data/hmm/pkinase.slx

# ID   pkinase
# AC   PF00069
# DE   Eukaryotic protein kinase domain
# AU   Sonnhammer ELL
# AL   Clustalw
# AM   hmma -qR
# SE   Unknown
# DR   PROSITE; PDOC00100;
# DR   PROSITE; PDOC00212;
# DR   PROSITE; PDOC00213;
# DR   PROSITE; PDOC00629;
# GA   Bic_raw 25 hmmfs 20
# NC   hmmfs 17.60 YPKA_YERPS/2-292
# CC   hmmfs breaks up some members too much, e.g. KS61_MOUSE, which
# CC   hmmls does not.  However, hmmls inserts too many unwelcome insertions.
# **   hmmls fails badly: NINL_DROME gets the whole myosin domain inserted.
# **   Remaking SEED from more seqs only made things worse.
# DR   SCOP; 1apm; sf;
# DR   URL; http://www.sdsc.edu/Kinases/pk_home.html;
# RN   [1]
# RM   92065863
# RA   S.K. Hanks, A.M. Quinn;
# RL   Methods Enzymol. 200: 38-62 (1991)
# RN   [2]
# RM   95285959
# RA   S.K. Hanks, T. Hunter;
# RL   FASEB J. 9: 576-596 (1995)
# RN   [3]
# RM   97172697
# RA   T. Hunter, G.D. Plowman;
# RL   Trends Biochem. Sci. 22: 18-22 (1997)
# SQ   67
7LES_DROME/2209-2481 LKLLRFLGSGAFGEVYEGQLKTED....SEEPQRVAIKSLRKG.......
ABL1_CAEEL/296-547   IIMHNKLGGGQYGDVYEGYWKR........HDCTIAVKALK.........
ARK1_BOVIN/191-453   FSVHRIIGRGGFGEVYGCRKA........DTGKMYAMKCLD.........
AVR2_HUMAN/192-479   LQLLEVKARGRFGCVWKAQLL..........NEYVAVKIFP.........
BFR2_HUMAN/367-643   LTLGKPLGEGCFGQVVMAEAVGIDK.DKPKEAVTVAVKMLKDDAT.....
BYR1_SCHPO/66-320    LEVVRHLGEGNGGAVSLVKHR..........NIFMARKTVYVG......S
BYR2_SCHPO/394-658   WIRGALIGSGSFGQVYLGMNAS........SGELMAVKQVILD.......
CC15_YEAST/25-272    YHLKQVIGRGSYGVVYKAINK........HTDQVVAIKEVVYE......N
CC21_MEDSA/1-284     GENVEKIGEGTYGVVYKARDR........VTNETIALKKIR........L
CC5_YEAST/82-337     YHRGHFLGEGGFARCFQIKDD.........SGEIFAAKTVA.........
CDPK_SOYBN/34-292    YEVGRKLGQGQFGTTFECTRR........ASGGKFACKSIP.........
CDR1_SCHPO/12-258    WRLGKTLGTGSTSCVRLAKHA........KTGDLAAIKIIP.........
CHK1_SCHPO/10-272    YHIGREIGTGAFASVRLCYDD.........NAKIYAVKFVN........K
CLK1_MOUSE/160-476   YEIVDTLGEGAFGKVVECIDHK.......VGGRRVAVKIVKN.......V
CTK1_YEAST/183-469   YLRIMQVGEGTYGKVYKAKNTN........TEKLVALKKLRLQ.......
ERK1_CANAL/68-371    YQILEIVGEGAYGIVCSAIHK........PSQQKVAIKKIEP.......F
ERK3_HUMAN/20-312    FVDFQPLGFGVNGLVLSAVDS........RACRKVAVKKIALS......D
FUSE_DROME/4-254     YAVSSLVGQGSFGCVYKATRK........DDSKVVAIKVIS.........
HR25_YEAST/9-273     FRIGRKIGSGSFGDIYHGTNL........ISGEEVAIKLES.........
JAK1_HUMAN/571-833   LVQGEHLGRGTRTHIYSGTLMDYKD..DEGTSEEKKIKVIL.........
JAK1_HUMAN/864-1137  LKRIRDLGEGHFGKVELCRYDPED.....NTGEQVAVKSLK.........
KAB7_YEAST/1096-1354 FVSLQKMGEGAYGKVNLCIHK........KNRYIVVIKMIFK.......E
KAKT_MLVAT/171-429   FEYLKLLGKGTFGKVILVKEK........ATGRYYAMKILK.........
KC21_CHICK/39-324    YQLVRKLGRGKYSEVFEAINIT........NNEKVVVKILK.........
KCC4_MOUSE/42-296    FEVESELGRGATSIVYRCKQK........GTQKPYALKVL..........
KCR8_YEAST/316-590   GRCQEVLGKGAFGVVRICQKKNVSSQDGNKSEKLYAVKEFKR........
KG3A_RAT/119-403     YTDIKVIGNGSFGVVYQARLA........ETRELVAIKKVLQ........
KGP1_DROME/457-717   LEVVSTLGIGGFGRVELVKAHH......QDRVDIFALKCLK.........
KI28_YEAST/7-290     YTKEKKVGEGTYAVVYLGCQHS........TGRKIAIKEIK.........
KI82_YEAST/324-602   FEKIRLLGQGDVGKVYLVRER........DTNQIFALKVLN.........
KIN1_SCHPO/125-395   YVLGKTIGAGSMGKVKDAHHL........KTGEQFAIKIVTRLHPDITKA
KIR1_HUMAN/208-495   ITLLECVGKGRYGEVWRGSWQ..........GENVAVKIFS.........
KKIA_HUMAN/5-288     YEKIGKIGEGSYGVVFKCRNR........DTGQIVAIKKFLE........
KKL6_YEAST/192-508   WKKVRPIGSGNFSTVLLYELMDQS....NPKLKQVAVKRLKYPEELSNVE
KMIL_AVIMH/82-339    VLLSTRIGSGSFGTVYKGKWHG........DVAVKILKVVDP.......T
KML2_CHICK/1453-1708 YNIEERLGSGKFGQVFRLVEK........KTGKVWAGKFFK.........
KMOS_CERAE/60-338    VCLLQRLGAGGFGSVYKATYH..........GVPVAIKQVN.........
KPBH_RAT/24-291      YDPKDIIGRGVSSVVRRCVHRA......TGDEFAVKIMEVS.........
KPIM_HUMAN/38-290    YQVGPLLGSGGFGSVYSGIRV........SDNLPVAIKHVE.........
KPK2_PLAFK/111-364   YVLNKKIGKGSFSTAYIGTNI........LYGNRVVVKEVD.........
KPRO_MAIZE/534-812   RKFKVELGRGESGTVYKGVLE.........DDRHVAVKKLEN........
KR1_HSV11/191-478    FTIHGALTPGSEGCVFDSSHP.........DYPQRVIVKA..........
KR1_PRVKA/53-332     FEVLQPLQSGSEGRVFVARRP.........GEADTVVLKV..........
KS61_MOUSE/407-664   YVVKETIGVGSYSVCKRCVHK........ATNMEYAVKVID.........
KYK1_DICDI/1289-1559 LEFGQTIGKGFFGEVKRGYWR..........ETDVAIKIIY.........
KYK2_DICDI/108-364   IQFIQKVGEGAFSEVWEGWWK..........GIHVAIKKLKIIG.....D
MAK_RAT/4-284        YTTMRQLGDGTYGSVLMGKSN........ESGELVAIKRMK.........
MEK1_YEAST/162-444   EITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIK.........
MET_HUMAN/1078-1337  VHFNEVIGRGHFGCVYHGTLLDND.....GKKIHCAVKSLN.........
MKK1_YEAST/221-488   IETLGILGEGAGGSVSKCKLK........NGSKIFALKVIN.........
MLK1_HUMAN/3-262     LTLEEIIGIGGFGKVYRAFWI..........GDEVAVKAARHD......P
NINL_DROME/16-282    FEIYEEIAQGVNAKVFRAKELD........NDRIVALKIQHYD......E
NPR1_YEAST/438-742   IKTGADLGAGAGGSVKLAQRIS........DNKIFAVKEFR........T
PHY_CERPU/1004-1282  IQITGSLGSGSSATVEKAVWL..........GTPVAKKTFYG........
PKD1_DICDI/36-291    FNFYGSLGSGSFGTAKLCRHR........GSGLFFCSKTLR.........
PKN1_MYXXA/59-321    FRLVRRLGRGGMGAVYLGEHVS........IGSRVAVKVLH.........
RAN1_SCHPO/18-295    LRFVSIIGAGAYGVVYKAEDIY........DGTLYAVKALC.........
RYK_HUMAN/327-593    ITLKDVLQEGTFGRIFHGILIDEKD...PNKEKQAFVKTVKD.......Q
SGV1_YEAST/60-366    YREDEKLGQGTFGEVYKGIHL........ETQRQVAMKKIIVS......V
SPK1_YEAST/198-466   SIIDEVVGQGAFATVKKAIER........TTGKTFAVKIIS.........
ST20_YEAST/620-871   YANLVKIGQGASGGVYTAYEIG........TNVSVAIKQMNLE.......
STE7_YEAST/191-466   LVQLGKIGAGNSGTVVKALHVP........DSKIVAKKTIP........V
SYK_PIG/364-619      TLEDKELGSGNFGTVKKGYYQMK......KVVKTVAVKILKN........
TOP_DROME/938-1194   LRKGGVLGMGAFGRVYKGVWVPEG....ENVKIPVAIKELLKSTG.....
TRKA_HUMAN/504-775   IVLKWELGEGAFGKVFLAECHNLLP...EQDKMLVAVKALK.........
TTK_HUMAN/509-775    YSILKQIGSGGSSKVFQVLNE.........KKQIYAIKYVN........L
WEE1_HUMAN/299-569   FHELEKIGSGEFGSVFKCVKR........LDGCIYAIKRS..........

7LES_DROME/2209-2481 ASEFAE............LLQEAQLMSNFK......HENIVRLVGICF..
ABL1_CAEEL/296-547   EDAMPLH..........EFLAEAAIMKDLH......HKNLVRLLGVCT..
ARK1_BOVIN/191-453   KKRIKMKQGE......TLALNERIMLSLVSTG...DCPFIVCMSYAFH..
AVR2_HUMAN/192-479   IQDKQS..........WQNEYEVYSLPGMK......HENILQFIGAEKRG
BFR2_HUMAN/367-643   EKDLSD............LVSEMEMMKMIG.....KHKNIINLLGACTQ.
BYR1_SCHPO/66-320    DSKLQK...........QILRELGVLHHCR......SPYIVGFYGAFQ..
BYR2_SCHPO/394-658   SVSESKDRHAKLL...DALAGEIALLQELS......HEHIVQYLGSNL..
CC15_YEAST/25-272    DEELN............DIMAEISLLKNLN......HNNIVKYHGFIR..
CC21_MEDSA/1-284     EQEDEG.....VP...STAIREISLLKEMQ......HRNIVRLQDVVH..
CC5_YEAST/82-337     KASIK...SEKTR...KKLLSEIQIHKSMS......HPNIVQFIDCFE..
CDPK_SOYBN/34-292    KRKLLCKEDYED......VWREIQIMHHLSE.....HANVVRIEGTYE..
CDR1_SCHPO/12-258    IRYAS.............IGMEILMMRLLR......HPNILRLYDVWT..
CHK1_SCHPO/10-272    KHATSCMNAGVWA...RRMASEIQLHKLCNG.....HKNIIHFYNTAE..
CLK1_MOUSE/160-476   DRYCEA............AQSEIQVLEHLNTTDP..HSTFRCVQMLEWF.
CTK1_YEAST/183-469   GEREG......FP...ITSIREIKLLQSFD......HPNVSTIKEIMVE.
ERK1_CANAL/68-371    ERSMLCLR..........TLRELKLLKHFN......HENIISILAIQRPI
ERK3_HUMAN/20-312    ARSMKH............ALREIKIIRRLD......HDNIVKVYEVLGPK
FUSE_DROME/4-254     KRGRATKELKN.......LRRECDIQARLK......HPHVIEMIESFE..
HR25_YEAST/9-273     IRSRHP...........QLDYESRVYRYLS......GGVGIPFIRWFGR.
JAK1_HUMAN/571-833   KVLDPSHRDIS.....LAFFEAASMMRQVS......HKHIVYLYGVCV..
JAK1_HUMAN/864-1137  PESGGN........HIADLKKEIEILRNLY......HENIVKYKGICTED
KAB7_YEAST/1096-1354 RILVDTWVRDRKL...GTIPSEIQIMATLNKK...PHENILRLLDFFE..
KAKT_MLVAT/171-429   KEVIVAKDEVAH......TLTENRVLQNSR......HPFLTALKYSFQ..
KC21_CHICK/39-324    PVKKKK............IKREIKILENLRG.....GPNIITLADIVKDP
KCC4_MOUSE/42-296    KKTVD....KKI......VRTEIGVLLRLS......HPNIIKLKEIFE..
KCR8_YEAST/316-590   RTSESAEKYSKR......LTSEFCISSSLH......HTNIVTTLDLFQD.
KG3A_RAT/119-403     DKRFK..............NRELQIMRKLD......HCNIVRLRYFFYSS
KGP1_DROME/457-717   KRHIVDTKQEE......HIFSERHIMLSSR......SPFICRLYRTFR..
KI28_YEAST/7-290     TSEFKDGLDMS.......AIREVKYLQEMQ......HPNVIELIDIFM..
KI82_YEAST/324-602   KHEMIK...RKKI...KRVLTEQEILATSD......HPFIVTLYHSFQ..
KIN1_SCHPO/125-395   KAAASAEATKAAQ...SEKNKEIRTVREAALSTLLRHPYICEARDVYI..
KIR1_HUMAN/208-495   SRDEKS............WFRETELYNTVMLR....HENILGFIASDMTS
KKIA_HUMAN/5-288     SEDDP.....VIK...KIALREIRMLKQLK......HPNLVNLLEVFR..
KKL6_YEAST/192-508   QINTSLRYKETLSRLENSLTRELQVLKSLN......HPCIVKLLGINNPI
KMIL_AVIMH/82-339    PEQFQA............FRNEVAVLRKTR......HVNILLFMGYMT..
KML2_CHICK/1453-1708 AYSAK...EKEN......IRDEISIMNCLH......HPKLVQCVDAFE..
KMOS_CERAE/60-338    KCTKNRLASRR.......SFWAELNVARLR......HDNIVRVVAASTRT
KPBH_RAT/24-291      AERLSLEQLEEVR...DATRREMHILRQVAG.....HPHIITLIDSYE..
KPIM_HUMAN/38-290    KDRISDWGELPNG...TRVPMEVVLLKKVSSG....FSGVIRLLDWFE..
KPK2_PLAFK/111-364   KSKVK....ESN......VYTEIEVLRKVM......HKYIIKLISAYE..
KPRO_MAIZE/534-812   VRQGKE...........VFQAELSVIGRIN......HMNLVRIWGFCS..
KR1_HSV11/191-478    GWYTS.............TSHEARLLRRLD......HPAILPLLDLHV..
KR1_PRVKA/53-332     GQKPS.............TLMEGMLLQRLS......HDNVMRMKQMLA..
KS61_MOUSE/407-664   KSKRD.............PSEEIEILLRYGQ.....HPNIITLKDVYD..
KYK1_DICDI/1289-1559 RDQFKT...KSSL...VMFQNEVGILSKLR......HPNVVQFLGACTAG
KYK2_DICDI/108-364   EEQFKER...........FIREVQNLKKGN......HQNIVMFIGACY..
MAK_RAT/4-284        RKFYSWDECMN........LREVKSLKKLN......HANVIKLKEVIR..
MEK1_YEAST/162-444   LKPNK.............FDKEARILLRLD......HPNIIKVYHTFCD.
MET_HUMAN/1078-1337  RITDIGEVS........QFLTEGIIMKDFS......HPNVLSLLGICLR.
MKK1_YEAST/221-488   TLNTDPEYQKQ.......IFRELQFNRSFQ......SEYIVRYYGMFTDD
MLK1_HUMAN/3-262     DEDISQTIEN........VRQEAKLFAMLK......HPNIIALRGVCL..
NINL_DROME/16-282    EHQVS.............IEEEYRTLRDYCD.....HPNLPEFYGVYKLS
NPR1_YEAST/438-742   KFENES..KRDYV...KKITSEYCIGTTLN......HPNIIETIEIVY..
PHY_CERPU/1004-1282  RNNED.............FKREVEILAELC......HPNITSMFCSPL..
PKD1_DICDI/36-291    RETIVHEKHKEH......VNNEINIMLNIS......HPYIVKTYSTFN..
PKN1_MYXXA/59-321    AHLTMYPELVQR......FHAEARAVNLIG......HENIVSIFDMDA..
RAN1_SCHPO/18-295    KDGLNEKQKK.......LQARELALHARVSS.....HPYIITLHRVLE..
RYK_HUMAN/327-593    ASEIQVT..........MMLTESCKLRGLH......HRNLLPITHVCIE.
SGV1_YEAST/60-366    EKDLFP..........ITAQREITILKRLN......HKNIIKLIEMVYDH
SPK1_YEAST/198-466   KRKVIGNMDG........VTRELEVLQKLN......HPRIVRLKGFYE..
ST20_YEAST/620-871   KQPKKE...........LIINEILVMKGSK......HPNIVNFIDSYV..
STE7_YEAST/191-466   EQNNS.....TII...NQLVRELSIVKNVKP.....HENIITFYGAYYN.
SYK_PIG/364-619      EANDPALKD........ELLAEANVMQQLD......NPYIVRMIGICE..
TOP_DROME/938-1194   AESSEE............FLREAYIMASEE......HVNLLKLLAVCM..
TRKA_HUMAN/504-775   EASESAR.........QDFQREAELLTMLQ......HQHIVRFFGVCTE.
TTK_HUMAN/509-775    EEADNQTLDS........YRNEIAYLNKLQQH....SDKIIRLYDYEI..
WEE1_HUMAN/299-569   KKPLAGSVDEQN......ALREVYAHAVLGQ.....HSHVVRYFSAWA..

7LES_DROME/2209-2481 .................DTESISLIMEHMEAG......DLLSYLRAARAT
ABL1_CAEEL/296-547   .................HEAPFYIITEFMCNG......NLLEYLRRTDKS
ARK1_BOVIN/191-453   .................TPDKLSFILDLMNGG......DLHYHLSQHG..
AVR2_HUMAN/192-479   ...............TSVDVDLWLITAFHEKG......SLSDFLKANV..
BFR2_HUMAN/367-643   ..................DGPLYVIVEYASKG......NLREYLRARRPP
BYR1_SCHPO/66-320    .................YKNNISLCMEYMDCG......SLDAILREGG..
BYR2_SCHPO/394-658   .................NSDHLNIFLEYVPGG......SVAGLLTMYG..
CC15_YEAST/25-272    .................KSYELYILLEYCANG......SLRRLISRSS..
CC21_MEDSA/1-284     .................SDKRLYLVFEYLDL.......DLKKHMDSSPE.
CC5_YEAST/82-337     .................DDSNVYILLEICPNG......SLMELLKRRK..
CDPK_SOYBN/34-292    .................DSTAVHLVMELCEGG......ELFDRIVQKG..
CDR1_SCHPO/12-258    .................DHQHMYLALEYVPDG......ELFHYIRKHG..
CHK1_SCHPO/10-272    .................NPQWRWVVLEFAQGG......DLFDKIEPDVG.
CLK1_MOUSE/160-476   ................EHRGHICIVFELLGLS.......TYDFIKENS..
CTK1_YEAST/183-469   .................SQKTVYMIFEYADN.......DLSGLLLNKEV.
ERK1_CANAL/68-371    N..............YESFNEIYLIQELMET.......DLHRVIRTQN..
ERK3_HUMAN/20-312    G........TDLQGELFKFSVAYIVQEYMET.......DLARLLEQGT..
FUSE_DROME/4-254     .................SKTDLFVVTEFALM.......DLHRYLSYNG..
HR25_YEAST/9-273     .................EGEYNAMVIDLLGP.......SLEDLFNYCHR.
JAK1_HUMAN/571-833   .................RDVENIMVEEFVEGG......PLDLFMHRKSD.
JAK1_HUMAN/864-1137  .................GGNGIKLIMEFLPSG......SLKEYLPKNKN.
KAB7_YEAST/1096-1354 .................DDDYYYIETPVHGETGC...IDLFDLIEFKT..
KAKT_MLVAT/171-429   .................THDRLCFVMEYANGG......ELFFHLSRER..
KC21_CHICK/39-324    .................VSRTPALVFEHVNNT......DFKQLYQTLT..
KCC4_MOUSE/42-296    .................TPTEISLVLELVTGG......ELFDRIVEKG..
KCR8_YEAST/316-590   .................AKGEYCEVMEYCAGG......DLFTLVVAAG..
KG3A_RAT/119-403     G.............EKKDELYLNLVLEYVPET....VYRVARHFTKAK..
KGP1_DROME/457-717   .................DEKYVYMLLEACMGG......EIWTMLRDRG..
KI28_YEAST/7-290     .................AYDNLNLVLEFLPT.......DLEVVIKDKS..
KI82_YEAST/324-602   .................TKDYLYLCMEYCMGG......EFFRALQTRKS.
KIN1_SCHPO/125-395   .................TNSHYYMVFEFVDGG......QMLDYIISHG..
KIR1_HUMAN/208-495   R...............HSSTQLWLITHYHEMG......SLYDYLQLTT..
KKIA_HUMAN/5-288     .................RKRRLHLVFEYCDHT......VLHELDRYQR..
KKL6_YEAST/192-508   FVTSKKPLCDLIIKTPRALPPCDMIMSYCPAG......DLLAAVMARNG.
KMIL_AVIMH/82-339    ..................KDNLAIVTQWCEGS......SLYKHLHVQET.
KML2_CHICK/1453-1708 .................EKANIVMVLEMVSGG......ELFERIIDED..
KMOS_CERAE/60-338    PAG..............SNSLGTIIMEFGGNV......TLHQVIYGAASH
KPBH_RAT/24-291      .................SSSFMFLVFDLMRKG......ELFDYLTEKV..
KPIM_HUMAN/38-290    .................RPDSFVLILERPEPV.....QDLFDFITERG..
KPK2_PLAFK/111-364   .................QEGFVYLVLEYLKGG......ELFEYLNNNG..
KPRO_MAIZE/534-812   .................EGSHRLLVSEYVENG......SLANILFSEGG.
KR1_HSV11/191-478    .................VSGVTCLVLPKYQA.......DLYTYLSRRLN.
KR1_PRVKA/53-332     .................RGPATCLVLPHFRC.......DLYSYLTMRD..
KS61_MOUSE/407-664   .................DGKHVYLVTELMRGG......ELLDKILRQK..
KYK1_DICDI/1289-1559 .................GEDHHCIVTEWMGGG......SLRQFLTDHFN.
KYK2_DICDI/108-364   ...................KPACIITEYMAGG......SLYNILHNPNS.
MAK_RAT/4-284        .................ENDHLYFIFEYMKEN......LYQLMKDRNK..
MEK1_YEAST/162-444   .................RNNHLYIFQDLIPGG......DLFSYLAKGDCL
MET_HUMAN/1078-1337  .................SEGSPLVVLPYMKHG......DLRNFIRNETH.
MKK1_YEAST/221-488   .................ENSSIYIAMEYMGGRSL...DAIYKNLLERGG.
MLK1_HUMAN/3-262     .................KEPNLCLVMEFARGG......PLNRVLSGKR..
NINL_DROME/16-282    KPN..............GPDEIWFVMEYCAGGTA...VDMVNKLLKLDR.
NPR1_YEAST/438-742   .................ENDRILQVMEYCEY.......DLFAIVMSNK..
PHY_CERPU/1004-1282  .................YRRKCSIIMELMDG.......DLLALMQRRLDR
PKD1_DICDI/36-291    .................TPTKIHFIMEYAGKK......DLFHHLRANK..
PKN1_MYXXA/59-321    .................TPPRPYLIMEFLDG.......APLSAWVGTP..
RAN1_SCHPO/18-295    .................TEDAIYVVLQYCPNG......DLFTYITEKKVY
RYK_HUMAN/327-593    .................EGEKPMVILPYMNWG......NLKLFLRQCKLV
SGV1_YEAST/60-366    SPDITN......AASSNLHKSFYMILPYMVA.......DLSGVLHNPR..
SPK1_YEAST/198-466   .................DTESYYMVMEFVSGG......DLMDFVAAHG..
ST20_YEAST/620-871   .................LKGDLWVIMEYMEGG......SLTDVVTHCI..
STE7_YEAST/191-466   ...............QHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTV
SYK_PIG/364-619      ..................AESWMLVMEMAELG......PLNKYLQQNR..
TOP_DROME/938-1194   ..................SSQMMLITQLMPLG......CLLDYVRNNRD.
TRKA_HUMAN/504-775   ..................GRPLLMVFEYMRHG......DLNRFLRSHGPD
TTK_HUMAN/509-775    .................TDQYIYMVMECGNI.......DLNSWLKKKK..
WEE1_HUMAN/299-569   .................EDDHMLIQNEYCNGG......SLADAISENYRI

7LES_DROME/2209-2481 STQEP.....QPTAGLSLSELLAMCIDVANGCSYLEDMH..........F
ABL1_CAEEL/296-547   ..............LLPPIILVQMASQIASGMSYLEARH..........F
ARK1_BOVIN/191-453   ..............VFSEADMRFYAAEIILGLEHMHNRF..........V
AVR2_HUMAN/192-479   ...............VSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAI
BFR2_HUMAN/367-643   GMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQK..........C
BYR1_SCHPO/66-320    ..............PIPLDILGKIINSMVKGLIYLYNVLH.........I
BYR2_SCHPO/394-658   ..............SFEETLVKNFIKQTLKGLEYLHSRG..........I
CC15_YEAST/25-272    .T............GLSENESKTYVTQTLLGLKYLHGEG..........V
CC21_MEDSA/1-284     .............FIKDPRQVKMFLYQMLCGIAYCHSHR..........V
CC5_YEAST/82-337     ..............VLTEPEVRFFTTQICGAIKYMHSRR..........V
CDPK_SOYBN/34-292    ..............HYSERQAARLIKTIVEVVEACHSLG..........V
CDR1_SCHPO/12-258    ..............PLSEREAAHYLSQILDAVAHCHRFR..........F
CHK1_SCHPO/10-272    ..............ID.EDVAQFYFAQLMEGISFMHSKG..........V
CLK1_MOUSE/160-476   ............FLPFRMDHIRKMAYQICKSVNFLHSNK..........L
CTK1_YEAST/183-469   ..............QISHSQCKHLFKQLLLGMEYLHDNK..........I
ERK1_CANAL/68-371    ...............LSDDHIQYFIYQTLRALKAMHSAN..........V
ERK3_HUMAN/20-312    ...............LAEEHAKLFMYQLLRGLKYIHSAN..........V
FUSE_DROME/4-254     ..............AMGEEPARRVTGHLVSALYYLHSNR..........I
HR25_YEAST/9-273     ..............RFSFKTVIMLALQMFCRIQYIHGRS..........F
JAK1_HUMAN/571-833   ..............VLTTPWKFKVAKQLASALSYLEDKD..........L
JAK1_HUMAN/864-1137  ..............KINLKQQLKYAVQICKGMDYLGSRQ..........Y
KAB7_YEAST/1096-1354 ..............NMTEFEAKLIFKQVVAGIKHLHDQG..........I
KAKT_MLVAT/171-429   ..............VFSEDRARFYGAEIVSALDYLHSEKN.........V
KC21_CHICK/39-324    .................DYDIRFYMYEILKALDYCHSMG..........I
KCC4_MOUSE/42-296    ..............YYSERDARDAVKQILEAVAYLHENG..........I
KCR8_YEAST/316-590   ..............KLEYMEADCFFKQLIRGVVYMHEMG..........V
KG3A_RAT/119-403     .............LIIPIIYVKVYMYQLFRSLAYIHSQG..........V
KGP1_DROME/457-717   ..............SFEDNAAQFIIGCVLQAFEYLHARG..........I
KI28_YEAST/7-290     .............ILFTPADIKAWMLMTLRGVYHCHRNF..........I
KI82_YEAST/324-602   .K............CIAEEDAKFYASEVVAALEYLHLLG..........F
KIN1_SCHPO/125-395   ..............KLKEKQARKFERQIGSALSYLHQNS..........V
KIR1_HUMAN/208-495   ...............LDTVSCLRIVLSIASGLAHLHIEIFGTQGK..PAI
KKIA_HUMAN/5-288     ..............GVPEHLVKSITWQTLQAVNFCHKHN..........C
KKL6_YEAST/192-508   ..............RLEAWLIQRIFTEVVLAVKYLHENS..........I
KMIL_AVIMH/82-339    ..............KFQMFQLIDIARQTAQGMDYLHAKN..........I
KML2_CHICK/1453-1708 .F............ELTERECIKYMRQISEGVEYIHKQG..........I
KMOS_CERAE/60-338    PEGDAGEPHCSTGGPLTLGKCLKYSLDVVNGLLFLHSQS..........I
KPBH_RAT/24-291      ..............ALSEKETRSIMRSLLEAVNFLHVNN..........I
KPIM_HUMAN/38-290    ..............ALQEELARSFFWQVLEAVRHCHNCG..........V
KPK2_PLAFK/111-364   ..............PYTEQVAKKAMKRVLIALEALHSNG..........V
KPRO_MAIZE/534-812   ............NILLDWEGRFNIALGVAKGLAYLHHECL.......EWV
KR1_HSV11/191-478    ..............PLGRPQIAAVSRQLLSAVDYIHRQG..........I
KR1_PRVKA/53-332     G.............PLDMRDAGCVIRAVLRGLAYLHGMR..........I
KS61_MOUSE/407-664   ..............FFSEREASFVLHTISKTVEYLHSQG..........V
KYK1_DICDI/1289-1559 ............LLEQNPHIRLKLALDIAKGMNYLHGWTP.......P.I
KYK2_DICDI/108-364   ..S.......TPKVKYSFPLVLKMATDMALGLLHLHSIT..........I
MAK_RAT/4-284        ..............LFPESVIRNIMYQILQGLAFIHKHG..........F
MEK1_YEAST/162-444   T.............SMSETESLLIVFQILQALNYLHDQD..........I
MET_HUMAN/1078-1337  ..............NPTVKDLIGFGLQVAKGMKYLASKK..........F
MKK1_YEAST/221-488   ..............RISEKVLGKIAEAVLRGLSYLHEKK..........V
MLK1_HUMAN/3-262     ...............IPPDILVNWAVQIARGMNYLHDEAI.......VPI
NINL_DROME/16-282    ..............RMREEHIAYIIRETCRAAIELNRNH..........V
NPR1_YEAST/438-742   ...............MSYEEICCCFKQILTGVQYLHSIG..........L
PHY_CERPU/1004-1282  NED.......HDSPPFSILEVVDIILQTSEGMNYLHEKG..........I
PKD1_DICDI/36-291    ..............CFTEQTTKLIVAEIVLAIEYLHAEN..........I
PKN1_MYXXA/59-321    ...............LAAGAVVSVLSQVCDALQAAHARG..........I
RAN1_SCHPO/18-295    ..............QGNSHLIKTVFLQLISAVEHCHSVG..........I
RYK_HUMAN/327-593    EAN........NPQAISQQDLVHMAIQIACGMSYLARRE..........V
SGV1_YEAST/60-366    .............INLEMCDIKNMMLQILEGLNYIHCAK..........F
SPK1_YEAST/198-466   ..............AVGEDAGREISRQILTAIKYIHSMG..........I
ST20_YEAST/620-871   ..............LT.EGQIGAVCRETLSGLEFLHSKG..........V
STE7_YEAST/191-466   SSK.......K..TWFNELTISKIAYGVLNGLDHLYRQYK.........I
SYK_PIG/364-619      ..............HVKDKNIIELVHQVSMGMKYLEECN..........F
TOP_DROME/938-1194   ..............KIGSKALLNWSTQIAKGMSYLEEKR..........L
TRKA_HUMAN/504-775   AKLLAGGED.VAPGPLGLGQLLAVASQVAAGMVYLAGLH..........F
TTK_HUMAN/509-775    ..............SIDPWERKSYWKNMLEAVHTIHQHG..........I
WEE1_HUMAN/299-569   MS............YFKEAELKDLLLQVGRGLRYIHSMS..........L

7LES_DROME/2209-2481 VHRDLACRNCLVTESTGSTD............RRRTVKIGDFGLARDIYK
ABL1_CAEEL/296-547   IHRDLAARNCLVSEH...................NIVKIADFGLARFMKE
ARK1_BOVIN/191-453   VYRDLKPANILLDEH...................GHVRISDLGLACDFS.
AVR2_HUMAN/192-479   SHRDIKSKNVLLKNN...................LTACIADFGLALKFEA
BFR2_HUMAN/367-643   IHRDLAARNVLVTEN...................NVMKIADFGLARDINN
BYR1_SCHPO/66-320    IHRDLKPSNVVVNSR...................GEIKLCDFGVSGELVN
BYR2_SCHPO/394-658   VHRDIKGANILVDNK...................GKIKISDFGISKKLEL
CC15_YEAST/25-272    IHRDIKAANILLSAD...................NTVKLADFGVSTIVN.
CC21_MEDSA/1-284     LHRDLKPQNLLIDRR..................TNSLKLADFGLARAFG.
CC5_YEAST/82-337     IHRDLKLGNIFFDSN...................YNLKIGDFGLAAVLAN
CDPK_SOYBN/34-292    MHRDLKPENFLFDTID.....E...........DAKLKATDFGLSVFYK.
CDR1_SCHPO/12-258    RHRDLKLENILIKVN..................EQQIKIADFGMATVEP.
CHK1_SCHPO/10-272    AHRDLKPENILLDYN...................GNLKISDFGFASLFSY
CLK1_MOUSE/160-476   THTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDD.
CTK1_YEAST/183-469   LHRDVKGSNILIDNQ...................GNLKITDFGLARKMN.
ERK1_CANAL/68-371    LHRDLKPSNLLLNSN...................CDLKICDFGLARSIAS
ERK3_HUMAN/20-312    LHRDLKPANIFISTED..................LVLKIGDFGLARIVDQ
FUSE_DROME/4-254     LHRDLKPQNVLLDKN...................MHAKLCDFGLARNMT.
HR25_YEAST/9-273     IHRDIKPDNFLMGVGRR................GSTVHVIDFGLSKKYRD
JAK1_HUMAN/571-833   VHGNVCTKNLLLAREG..................IDSECGPFIKLSDPG.
JAK1_HUMAN/864-1137  VHRDLAARNVLVESE...................HQVKIGDFGLTKAIET
KAB7_YEAST/1096-1354 VHRDIKDENVIVDSK...................GFVKIIDFGSAAYVK.
KAKT_MLVAT/171-429   VYRDLKLENLMLDKD...................GHIKITDFGLCKEGIK
KC21_CHICK/39-324    MHRDVKPHNVMIDHEH..................RKLRLIDWGLAEFYHP
KCC4_MOUSE/42-296    VHRDLKPENLLYATP.A....P...........DAPLKIADFGLSKIV..
KCR8_YEAST/316-590   CHRDLKPENLLLTHD...................GVLKITDFGNSECFKM
KG3A_RAT/119-403     CHRDIKPQNLLVDPDT..................AVLKLCDFGSAKQLVR
KGP1_DROME/457-717   IYRDLKPENLMLDER...................GYVKIVDFGFAKQIG.
KI28_YEAST/7-290     LHRDLKPNNLLFSPD...................GQIKVADFGLARAIP.
KI82_YEAST/324-602   IYRDLKPENILLHQS...................GHVMLSDFDLSIQATG
KIN1_SCHPO/125-395   VHRDLKIENILISKT...................GDIKIIDFGLSNLYR.
KIR1_HUMAN/208-495   AHRDLKSKNILVKKN...................GQCCIADLGLAVMHSQ
KKIA_HUMAN/5-288     IHRDVKPENILITKH...................SVIKLCDFGFARLLTG
KKL6_YEAST/192-508   IHRDLKLENILLKYSFDDINSFRDSPIY...CKQNFIELADFGLCKKIE.
KMIL_AVIMH/82-339    IHRDMKSNNIFLHGG...................LTVKIGDFGLATVKSR
KML2_CHICK/1453-1708 VHLDLKPENIMCVNKTG.................TSIKLIDFGLARRLE.
KMOS_CERAE/60-338    VHLDLKPANILISEQ...................DVCKISDFGCSEKLED
KPBH_RAT/24-291      VHRDLKPENILLDDN...................MQIRLSDFGFSCHLE.
KPIM_HUMAN/38-290    LHRDIKDENILIDLN..................RGELKLIDFGSGALLK.
KPK2_PLAFK/111-364   VHRDLKMENLMLENPN.....D...........PSSLKIIDFGLASFLN.
KPRO_MAIZE/534-812   IHCDVKPENILLDQA...................FEPKITDFGLVKLLNR
KR1_HSV11/191-478    IHRDIKTENIFINTP...................EDICLGDFGAACFVQG
KR1_PRVKA/53-332     MHRDVKAENIFLEDV...................DTVCLGDLGAARCN..
KS61_MOUSE/407-664   VHRDLKPSNILYVDESG....N...........PECLRICDFGFAKQLR.
KYK1_DICDI/1289-1559 LHRDLSSRNILLDHNIDPKNPVVSS......RQDIKCKISDFGLSRLKKE
KYK2_DICDI/108-364   VHRDLTSQNILLDEL...................GNIKISDFGLSAEKSR
MAK_RAT/4-284        FHRDMKPENLLCMGP...................ELVKIADFGLARELR.
MEK1_YEAST/162-444   VHRDLKLDNILLCTP.E....P...........CTRIVLADFGIAKDLN.
MET_HUMAN/1078-1337  VHRDLAARNCMLDEK...................FTVKVADFGLARDMYD
MKK1_YEAST/221-488   IHRDIKPQNILLNEN...................GQVKLCDFGVSGEAV.
MLK1_HUMAN/3-262     IHRDLKSSNILILQKVENGDLS...........NKILKITDFGLAREWH.
NINL_DROME/16-282    LHRDIRGDNILLTKN...................GRVKLCDFGLSRQVDS
NPR1_YEAST/438-742   AHRDLKLDNCVINEK...................GIVKLIDFGAAVVFSY
PHY_CERPU/1004-1282  IHRDLKSMNILVKSVKVTKSEIG..........YVHVKVADFGLSKTKDS
PKD1_DICDI/36-291    IYRDLKPENILIDEK...................GHIKLTDFGFSKKTVG
PKN1_MYXXA/59-321    VHRDLKPDNIFLVRRNGN...............APFVKVLDFGIAKLADA
RAN1_SCHPO/18-295    YHRDLKPENIMVGNDG..................NTVYLADFGLATTEPY
RYK_HUMAN/327-593    IHKDLAARNCVIDDT...................LQVKITDNALSRDLFP
SGV1_YEAST/60-366    MHRDIKTANILIDHN...................GVLKLADFGLARLYYG
SPK1_YEAST/198-466   SHRDLKPDNILIEQD......D...........PVLVKITDFGLAKVQG.
ST20_YEAST/620-871   LHRDIKSDNILLSME...................GDIKLTDFGFCAQIN.
STE7_YEAST/191-466   IHRDIKPSNVLINSK...................GQIKLCDFGVSKKLIN
SYK_PIG/364-619      VHRDLAARNVLLVTQ...................HYAKISDFGLSKALRA
TOP_DROME/938-1194   VHRDLAARNVLVQTP...................SLVKITDFGLAKLLSS
TRKA_HUMAN/504-775   VHRDLATRNCLVGQG...................LVVKIGDFGMSRDIYS
TTK_HUMAN/509-775    VHSDLKPANFLIVDG....................MLKLIDFGIANQMQP
WEE1_HUMAN/299-569   VHMDIKPSNIFISRTSI....P...........NAASEEGDEDDWASN..

7LES_DROME/2209-2481 S.................DYYRKEGEGLLPVRWMSPES............
ABL1_CAEEL/296-547   D.................TYTAHAGAKFPIKWT.APEG............
ARK1_BOVIN/191-453   ...................KKKPHASVGTHGYM.APEV............
AVR2_HUMAN/192-479   G................KSAGDTHGQVGTRRYM.APEV............
BFR2_HUMAN/367-643   .................IDYYKKTTNGRLPVKWMAPEA............
BYR1_SCHPO/66-320    ....................SVAQTFVGTSTYM.SPER............
BYR2_SCHPO/394-658   N............STSTKTGGARPSFQGSSFWM.APEV............
CC15_YEAST/25-272    ....................SSALTLAGTLNWM.APEI............
CC21_MEDSA/1-284     .................IPVRTFTHEVVTLWYR.APEIL...........
CC5_YEAST/82-337     ..................ESERKYTICGTPNYI.APEV............
CDPK_SOYBN/34-292    ..................PGESFCDVVGSPYYV.APEV............
CDR1_SCHPO/12-258    ..................NDSCLENYCGSLHYL.APEI............
CHK1_SCHPO/10-272    K................GKSRLLNSPVGSPPYA.APEI............
CLK1_MOUSE/160-476   ....................EHHSTLVSTRHYR.APEV............
CTK1_YEAST/183-469   ..................SRADYTNRVITLWYR.PPEL............
ERK1_CANAL/68-371    Q...............EDNYGFMTEYVATRWYR.APEI............
ERK3_HUMAN/20-312    HYS...............HKGYLSEGLVTKWYR.SPRL............
FUSE_DROME/4-254     .................LGTHVLTSIKGTPLYM.APEL............
HR25_YEAST/9-273     FN...........THRHIPYRENKSLTGTARYA.SVNT............
JAK1_HUMAN/571-833   ................IPITVLSRQECIERIPWIAPEC............
JAK1_HUMAN/864-1137  D................KEYYTVKDDRDSPVFWYAPEC............
KAB7_YEAST/1096-1354 ...................SGPFDVFVGTIDYA.APEV............
KAKT_MLVAT/171-429   ..................DGATMKTFCGTPEYL.APEV............
KC21_CHICK/39-324    ...................GQEYNVRVASRYFK.GPEL............
KCC4_MOUSE/42-296    .................EHQVLMKTVCGTPGYC.APEI............
KCR8_YEAST/316-590   AWEK..............NIHLSGGVCGSSPYI.APEEY...........
KG3A_RAT/119-403     ...................GEPNVSYICSRYYR.APEL............
KGP1_DROME/457-717   ..................TSSKTWTFCGTPEYV.APEI............
KI28_YEAST/7-290     .................APHEILTSNVVTRWYR.APEL............
KI82_YEAST/324-602   SKKPTMKDSTYLDTKICSDGFRTNSFVGTEEYL.APEV............
KIN1_SCHPO/125-395   ..................RQSRLRTFCGSLYFA.APEL............
KIR1_HUMAN/208-495   STN..............QLDVGNNPRVGTKRYM.APEV............
KKIA_HUMAN/5-288     ..................PSDYYTDYVATRWYR.SPEL............
KKL6_YEAST/192-508   ..................NNEMCTARCGSEDYV.SPEI............
KMIL_AVIMH/82-339    WS................GSQQVEQPTGSILWM.APEVIR..........
KML2_CHICK/1453-1708 ..................SAGSLKVLFGTPEFV.APEV............
KMOS_CERAE/60-338    ...............LLCFQTPLYPLGGTYTHR.APEL............
KPBH_RAT/24-291      ..................PGEKLRELCGTPGYL.APEI............
KPIM_HUMAN/38-290    ...................DTVYTDFDGTRVYS.PPEW............
KPK2_PLAFK/111-364   ...................SPSMNMRCGSPGYV.APEI............
KPRO_MAIZE/534-812   G................GSTQNVSHVRGTLGYI.APEW............
KR1_HSV11/191-478    S................RSSPFPYGIAGTIDTN.APEV............
KR1_PRVKA/53-332     .................VAAPNFYGLAGTIETN.APEV............
KS61_MOUSE/407-664   .................AENGLLMTPCYTANFV.APEV............
KYK1_DICDI/1289-1559 ..................QASQMTQSVGCIPYM.APEV............
KYK2_DICDI/108-364   E................GSMTMTNGGICNPRWR.PPEL............
MAK_RAT/4-284        ..................SQPPYTDYVSTRWYR.APEVL...........
MEK1_YEAST/162-444   .................SNKERMHTVVGTPEYC.APEVGFRANRKAYQSF
MET_HUMAN/1078-1337  K...............EYYSVHNKTGAKLPVKWMALES............
MKK1_YEAST/221-488   ...................NSLATTFTGTSFYM.APER............
MLK1_HUMAN/3-262     ...................RTTKMSAAGTYAWM.APEV............
NINL_DROME/16-282    ..................TLGKRGTCIGSPCWM.APEVVS..........
NPR1_YEAST/438-742   P..............FSKNLVEASGIVGSDPYL.APEVC...........
PHY_CERPU/1004-1282  S................TRYSNQTWNRGTNRWM.APEVINLG........
PKD1_DICDI/36-291    ...................GKNTSSVCGTFDYM.APEI............
PKN1_MYXXA/59-321    H................MPQTHAGIIVGTPEYM.APEQ............
RAN1_SCHPO/18-295    SSDFGCG..SLFYMSPECQREVKKLSSLSDMLPVTPEP............
RYK_HUMAN/327-593    .................MDYHCLGDNENRPVRWMALES............
SGV1_YEAST/60-366    CPPNLKYPG......GAGSGAKYTSVVVTRWYR.APELV...........
SPK1_YEAST/198-466   ..................NGSFMKTFCGTLAYV.APEVIR..........
ST20_YEAST/620-871   .................ELNLKRTTMVGTPYWM.APEV............
STE7_YEAST/191-466   ....................SIADTFVGTSTYM.SPER............
SYK_PIG/364-619      D................ENYYKAQTHGKWPVKWYAPEC............
TOP_DROME/938-1194   D.................SNEYKAAGGKMPIKWLALEC............
TRKA_HUMAN/504-775   .................TDYYRVGGRTMLPIRWMPPES............
TTK_HUMAN/509-775    ................DTTSVVKDSQVGTVNYM.PPEAIKDMS.......
WEE1_HUMAN/299-569   ..................KVMFKIGDLGHVTRISSPQV............

7LES_DROME/2209-2481 .....LVD......GLFTTQSDVWAFGVLCWEILTLG.............
ABL1_CAEEL/296-547   .....LAF......NTFSSKSDVWAFGVLLWEIATYG.............
ARK1_BOVIN/191-453   .....LQKG.....VAYDSSADWFSLGCMLFKLLRG..............
AVR2_HUMAN/192-479   .....LEGAIN.FQRDAFLRIDMYAMGLVLWELASRCTAADG........
BFR2_HUMAN/367-643   .....LFD......RVYTHQSDVWSFGVLMWEIFTLG.............
BYR1_SCHPO/66-320    .....IRG......GKYTVKSDIWSLGISIIELATQ..............
BYR2_SCHPO/394-658   .....VKQ......TMHTEKTDIWSLGCLVIEMLTS..............
CC15_YEAST/25-272    .....LGN......RGASTLSDIWSLGATVVEMLTK..............
CC21_MEDSA/1-284     .....LGS......RHYSTPVDVWSVGCIFAEMANRRP............
CC5_YEAST/82-337     .....LMG....KHSGHSFEVDIWSLGVMLYALLIG..............
CDPK_SOYBN/34-292    .....LR.......KLYGPESDVWSAGVILYILLS...............
CDR1_SCHPO/12-258    .....VSHK.....PYRGAPADVWSCGVILYSLLSN..............
CHK1_SCHPO/10-272    ......TQ......QYDGSKVDVWSCGIILFALLLG..............
CLK1_MOUSE/160-476   .....ILA......LGWSQPCDVWSIGCILIEYYLGFTVFPTHD......
CTK1_YEAST/183-469   .....LLG.....TTNYGTEVDMWGCGCLLVELFNKTAIFQ.........
ERK1_CANAL/68-371    .....MLT.....FQEYTTAIDVWSVGCILAEMLSGRPLFPGRDYHNQLW
ERK3_HUMAN/20-312    .....LLSP.....NNYTKAIDMWAAGCILAEMLTG..............
FUSE_DROME/4-254     .....LAD......EPYDHHADMWSLGCIAYESMAG..............
HR25_YEAST/9-273     .....HLG......IEQSRRDDLESLGYVLIYFCKG..............
JAK1_HUMAN/571-833   .....VEDS.....KNLSVAADKWSFGTTLWEICYNG.............
JAK1_HUMAN/864-1137  .....LMQ......SKFYIASDVWSFGVTLHELLTYCD............
KAB7_YEAST/1096-1354 .....LGGN.....PYEGQPQDIWAIGILLYTVVFK..............
KAKT_MLVAT/171-429   .....LED......NDYGRAVDWWGLGVVMYEMMCG..............
KC21_CHICK/39-324    .....LVDY.....QMYDYSLDMWSLGCMLASMIFRKEP...........
KCC4_MOUSE/42-296    .....LRG......CAYGPEVDMWSVGIITYILL................
KCR8_YEAST/316-590   .....IKE......EFDPRPVDIWACGVIYMAMRTG..............
KG3A_RAT/119-403     .....IFG.....ATDYTSSIDVWSAGCVLAELLLGQPIFP.........
KGP1_DROME/457-717   .....ILN......KGHDRAVDYWALGILIHELLNG..............
KI28_YEAST/7-290     .....LFG.....AKHYTSAIDIWSVGVIFAELMLRIPYLP.........
KI82_YEAST/324-602   .....IRG......NGHTAAVDWWTLGILIYEMLFG..............
KIN1_SCHPO/125-395   .....LNAQ.....PYIGPEVDVWSFGIVLYVLVCG..............
KIR1_HUMAN/208-495   .....LDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNG.........
KKIA_HUMAN/5-288     .....LVG.....DTQYGPPVDVWAIGCVFAELLSGVPLWP.........
KKL6_YEAST/192-508   .....LMG.....VPYDGHLSDTWALGVILYSLFED..............
KMIL_AVIMH/82-339    .....MQDS.....NPFSFQSDVYSYGIVLYELMTG..............
KML2_CHICK/1453-1708 .....INY......EPIGYETDMWSIGVICYILVSG..............
KMOS_CERAE/60-338    .....LKG......EGVTPKADIYSFAITLWQMTTK..............
KPBH_RAT/24-291      .....LKCSMDETHPGYGKEVDLWACGVILFTLLAG..............
KPIM_HUMAN/38-290    .....IRYH.....RYHGRSAAVWSLGILLYDMVCG..............
KPK2_PLAFK/111-364   .....LKC......ASYGTKVDIFSLGVILFNIL................
KPRO_MAIZE/534-812   .....VSS......LPITAKVDVYSYGVVLLELLTG..............
KR1_HSV11/191-478    .....LAG......DPYTTTVDIWSAGLVIFETAVHNASLFSAPRGP...
KR1_PRVKA/53-332     .....LAR......DRYDTKVDVWGAGVVLFETLAYPKTITGG.DEP...
KS61_MOUSE/407-664   .....LKR......QGYDEGCDIWSLGILLYTMLAG..............
KYK1_DICDI/1289-1559 .....FKG......DSNSEKSDVYSYGMVLFELLTS..............
KYK2_DICDI/108-364   .....TKN.....LGHYSEKVDVYCFSLVVWEILTG..............
MAK_RAT/4-284        .....LRS......SVYSSPIDVWAVGSIMAELYTFRPLFPG........
MEK1_YEAST/162-444   SRAATLEQ......RGYDSKCDLWSLGVITHIMLTG..............
MET_HUMAN/1078-1337  .....LQT......QKFTTKSDVWSFGVVLWELMTRG.............
MKK1_YEAST/221-488   .....IQG......QPYSVTSDVWSLGLTILEVANG..............
MLK1_HUMAN/3-262     .....IRA......SMFSKGSDVWSYGVLLWELLTG..............
NINL_DROME/16-282    ....AMESR....EPDITVRADVWALGITTIELADG..............
NPR1_YEAST/438-742   .....IFA......KYDPRPVDIWSSAIIFACMILKKFPWKIPKLRDNSF
PHY_CERPU/1004-1282  YESTEGEISFDGKVPKYPLKSDVYSFGMVCYEVLTG..............
PKD1_DICDI/36-291    .....LNSS.....NGHGKPVDWWALGVVVYELVTG..............
PKN1_MYXXA/59-321    .....SLG......RGVDGRADLYALGVIAYQLLTG..............
RAN1_SCHPO/18-295    .....IESQ...SSSFATAPNDVWALGIILINLCCK..............
RYK_HUMAN/327-593    .....LVN......NEFSSASDVWAFGVTLWELMTLG.............
SGV1_YEAST/60-366    .....LGD......KQYTTAVDIWGVGCVFAEFFEKKP............
SPK1_YEAST/198-466   GKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTG..............
ST20_YEAST/620-871   .....VSR......KEYGPKVDIWSLGIMIIEMIEG..............
STE7_YEAST/191-466   .....IQG......NVYSIKGDVWSLGLMIIELVTG..............
SYK_PIG/364-619      .....INY......YKFSSKSDVWSFGVLMWEAFSYG.............
TOP_DROME/938-1194   .....IRN......RVFTSKSDVWAFGVTIWELLTFG.............
TRKA_HUMAN/504-775   .....ILY......RKFTTESDVWSFGVVLWEIFTYG.............
TTK_HUMAN/509-775    .....SSRENGKSKSKISPKSDVWSLGCILYYMTYG..............
WEE1_HUMAN/299-569   .....EEG......DSRFLANEVLQENYTHLPKA....DIFAL.......

7LES_DROME/2209-2481 .....................QQPYAAR.......NNFEVLAHVKEG...
ABL1_CAEEL/296-547   .....................MAPYPG........VELSNVYGLLENG..
ARK1_BOVIN/191-453   .....................HSPFRQ........HKTKDKHEIDRMT..
AVR2_HUMAN/192-479   ................PVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKR..
BFR2_HUMAN/367-643   .....................GSPYPG........IPVEELFKLLKEG..
BYR1_SCHPO/66-320    .....................ELPWSFSNI.DDSIGILDLLHCIVQE...
BYR2_SCHPO/394-658   .....................KHPYPN.......CDQMQAIFRIGEN...
CC15_YEAST/25-272    .....................NPPYHN........LTDANIYYAVEN...
CC21_MEDSA/1-284     ...LSPGDSEIDELFKIFRILGTPNED......TWPGVTSLPDFKSTFPR
CC5_YEAST/82-337     .....................KPPFQAR.......DVNTIYERIKCR...
CDPK_SOYBN/34-292    ....GVPP...........FWAESEP.........GIFRQILLGKLD...
CDR1_SCHPO/12-258    .....................KLPFGG........QNTDVIYNKIRHG..
CHK1_SCHPO/10-272    .....................NTPWDEA......ISNTGDYLLYKKQCE.
CLK1_MOUSE/160-476   ..........SREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDEHS
CTK1_YEAST/183-469   ......GSNELEQIESIFKIMGTPTINSWP.TLYDMPWFFMIMPQQTTKY
ERK1_CANAL/68-371    LIMEVLGTPNMEDYYNIKSKRAREYIRSLP.FCKKIPFSELFANTNNN..
ERK3_HUMAN/20-312    ...RMLFAGAHELEQMQLILETIPVIRE....EDKDELLRVMPSFVSSTW
FUSE_DROME/4-254     .....................QPPFCA........SSILHLVKMIKH...
HR25_YEAST/9-273     .....................SLPWQG....LKATTKKQKYDRIMEKK..
JAK1_HUMAN/571-833   .....................EIPLKD........KTLIEKERFYES...
JAK1_HUMAN/864-1137  ...................SDSSPMALFLKMIGPTHGQMTVTRLVNTLK.
KAB7_YEAST/1096-1354 .....................ENPFY..........NIDEILEGDLK...
KAKT_MLVAT/171-429   .....................RLPFYN........QDHEKLFELILM...
KC21_CHICK/39-324    ..FFHGHDNYDQLVRIAKVLGTEDLYDYID.KYNIELDPRFNDILGRHSR
KCC4_MOUSE/42-296    ......CG.............FEPFYD........ERGDQFMFRRILNC.
KCR8_YEAST/316-590   .....................RQLWSSAE...KDDPFYMNYLKGRKEK..
KG3A_RAT/119-403     ......GDSGVDQLVEIIKVLGTPTREQIR.EMNPNYTEFKFPQIKAHP.
KGP1_DROME/457-717   .....................TPPFSAP.......DPMQTYNLILKG...
KI28_YEAST/7-290     ......GQNDVDQMEVTFRALGTPTDRDWP.EVSSFMTYNKLQIYPPPS.
KI82_YEAST/324-602   .....................CTPFKG........DNSNETFSNILT...
KIN1_SCHPO/125-395   .....................KVPFDD........QNMSALHAKIKK...
KIR1_HUMAN/208-495   ................IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQ...
KKIA_HUMAN/5-288     ....GKSDVDQLYLIRKTLGDLIPRHQ......QVFSTNQYFSGVKIPDP
KKL6_YEAST/192-508   .....................RLPFDPP.....PNASARQRSRATSHR..
KMIL_AVIMH/82-339    .....................ELPYSHIN...NRDQIIFMVGRGYASP..
KML2_CHICK/1453-1708 .....................LSPFMG....DNDNETLANVTSATWD...
KMOS_CERAE/60-338    .....................QAPYSGE.....RQHILYAVVAYDLRP..
KPBH_RAT/24-291      ......SP...............PFWHR....RQILMLRMIMEGQYQ...
KPIM_HUMAN/38-290    .....................DIPFEH..........DEEIIRGQVF...
KPK2_PLAFK/111-364   ......CG.............YPPFRG........NNVKEIFKKNMR.C.
KPRO_MAIZE/534-812   ............TRVSELVGGTDEVHSMLR.KLVRMLSAKLEGEEQSWID
KR1_HSV11/191-478    ..KRGPCDSQITRIIRQAQVHVDEFSPHPE.SRLTSRYRSRAAGNNRPP.
KR1_PRVKA/53-332     .AINGEMH..LIDLIRALGVHPEEFP..PD.TRLRSEFVRYAGTHRQP..
KS61_MOUSE/407-664   ..YTPFAN............GPSDTP........EEILTRIGSGKFT...
KYK1_DICDI/1289-1559 .....................DEPQQD.......MKPMKMAHLAAYES..
KYK2_DICDI/108-364   .....................EIPFSD.......LDGSQRSAQVAYAG..
MAK_RAT/4-284        .......TSEVDEIFKICQVLGTPKKSD.....WPEGYQLASSMNFRFPQ
MEK1_YEAST/162-444   .....................ISPFYG........DGSERSIIQNAKIG.
MET_HUMAN/1078-1337  .....................APPYPD.......VNTFDITVYLLQG...
MKK1_YEAST/221-488   .....................KFPCSSEKM.AANIAPFELLMWILTFTP.
MLK1_HUMAN/3-262     .....................EVPFRG.......IDGLRVAYGVAMN...
NINL_DROME/16-282    .....................KPPFAD.......MHPTRAMFQIIRNP..
NPR1_YEAST/438-742   KLFCSGRD.CDSLSSLVTRTPDPPSYDESH.STEKKKPESSSNNVSDPNN
PHY_CERPU/1004-1282  .....................DVPFPE.......EKNPNNVKRMVLEG..
PKD1_DICDI/36-291    .....................KLPFS.........NSKESLLNRKAD...
PKN1_MYXXA/59-321    .....................RLPFND.......EGLAAQLVAHQLRPP.
RAN1_SCHPO/18-295    .....................RNPWKR......ACSQTDGTYRSYVHN..
RYK_HUMAN/327-593    .....................QTPYVD.......IDPFEMAAYLKDG...
SGV1_YEAST/60-366    ...ILQGKTDIDQGHVIFKLLGTPTEEDWA.VARYLPGAELTTTNYKP..
SPK1_YEAST/198-466   .....................HLPFSG....STQDQLYKQIGRGSYH...
ST20_YEAST/620-871   .....................EPPYLN.......ETPLRALYLIATNG..
STE7_YEAST/191-466   .....................EFPLGG......HNDTPDGILDLLQRIVN
SYK_PIG/364-619      .....................QKPYRG........MKGSEVSAMLEKG..
TOP_DROME/938-1194   .....................QRPHEN........IPAKDIPDLIEVG..
TRKA_HUMAN/504-775   .....................KQPWYQ.......LSNTEAIDCITQG...
TTK_HUMAN/509-775    .....................KTPFQQ......IINQISKLHAIIDPN..
WEE1_HUMAN/299-569   .ALTVVCA...........AGAEPLP.........RNGDQWHEIRQG...

7LES_DROME/2209-2481 ..........GRLQQPPMCTEK....LYSLLLLCWRTDPWERP.....SF
ABL1_CAEEL/296-547   ..........FRMDGPQGCPPS....VYRLMLQCWNWSPSDRP.....RF
ARK1_BOVIN/191-453   ........LTMAVELPDSFSPE....LRSLLEGLLQRDVNRRLGCLGRGA
AVR2_HUMAN/192-479   .........PVLRDYWQKHAGMA..MLCETIEECWDHDAEARL.....SA
BFR2_HUMAN/367-643   ..........HRMDKPANCTNE....LYMMMRDCWHAVPSQRP.....TF
BYR1_SCHPO/66-320    ..........EPPRLPSSFPED....LRLFVDACLHKDPTLRAS.....P
BYR2_SCHPO/394-658   ..........ILPEFPSNISSS....AIDFLEKTFAIDCNLRP.....TA
CC15_YEAST/25-272    ..........DTYYPPSSFSEP....LKDFLSKCFVKNMYKRP.....TA
CC21_MEDSA/1-284     W......PSKDLATVVPNLEPA....GLDLLNSMLCLDPTKRI.....TA
CC5_YEAST/82-337     .........DFSFPRDKPISDE....GKILIRDILSLDPIERP.....SL
CDPK_SOYBN/34-292    ..........FHSEPWPSISDS....AKDLIRKMLDQNPKTRL.....TA
CDR1_SCHPO/12-258    ...........AYDLPSSISSA....AQDLLHRMLDVNPSTRI.....TI
CHK1_SCHPO/10-272    .........RPSYHPWNLLSPG....AYSIITGMLRSDPFKRY.....SV
CLK1_MOUSE/160-476   SAGRYVSRRCKPLKEFMLSQDAEHEFLFDLVGKILEYDPAKRI.....TL
CTK1_YEAST/183-469   V......NNFSEKFKSVLPSSK....CLQLAINLLCYDQTKRF.....SA
ERK1_CANAL/68-371    .......TSTSNTGGRTNINPL....ALDLLEKLLIFNPAKRI.....TV
ERK3_HUMAN/20-312    E......VKRPLRKLLPEVNSE....AIDFLEKILTFNPMDRL.....TA
FUSE_DROME/4-254     ..........EDVKWPSTLTCE....CRSFLQGLLEKDPGLRI.....SW
HR25_YEAST/9-273     ..........LNVSVETLCSGLP.LEFQEYMAYCKNLKFDEKP......D
JAK1_HUMAN/571-833   ..........RCRPVTPSCKE.....LADLMTRCMNYDPNQRP.....FF
JAK1_HUMAN/864-1137  ........EGKRLPCPPNCPDE....VYQLMRKCWEFQPSNRT.....SF
KAB7_YEAST/1096-1354 ............FNNAEEVSED....CIELIKSILNRCVPKRP.....TI
KAKT_MLVAT/171-429   ..........EEIRFPRTLGPE....AKSLLSGLLKKDPTQRLGGGSEDA
KC21_CHICK/39-324    KR....WERFVHSENQHLVSPE....ALDFLDKLLRYDHQSRL.....TA
KCC4_MOUSE/42-296    .......EYYFISPWWDEVSLN....AKDLVKKLIVLDPKKRL.....TT
KCR8_YEAST/316-590   .........GGYEPIESLKRAR....CRNVIYSMLDPVPYRRI.....NG
KG3A_RAT/119-403     ..........WTKVFKSRTPPE....AIALCSSLLEYTPSSRL.....SP
KGP1_DROME/457-717   .........IDMIAFPKHISRW....AVQLIKRLCRDVPSERLGYQTGGI
KI28_YEAST/7-290     ........RDELRKRFIAASEY....ALDFMCGMLTMNPQKRW.....TA
KI82_YEAST/324-602   ........KDVKFPHDKEVSKN....CKDLIKKLLNKNEAKRLGSKS.GA
KIN1_SCHPO/125-395   ..........GTVEYPSYLSSD....CKGLLSRMLVTDPLKRA.....TL
KIR1_HUMAN/208-495   ..........RPNIPNRWFSDPTLTSLAKLMKECWYQNPSARL.....TA
KKIA_HUMAN/5-288     E......DMEPLELKFPNISYP....ALGLLKGCLHMDPTERL.....TC
KKL6_YEAST/192-508   ........IARFDWRWYRLSDY....KTNVG.KQIVENTLTRKN.QRWSI
KMIL_AVIMH/82-339    ..........DLSKLYKNCPKA....MKRLVADCLKKVREERP.....LF
KML2_CHICK/1453-1708 ..........FDDEAFDEISDD....AKDFISNLLKKDMKSRL.....NC
KMOS_CERAE/60-338    ........SLSAAVFQDSLPGQ...RLGDVIRRCWRPSAAQRP.....SA
KPBH_RAT/24-291      ..........FSSPEWDDRSNT....VKDLIAKLLQVDPNARL.....TA
KPIM_HUMAN/38-290    ..............FRQRVSSE....CQHLIRWCLALRPSDRP.....TF
KPK2_PLAFK/111-364   .......HISFNTKHWINKSES....VKEIILWMCCKNPDDRC.....TA
KPRO_MAIZE/534-812   GY....LDSKLNRPVNYVQART....LIKLAVSCLEEDRSKRP.....TM
KR1_HSV11/191-478    .......YTRPAWTRYYKMDID....VEYLVCKALTFDGALRP.....SA
KR1_PRVKA/53-332     .......YTQYARVARLGLPET....GAFLIYKMLTFDPVRRP.....SA
KS61_MOUSE/407-664   ..........LSGGNWNTVSET....AKDLVSKMLHVDPHQRL.....TA
KYK1_DICDI/1289-1559 ..........YRPPIPLTTSSK....WKEILTQCWDSNPDSRP.....TF
KYK2_DICDI/108-364   ..........LRPPIPEYCDPE....LKLLLTQCWEADPNDRP.....PF
MAK_RAT/4-284        C......IPINLKTLIPNASSE....AIQLMTEMLNWDPKKRP.....TA
MEK1_YEAST/162-444   .......KLNFKLKQWDIVSDN....AKSFVKDLLQTDVVKRL.....NS
MET_HUMAN/1078-1337  ..........RRLLQPEYCPDP....LYEVMLKCWHPKAEMRP.....SF
MKK1_YEAST/221-488   .......ELKDEPESNIIWSPS....FKSFIDYCLKKDSRERP.....SP
MLK1_HUMAN/3-262     .........KLALPIPSTCPEP....FAKLMEDCWNPDPHSRP.....SF
NINL_DROME/16-282    .........PPTLMRPTNWSKQ....INDFISESLEKNAENRP.....MM
NPR1_YEAST/438-742   .......VNIGPQRLLHSLPEE....TQHIVGRMIDLAPACRG.....NI
PHY_CERPU/1004-1282  ..........VRPDLPAHCPIE....LKALITDCWNQDPLKRP......S
PKD1_DICDI/36-291    .........FQLIFQNSYLSDE....IKDFIFQLLSVDPSKRLG..TFDS
PKN1_MYXXA/59-321    .........PPPSSVYPAVSAA....LEHVILRALAKKPEDRY....ASI
RAN1_SCHPO/18-295    .........PSTLLSILPISRE....LNSLLNRIFDRNPKTRI.....TL
RYK_HUMAN/327-593    ..........YRIAQPINCPDE....LFAVMACCWALDPEERP.....KF
SGV1_YEAST/60-366    .........TLRERFGKYLSET....GLDFLGQLLALDPYKRL.....TA
SPK1_YEAST/198-466   ..........EGPLKDFRISEE....ARDFIDSLLQVDPNNRS.....TA
ST20_YEAST/620-871   .........TPKLKEPENLSSS....LKKFLDWCLCVEPEDRA.....SA
STE7_YEAST/191-466   .......EPSPRLPKDRIYSKE....MTDFVNRCCIKNERERS.....SI
SYK_PIG/364-619      ..........ERMGCPPGCPRE....MYELMTLCWTYDVENRP.....GF
TOP_DROME/938-1194   ..........LKLEQPEICSLD....IYCTLLSCWHLDAAMRP.....TF
TRKA_HUMAN/504-775   ..........RELERPRACPPE....VYAIMRGCWQREPQQRH.....SI
TTK_HUMAN/509-775    ..........HEIEFPDIPEKD....LQDVLKCCLKRDPKQRI.....SI
WEE1_HUMAN/299-569   .........RLPRIPQVLSQE.....FTELLKVMIHPDPERRP.....SA

7LES_DROME/2209-2481 RRCYNTL...
ABL1_CAEEL/296-547   RDIHFNL...
ARK1_BOVIN/191-453   QEVKESPFF.
AVR2_HUMAN/192-479   GCVGERI...
BFR2_HUMAN/367-643   KQLVEDL...
BYR1_SCHPO/66-320    QQLCAMPYF.
BYR2_SCHPO/394-658   SELLSHPFV.
CC15_YEAST/25-272    DQLLKHVWI.
CC21_MEDSA/1-284     RSAVEHEYF.
CC5_YEAST/82-337     TEIMDYVWF.
CDPK_SOYBN/34-292    HEVLRHPWI.
CDR1_SCHPO/12-258    PEFFSHPFL.
CHK1_SCHPO/10-272    KHVVQHPWL.
CLK1_MOUSE/160-476   KEALKHPFF.
CTK1_YEAST/183-469   TEALQSDYF.
ERK1_CANAL/68-371    EDALKHPYL.
ERK3_HUMAN/20-312    EMGLQHPYM.
FUSE_DROME/4-254     TQLLCHPFV.
HR25_YEAST/9-273     YLFLARLF..
JAK1_HUMAN/571-833   RAIMRDI...
JAK1_HUMAN/864-1137  QNLIEGF...
KAB7_YEAST/1096-1354 DDINNDKWL.
KAKT_MLVAT/171-429   KEIMQHRFF.
KC21_CHICK/39-324    REAMEHPYF.
KCC4_MOUSE/42-296    FQALQHPWV.
KCR8_YEAST/316-590   KQILNSEWG.
KG3A_RAT/119-403     LEACAHSFF.
KGP1_DROME/457-717   QDIKKHKWF.
KI28_YEAST/7-290     VQCLESDYF.
KI82_YEAST/324-602   ADIKRHPFF.
KIN1_SCHPO/125-395   EEVLNHPWM.
KIR1_HUMAN/208-495   LRIKKTL...
KKIA_HUMAN/5-288     EQLLHHPYF.
KKL6_YEAST/192-508   NEIYESPFV.
KMIL_AVIMH/82-339    PQILSSI...
KML2_CHICK/1453-1708 TQCLQHPWL.
KMOS_CERAE/60-338    RPLLVDL...
KPBH_RAT/24-291      EQALQHPFF.
KPIM_HUMAN/38-290    EEIQNHPWM.
KPK2_PLAFK/111-364   LQALGHQWF.
KPRO_MAIZE/534-812   EHAVQTL...
KR1_HSV11/191-478    AELLCLPLF.
KR1_PRVKA/53-332     DEILNFGMW.
KS61_MOUSE/407-664   KQVLQHPWI.
KYK1_DICDI/1289-1559 KQIIVHL...
KYK2_DICDI/108-364   TYIVNKL...
MAK_RAT/4-284        SQALKHPYF.
MEK1_YEAST/162-444   KQGLKHIWI.
MET_HUMAN/1078-1337  SELVSRI...
MKK1_YEAST/221-488   RQMINHPWI.
MLK1_HUMAN/3-262     TNILDQL...
NINL_DROME/16-282    VEMVEHPFL.
NPR1_YEAST/438-742   EEIMEDPWI.
PHY_CERPU/1004-1282  FAVICQKL..
PKD1_DICDI/36-291    CSIRNHKWF.
PKN1_MYXXA/59-321    AAFRNALQVA
RAN1_SCHPO/18-295    PELSTLV...
RYK_HUMAN/327-593    QQLVQCL...
SGV1_YEAST/60-366    MSAKHHPWF.
SPK1_YEAST/198-466   AKALNHPWI.
ST20_YEAST/620-871   TELLHDEYI.
STE7_YEAST/191-466   HELLHHDLI.
SYK_PIG/364-619      VAVELRL...
TOP_DROME/938-1194   KQLTTVF...
TRKA_HUMAN/504-775   KDVHARL...
TTK_HUMAN/509-775    PELLAHPYV.
WEE1_HUMAN/299-569   MALVKHSVL.