1LOCUS       SCX3_BUTOC                64 aa            linear   INV 16-OCT-2001
2DEFINITION  Neurotoxin III.
3ACCESSION   P01485
4PID         g134354
5VERSION     P01485  GI:134354
6DBSOURCE    swissprot: locus SCX3_BUTOC, accession P01485;
7            class: standard.
8            created: Jul 21, 1986.
9            sequence updated: Jul 21, 1986.
10            annotation updated: Oct 16, 2001.
11            xrefs: gi: gi: 69530
12            xrefs (non-sequence databases): HSSP P01484, InterPro IPR003614,
13            InterPro IPR002061, InterPro IPR001219, Pfam PF00537, PRINTS
14            PR00284, ProDom PD000908, SMART SM00505
15KEYWORDS    Neurotoxin; Sodium channel inhibitor; Amidation.
16SOURCE      Tunisian scorpion.
17  ORGANISM  Buthus occitanus tunetanus
18            Eukaryota; Metazoa; Arthropoda; Chelicerata; Arachnida; Scorpiones;
19            Buthoidea; Buthidae; Buthus.
20REFERENCE   1  (residues 1 to 64)
21  AUTHORS   Vargas,O., Gregoire,J., Martin,M.-F., Bechis,G. and Rochat,H.
22  TITLE     Neurotoxins from the venoms of two scorpions: Buthus occitanus
23            tunetanus and Buthus occitanus mardochei
24  JOURNAL   Toxicon 20, 79-79 (1982)
25  REMARK    SEQUENCE.
26COMMENT     [FUNCTION] BINDS TO SODIUM CHANNELS AND INHIBITS THE INACTIVATION
27            OF THE ACTIVATED CHANNELS, THEREBY BLOCKING NEURONAL TRANSMISSION.
28            [SUBCELLULAR LOCATION] SECRETED.
29            [SIMILARITY] BELONGS TO THE ALPHA/BETA-SCORPION TOXIN FAMILY.
30            ALPHA-TOXIN SUBFAMILY.
31FEATURES             Location/Qualifiers
32     source          1..64
33                     /organism="Buthus occitanus tunetanus"
34                     /db_xref="taxon:6871"
35     Protein         1..64
36                     /product="Neurotoxin III"
37     Bond            bond(12,63)
38                     /bond_type="disulfide"
39                     /note="BY SIMILARITY."
40     Bond            bond(16,36)
41                     /bond_type="disulfide"
42                     /note="BY SIMILARITY."
43     Bond            bond(22,46)
44                     /bond_type="disulfide"
45                     /note="BY SIMILARITY."
46     Bond            bond(26,48)
47                     /bond_type="disulfide"
48                     /note="BY SIMILARITY."
49     Site            64
50                     /site_type="amidation"
51ORIGIN
52        1 vkdgyivddr nctyfcgrna ycneectklk gesgycqwas pygnacycyk vpdhvrtkgp
53       61 grcn
54//
55