1# STOCKHOLM 1.0 2#=GF ID LuxC 3#=GF AC PF05893.5 4#=GF DE Acyl-CoA reductase (LuxC) 5#=GF AU Moxon SJ 6#=GF SE Pfam-B_9766 (release 8.0) 7#=GF GA -133.50 -133.50; 14.60 14.60; 8#=GF TC -133.50 -133.50; 20.40 15.50; 9#=GF NC -133.70 -133.70; 11.20 12.90; 10#=GF TP Family 11#=GF BM hmmbuild -F HMM_ls SEED 12#=GF BM hmmcalibrate --seed 0 HMM_ls 13#=GF BM hmmbuild -f -F HMM_fs SEED 14#=GF BM hmmcalibrate --seed 0 HMM_fs 15#=GF AM globalfirst 16#=GF RN [1] 17#=GF RM 9128139 18#=GF RT Cysteine-286 as the site of acylation of the Lux-specific 19#=GF RT fatty acyl-CoA reductase. 20#=GF RA Lee CY, Meighen EA; 21#=GF RL Biochim Biophys Acta 1997;1338:215-222. 22#=GF DC The following Pfam-B families contain sequences that according to Prodom 23#=GF DC are members of this Pfam-A family. 24#=GF DR PFAMB; PB029697; 25#=GF DR PFAMB; PB044036; 26#=GF DR PFAMB; PB056333; 27#=GF DR INTERPRO; IPR008670; 28#=GF CC This family consists of several bacterial Acyl-CoA reductase (LuxC) 29#=GF CC proteins. The channelling of fatty acids into the fatty aldehyde substrate 30#=GF CC for the bacterial bioluminescence reaction is catalysed by a fatty acid 31#=GF CC reductase multienzyme complex, which channels fatty acids through the 32#=GF CC thioesterase (LuxD), synthetase (LuxE) and reductase (LuxC) components [1]. 33#=GF SQ 13 34#=GS Q9KV99_VIBCH/423-818 AC Q9KV99.1 35#=GS Q2WLE3_CLOBE/35-425 AC Q2WLE3.1 36#=GS Q97GS8_CLOAB/45-446 AC Q97GS8.1 37#=GS Q3WCI9_9ACTO/68-470 AC Q3WCI9.1 38#=GS LUXC_VIBHA/49-443 AC P08639.1 39#=GS Q93CP6_PHOLU/52-446 AC Q93CP6.1 40#=GS Q4A539_9VIBR/49-442 AC Q4A539.1 41#=GS LUXC_VIBFI/51-445 AC P12748.3 42#=GS LUXC2_PHOLE/50-444 AC P29236.1 43#=GS Q3KD56_PSEPF/30-413 AC Q3KD56.1 44#=GS Q7NQ23_CHRVO/30-413 AC Q7NQ23.1 45#=GS Q7MZU4_PHOLL/30-413 AC Q7MZU4.1 46#=GS Q8G6W7_BIFLO/65-480 AC Q8G6W7.1 47Q9KV99_VIBCH/423-818 LANQPLEAILGLINEARKSWSST............PELDPYRHTGLNF.......LADWCEPNRLKNLLDSALNGQRAFLDNFL..PRKDISHSSQKAMPRGIVSHWLSGNVPLLGMFALVQSILSKNANILKVSASESQALPVLLATFKGLSYTTPGGYTIHGDDLLGTLAVVYF.DRHQTKIAEKFS..ANADVRIAWGGREAIESVSGLPKKYNSQDILFGPKLSMMVVGSDALDSDKAIRKLIRRAATDSSVFDQFACASPHTIFVEKGGLITPKEFAEKLASAMDKALVRLPTQVPDIGQANKIRSKIAE....YAFIGE....YW.HDKHLRWTVLFDEG.........IELVEPTYQRVITVKAVDNVFDVVDSVHED.I...QTVGL.AMNGEKRLRFANEIMLKGAMRCPDVGYMTHFDS..PWDGVVALDRMVRW 48Q2WLE3_CLOBE/35-425 IYSYPSEAMIEIINEYSKILCSD............RKFLSYEGVPF.........LVLWLKKDNIKKLLHQDL.KKQEFLDDFI..EIAD..NKFMKAQPRGMVCHFMAGNVPTLPIYYLVQAIICRNVNLCRIPIGSIDIVIELLKPLKDIVINF.RGEKYYGSTLLKSISIINF.SSNDLKLNTEIS..QVADVRVICGGEEAVKTLSVLPKKTTCKDVIFGPKYSFAVFEKSAMESL.KITKTFDNFAKDIISFDQRACSSPQVLFIEKS.TVGINEAAQMLAQALEKSLKRYPKVEINQGAAANIINKRGE....YLISLEK..DII.CSKDLKYTILIDKE.........IILEEPVQHTTIFLKEIEDIFEVCKLITPR....IQTIGIASENNSRIINFANKASLHGVDRLVKVGLMNLYDS..PWDGILFMSEIVKW 49Q97GS8_CLOAB/45-446 VHDIKTEETIDLLDRCAKLWLDDNYSKK..HIETLAQITNQSFELVNYEFKS...MMQMLLRENIQNTIKREL.GEVDILDSWH..KTNY...GYEHRQPRGIIFHNISGNAFVVIPMSISMGLLSKNCNLVKVSKDEPYFAYAFYKSLCELDE...........TVKDRLSVLYF.DSSKTEIYDTIV..KNSDGVIHWGGEYSSRIIGEMCAKYQKHMIMHGAKISFEVVDKCD.....DLNKVSEEIAKDIICWEQKACLSPRVVFLN..DKIDVDEFSHCLSASLRKITEVIPKAYLSEWNSVKTIQDRQYCTLKYGMKNERRFKVY.SSFNADYTVILSDGMPEK.....EDINKCF.YRFIFVCPYSSKSDVVNYVSENLKDYLQTMG....YSGNDEEFIEKMTLLGVSIVTKPGKMSLHEPGTSHDGIHNLKEFTFL 50Q3WCI9_9ACTO/68-470 LLNVPLKEIIDFLVETGERIRDPRNTFMQDCIDRMAGTHVLPRAVLEGQVKG...AAAYLDKRLLETVVEQNF.PDPRALDEWVPKQDFTGRKSYIRAFAPRLI.HVLPGNSPGVAVKSIAQGALVKAVNLFKMSSSDPFTTVAVLRTMADIDPGH.........PIVRSMSAVYW.RGGDNTVEQVLYRPQYFDKIVAWGGGDAINNVIK.YLGPGFQLVSFDPKTSISMVGREAFASEEALDTAAELAAGDVMVLNQEACVASRFVFVEAD.QAEADRFSERL......HARIVEKAAASGDARPLDADLREQIDVLMMLDDEF..GVW.GKTDGHGLVIRSDE.........PVDFHPI.NKTANVVRVNSLDEAMRYVNVA....TQTVGF.YPFARMADYRDR.LASGGAQRIVRLGEAGPSTIGNPHDAMYPLHRFVHW 51LUXC_VIBHA/49-443 LNDLNINNIINFLYTTGQRWKSEEYSRRRAYIRSLITYLGYSPQMAK..LEANWIAMILCSKSALYDIIDTEL.GSTHIQDEWL..PQGE...CYVRAFPKGRTMHLLAGNVPLSGVTSILRGILTRNQCIVRMSASDPFTAHALAMSFIDVDPNH.........PISRSISVLYWPHASDTTLAEELL..SHMDAVVAWGGRDAIDWAVK.HSPSHIDVLKFGPKKSFTVLDHPA.....DLEEAASGVAHDICFYDQNACFSTQNIYFS...GDKYEEFKLKLVEKLNLYQEVLPKSKQSFDDEALFSMTRLE.....CQFSGL..KVI.SEPENNWMIIESEPG........VEYNHPL.SRCVYVHKINKVDDVVQYIEKH.QT..QTISF.YPWESSKKYRDA.FAAKGVERIVESGMNNIFRAGGAHDAMRPLQRLVRF 52Q93CP6_PHOLU/52-446 NNKLRLHNIVNFLYTVGQRWKNEEYSRRRTYIRDLKKYMGYSEAMAK..LEANWISMILCSKGGLYDVVENEL.GSRHIMDEWL..PQDE...SYIKAFPKGKSIHLLAGNVPLSVIMSILRAILTKNQCIIKTSSTDPFTANALALSFIDVDPNH.........PITRSLSVVYWPHQGDTSLAKEIM..QHMDVIVAWGGEDAINWAVE.HAPPYADVIKFGSKKSFCIIDNPV.....DLTSAATGAAHDICFYDQRACFSAQNIYYM...GNQYEEFKLALIEKLNLYAHILPNAKKDFDEKAAYSLVQKE.....SLFAGL..KVE.VDVHQRWMIIESNAG........VEFNQPL.GRCVYLHHVDNIEQVLPYVQKN.KT..QTISI.FPWESAFKYRDA.LALRGAERIVEAGMNNIFRVGGSHDGMRPLQRLVTY 53Q4A539_9VIBR/49-442 VNNLRLNQVVNFLYTVGQRWRSEEYTRRRTYIRDLTNFLGYSNEMAK..LEANWIAMLLCSKSALYDIVQHDL.GSLHIIDEWI..PQGD...CYIKALPKGKSVHLLAGNVPLSGVTSILRAILTKNECIIKTSSTDPFTATALVSSFIDVNADH.........PITRSMSVMYWSHNEDMSLPKKIM..NHADVV.AWGGDEAIKWAVK.HSPHHVDIVKFGPKKSLSIIDDPE.....DITAAATGVAHDICFYDQQACFSTQNIYYI...GNKLNLFIDELEKKLNVYAKILPKGCQNFDEKAAFTLTEKE.....CLFAGY..QVR.KGENQSWIIIQSPLD........AFGNQPL.SRSVYIHQVSSIEDILPFINKN.TT..QTVSI.APWESSFKYRDE.LAKHGAERIVESGMNNIFRVGGAHDGMRPLQYLVNY 54LUXC_VIBFI/51-445 RINLNLNQIVNFLYTVGQRWKSEEYNRRRTYIRELKTYLGYSDEMAR..LEANWIAMLLCSKSALYDIVNYDL.GSIHVLDEWL..PRGD...CYVKAQPKGVSVHLLAGNVPLSGVTSILRAILTKNECIIKTSSSDPFTANALVSSFIDVNADH.........PITKSMSVMYWPHDEDMTLSQRIM..NHADVVIAWGGDEAIKWAVK.YSPPHVDILKFGPKKSLSIIEAPK.....DIEAAAMGVAHDICFYDQQACFSTQDVYYI...GDNLPLFLNELEKQLDRYAKILPKGSNSFDEKAAFTLTEKE.....SLFAGY..EVR.KGDKQAWLIVVSPTN........SFGNQPL.SRSVYVHQVSDIKEIIPFVNKN.RT..QTVSI.YPWEASLKYRDK.LARSGVERIVESGMNNIFRVGGAHDSLSPLQYLVRF 55LUXC2_PHOLE/50-444 ENKLTINQIVNFLYTVGQKWKSETYSRRLTYIRDLIKFLGYSQEMAK..LEANWISMILCSKSALYDIVENDL.SSRHIIDEWI..PQGE...CYVKALPKGKSVHLLAGNVPLSGVTSILRAILTKNECIIKTSSADPFTATALVNSFIDVDAEH.........PITRSISVMYWSHSEDLAIPKQIM..SCADVVIAWGGDDAIKWATE.HAPSHADILKFGPKKSISIVDNPT.....DIKAAAIGVAHDICFYDQQACFSTQDIYYI...GDSIDIFFDELAQQLNKYKDILPKGERNFDEKAAFSLTERE.....CLFAKY..KVQ.KGESQSWLLTQSPAG........SFGNQPL.SRSAYIHQVNDISEVIPFVHKA.VT..QTVAI.APWESSFKYRDI.LAEHGAERIIEAGMNNIFRVGGAHDGMRPLQRLVNY 56Q3KD56_PSEPF/30-413 ARALDTTTVLGAAAIFAERLQDP............DMAMPIEPEQRQA.......LIGFCQPDALRRKLERELGEQPGSLRRLD..YRQS...RFERWSPLGLVVHITPGNAPLLAFCAVIEGLLAGNVNWLRPSSSDQGLTAQLLHGLAQCDATG.........QIAGHIAVV...PASTAQVGQLC...QRANGVSAWGGESALQAIRQ.QLAPGCRWIDWGHRISFIYLTPAA.....ATPEALDAVADEVCRLDQQACSSPQWLLVDSDDESILRAIGNDLAEAFERRSRHWPVLLPSIQEASEITTRTAMARLAQSFSEVD..GQV..WQAPDWRVIWTHDQ........QLAPSPL.FRSLLLKPLPRA.QVSEQLLPW.RNVLQSAGL.MCAEHETAELAQTLIAAGVTRITPVQAIHDGYEGEPHDGVYALQRLSRR 57Q7NQ23_CHRVO/30-413 AAEPDVDAVLSCAERFADALAGA............ERHPLLDEPGRAQ.......LAAFCRREALQAKLERELGERPFSLRRPD..YREP...RFEAWRPLGLVLHVTPSNAALLPFMAALEGLLAGNVNWLRPSSSDQGLSSRLLAELLRHDASG.........RLAARVAVL...PAPSDALPRLM...ADADGVSAWGGDAALSAIRA.RLPAGCRWIDWGHRVSFAYLDPAA.....AADEALDALADDICRFDQQACSSPQALLVDSDDPAAIHEMARRLAAALARRAPLWPALTPDLQEAAEISARMAFHKLDQAFADDQ..GQV..LSGQGWRLAWSMEQ........ELAPSPL.FRTVELRPAPRA.ALARILRPW.RTHLQSCGL.IAPPARLPELSRMLLAAGVSRVAPAGRMHDGYHGEPHDGVYALQRLSRR 58Q7MZU4_PHOLL/30-413 ACPPSVQQVLACAERFVDDLDNV............AVKLALDTAALTA.......LRHFCHRDSLEAKLRHELGEQPFSLRRFD..YTQP...RFETWQPLGLVVHITPANAPLLPFMAVLESLLVGNVNWLRPSSSDHGLNAQILAEFLRHDLSG.........TLAPYISVL...PLPSDQLSELL...ACADAVSAWGSNSALTAIRS.QLRPGCRWIDWGHRISFAYFDPMA.....ASDADYDALADDVCRFDQQACSSPQCLLVDSADENVLREVVSAVAAALARRATIWPALQTDIQEAAEISSQMAFLKLDHTFAELR..GSV..EEGNGWRVAWIQRQ........ELAPSPL.YRTLQVRPAPRA.QLVEILLPW.RPYLQSCAL.IVKEKELPMLSRQLLAAGVSRICQAGVMHDGYEGEPHDGVYALTRLARR 59Q8G6W7_BIFLO/65-480 LAAMSVNDILDIVADAAQLWADPDFELRRQAELLIPAITGYEPDMVRIELKR...YMRQFRRRELLRFLDSEI.GQPSMLDEFR..PNKA..GGYSKYVGPALTYQVFSSNVPGIPVWSMAMTLLVKGAILGKSSFSEPVMPAFFARSIAMVNSD...........LADAIAVVPW.KGGSQQLEDSAI..DAADAVIVYGSSQTTKLIAG.KVAGSKPCLGYGAKVGLAFIGREALRPD.TYADTVHRVAVDIATYDQQSCLAPQTVFVETDGALTPREVAQLLGGELENQQRKYPRSVLSDAENVAIQRARTDAEMRALMGGKA..AVFASGHSTAWSVLYRELDGSGADEDVASLMSPL.NRTVNVVAVPDLLDAARRLTSC.RGWLQSCGV.AVDSTRLFGLADTLAEVGVNRICPLGEMDRAKSGWHHDGGFNLIDLLRA 60#=GC seq_cons hsslslppllshlhpsupcWpssp.phh..h...htphhuYspphhp..hct...hhhhCp+suLhcll-p-L.up.chLD-al...pts...sY.+AhP+GlshHlluGNVPLlslhSllculLsKNssllKsSSSDPhhsssLlpohh-lDsst.........slscolSVlYa.cuscspLscplh..spADsVlAWGG--Alchlsp.ptsspschlcFGsKhShull-ssA.....slspAsculAcDIChaDQpAChSsQslalp...ssslcEFspcLuptLs+hscllP+up.shsEpAthotpct-.....shhsth..tVh.pspspsWhllhSptt........thhspPL.pRolhl+tlscl.-llphlpps.ps..QTlul.hshpuphthhsp.LuttGVpRIscsGhhshacsGtsHDGhhsLpRLV+a 61// 62