeLagleeptllaeakkeeeeeaepeeleveldeeateaLeelarsqgvTlntlvqaawallLsrltgrddvvFGatvsgRpae 278 1895 ke a+aaWr+eLagl++pt++a ++++ + ++ vel++e t+ L+++ar + +Tlnt+vq+awa++L++l+grddvvFGat sgRpa+ 1896 bpsC 199 KEVARAAWRAELAGLDTPTTVAAPDPAR--VPDIHTAVVELPAELTDGLAQFARGHDLTLNTVVQGAWAVVLAQLAGRDDVVFGATASGRPAD 289 1897 *********************9988877..57889999******************************************************* PP 1898 1899 Condensation_DCL 279 lpgvesmvGlfiNtvPvrvrld 300 1900 lpgve+mvG ++Nt+Pvrvrld 1901 bpsC 290 LPGVEAMVGQLLNTLPVRVRLD 311 1902 *******************986 PP 1903 1904 == domain 2 score: 119.1 bits; conditional E-value: 1.6e-37 1905 Condensation_DCL 29 qlvlelegeldverlraaaqalvdrheiLrtaFveeeleepvqvvlkevelelreldlselaeeeqeeelealaaedrergFdlarapllr 119 1906 ++l+l+g++dv +l+aa+ + +rheiLrt+F + +++ q v++ ++el+ + ++e e l l+ae r+ Fdl+r+++ r 1907 bpsC 1077 SVALRLHGRVDVPALAAALGDVAARHEILRTTFPG-DAQSVHQHVHDALAVELTPVGVTE-------EDLPGLLAERRDLLFDLTRDVPWR 1159 1908 57899****************************55.9999***********999999988.......67999******************* PP 1909 1910 Condensation_DCL 120 ltlirlaeeryrlvltnHhillDGWslplllkellelYqalaegepaal.paarpYrdYiawlarq..dk.......eaaeaaWreeLagl 200 1911 + l+ l+++++ l l H il D sl +++++l + Y a++eg+ ++ p a ++ dY w +r d+ +++ a+Wr++Lagl 1912 bpsC 1160 CDLFALSDNEHVLHLQVHRILADDDSLDVFFRDLAAAYGARREGRVPERaPLALQFADYALWEQRLltDEnepgsliNEQVAFWRDNLAGL 1250 1913 ********************************************9998615569********88863333112222235679********* PP 1914 1915 Condensation_DCL 201 eeptllaeakkeeee.eaepeeleveldeeateaLeelarsqgvTlntlvqaawallLsrltgrddvvFGatvsgRpaelpgvesmvGlfi 290 1916 +++t+l+ ++++ + +++ +++ ++l++ +++L+e+a+ g +v+aa a+lL++l +dvv G++ R+ el + e m+G f 1917 bpsC 1251 DGETVLPFDRPRPAVpSRRAGTVALRLEAGPHARLTEAAEPPGADTLEMVHAALAMLLAKLGAGHDVVIGTAL-PRDEELFDLEPMIGPFT 1340 1918 ********999998889999**************************************************887.6**************** PP 1919 1920 Condensation_DCL 291 NtvPvrvrl 299 1921 +++r+++ 1922 bpsC 1341 RALALRTDV 1349 1923 *99999875 PP 1924 1925>> Condensation_LCL 1926 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1927 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1928 1 ! 184.6 0.0 1.7e-57 4.5e-57 3 296 .] 17 311 .. 15 311 .. 0.90 1929 2 ! 246.6 0.0 2.3e-76 5.9e-76 2 296 .] 1050 1350 .. 1049 1350 .. 0.97 1930 1931 Alignments for each domain: 1932 == domain 1 score: 184.6 bits; conditional E-value: 1.7e-57 1933 Condensation_LCL 3 rlplSfaQqrlwflnqlepesa.ayniplalrltgeldvealeaAladlvaRheiLRtvfpeedgep.vqvvlpaaelelevedls....... 86 1934 +plS+ Q+ + + l+++ + +y +++++ ++g+ld l+a++++lv+Rh +LR +f+ + g + vqv++ +ae++++++dls 1935 bpsC 17 VWPLSPLQEGMLYHTALDDDGPdTYTVQTVYGIDGPLDPGLLRASWQALVDRHAALRACFRYVSGAQmVQVIAREAEVPWRETDLSglpddia 109 1936 68***************9776527************************************776665549999999****************** PP 1937 1938 Condensation_LCL 87 eaeleelveeeaarpFdLekepllrvrllrlaeeehvLllvvHHiiaDgwSlgvllrelaalYaarlagqapelaplpvqYaDYalwqrelle 179 1939 e e+++l+++e+a++ +e++pl++++l+rl +++h L+ ++HH+ +DgwS+ +l relaa+Yaa g+a+ l+ +v+Y+DY +w 1940 bpsC 110 EGEVDRLAADEVAERLRIEAAPLMKLHLIRLGPDRHRLVHTLHHVLVDGWSMPILHRELAAIYAA--GGDASGLP-PTVSYRDYLAWLG---- 195 1941 ***************************************************************44..77777777.679******9875.... PP 1942 1943 Condensation_LCL 180 eeelarqlaYWreqLaglpelleLptdrprpavqsyrGarvefeldaelsaklkelarehgvtlFmvllaalavlLsrlsgqeDivvGtpvag 272 1944 +++ + +a Wr++Lagl + +++ + p + ++ +el+ael++ l+++ar h+ tl +v++ a+av+L++l+g++D+v G+ +g 1945 bpsC 196 RQDKEVARAAWRAELAGLDTPTTVAAPDPARVPDI---HTAVVELPAELTDGLAQFARGHDLTLNTVVQGAWAVVLAQLAGRDDVVFGATASG 285 1946 5556666778********99888766555444333...456799************************************************* PP 1947 1948 Condensation_LCL 273 Rtr..aeledliGfFvNtlvlrteld 296 1949 R + +e ++G +Ntl++r++ld 1950 bpsC 286 RPAdlPGVEAMVGQLLNTLPVRVRLD 311 1951 *863379***************9975 PP 1952 1953 == domain 2 score: 246.6 bits; conditional E-value: 2.3e-76 1954 Condensation_LCL 2 erlplSfaQqrlwflnqlepesaayniplalrltgeldvealeaAladlvaRheiLRtvfpeedgepvqvvlpaaelelevedlseaelee 92 1955 +r+p+ Q r w+l+ +e+a + ++alrl+g++dv al+aAl d++aRheiLRt+fp + ++++q+v++a+++el+ + ++e++l 1956 bpsC 1050 DRVPVTARQLRAWLLADPGGETAGLHTSVALRLHGRVDVPALAAALGDVAARHEILRTTFPGDAQSVHQHVHDALAVELTPVGVTEEDLPG 1140 1957 789**************************************************************************************** PP 1958 1959 Condensation_LCL 93 lveeeaarpFdLekepllrvrllrlaeeehvLllvvHHiiaDgwSlgvllrelaalYaarlagqapelaplpvqYaDYalwqrelle.... 179 1960 l++e FdL++++++r+ l+ l+++ehvL l+vH i aD+ Sl+v++r+laa+Y ar++g+ pe apl++q+aDYalw+++ll+ 1961 bpsC 1141 LLAERRDLLFDLTRDVPWRCDLFALSDNEHVLHLQVHRILADDDSLDVFFRDLAAAYGARREGRVPERAPLALQFADYALWEQRLLTdene 1231 1962 ***************************************************************************************9999 PP 1963 1964 Condensation_LCL 180 .eeelarqlaYWreqLaglpelleLptdrprpavqsyrGarvefeldaelsaklkelarehgvtlFmvllaalavlLsrlsgqeDivvGtp 269 1965 ++ +++q+a+Wr++Lagl ++ Lp drprpav s r+ +v+++l+a +a+l+e a+ g+ + +++aala+lL++l++ +D+v+Gt 1966 bpsC 1232 pGSLINEQVAFWRDNLAGLDGETVLPFDRPRPAVPSRRAGTVALRLEAGPHARLTEAAEPPGADTLEMVHAALAMLLAKLGAGHDVVIGTA 1322 1967 9999**************************************************************************************9 PP 1968 1969 Condensation_LCL 270 vagRtr.aeledliGfFvNtlvlrteld 296 1970 + ++ +le +iG F l+lrt+++ 1971 bpsC 1323 LPRDEElFDLEPMIGPFTRALALRTDVS 1350 1972 864433269****************985 PP 1973 1974>> AMP-binding AMP-binding enzyme 1975 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 1976 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1977 1 ! 355.7 0.2 2e-109 5.2e-109 1 418 [] 493 887 .. 493 887 .. 0.95 1978 1979 Alignments for each domain: 1980 == domain 1 score: 355.7 bits; conditional E-value: 2e-109 1981 EHHHHHHHHHHHHHHHHH----TT-EEEEE-SSSHHHHHHHHHHHHTT-EEEE--TTS-HHHHHHHHHHCTESEEEEESBCHCCHHHHHHHHHCHHEC CS 1982 AMP-binding 1 TYreldervnrlaagLrklGvkpgdrVaillpnspewviaflaclkaGavyvpvyptlpaerlayilndseakvlitddelltklkeaaskelakeal 98 1983 TY+e+d+ +nrla +L +Gv++gdrV++ +++sp+++iafla++kaGa+yvpv+ +paer++++++ds++++++++ + + ++ a + a+ 1984 bpsC 493 TYAEVDQASNRLAGYLAVRGVGRGDRVGVAMERSPDLLIAFLAIWKAGAAYVPVDVEYPAERISFVFDDSGVSTVLCTLATSAVAPGNAIVLDAP--- 587 1985 9*******************************************************************************999999988888765... PP 1986 1987 CETTCCEESECCCCCCEHCHHHHGTSTSS-CCCSBTTTSEEEEEEE-------EEEEEEHHHHHHHHHHHHHHHTTTTT.EEEEES-TTSTHHHCCCH CS 1988 AMP-binding 99 iivrsepaesvgeeellleleslkkasteppkvplkpddlayiiyTSGtTGkPKgVmlthrnllalvagiakrvglkpddrvlsllplafdgsvleil 196 1989 ++ + ++ + p+ + +ddlay++yTSG+TG PKgV + h++++ l+ +++++g +d vl+ + + fd s+++++ 1990 bpsC 588 -------------------ETRVAVRDCAAPEIRPHADDLAYVMYTSGSTGLPKGVAIPHGAVAGLAGDAGWQIGP--GDGVLMHATHVFDPSLYAMW 664 1991 ...................3334444444444444889******************************99999999..556***************** PP 1992 1993 HHHTTT-EEEEESSCCTCSHHHHHHHHHHTT-SEEEE-HHHHHHHHHHHHCCCTTTTT--EEEE-----THHHHHHHHHHCTTSEEEEEE--GGGSSE CS 1994 AMP-binding 197 gplllGatlvlvspedlkdpalllddiekykvtvlalvptllelllkapekkkldlsslrlilsggeplspellrrlreafggipivngYGltEttvi 294 1995 +pl++Ga++ l++p l d+a + +++ + ++t+++l+ +++l+++++ + + l i +gg+ ++ + +++lr+a +g ++ n+YG+tEtt++ 1996 bpsC 665 VPLVSGARVLLTEPGVL-DAAGVRQAV-HRGATFVHLTAGTFRALAETAP---ECFEGLVEIGTGGDVVPLQSVENLRRAQPGLRVRNTYGPTETTLC 757 1997 ****************6.777776666.669******************8...9******************************************** PP 1998 1999 SEEEECGHHH..-SSC---EBSTTTEEEEEBSTT-BEE-S----EEEESTTS--B-TT-HHHHHHHEEESTT-....EEE---EEEE-TT--EEEEEG CS 2000 AMP-binding 295 vtvslpgdee..tkpgsiGrplpgveikivdeegkevppgevGEllirgpsvakGYlkdpeltaeafvedgwk....lyrTGDlgridedGyleiiGR 386 2001 +t+ ++++ e + +iG+p+++ +i+++d ++vppg+ GEl+i+g ++a GYlk p lta +fv+ +++ +yrTGD +r++ dG++ ++GR 2002 bpsC 758 ATWLPIEPGEvlGRELPIGHPMTNRRIYLLDAFLRPVPPGVAGELYIAGTGLAHGYLKSPGLTAGRFVACPFAagerMYRTGDRARWTRDGEVVFLGR 855 2003 ************************************************************************************************** PP 2004 2005 GGCEEEB---EEEHHHHHHHHHTSTTEEEEEE CS 2006 AMP-binding 387 kkdqvkirGeriepgeiEsvllehpgvaeaaV 418 2007 ++dqvkirG+r+e+ge+E++l++ pgv ea+V 2008 bpsC 856 ADDQVKIRGYRVELGEVEAALAAQPGVVEAVV 887 2009 ******************************98 PP 2010 2011>> Condensation_Starter 2012 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 2013 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 2014 1 ! 142.4 0.0 1.5e-44 3.9e-44 3 299 .. 17 310 .. 15 311 .. 0.93 2015 2 ! 94.8 0.0 4.7e-30 1.3e-29 3 298 .. 1051 1348 .. 1049 1350 .. 0.87 2016 2017 Alignments for each domain: 2018 == domain 1 score: 142.4 bits; conditional E-value: 1.5e-44 2019 Condensation_Starter 3 rlpLtaaQrgiWlaqqldpdsp.vynigeyveikgeldlelLeeAirqvvaeadalrvrl.veeegepvqavaeelpveleviDlsaee 89 2020 pL++ Q+g+ + +ld+d p +y++ ++ i+g+ld lL+++ + +v+++ alr+ + + + vq +a+e++v+++ +Dls+ + 2021 bpsC 17 VWPLSPLQEGMLYHTALDDDGPdTYTVQTVYGIDGPLDPGLLRASWQALVDRHAALRACFrYVSGAQMVQVIAREAEVPWRETDLSGLP 105 2022 57**************99987659************************************99999999********************9 PP 2023 2024 Condensation_Starter 90 d..peaaaeawmradlarpldldgdpLfrfallrlgeeryywyqrvHHiilDGfgfalltrriaeiYtalaageaapeapfgslsdlla 176 2025 d +e ++ ++ +++a+ l++++ pL++ l+rlg++r+ ++++ HH+++DG+++ +l r++a+iY a +a p+ s+ d+la 2026 bpsC 106 DdiAEGEVDRLAADEVAERLRIEAAPLMKLHLIRLGPDRHRLVHTLHHVLVDGWSMPILHRELAAIYAAGG--DASGLPPTVSYRDYLA 192 2027 9445789************************************************************9987..5555777899999886 PP 2028 2029 Condensation_Starter 177 eeqaYraSerfakDrayWleklaalpepvslseraapakeasasalrrsaelpaallerlkelaeasgisvaelliAalaaylsrltge 265 2030 + ++ + +ra W+++la+l p+++++ ++ + + +++++elpa+l++ l ++a+ +++++++++ a a+ l++l+g+ 2031 bpsC 193 ----WLGRQDKEVARAAWRAELAGLDTPTTVAAPDPA---RVPDIHTAVVELPAELTDGLAQFARGHDLTLNTVVQGAWAVVLAQLAGR 274 2032 ....5566677899999**************877777...99*********************************************** PP 2033 2034 Condensation_Starter 266 ddvvlglpvmnRlgs..aakrtpGmvanvlPLrlsv 299 2035 ddvv+g ++R ++G ++n+lP+r+++ 2036 bpsC 275 DDVVFGATASGRPADlpGVEAMVGQLLNTLPVRVRL 310 2037 ************986225799************987 PP 2038 2039 == domain 2 score: 94.8 bits; conditional E-value: 4.7e-30 2040 Condensation_Starter 3 rlpLtaaQrgiWlaqqldpdspvynigeyveikgeldlelLeeAirqvvaeadalrvrlveeegepvqavaeelpveleviDlsaee 89 2041 r+p+ta Q + Wl +++ ++ ++++g++d+++L++A+ v+a+++ lr+++ ++ ++++q+v ++l vel+ + +++e+ 2042 bpsC 1051 RVPVTARQLRAWLLADPGGETAGLHTSVALRLHGRVDVPALAAALGDVAARHEILRTTFPGDAQSVHQHVHDALAVELTPVGVTEED 1137 2043 78**********************************************************************************999 PP 2044 2045 Condensation_Starter 90 dpeaaaeawmradlarpldldgdpLfrfallrlgeeryywyqrvHHiilDGfgfalltrriaeiYtalaageaapeap.fgslsdll 175 2046 p ++ + + +dl++d +r l+ l+++++ + +vH i++D ++ +++r +a++Y a+++g+ ++ ap + +++d++ 2047 bpsC 1138 LPG-----LLAERRDLLFDLTRDVPWRCDLFALSDNEHVLHLQVHRILADDDSLDVFFRDLAAAYGARREGRVPERAPlALQFADYA 1219 2048 877.....88899999*******************************************************9866665266899988 PP 2049 2050 Condensation_Starter 176 aeeqaYraSer.....fakDrayWleklaalpepvslse.raapake.asasalrrsaelpaallerlkelaeasgisvaelliAal 255 2051 eq+ e+ ++ a+W+++la+l + l r++p + +s++a ++ ++l+a ++rl+e+ae g+ e++ Aal 2052 bpsC 1220 LWEQRLLTDENepgslINEQVAFWRDNLAGLDGETVLPFdRPRP--AvPSRRAGTVALRLEAGPHARLTEAAEPPGADTLEMVHAAL 1304 2053 777765443322222289999**********9888876535555..55*************************************** PP 2054 2055 Condensation_Starter 256 aaylsrltgeddvvlglpvmnRlgs.aakrtpGmvanvlPLrls 298 2056 a++l++l dvv+g+ + + + ++G ++ l+Lr++ 2057 bpsC 1305 AMLLAKLGAGHDVVIGTALPRDEELfDLEPMIGPFTRALALRTD 1348 2058 ****************9876544431233466666666666665 PP 2059 2060>> Condensation_Dual 2061 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 2062 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 2063 1 ! 157.1 0.0 4.8e-49 1.3e-48 1 296 [] 15 311 .. 15 311 .. 0.91 2064 2 ! 42.8 0.0 3.3e-14 8.7e-14 31 295 .. 1079 1349 .. 1070 1350 .. 0.78 2065 2066 Alignments for each domain: 2067 == domain 1 score: 157.1 bits; conditional E-value: 4.8e-49 2068 Condensation_Dual 1 qdiYpLapLqeGilfHhllaeeg.DpYllqallafasrerldaflaalqqvidRhdiLrtavlWegleepvqvvwrqaeleveeleldsadg 91 2069 +d++pL+pLqeG+l+H l ++g D+Y +q+++ ++ a+ q+++dRh Lr+ + + + vqv+ r+ae++ +e++l+ + 2070 bpsC 15 EDVWPLSPLQEGMLYHTALDDDGpDTYTVQTVYGIDGPLDPGLLRASWQALVDRHAALRACFRYVSGAQMVQVIAREAEVPWRETDLSGLPD 106 2071 59***************9999877************99999999999*****************************************9999 PP 2072 2073 Condensation_Dual 92 evaeqlear..fdprrarldlsqapllrlvvaedaaegrllllllfHHlilDhttlevlseEvqallq..gqeealpapvpyRnfvaqarlg 179 2074 ++ae +r d ++rl ++ apl++l++ + +r l+ ++HH+++D ++ +l++E+ a+ + g+++ lp++v+yR+++a + 2075 bpsC 107 DIAEGEVDRlaADEVAERLRIEAAPLMKLHLIRL-GPDRHRLVHTLHHVLVDGWSMPILHRELAAIYAagGDASGLPPTVSYRDYLAWL-GR 196 2076 99986655411577889*************9987.67788888999******************98753378889************98.55 PP 2077 2078 Condensation_Dual 180 vseaeheafFrekLadvdeptlpfglaevqgdgseieearraleaeLsqrlreqarrlgvsaasllHlawaqvlartsgredvvFGtvllGR 271 2079 ++++ ++a +r++La +d+pt+ + +i+ a +l+aeL++ l + ar ++ + +++ awa vla+++gr+dvvFG+ +GR 2080 bpsC 197 QDKEVARAAWRAELAGLDTPTTVAAPDP--ARVPDIHTAVVELPAELTDGLAQFARGHDLTLNTVVQGAWAVVLAQLAGRDDVVFGATASGR 286 2081 6777788889***********9866554..44567889999*************************************************** PP 2082 2083 Condensation_Dual 272 lqggegadralGlfintLPlrldld 296 2084 + g++ ++G ++ntLP+r++ld 2085 bpsC 287 PADLPGVEAMVGQLLNTLPVRVRLD 311 2086 **********************986 PP 2087 2088 == domain 2 score: 42.8 bits; conditional E-value: 3.3e-14 2089 Condensation_Dual 31 llafasrerldaflaalqqvidRhdiLrtavlWegleepvqvvwrqaeleveeleldsadgevaeqlearfdprrarldlsqapllrlvv 120 2090 l+++ r + a +aal v +Rh+iLrt++ + ++ q v+ +e++ + +++++ l++r d +dl++ r+ + 2091 bpsC 1079 ALRLHGRVDVPALAAALGDVAARHEILRTTFPGDA-QSVHQHVHDALAVELT--PVGVTEEDLPGLLAERRD---LLFDLTRDVPWRCDL 1162 2092 56677777888999***************997654.4555666665555555..555555566788887766...789****99999999 PP 2093 2094 Condensation_Dual 121 aedaaegrllllllfHHlilDhttlevlseEvqall.qgqe....ealpapvpyRnfva.qarlgvse.......aeheafFrekLadvd 197 2095 + ++++ +l l++H ++ D+ +l+v+ +++ a + +e e+ p ++++ ++ + rl ++e +e+ af+r++La +d 2096 bpsC 1163 FAL-SDNEHVLHLQVHRILADDDSLDVFFRDLAAAYgARREgrvpERAPLALQFADYALwEQRLLTDEnepgsliNEQVAFWRDNLAGLD 1251 2097 987.77889999****************9999876514444111234566788999965244555544122222246889********** PP 2098 2099 Condensation_Dual 198 ept.lpfglaevqgdgseieearraleaeLsqrlreqarrlgvsaasllHlawaqvlartsgredvvFGtvllGRlqggegadralGlfi 286 2100 t lpf+ +++ ++ +lea ++rl e a g + ++H a a++la++ +dvv Gt l R + + + ++G f 2101 bpsC 1252 GETvLPFDRPRPAVPSRRAGTVALRLEAGPHARLTEAAEPPGADTLEMVHAALAMLLAKLGAGHDVVIGTAL-PRDEELFDLEPMIGPFT 1340 2102 66538*****************************************************************98.47777778888888888 PP 2103 2104 Condensation_Dual 287 ntLPlrldl 295 2105 L lr d+ 2106 bpsC 1341 RALALRTDV 1349 2107 888888765 PP 2108 2109>> Heterocyclization 2110 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 2111 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 2112 1 ! 81.2 0.0 7e-26 1.8e-25 40 296 .. 53 307 .. 19 311 .. 0.90 2113 2 ! 59.7 0.0 2.3e-19 6.2e-19 39 299 .. 1085 1349 .. 1073 1350 .. 0.84 2114 2115 Alignments for each domain: 2116 == domain 1 score: 81.2 bits; conditional E-value: 7e-26 2117 Heterocyclization 40 ldlarleaaiealiarHpMLrvvvle.dGeQ..rilpavpkkkievhDlrevkadevearlaalRerlshqvldvergelfeleltllpegk 128 2118 ld+ l+a ++al+ rH Lr+ ++ G Q +++++ +++ + +Dl+ +d +e ++++l + ++l++e +l++l+l++l ++ 2119 bpsC 53 LDPGLLRASWQALVDRHAALRACFRYvSGAQmvQVIAREAEVPWRETDLSGLPDDIAEGEVDRLAADEVAERLRIEAAPLMKLHLIRLGPDR 144 2120 89999*******************85389993334556667778899********************************************* PP 2121 2122 Heterocyclization 129 trlhlslDllvaDaaSfrlLlaeLaalyege.eleaaplevsFrdyllaeraqreaarerdrayWqarlpeLpaaPeLPlakepekleeprf 219 2123 +rl l +++D +S+ +L +eLaa+y+ ++ p +vs+rdyl+ +q++++ +ra W a l+ L +P+ a +p++ p + 2124 bpsC 145 HRLVHTLHHVLVDGWSMPILHRELAAIYAAGgDASGLPPTVSYRDYLAWLGRQDKEV---ARAAWRAELAGLD-TPTTVAAPDPAR--VPDI 230 2125 ****************************855499999**********9998887765...5999********6.455555555555..8999 PP 2126 2127 Heterocyclization 220 trrrhsldpeewqalkaraaeagvtpsmvllaafaevlarwsessrflLnltlfnrqplhpdvdklvgDFtslllle 296 2128 + ++l++e + l+++a+ +++t+ +v+ a+a vla+ ++++ +++ t r++ p v+++vg + l + 2129 bpsC 231 HTAVVELPAELTDGLAQFARGHDLTLNTVVQGAWAVVLAQLAGRDDVVFGATASGRPADLPGVEAMVGQLLNTLPVR 307 2130 999*****************************************************************887766555 PP 2131 2132 == domain 2 score: 59.7 bits; conditional E-value: 2.3e-19 2133 Heterocyclization 39 dldlarleaaiealiarHpMLrvvvledGeQrilpavpkkkievhDlrevkadevearlaalRerlshqvldvergelfeleltllpegk 128 2134 ++d+ +l aa+ +++arH++Lr+++ d+ Q + ++ + +++v+ l v +e++l l +++ + d++r l l++++ 2135 bpsC 1085 RVDVPALAAALGDVAARHEILRTTFPGDA-QSVHQH-VHDALAVE-LTPVGV--TEEDLPGLLAERRDLLFDLTRDVPWRCDLFALSDNE 1169 2136 78999********************6554.444444.44455554.333333..34568888888888888999999999********** PP 2137 2138 Heterocyclization 129 trlhlslDllvaDaaSfrlLlaeLaalyege....eleaaplevsFrdyllaera......qreaarerdrayWqarlpeLpaaPeLPla 208 2139 ++lhl++ ++aD S+ +++++Laa+y + e apl+++F+dy l e++ ++ + +++ a+W + l+ L ++ LP++ 2140 bpsC 1170 HVLHLQVHRILADDDSLDVFFRDLAAAYGARregrVPERAPLALQFADYALWEQRlltdenEPGSLINEQVAFWRDNLAGLDGETVLPFD 1259 2141 ***************************97664342567789999****97766651111003344558999******************* PP 2142 2143 Heterocyclization 209 kepekleeprftrrrhsldpeewqalkaraaeagvtpsmvllaafaevlarwsessrflLnltlfnrqplhpdvdklvgDFtsllllevd 298 2144 ++ + ++r + +l++ ++l+++a+ g ++ aa a +la+ + + +++ t + r + d++ ++g Ft l l +d 2145 bpsC 1260 RPRPAVPSRRAGTVALRLEAGPHARLTEAAEPPGADTLEMVHAALAMLLAKLGAGHDVVIG-TALPRDEELFDLEPMIGPFTRALALRTD 1348 2146 999999*****************************999999*************9999987.8899*******************99988 PP 2147 2148 Heterocyclization 299 l 299 2149 + 2150 bpsC 1349 V 1349 2151 6 PP 2152 2153>> Thioesterase Thioesterase domain 2154 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 2155 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 2156 1 ! 127.5 0.1 8e-40 2.1e-39 1 222 [. 1622 1836 .. 1622 1847 .. 0.87 2157 2158 Alignments for each domain: 2159 == domain 1 score: 127.5 bits; conditional E-value: 8e-40 2160 EEEEES---TT-HGGGHHHHHHHTSCEEEEEEECSTTC----TTTTHHHHHHHHHHHHHHHH--S-SEEEE------HHHHHHHHHHHHHS--CE CS 2161 Thioesterase 1 rpLfcfppagGsasvyrklarklpdplveflaiqlpgrerdepllesieelaeeyaealrqiqpegPyaLfGySlGGllAfevArqLerqgeeva 95 2162 +pLfc++ +gG ++ y +l r lp++ +++++q++g r+epl+ s+ee+a++y+e++r+ qp gPy+L+G+SlGG +A ++Ar Le+ ge++ 2163 bpsC 1622 PPLFCVHASGGLSWNYEPLLRYLPPN-QPVYGVQARGLARTEPLPGSVEEMAADYLEQIRAVQPAGPYHLLGWSLGGRIAQAMARLLEADGERLG 1715 2164 59***********************8.******************************************************************** PP 2165 2166 EEEEESSSESSS-CCCHCCHHHHHCHHHHHSCCCHHCCCCTHHHHCCHHHHHHHHHHHHHHTTT--CTSECCHHCEEEEEEGCS-CCCCCCCCCC CS 2167 Thioesterase 96 sLiliDapapsekakeashllgdeelvaelrdiggtpealledeellsellpalradkralenysirpiaaqkvdatlfygsddplneldtllaa 190 2168 L l Da++ + ++k++ + ++++l + +++ + +l + +++s+l+ ++r + ++ + p+a + +lf+ d+ ++l+ + a+ 2169 bpsC 1716 LLALLDAYPVYMGRKTTGAASEEAALEQRNQQDLDLAGQLVKGVAARSRLEAVMRNLWKVGPRHTRSPFAGD---VLLFVATVDRPAHLPVPVAK 1807 2170 ********9999999999999999888888888877777777775555555555555555555555566666...999*999999999*999999 PP 2171 2172 SSCSCTCSSSEEEEEE---TTHCHCCCHHHHH CS 2173 Thioesterase 191 arwreytpgafsvhvlpgdhftlledaaeell 222 2174 a+w+e t+ga++ h +p++h ++++ + l 2175 bpsC 1808 ASWKEFTSGAVEAHEIPSNHYDMVQ---SAAL 1836 2176 99**********************9...3333 PP 2177 2178>> PCP 2179 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 2180 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 2181 1 ! 73.8 0.0 6.8e-24 1.8e-23 1 68 [. 970 1037 .. 970 1039 .. 0.97 2182 2183 Alignments for each domain: 2184 == domain 1 score: 73.8 bits; conditional E-value: 6.8e-24 2185 PCP 1 EteLaeiwaevLgverVgidDdFFelGGhSLlatrliarirqelgvelsvkdLfaaptvaalaallse 68 2186 E+ L++++ae+L +++Vg+dD F +lGG S la+rl+arir+elg +l +++Lf++pt a la++l++ 2187 bpsC 970 EKVLCALFAEILSIDQVGVDDTFHDLGGSSALAMRLVARIREELGADLPIRQLFSSPTPAGLARALAA 1037 2188 789*************************************************************9986 PP 2189 2190>> CAL_domain 2191 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 2192 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 2193 1 ! 63.0 3.4 6.1e-21 1.6e-20 1 156 [. 493 628 .. 493 630 .. 0.89 2194 2195 Alignments for each domain: 2196 == domain 1 score: 63.0 bits; conditional E-value: 6.1e-21 2197 CAL_domain 1 syaeLerrarrlAGhLqdlGlkpGdrVvillgnrvefVeayLAclrAgaVAVPlnpdsadaelahllrdsGiravl.tdaAhaavLdkvrrtapalalv 98 2198 +yae ++ rlAG+L+ +G+ +GdrV +++ + a+LA+ Aga VP++ + + +dsG+ vl t+a++ ++ap a+v 2199 bpsC 493 TYAEVDQASNRLAGYLAVRGVGRGDRVGVAMERSPDLLIAFLAIWKAGAAYVPVDVEYPAERISFVFDDSGVSTVLcTLATS--------AVAPGNAIV 583 2200 8*********************************************************999999*******97776367777........9******** PP 2201 2202 CAL_domain 99 dahaagrelagfasyeelatpesalpArDDPvlglDelAwmlYTSGsTGrPKGVlsth 156 2203 ++a++++ ++ + + ++ + +D+lA+ +YTSGsTG PKGV h 2204 bpsC 584 -LDAPETR----VA--VRDCAAPEIR------PHADDLAYVMYTSGSTGLPKGVAIPH 628 2205 .8877665....44..5555566777......899*******************7666 PP 2206 2207>> Epimerization 2208 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 2209 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 2210 1 ! 57.2 17.0 5.1e-19 1.3e-18 35 240 .. 52 243 .. 49 247 .. 0.93 2211 2212 Alignments for each domain: 2213 == domain 1 score: 57.2 bits; conditional E-value: 5.1e-19 2214 Epimerization 35 gldedaLraALqaLldhHDALRlRfreedgg.wrqrnvperGavdeaaflLevvdlsggdd..ldaaiea.aaneaQasLDlaaGpLlrAvlfdag 126 2215 +ld+ Lra qaL+d+H ALR++fr + g +q++ a + a+++ ++ dlsg++d + +++ aa+e++ +L+++a pL+++ l ++g 2216 bpsC 52 PLDPGLLRASWQALVDRHAALRACFRYVSGAqMVQVI-----ARE-AEVPWRETDLSGLPDdiAEGEVDRlAADEVAERLRIEAAPLMKLHLIRLG 141 2217 69***********************777777699999.....777.99***************66666662678999******************* PP 2218 2219 Epimerization 127 dgdpgrLlLviHHLVVDGVSWRILLEDLaaAYeQaaaGqaiaLppKTtSfrrWAerLaeyAqseallaEldYWrevlagpdppLPadrpdgdkadd 222 2220 +++ +rL+ + HH VDG S IL Laa Y++ G +++ p+T S+r++ + L ++ +++ ++ Wr+ lag d+p + +pd+ 2221 bpsC 142 PDR-HRLVHTLHHVLVDGWSMPILHRELAAIYAA---GGDASGLPPTVSYRDYLAWLGRQ--DKE--VARAAWRAELAGLDTPTTVAAPDP----A 225 2222 ***.*****************************6...***********************..444..6789********************....* PP 2223 2224 Epimerization 223 tagtartvsvtLsaeeTr 240 2225 ++ + +t+ v+L+ae T+ 2226 bpsC 226 RVPDIHTAVVELPAELTD 243 2227 *****************7 PP 2228 2229>> ACP 2230 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 2231 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 2232 1 ! 44.0 0.0 1.5e-14 4.1e-14 5 71 .. 974 1037 .. 970 1039 .. 0.90 2233 2234 Alignments for each domain: 2235 == domain 1 score: 44.0 bits; conditional E-value: 1.5e-14 2236 ACP 5 reevaavlglasasdvdpdraFkdlGvDSltaveLrnrLeaatGlrLpatlvfdhptpraLaehLle 71 2237 ++ a+ l + ++v +d++F dlG +S a++L+ r+++++G +Lp ++f ptp+ La++L + 2238 bpsC 974 CALFAEILSI---DQVGVDDTFHDLGGSSALAMRLVARIREELGADLPIRQLFSSPTPAGLARALAA 1037 2239 5556666666...9**************************************************986 PP 2240 2241>> NRPS-COM_Nterm 2242 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc 2243 --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 2244 1 ! 38.4 0.0 3.8e-13 9.9e-13 5 31 .. 9 35 .. 6 37 .. 0.89 2245 2246 Alignments for each domain: 2247 == domain 1 score: 38.4 bits; conditional E-value: 3.8e-13 2248 NRPS-COM_Nterm 5 tkkknIedIYpLSPMQeGMLFHsLldp 31 2249 + ++++ed++pLSP+QeGML+H+ ld 2250 bpsC 9 KRRSSVEDVWPLSPLQEGMLYHTALDD 35 2251 67899******************9986 PP 2252 2253 2254 2255Internal pipeline statistics summary: 2256------------------------------------- 2257Query sequence(s): 1 (1858 residues) 2258Target model(s): 37 (9277 nodes) 2259Passed MSV filter: 19 (0.513514); expected 0.7 (0.02) 2260Passed bias filter: 17 (0.459459); expected 0.7 (0.02) 2261Passed Vit filter: 15 (0.405405); expected 0.0 (0.001) 2262Passed Fwd filter: 14 (0.378378); expected 0.0 (1e-05) 2263Initial search space (Z): 37 [actual number of targets] 2264Domain search space (domZ): 14 [number of targets reported over threshold] 2265# CPU time: 0.06u 0.02s 00:00:00.08 Elapsed: 00:00:00.08 2266# Mc/sec: 215.46 2267// 2268