1# STOCKHOLM 1.0 2#=GF ID Orn_DAP_Arg_deC 3#=GF AC PF00278.15 4#=GF DE Pyridoxal-dependent decarboxylase, C-terminal sheet domain 5#=GF AU Finn RD, Griffiths-Jones SR 6#=GF SE Prosite 7#=GF GA 20.10 20.10; 8#=GF TC 20.40 20.10; 9#=GF NC 19.80 20.00; 10#=GF BM hmmbuild HMM.ann SEED.ann 11#=GF SM hmmsearch -Z 9421015 -E 1000 HMM pfamseq 12#=GF TP Domain 13#=GF RN [1] 14#=GF RM 10378276 15#=GF RT Structure of mammalian ornithine decarboxylase at 1.6 A 16#=GF RT resolution: stereochemical implications of PLP-dependent amino 17#=GF RT acid decarboxylases. 18#=GF RA Kern AD, Oliveira MA, Coffino P, Hackert ML; 19#=GF RL Structure Fold Des 1999;7:567-581. 20#=GF DR INTERPRO; IPR000183; 21#=GF DR PROSITE; PDOC00685; 22#=GF DR SCOP; 1qu4; fa; 23#=GF DR HOMSTRAD; Orn_Arg_deC_NC; 24#=GF DR HOMSTRAD; Orn_DAP_Arg_deC; 25#=GF CC These pyridoxal-dependent decarboxylases act on ornithine, 26#=GF CC lysine, arginine and related substrates. 27#=GF SQ 105 28#=GS O14439_USTMA/296-443 AC O14439.1 29#=GS O01579_CAEEL/298-416 AC O01579.1 30#=GS AZIN1_HUMAN/282-406 AC O14977.2 31#=GS ADC_MOUSE/286-408 AC Q8BVM4.1 32#=GS Q7DFY1_SELRU/266-371 AC Q7DFY1.1 33#=GS Q7UFM7_RHOBA/290-397 AC Q7UFM7.1 34#=GS Q7MC63_VIBVY/293-399 AC Q7MC63.1 35#=GS Q70GM6_CHLRE/256-376 AC Q70GM6.1 36#=GS A8BFD3_GIALA/305-445 AC A8BFD3.1 37#=GS DCOR_SOLLC/308-424 AC O22616.2 38#=GS Q7PV11_ANOGA/282-398 AC Q7PV11.4 39#=GS Q7Q083_ANOGA/289-408 AC Q7Q083.4 40#=GS Q7PZ99_ANOGA/280-394 AC Q7PZ99.4 41#=GS DCOR2_DROME/276-390 AC P40808.2 42#=GS A9NCJ9_COXBR/264-371 AC A9NCJ9.1 43#=GS Q98K89_RHILO/273-385 AC Q98K89.1 44#=GS Q6SF82_9BACT/264-372 AC Q6SF82.1 45#=GS Q9X2I6_THEMA/263-370 AC Q9X2I6.1 46#=GS Q82VZ0_NITEU/286-391 AC Q82VZ0.1 47#=GS Q5LXE4_SILPO/280-393 AC Q5LXE4.1 48#=GS Q7CRV2_AGRT5/264-377 AC Q7CRV2.2 49#=GS Q8PS97_METMA/278-390 AC Q8PS97.1 50#=GS Q5YT58_NOCFA/255-366 AC Q5YT58.1 51#=GS O69865_STRCO/277-392 AC O69865.1 52#=GS Q5XQ82_9ARCH/314-419 AC Q5XQ82.1 53#=GS Q604F1_METCA/244-348 AC Q604F1.1 54#=GS Q7VZY7_BORPE/241-343 AC Q7VZY7.1 55#=GS Q88IS0_PSEPK/241-343 AC Q88IS0.1 56#=GS Q5HSR6_CAMJR/244-361 AC Q5HSR6.1 57#=GS P73562_SYNY3/258-365 AC P73562.1 58#=GS Q9RUH6_DEIRA/278-394 AC Q9RUH6.1 59#=GS Q7MAL4_WOLSU/251-357 AC Q7MAL4.1 60#=GS O24865_HELPY/267-385 AC O24865.1 61#=GS Q5LVU5_SILPO/266-369 AC Q5LVU5.1 62#=GS Q72EZ9_DESVH/261-367 AC Q72EZ9.1 63#=GS Q57LZ4_SALCH/318-441 AC Q57LZ4.1 64#=GS Q82HL1_STRAW/330-442 AC Q82HL1.1 65#=GS Q75JL7_DICDI/295-407 AC Q75JL7.1 66#=GS Q7WXK3_RALEH/291-407 AC Q7WXK3.1 67#=GS Q7A862_STAAN/277-393 AC Q7A862.1 68#=GS Q5SEM5_RALSO/282-398 AC Q5SEM5.1 69#=GS Q76KY1_STRHA/280-393 AC Q76KY1.1 70#=GS Q8RKC5_ERWCH/297-409 AC Q8RKC5.1 71#=GS Q7CYS1_AGRT5/270-383 AC Q7CYS1.2 72#=GS Q7N8H2_PHOLL/306-419 AC Q7N8H2.1 73#=GS Q82VG2_NITEU/296-409 AC Q82VG2.1 74#=GS Q5YWM9_NOCFA/340-451 AC Q5YWM9.1 75#=GS Q72WM6_DESVH/318-424 AC Q72WM6.1 76#=GS Q62F85_BURMA/278-395 AC Q62F85.1 77#=GS Q7NPE5_GLOVI/307-415 AC Q7NPE5.1 78#=GS Q7A0X5_STAAW/290-398 AC Q7A0X5.1 79#=GS DCDA_MYCS2/336-449 AC Q9X5M1.1 80#=GS DCDA_ACTPA/309-415 AC O69203.1 81#=GS Q8TY23_METKA/277-383 AC Q8TY23.1 82#=GS Q7N7F9_PHOLL/289-407 AC Q7N7F9.1 83#=GS Q8F7A1_LEPIN/276-395 AC Q8F7A1.1 84#=GS Q8GGR7_STRAZ/284-405 AC Q8GGR7.1 85#=GS DCDA_METJA/305-410 AC Q58497.1 86#=GS DCDA_METJA/305-410 DR PDB; 1tuf B; 315-420; 87#=GS DCDA_METJA/305-410 DR PDB; 1twi D; 315-420; 88#=GS DCDA_METJA/305-410 DR PDB; 1tuf A; 315-420; 89#=GS DCDA_METJA/305-410 DR PDB; 1twi A; 315-420; 90#=GS DCDA_METJA/305-410 DR PDB; 1twi C; 315-420; 91#=GS DCDA_METJA/305-410 DR PDB; 1twi B; 315-420; 92#=GS Q7ULZ0_RHOBA/283-389 AC Q7ULZ0.1 93#=GS Q6SHW6_9BACT/289-395 AC Q6SHW6.1 94#=GS Q5V5E3_HALMA/306-412 AC Q5V5E3.1 95#=GS DCDA_METTH/292-398 AC O27390.1 96#=GS Q87EA9_XYLFT/758-866 AC Q87EA9.1 97#=GS DCDA1_ARATH/351-459 AC Q949X7.1 98#=GS DCDA_PSEFL/285-390 AC O05321.1 99#=GS Q5FPL4_GLUOX/282-390 AC Q5FPL4.1 100#=GS Q9A681_CAUCR/288-394 AC Q9A681.1 101#=GS Q5FEQ0_EHRRW/291-397 AC Q5FEQ0.1 102#=GS Q7MT14_PORGI/263-379 AC Q7MT14.1 103#=GS Q6MM66_BDEBA/286-391 AC Q6MM66.1 104#=GS Q6L350_PICTO/286-391 AC Q6L350.1 105#=GS Q97AJ0_THEVO/281-380 AC Q97AJ0.1 106#=GS Q728N7_DESVH/285-394 AC Q728N7.1 107#=GS Q62B72_BURMA/307-413 AC Q62B72.1 108#=GS Q66B85_YERPS/267-374 AC Q66B85.1 109#=GS Q5NIN9_FRATT/298-400 AC Q5NIN9.1 110#=GS Q8XS02_RALSO/281-396 AC Q8XS02.1 111#=GS SPEA_XYLFT/343-555 AC Q87F25.1 112#=GS Q5NHM0_FRATT/327-467 AC Q5NHM0.1 113#=GS SPEA_PROMP/355-574 AC Q7V3M9.1 114#=GS SPEA_GLOVI/346-557 AC Q7NE10.1 115#=GS Q6MQU4_BDEBA/373-587 AC Q6MQU4.1 116#=GS Q72F01_DESVH/373-585 AC Q72F01.1 117#=GS Q5SHU0_THET8/347-559 AC Q5SHU0.1 118#=GS SPEA_BACTN/346-558 AC Q8A2B1.1 119#=GS O25176_HELPY/412-542 AC O25176.1 120#=GS SPE2_ARATH/396-596 AC O23141.1 121#=GS O04429_DIACA/405-605 AC O04429.1 122#=GS SPE1_AVESA/355-532 AC P22220.1 123#=GS Q5X0L3_LEGPL/343-556 AC Q5X0L3.1 124#=GS SPEA_CHRVO/343-556 AC Q7NU27.1 125#=GS SPEA_VIBVY/354-570 AC Q7MK24.1 126#=GS Q7PZA0_ANOGA/274-386 AC Q7PZA0.3 127#=GS Q60D03_SOLDE/147-257 AC Q60D03.2 128#=GS DCOR_NEUCR/326-471 AC P27121.1 129#=GS DCOR_YEAST/329-460 AC P08432.1 130#=GS DCOR_CANAL/324-468 AC P78599.1 131#=GS Q84527_PBCV1/263-371 AC Q84527.1 132#=GS Q84527_PBCV1/263-371 DR PDB; 2nv9 A; 263-371; 133#=GS Q84527_PBCV1/263-371 DR PDB; 2nv9 H; 263-371; 134#=GS Q84527_PBCV1/263-371 DR PDB; 2nv9 C; 263-371; 135#=GS Q84527_PBCV1/263-371 DR PDB; 2nv9 F; 263-371; 136#=GS Q84527_PBCV1/263-371 DR PDB; 2nva H; 263-371; 137#=GS Q84527_PBCV1/263-371 DR PDB; 2nv9 E; 263-371; 138#=GS Q84527_PBCV1/263-371 DR PDB; 2nva D; 263-371; 139#=GS Q84527_PBCV1/263-371 DR PDB; 2nv9 D; 263-371; 140#=GS Q84527_PBCV1/263-371 DR PDB; 2nv9 G; 263-371; 141#=GS Q84527_PBCV1/263-371 DR PDB; 2nva C; 263-371; 142#=GS Q84527_PBCV1/263-371 DR PDB; 2nva E; 263-371; 143#=GS Q84527_PBCV1/263-371 DR PDB; 2nv9 B; 263-371; 144#=GS Q84527_PBCV1/263-371 DR PDB; 2nva B; 263-371; 145#=GS Q84527_PBCV1/263-371 DR PDB; 2nva F; 263-371; 146#=GS Q84527_PBCV1/263-371 DR PDB; 2nva A; 263-371; 147#=GS Q84527_PBCV1/263-371 DR PDB; 2nva G; 263-371; 148#=GS Q5MNH7_NEOUN/277-400 AC Q5MNH7.1 149#=GS Q58P26_ENTHI/268-382 AC Q58P26.1 150#=GS O15696_PLAFA/807-931 AC O15696.1 151#=GS DCOR_LEIDO/509-682 AC P27116.1 152#=GS P78829_SCHPO/238-357 AC P78829.1 153#=GS O76203_HAECO/287-407 AC O76203.1 154#=GS DCOR_PANRE/294-416 AC P49725.1 155O14439_USTMA/296-443 ALATNIIAVRRGEPSAAM..................................................................................DHVEAT........PKAQVMYY.QNDGLYGS.FNCVIFDHVKFIQSSDAGPRVRVRADDWVARG........................ASGECGRLALQQEAMTLESCSVWGPTCDSID.CV...RD.........HVELPK........GLQVGDWLVYENMGAYTICAAS.TFNGIR..RSEIRYT 156O01579_CAEEL/298-416 TLCTNVIGKRAMDAKFI...................................................................................TNDDFD.........DGVGFVYQTNDGVYGS.FGCKQMDI....KPLCKPLDVE............................................NDSEEQLHFGTILGPTLDGTD.VA..............QRLMKS.......RQLRVGEWLVWEQMGAFTIPVDS.EHS.....VPPVYYY 157AZIN1_HUMAN/282-406 TLAVNIIAKKVVENDKFP.................................................................................SGVEKTG.......SDEPAFMYY.MNDGVYGS.FASKLSED....LNTIPEVHKK............................................YKEDEPLFTSSLWGPSCDELD.QI...VE.........SCLLP.........ELNVGDWLIFDNMGADSFHEPS.AFNDFQ..RPAIYYM 158ADC_MOUSE/286-408 TVAVSIVAKREVLDQASR..................................................................................EEQTGA........APKSIVYY.LDEGVYGV.FNSVLFDN....TCPTPALQKK............................................PSADQPLYSSSLWGPAVEGCD.CV...AE.........GLWLP.........QLQVGDWLVFDNMGAYTVDTKS.LLGGTQ..ARRVTYA 159Q7DFY1_SELRU/266-371 NLVTSVIGTKTRG...........................................................................................EQ.............PWYILDEGIYGC.FSGIMYDH....WTYPLHCF................................................GKGNKKPSTFGGPSCDGID.VL...YR.........DFMAP.........ELKIGDKVLVTEMGSYTSVSAT.RFNGFY..LAPTIIF 160Q7UFM7_RHOBA/290-397 TLITRVIGKSRRWE..........................................................................................LP.............WFF.LDDGIYGS.FSGKIFDH....TDFPLLVEN..............................................DGSRETVPCVVAGPTCDSTD.IV...SR.........DQWLP.........DLEVGELVLVPSMGAYAAASAS.PFNGLP..MANSVAI 161Q7MC63_VIBVY/293-399 TSVASVMGQAEREG..........................................................................................QI.............WYY.LDDGIYGS.FSGLMFDD....ARYPLTTI...............................................KQGGELIPSVLSGPTCDSVD.VI...AE.........NILLP.........KLNNGDLVIGRTMGAYTSATAT.DFNFFK..RAQTIAL 162Q70GM6_CHLRE/256-376 TLLTPVYGQRDRVAAD.....................................................................................GSVKK.............DYW.LTDGLYGS.FNCILYDG....QNPGYKVVRSPL........................................MADSTDSRTFLSTLWGPTCDSAD.CV...YK.........DVTLP.........VLRNGDWLMWNNAGAYTVAGAC.DFNGIEFTTPGKLYV 163A8BFD3_GIALA/305-445 TLGTRIYGRRIIFDKIEDNS.............................................................................CLTEKEIME....SGKASINEVKYY.VGDGVYGY.YNAILFDH....VVPHLRFTDKHGNR...................................KELSGAHAGSSLNTSSIFGPTCDSLD.CI...LK.........ERKLP.........LLDVGDWVITDAFGAYTYAAAT.EFNGIP..HVSVVCC 164DCOR_SOLLC/308-424 TLATTIIGKRVRGE..........................................................................................LK.............EYW.INDGLYGS.MNCVLYDHATVTATPLACMSNRN.........................................NLNCGGSKTFPSTVFGPTCDALD.TV...LR.........DYQLP.........ELQVNDWLIFPNMGAYTKAAGS.NFNGFN..TSAIVTH 165#=GR DCOR_SOLLC/308-424 sAS ......................................................................................................................................................................................................................*......................................................................... 166Q7PV11_ANOGA/282-398 TLVSFVDSKRVMKEKQPD..................................................................................GTEKTR.............MYYYLNDGIFGT.FYCTAHEA....QPAIPIVER..............................................KTGAKDFPTSVWGPTCDVMD.LI...LP.........DVMLP.........ELNVGDSVVFENCGAYGQVLAC.RFNGFP..LPKVIAY 167Q7Q083_ANOGA/289-408 TLLTTVQGKKIVRDDA.....................................................................................GQIQQ.............MMYYINDGVFGTLFDWLSLREIKDLKRAVPLVRR.............................................EREHEPAFPTTIWGPTCDSTD.IV...CE.........DVPYP.........EHHIGDYIVFENLGAYGMTFAT.NFNGFP..KPTVQVY 168Q7PZ99_ANOGA/280-394 TLVTNVQSKRV.CLNAR...................................................................................TGTIDR.............MMYYLNDGVYAS.FNSILYDH....QVPQPKLIG..............................................GQAGKQYKSTLWGPTCDALD.QL...IE.........TIALP.........ELQIDDWVVFENMGAYTIPVAS.PFNGFE..LPKVYCY 169DCOR2_DROME/276-390 TLICKVHAKREVRSKD.....................................................................................GKLDT.............MMYYLNDGIFGAFAGMFYYPE....EVAPELYLD.............................................EAESLPKLKSVIWGPSCDAMD.KI...S..........DLLLP.........NLNPGDLLGFRNMGAYTMPIAS.PFNGFD..VPETRFF 170#=GR DCOR2_DROME/276-390 sAS ......................................................................................................................................................................................................................*......................................................................... 171A9NCJ9_COXBR/264-371 SVIVNVELRKDD...........................................................................................................ILY.INDGTYGSLFDAGIPHF....IFPVHLLRPK............................................HTADVDLLPFSFYGPTCDSLD.YM...KG.........PFYLPN........DIKAGDYIEIGQMGAYGRTLST.AFNGFK..QREGVIM 172Q98K89_RHILO/273-385 SLIVRVLLRKGK...........................................................................................................RLY.INDGIWASLSDSWTGKI....TLPARFIPDPAI.......................................RTRNGAEKNVVPFKVCGATCDSVD.IL...SR.........PFWLPE........TVDTGDWIEIGHIGAYSLSLRT.RFNGFY..PDTFVEV 173Q6SF82_9BACT/264-372 TLATQIKALRGL...........................................................................................................RTVFLNDGVYGL.LSEFRDLG....VSQRYQAWRA...........................................GSKLAGPSAAYTVFGPTCDSID.KL...PS.........PLHLPK........SIQEGDYLLFSEIGAYSLSLAT.AFNGYG..GCEIVAV 174Q9X2I6_THEMA/263-370 WLVTKVLLKSERSG..........................................................................................EK.............WVY.IDAGVFHG.LAETIQNF....EYEIRVLG...............................................KEREELEEYHLAGPTCDSVD.VI...YD.........RIFLPK........SITLNDLVCFINAGAYTVEYNT.RFNGIE..PPKMVFI 175Q82VZ0_NITEU/286-391 CFVCRVVGTATRNG..........................................................................................KR.............WMY.WDAGIFGGIIE..VSEG....LRYEILTQ................................................RNGSLIPWSVAGPTCDSVD.VL...MH.........DEMLPE........DIQENDFIFIPNAGAYTTSYAS.NFNGFP..LPDVVVI 176Q5LXE4_SILPO/280-393 AIAAEVLLVSRKSGH.......................................................................................DLHR.............WVY.LDIGKFSG.LAETMDEA....IRYQFLTE...............................................REHEPTGPCILAGPSCDSAD.VLY.EKK.........PVQLPL........GLRDGDRIVIRNCGAYTSTYASVGFNGFP..PLDVVAI 177Q7CRV2_AGRT5/264-377 VIKAEVVLVSK....................................................................................................KSDNDNHRWVF.LDIGKFGG.LAETMDEA....IRYPIRTE...............................................RDQDEMQPCVLAGPTCDSAD.VL...YEK.......NMYPLPV........SLTIGDEVLIEGTGAYTTTYSAVAFNGFE..PLKAYVI 178Q8PS97_METMA/278-390 IIVSEVIMIAKKARF.......................................................................................NQYK.............WVY.LDIGKFGG.LIETLDEC....IKYPIFCD................................................KKGCAEEVILAGPTCDSMD.ILY.EHH.........KYSFPH........TMRDGNRVYIFTTGAYTQSYSSICFNGFP..PLKAYVI 179Q5YT58_NOCFA/255-366 TIHAEVVAVRIAPD.........................................................................................GRR.............WVY.LDIGRYNG.MAETENEY....IAYRFVTE...............................................RDGDPVDEAVVAGPTCDGDD.VLY.QRT.........RVLLPT........TLRAGDRVQILDTGAYTASYSSVSFNGFP..PLTVHVS 180O69865_STRCO/277-392 AIRAHVVRLTERRAAD.....................................................................................GERQH.............WLY.LSCGKFNG.LYEM..DA....LQYRLVFPG..............................................HPDGPCVPAVVAGPTCDSDD.AYSHEEG.........LVPVPA........ALASGDPVWVLSCGAYATSYTTRGFNGFA..PLPYAFA 181Q5XQ82_9ARCH/314-419 MVVSVIGTAKRGD...........................................................................................NM.............WAY.IDAGIYSGLLDYVIKDK....VFEISILDR.............................................TEPSSKTYKYLLSGPTSDALD.FL...G..........EYSFKK........QLNAGDKLIIKNCGAYTFVLGT.HFGGFN.....HFGF 182Q604F1_METCA/244-348 YLVASVIDVFNSG...........................................................................................GK.............TVAVLDSSINHH.PEVFEYQR....SPRLAEV.................................................CEEGRETAILAGGTCLAGD.LF...G..........EYALPT........RPRIGDRLVFEDVGAYTLVKAN.RFNGHN..LPSIYRW 183Q7VZY7_BORPE/241-343 TLEVTVLDVMRNE............................................................................................K.............NLAIVDAATEAHMLDLLIYRM....SARVQP...................................................DQGPHRYVIYGNSCLAGD.VF...G..........EFSFES........PLQPGSRISIQDAAGYTMVKKN.WFNGVR..MPAIAIR 184Q88IS0_PSEPK/241-343 SLEVTVLDTLYNG............................................................................................K.............HLAVVDSSIEAHLLDLLIYRL....NAKMAP...................................................NDGEHTYMVCGKSCLAGD.IF...G..........EYQFDR........PLAIGDRLSFIDTAGYTMVKKN.WFNGLK..MPSIVVK 185Q5HSR6_CAMJR/244-361 NLVASVVDIIENE............................................................................................K.............QIAILDTSSEAHMPDTIIMPY....TSEVLNARILATRE....................................NEKISDLKENEFSYLLTGNTCLAGD.VM...G..........EYAFDK........KLKIGDKIVFLDQIHYTIVKNT.TFNGIR..LPNLMLL 186P73562_SYNY3/258-365 FLLSTVEDLIETP...........................................................................................EF.............THAMLDVSFTAHMPDCLEMPY....RPEVRGAR...............................................VPQTGDTVYRLGGSSCLAGD.FL...G..........DYAFDQ........PLQVGDRLIFEDMMHYTMVKTT.TFNGVH..HPAIGCL 187Q9RUH6_DEIRA/278-394 WLVSSVLDVVHNV............................................................................................K.............DAALLDVSVSAHMPDVLEMPY....RPRILGAGDPPLD.....................................DHREAQDTGSGYPYIIGGTTCLAGD.VV...G..........EYVFPH........ELKVGSRVVFDDMIHYTMVKTT.FFNGVK..HPDIGIL 188Q7MAL4_WOLSU/251-357 FLLGEVVDVVRNG............................................................................................M.............EIAILDISAAAHMPDCLEMPY....RPMVRGSA...............................................EAGEKRYSYRLGGPTCLAGD.VI...G..........DYSFDS........PLKVGDQLIFEDMIHYTIVKNN.TFNGVP..LPSIGVI 189O24865_HELPY/267-385 FLIASVIDIVQND............................................................................................Q.............EIAILDASFSAHMPDCLEMPY....RPSIFKVSVENDEE...................................LIEVEKGENQGAFSYFLGGPTCLAGD.FM...G..........SFSFET........PLKRGDKIVFQDMLHYTIVKNN.SFNGVP..LPSLARL 190Q5LVU5_SILPO/266-369 ILVGEILDLPSNG............................................................................................M.............DLAITDISATCHMPDVIEAPY....RPALMDE..................................................ADSGHTYRLGGPSCLAGD.VI...G..........DYTWDQ........PLTIGQRFAFLDQAHYSMVKTN.TFNGVP..LPTIALW 191Q72EZ9_DESVH/261-367 VLLCSVLDVVQAD............................................................................................V.............PVVILDTSAAAHMPDVLEMPY....RPGCIGSG...............................................LPDEKAWTCRLAGKSCLAGD.VV...G..........DYSFDR........PLRPGDRLAFLDMAIYSMVKTT.TFNGLQ..LPAIALY 192Q57LZ4_SALCH/318-441 VLLTEVSCEKRK...........................................................................................................TNYDLNGNVECH.VEWKFVDA....GYSVLSDSQHFDWFF.................................YVYNASRMTAAHDAWVKLAGPLCDGGD.YFHMGVKG.......EEFLLPK........ETHVGDIVAFLDAGAYAIESQT.VYNNRP..RTGVVMI 193Q82HL1_STRAW/330-442 TVVARVEYAKSAGG..........................................................................................RA.............VAV.THAGVQVA.TRTVYAPA....SWPLRITAYDA.........................................KGHPKAGPEVVQDVAGPACFAGD.LL...AV.........GRALP.........LLEQGDHVAALDTGAYYFAHHY.AYNSLA..RPGIYGF 194Q75JL7_DICDI/295-407 VVVSTVEYTKSSGD..........................................................................................RE.............IAI.CHAGANMY.IRTVYQFP....LWRIRVTIFDS.........................................NGEYKTGNEKITDIAGPCCFAAD.VL...VK.........ERLLP.........PIKKDDFIMAHDSGAYMLSSYS.HYNLRL..APPIFSF 195Q7WXK3_RALEH/291-407 YYAMEVIDVKHAFD..........................................................................................RA.............FVV.ACGGTHHF.RTPYAQGH....SHPFRVLPVESWR......................................YPFARPGVRDARVSVVGQLCTPKD.VL...AQ.........DAPVD.........SVRAGDMVVFPYAGAYAWHISHHDFLRHP..HPQHCYL 196Q7A862_STAAN/277-393 YYVTEVLDIKKVHG..........................................................................................AW.............YAI.LRGGTQQF.RLPVSWQH....NHPFEIYRYKDNP......................................YSFEKVSISRQDTTLVGQLCTPKD.VF...AR.........EVQID.........AISTGDVIVFKYAGAYGWSISHHDFLSHP..HPEFIYL 197Q5SEM5_RALSO/282-398 YYVTEVVDIKRNHG..........................................................................................KW.............FAV.LRGGTHHF.RLTASWQH....NHPFAIVPNAQWT......................................YPFARPSVQAQAVTLCGELCTPKD.VL...AR.........DVVVD.........RLSVGDRIVFQLAGAYGWHISHHDFLSHP..HPERRFV 198Q76KY1_STRHA/280-393 TLLTRVVNIKVSRG..........................................................................................RK.............FVV.IDAGINTF.GGMSGLGR....LLPVAVEPEYT.........................................GSAEATELTDVASLAGPLCTPGD.IL...GR.........EIRLP.........ELAPGDLVTIPNAGAYGVTASLLMFLGRP..APVEVVL 199Q8RKC5_ERWCH/297-409 LFVTRVNTLKTAGG..........................................................................................KT.............FAV.CDGGANCH.SAAAGLNSMLRKNFPLLRLGD..............................................NQGRPLQPYQVSGPLCTPTD.LL...GD.........NVLLP.........TLEVDDLIGITHSGAYGLTASPGSFLSFG..YPVEVMV 200Q7CYS1_AGRT5/270-383 LYVVEVNSVKT.......................................................................................................SRGTTFVV.TDGGMHHHLAASGNLGQIVKRNYPIVAPAM..............................................MQAAHDETATIVGPLCTPLD.TL...AR.........NATLP.........KLNAGDLLAILQSGAYGASASPGGFLSHT..VAKEVLV 201Q7N8H2_PHOLL/306-419 IYVTKIVERKISHD..........................................................................................MT.............FLV.TDGGMNHHLSASGNLGQLIRRNYPAIIGNK..............................................IKGEKRETVNIVGPLCTPLD.IL...VH.........QGDMS.........VATPGDLVVIFQSGAYGLSASPNNFLSQT..NAVEVLV 202Q82VG2_NITEU/296-409 IYVCRVLEKKISRG..........................................................................................QT.............FLV.TNGGLHHHLAASGNFGQVIRKNYPVAIGNK..............................................MKIDETEIVSVVGPLCTPLD.LL...AD.........RMELS.........RAEPGDLVVVFQSGAYGLTASPTAFLSHP..ASLEVLI 203Q5YWM9_NOCFA/340-451 LTLASVEFVKELGD..........................................................................................GT.............VLVTLDLSRDTVTPADQEVMV....DPLVLPGAR..............................................RDDGPAVGVYFAGRLCLERDLIT...TR.........QVFLPG........LPAPGDVVVFPNTAAYHMDLSA.STAARW..APPRRWV 204Q72WM6_DESVH/318-424 LLLTRVKAVKERPG.........................................................................................AEP.............FAI.TDGGRLSQ.AYPCDFEW....HEAFLAND...............................................LRRPLARAYTVTGRVCTRSD.WL...YR.........GKVMP.........ELASGDILAVLDAGAYFSSYAM.NF.AFP..RAAVVGV 205Q62F85_BURMA/278-395 VFVTRVRAVKVWDD..........................................................................................RV.............IAV.CDGGMSHN.FLLAKTEAVLKTWAAPTLVPAGT.........................................ADAHRAPNARPITFVGNTCNRAD.VI...GR.........LERHPR........LPQPGDFVVFSQCGAYHHSYTVSGFLSHK...PAQVYI 206Q7NPE5_GLOVI/307-415 ATAYTVGSTKTIPS.........................................................................................IRK.............YFS.VDGGMSDN.PRPITYKA....LYTAVVANK..............................................MHDGRREKVTVAGKHCESGD.VL...LR.........DVELP.........PLERGDCLVVFSTGAYNCSMAS.NYNRIP..RPAAVLV 207Q7A0X5_STAAW/290-398 VTLYEVGTIKEIPE.........................................................................................INK.............YVS.IDGGMSDH.IRTALYDA....KYQALLVN...............................................RNEEADDSVTIAGKLCESGD.II...IK.........DAKLPS........SVKRGDYLAILSTGAYHYSMAS.NYNQMQ..KPSVFFL 208DCDA_MYCS2/336-449 ITLYEVGTVKDVAVSQ.....................................................................................TAHRR.............YVS.VDGGMSDN.IRTSLYAA....QYDARLVSR..............................................VSDAPPALARIVGKHCESGD.IV...VR.........DTWVSD........DIAPGDLIGVAATGAYCYSMSS.RYNLLC..RPAVVAV 209DCDA_ACTPA/309-415 VTLYRVAAVKR.GV.........................................................................................RRV.............FVA.VDGGMSDN.PRPALYGS....RYAVRLVR................................................RGGRRAPVTVVGRHCEAGD.VL...AE.........DVPLPE........DVRAGDLLAVPVTGAYHHALAS.NYNAVG..RPPVVGV 210Q8TY23_METKA/277-383 ILVTSVRQVKR.GR..........................................................................................RR.............WVF.VDTGMNAL.IRPALYDA....YHEVVVHG...............................................GDYSATEKASVAGPLCESGD.VL...AE.........DRELPI........DISEGDLVVFLSAGAYCESMAS.NYNCYP..IPGSVVV 211Q7N7F9_PHOLL/289-407 VLMTEVRAVKQ.MG.........................................................................................NRN.............YVL.VDAGFNDL.MRPVMYGS....YHHISVLPADG..........................................RKIEQLPLRETLVAGPLCESGD.IF...TQVEG..GGIAPRALP.........PVQVGDYLVFHDTGAYGASMSS.NYNSRP..LISEVLF 212Q8F7A1_LEPIN/276-395 SILTTVDDVVS.TGP.......................................................................................GGYT.............FVK.LDAGMDVN.TRPSLYAA....KHPLVVVSKE............................................GVHSGKTADYVYVGHCCESGD.LF..............TQAEGGGPITRITGEAKLGDYVVMEGAGAYCSSMSTKNYNSFP..ETAEVLV 213Q8GGR7_STRAZ/284-405 SLVTKVIDKAD.TGA.......................................................................................EGNS.............FLK.INSGLTEI.ARPSYYGV....QHPIVSVPATG.........................................GAERAADDREEFNVVGHCCIAGD.VL..TAK.........QEELAPVP....LGRTEIGDYVVIERAGSYCSSMSMKNFNSYP..EAAEVLR 214DCDA_METJA/305-410 YLLGKVHHIKE.TP.........................................................................................VTK.............WVM.IDAGMNDM.MRPAMYEA....YHHIINCK................................................VKNEKEVVSIAGGLCESSD.VF...GR.........DRELD.........KVEVGDVLAIFDVGAYGISMAN.NYNARG..RPRMVLT 215#=GR DCDA_METJA/305-410 SS -EE--EEEEEE.-S.........................................................................................S-E.............EEE.E-----S-.-HHHHH--....---EEESS................................................--SSEEEEEEE-----TT-.--...--.........-EEEE.........-------EEES-------TT-B.-TTT--..--EEEEE 216Q7ULZ0_RHOBA/283-389 YLITKVINQKS.SY..........................................................................................KD.............YVG.VDACMSNL.MRPGMYGA....YHHITVMGK..............................................EDQPADRTVDIVGSLCENND.KF...AI.........DRKMP.........ATEVGDIAVIHDAGAHGHSMGF.QYNGRL..RSAEIVF 217Q6SHW6_9BACT/289-395 ILLAQVTGIKD.SY..........................................................................................KT.............FIG.LDAGMETL.MRPALYGA....VHRIYKVGA..............................................LMEEQNLTVDITGRICENTD.RL...AI.........DIPFP.........DVAEGDLIAIMDTGAYGYAMAH.QFNTRP..RPAEVLI 218Q5V5E3_HALMA/306-412 CILTEVNTVKE.TP.........................................................................................AAT.............VVG.VDASLATL.IRPAMFGS....YHPIRNVT...............................................APEREAEPVSVGGPCCTSAD.VF...CT.........DRPLA.........RPERTDLLAIGNAGAYGYELAN.QFHSQP..RPAEVAF 219DCDA_METTH/292-398 YLLTRVNTIKE.SY..........................................................................................RK.............FAG.VDAGFNTL.LRPAMYGS....YHHILVAER..............................................PLDEPSEKMDVAGNVCESGD.LF...AR.........DRQLP.........EINEGDVLAIMNAGAYSFSMSS.QYNSRP..RPAEVLV 220Q87EA9_XYLFT/758-866 VLLTRVTQVIE.KD.........................................................................................DIL.............RVG.LEAGMHTL.IRPALYDA....WHGVENLTR..............................................LDETPHVLCDVVGPICESSD.VF...GR.........RRHLPA........ATASGDLMLIADAGAYGFSMAS.TYNLRG..LPAEVVL 221DCDA1_ARATH/351-459 CFVNHVTGVKT.NG.........................................................................................TKN.............FIV.IDGSMAEL.IRPSLYDA....YQHIELVSP.............................................PPAEAEVTKFDVVGPVCESAD.FL...GK.........DRELP.........TPPQGAGLVVHDAGAYCMSMAS.TYNLKM..RPPEYWV 222DCDA_PSEFL/285-390 VLLTQVEYLKH.TE.........................................................................................HKD.............FAI.VDAAMNDL.IRPALYQA....WMDVTAVR...............................................PRDTAARSYDIVGPICETGD.FL...AK.........GRELA..........LEEGDLLAVHSAGAYGFVMSS.NYNTRG..RCAEVLV 223Q5FPL4_GLUOX/282-390 ILLTRVIETKA.GN..........................................................................................PD.............FVV.LDAAMNDL.ARPSLYES....WHGIMPVAP.............................................NGLTSLTKLWDIVGPVCESSD.IF...AR.........DRALPA........DTKRGDLIALLDTGAYGSVMSS.TYNTRP..LAAQVLI 224Q9A681_CAUCR/288-394 VLVSEVIHVHERPE.........................................................................................GRK.............FLV.IDAAMNDL.VRPAMYDA....FHDIRPVI................................................QRTGETVYDVVGPVCETGD.TF...TR.........DRALP.........PFAAGDLVAFMSAGAYGAAMAS.EYNTRP..LVPEVLV 225Q5FEQ0_EHRRW/291-397 ILLAKVLYHKS.NY.........................................................................................EKN.............HLV.LDTGMNDL.IRPALYNA....EHTIIPAV...............................................VSSKSHLSFDIVGPICESDD.TF...AY.........SYWIN.........NVDNNEIVAICTVGAYGSSMSS.NYNSRP..LVPEVIV 226Q7MT14_PORGI/263-379 SLITQVLYIKE.GK.........................................................................................AKK.............FAI.VDAGMTDL.VRPALYEA....HHQIRLVQPGEWT.....................................MRATSPSAALTEKYDVVGPICESSD.VF...ER.........ELLMP.........ELKRGDYLAIRSAGAYGAVMAS.SYNMRP..LPGSLFS 227Q6MM66_BDEBA/286-391 ALITQVQYIKE.TS.........................................................................................AKT.............FVI.VDAGMNHL.IRPSLYEA....THRIEPLK................................................RKDAAFVVDVVGPICESSD.FF...AK.........EISLT.........KVQEGDFVAIMDSGAYGYSMAS.VYNLQE..LPLEICI 228Q6L350_PICTO/286-391 IALATVTDLKN.YG..........................................................................................RS.............IAG.TDLGMNIL.IRPALYGA....VHEIICIN...............................................KNDDKLFNYDITGQICENTD.FT...GL.........NVKLP.........GLEPGDILGIMNAGAYVSSMSS.NYNSLS..RAAEVLI 229Q97AJ0_THEVO/281-380 ILVGKVYDVYN..............................................................................................G.............FVG.TDIGMNIN.IRHALYGA....EHRFYALT................................................GRSDEAEYIVTGQICENTD.VT...GR............LTG........KVQIGDLVAMYDAGAYIYSMSS.NYNGRF..RPTEVIV 230Q728N7_DESVH/285-394 LLLGSVHSVKS.NG.........................................................................................ANR.............YVG.TDLGFNVL.ARPVMYDA....HHDIEVYRED............................................GAPSDLLLPQTVVGNICESGD.II...AR.........NRPLP.........PVEEGDILGVLDAGAYGYVMSS.SYNQRM..RPAEVLI 231Q62B72_BURMA/307-413 MLVLRVAYVELKRN..........................................................................................RR.............FVG.LNGGFNLA.IEPAFYDL...PCEPVPCVR................................................RPGPAQSVCVAGNINEALD.VW...GN.........DVSLP.........PVEPGDFIALLNAGGYASSMSS.NHCLRG..QFRELAL 232Q66B85_YERPS/267-374 YLVTRIVFAKCR.............................................................................................Y.............STNVITTAVPGTNIRSAQYHN....HRKVLIIPE.............................................RPVNCEHSVADVYGSNCYEND.II...AK.........NVPVPF........DLSLDDKIAIFSCGAYDIMNSSDWIRK....RPPIIVI 233Q5NIN9_FRATT/298-400 ALLTTIVGTREQNE.........................................................................................DFQ.............SLI.TDAGIHTI...PTISTY....RHPIYHLK................................................TDSYHKKTLLLGPSCMQHD.FL...HD.........DIFLP.........KLEYGDKLLIDGVGAYNISRNN.EFIHLK....PSVIL 234Q8XS02_RALSO/281-396 VLLTGIKRDIVQH...........................................................................................SL.............GNIVVTDGSRMLMPSAQLRNR....AHHTVFLDAAF.........................................NEVVDYSRRCVAKVRGRSILRNDYIL...PG.........DVVAPE........TVKAGEYMLILDVGAYCATQHM.EFLNVP..PAGEVLV 235SPEA_XYLFT/343-555 VLIANVTEVEAVPEGRVPGVCDDEPAVVRHMREIYGELDARPAIELFYEAQHFHA.......EGLAAYTLGQIDLVHRARIDDLFYAISHGVRERLSHEEKSHRPV....LDELNERLVDKYFVNFSVFESIPDVWAINQ....IFPIVPIER..............................................LNEVPTRRGVVCDLTCDSDG.TV...KQYVE..NESLDSALPLH.....VLRHGEAYRIGFFLVGAYQEILGD.IHNLFG..DTDAVEV 236Q5NHM0_FRATT/327-467 LLITKPLIKQHESDIENEILHQ..........................................................................QWLDREVSLGELQSYLPQNQKNTQQAWLNFSIFQSLPDHWGIDQ....KFPILPLEF..............................................FNSYVTSEVKLYDISCDVDG.VV.....K......STSEYIEI........ATDNIEYIVFMCVGAYQGMLSA.KHNMLG..NISAVNI 237SPEA_PROMP/355-574 VLIFNILGTSHVSSQVKVSDQKKQSLIITNLIETLNQIKNLRDKKEDLSEIIELWNDAKKFKEDCLVAFRLGFICLEERAYAEELTWACAKEIANQLENNEIIHPD....LSEITDTLASTYYANLSVFKSIPDTWAINQ....VFPIIPIHR..............................................HLEEPFCKGHFADLTCDSDG.KL...NNFID..NGKIKSLLNLH.....PPEKNNDYLIGIFMAGAYQEALGN.FHNLFG..NTNVIHI 238SPEA_GLOVI/346-557 VLVFDVMGVSHLQFGEPEPPARNEHSIIRNLYETYTQITPDNVQEAFNDASQFKE........EALSLFALGYLGLGERARAERLYWGCCEKILNLVRELDYIPDE....LADLEKNMASTYYCNFSVFQSAPDSWAIDQ....LFPIMPIHR..............................................LDEEPKARGTLADLTCDSDG.KI...DQFID..LRDVKGVLELH.....PVRPEEPYYLGMFLNGAYQEILGD.MHNLFG..DTNTVHI 239Q6MQU4_BDEBA/373-587 VLVFNVMGVNDLHRHEPPRPATKTDHSIMQDMQYIFEKVNKDNINECFNDLEQAK.......QETLQLFTYGVLSLEQRAWCESMYFAIATKMIKLARATPDCEDI....VAALGKELCDTYFSNFSVFQSVPDSWAVGQ....LFPVIPIHR..............................................LGEEPKREATLADLTCDSDG.VI...EKFIDTASGEPKETIRLH.....QFTEGQQYYLGVFLTGAYQEILGD.LHNLFG..DTDAVHI 240Q72F01_DESVH/373-585 MLLFNILDVSRVEIGNLPDALPEDTPEPVRNMREVLAGMTLRNLQECYNDALYYR.......DAVRQLFLTGQVTLRQRTLSERLFWAIMKRIAQEKQKLKHVPKD....LAEIDVALADIYYGNFSVFQSLPDSWAIDQ....LFPVMPVHR..............................................LQELPSRQGILSDITCDSDG.RI...DHFID..PQGMKGTLDLH.....PLRDGEEYYLGVFLVGAYQETLGD.LHNLLG..DTNVVSV 241Q5SHU0_THET8/347-559 VLVLQVIDVIAPPGEARPSPPPPEAHPLVKELWESLQSLSPKNFQEVYHDAFADK.......ETLQTLYDLGLVSLRDRALAEEIFYHIARRVQTIAQNLPYVPDE....LEDLEKLLADKLVCNFSVFQSLPDAWAIHQ....LFPVVPLSR..............................................LLEPPTRRATLVDISCDSDG.KM...DRFID..LHDVRQTLPVH.....PVRPGEPYYLGVFLVGAYQDVLGS.NHNLFG..QVGEAHV 242SPEA_BACTN/346-558 VLIFEVLETATLPEWDDEEEIAPDAHELVQELYSIWDSLNQNKMLEAWHDAQQIR.......EEALDLFSHGIVDLKTRAQIERLYWSITREINQIAGGLKHAPDE....FRGLSKLLADKYFCNFSLFQSLPDSWAIDQ....IFPIMPIQR..............................................LDEKPERSATLQDITCDSDG.KI...ANFIS..TRNVAHYLPVH.....SLKKTEPYYLAVFLVGAYQEILGD.MHNLFG..DTNAVHV 243O25176_HELPY/412-542 VL..........AHLIVKKAV............................................................................QLLYVKDHN.D..ILRIQEQVQERYLLNCSFFQSLPDYWGLRQ....NFPVMPLNK..............................................LDEKPTRSASLWDITCDSDG.EI...A.F......DSTKPLFLHD....IDIDEEEYFLAFFLVGAYQEVLGM.KHNLFT..HPTEFSV 244SPE2_ARATH/396-596 VLIFEAVSADKPMVHQATPGDIQFLLEGNEEARANYEDLYAAVMRGDHESCLLY..........VDQLKQRCVEGFKEGVLSIEQLASVDGLCEWVLKAIGASDPV.............HTYNINLSVFTSIPDLWGIDQ....LFPIVPIHK..............................................LDQRPGARGILSDLTCDSDG.KI...NKFI.....GGESSLPLHEL.DKNGSGGR.YFLGMFLGGAYEEALGG.VHNLFG..GPSVVRV 245O04429_DIACA/405-605 ILVFEAVSSSSSASPPMPGSTLALDYLVDGLTDEVKGEYRSLTAAAMRGEYESCL.......MYSGMLKQRCVELFKDGCLGMEQLAAVDGLCELVSKALGVADGV.............CTYNVNLSVFTSIPDFWGIGQ....LFPIMPIHR..............................................LDQQPKARGILSDLTCDSDG.KI...DKFI.....GDESSLPLH.....ELSGGEGYYLGMFLGGAYEEALGG.VHNLFG..GPSVVRV 246SPE1_AVESA/355-532 MIILEALSAIPEPKDDEDEATTEQLHGRIRDLSSKLQPTGLS..................................MSSHAVHIKKHGIEMYKLGKKLSKSVTTDA..........HTIYNYHMNLSVFSLMPDYWGIQH....LFPMMPVSR..............................................LDEKPTHKATLVDVTCDSDG.KV...DKFI.....RDTETMPLHP....LDPKLGGYYVAVLLTGAYQEALSN.KHNLFG..GPSLVRV 247Q5X0L3_LEGPL/343-556 VLISNITDVEIINKAPVLPEISEDDSHVIRDIYDTYQAITDSSPTEIYNYAAHSLN......EAHSLFKHGVISLQEKAKVEAFYTNICMEIKDKLDEENPSEKAL....LMRINECMAAKIFCNISFFQSIPDAWAIGQ....IFPVAPISQ..............................................LNRTLSMHSVLQDLTCDSDG.TI...KQYPG..SSCVTTTLMLP.....SYDINNPYNIGFFLVGAYQEILGN.LHNLFG..DTNSLDV 248SPEA_CHRVO/343-556 VLLMNVTDVERLPDTVAPIDKAEELSLPLRKLVELANLNDEELVTEIYYRASHCVS......EVSEMYAEGRLSLQEKALAEDLHATLCRRLHNQLQASQRSQRQV....YDELTDRLADKYFCNFSVFQSLPDTWAIDQ....VLPIMPVHR..............................................LAEQPTRRAVLQDLTCDSDG.KL...KQYVD..QQSIESSMSVH.....EVKQGDEYLIAVFLVGAYQEILGD.MHNLFG..DTDSVNV 249SPEA_VIBVY/354-570 VLISNVIGTETYKPETVTEPEEDFPLLLNNMWRSWLNLHNGTDARALIEIYNDTQSD...LAEVHSQFATGVLTLEHRAWAEQTSLRIYYELNRLMSTKNRFHRPI....LDELSERLADKFFVNFSLFQSLPDSWGIDQ....VFPVLPLSG..............................................LQNAADRRAVMLDITCDSDG.AI...DAYVD..GQGIESTLPVP.....AWNEDEPYLMGFFLVGAYQEILGD.MHNLFG..DTHSVVV 250Q7PZA0_ANOGA/274-386 TALVNVVSKSYEKDVD.....................................................................................GAVVR.............VRYYVDDGLYDT.FDWCDDQG....SGPLLQED...............................................KRGAPCVRSVIYGRTMCEHD.VI...RE.........EISLP.........EHEIGDCLVFPNRGAYAKLLGR.GHNGFR..PTGTKVC 251Q60D03_SOLDE/147-257 TLVTHVIGKRVRG...........................................................................................EK.............IEYWIDEGIYGS.FRPTLYNS...CFVGIKTISM..............................................KESCEIGESTIYGPSCDSLD.AV...AV.........DIKLP.........ELELDDLIVFYDMGAYSKCAGT.KFNGFDMLSTPTYIV 252DCOR_NEUCR/326-471 TLACNIIARRTIQDGSAVSV.............................................................................SDSSSMSDD.G..SVNNGDARYMVY.VNDGLYGN.FSSIMFDH....QHPVAKILRAGGRTMY................................NSVAAHESSAEDAIEYSIWGPTCDGID.RI...TE.........SIRFRE........ILDVGDWLYFEDMGAYTKCSAT.TFNGFS..NEHDVIY 253#=GR DCOR_NEUCR/326-471 sAS ......................................................................................................................................................................................................................*......................................................................... 254DCOR_YEAST/329-460 TLASHVIAKRKLSE.........................................................................................NEA.............MIY.TNDGVYGN.MNCILFDH....QEPHPRTLYHNLEFHYDDFE........................STTAVLDSINKTRSEYPYKVSIWGPTCDGLD.CI...AK.........EYYMKH........DVIVGDWFYFPALGAYTSSAAT.QFNGFE..QTADIVY 255#=GR DCOR_YEAST/329-460 sAS ......................................................................................................................................................................................................................*......................................................................... 256DCOR_CANAL/324-468 TLITHIIARRDLPTGGN...................................................................................NNNNDM.........TPSAMLY.INDGVYGN.LNCILFDH....QTPKVYVLTNENQLFYKQEM.......................MRSLSVNNNNNNNNKTDGFKFSIWGPTCDGLD.CV...SS.........LAKLSK........NVQVGDWLFFENVGAYTSCAST.KFNGLSSGETKTLYV 257#=GR DCOR_CANAL/324-468 sAS ......................................................................................................................................................................................................................*......................................................................... 258Q84527_PBCV1/263-371 VLATQVIGKRVRD...........................................................................................GL.............YEYFFNESTYGG.FSNVIFEK....SVPTPQLLRD............................................VPDDEEYVPSVLYGCTCDGVD.VI...NH.........NVALP.........ELHIGDWVYFPSWGAYTNVLTT.SFNGFG...EYDVYY 259#=GR Q84527_PBCV1/263-371 SS EEEEEB---EE--...........................................................................................--.............EEEEBS------.-THHHHS-....-----EESS-............................................--TT--EEEEEEE--------.-S...EE.........EEEEE.........------EEEES-----SGGG--.------...-EEEEE 260Q5MNH7_NEOUN/277-400 YLAVKVVARRVNATAF.....................................................................................GHEPA............TRLY.INDGIYSNFMMRFIVNM....TFSPAAVIREGVW......................................HDQADHTMRGEACSLWGRSCDSND.CI...NR.........DCRLGP........EVRVGDWLVFKDMGAYTTVCNT.TFNGFT..SSNHTIY 261Q58P26_ENTHI/268-382 HLVSSLHGKRVRIQN.......................................................................................GKKQ.............IEYTSGDGLHGSFGCCIWFEK....QKSCECITQK............................................VNENTKMYESIIYGPSCNGSD.KV...A..........TQELPE........MEPGKDWLLFPNMGAYTISMAT.NFNGFE..ERNHVIY 262O15696_PLAFA/807-931 SKLGNITNIKKKVVNI.....................................................................................NDNRY...........NYFSYYVSDSIYGC.FSGIIFDE....YNRCPIYVIKNKN.....................................NPNQNFMNFNLYLANVFGQSCDGLD.MI...NS.........ITYLP.........ECYINDWLLYEYAGAYTFVSSS.NFNGFK..KCKKVYI 263DCOR_LEIDO/509-682 ALLMNVFASRTLRLSDVEVS..............................................................................RQAFQSVV.....SMDEPEEYQYY.VNDGLYHS.FNCILFDH....AHPTLLLLNDGDGADGVESGTEAAAVCSEEEGETSLSGPLANDPLFMSAWDRRRSFARRPLRITTIFGPTCDSMD.CI...LK.........KQPFP.........EMKLGDWLLVPDMGSYTTAAAG.FFNGFA..TRRLEWV 264#=GR DCOR_LEIDO/509-682 sAS ......................................................................................................................................................................................................................*......................................................................... 265P78829_SCHPO/238-357 TLAVNVIAKRKLDDE........................................................................................EKV.............MYY.VNDGVYGS.LNCILFDH....QHPVARVLKCGSR.....................................FVYNDLVGTGQHRCFIWGPTCDSLD.VI...AN.........DAHLPY........EPNVGDWIYFEDAGAYTVAAAS.CFNGFK..TSRIVYL 266O76203_HAECO/287-407 TLVCNIIHATEVSAEKIT..................................................................................KRPEDV........EERGFMYY.VNDGVYGS.FNCILFDH....VQPVGTPLF..............................................DEIAQEYPSTIWGPTCDSLD.KI....E.........DQKLMR........MMSVGEWIVYRNMGAYTCSAST.TFNGFQ..RPNAIYM 267DCOR_PANRE/294-416 SVTTNVIASVKVPASRIT..................................................................................EKADDV........NRDGYMYY.MNDGVYGS.FNCKLFDH....YQPRGMPLAE............................................HDADEPRFPVCVWGPTCDGLD.QV...EE.........SSVMP.........RLYEGDWLYYPDMGAYTSVAAS.TFNGFD..KPKTYYF 268#=GR DCOR_PANRE/294-416 sAS ......................................................................................................................................................................................................................*......................................................................... 269#=GC SS_cons EEEEEEEEEEE--S.........................................................................................S-E.............EEEEES----S-.-CHHHHS-....---EEECSS-............................................--TTSSEEEEEEE-----TT-.-S...EE.........EEEEE.........------EEEES-----SGCC-B.-TTT--...-EEEEE 270#=GC seq_cons sLlspVhsh+p.st..........................................................................................tt.............hhh.lssGhhsp.hsshhhst....hhslhhht...............................................hpspstttsslsGsoC-usD.hl...sp.........chhLP.........plp.GDhlshhssGAYshshus.saNuhs..tsshlhl 271// 272# STOCKHOLM 1.0 273#=GF ID NIF3 274#=GF AC PF01784.11 275#=GF DE NIF3 (NGG1p interacting factor 3) 276#=GF PI DUF34; 277#=GF AU Bashton M, Bateman A 278#=GF SE Pfam-B_1006 (release 4.2) 279#=GF GA 23.40 23.40; 280#=GF TC 24.10 24.00; 281#=GF NC 22.00 23.30; 282#=GF BM hmmbuild HMM.ann SEED.ann 283#=GF SM hmmsearch -Z 9421015 -E 1000 HMM pfamseq 284#=GF TP Family 285#=GF RN [1] 286#=GF RM 8663102 287#=GF RT Transcriptional activation by yeast PDR1p is inhibited by its 288#=GF RT association with NGG1p/ADA3p. 289#=GF RA Martens JA, Genereaux J, Saleh A, Brandl CJ; 290#=GF RL J Biol Chem 1996;271:15884-15890. 291#=GF RN [2] 292#=GF RM 11124544 293#=GF RT Isolation and characterization of a novel human gene, NIF3L1, 294#=GF RT and its mouse ortholog, Nif3l1, highly conserved from bacteria 295#=GF RT to mammals. 296#=GF RA Tascou S, Uedelhoven J, Dixkens C, Nayernia K, Engel W, Burfeind 297#=GF RA P; 298#=GF RL Cytogenet Cell Genet 2000;90:330-336. 299#=GF DR INTERPRO; IPR002678; 300#=GF DR SCOP; 1nmp; fa; 301#=GF CC This family contains several NIF3 (NGG1p interacting factor 3) 302#=GF CC protein homologues. NIF3 interacts with the yeast 303#=GF CC transcriptional coactivator NGG1p which is part of the ADA 304#=GF CC complex, the exact function of this interaction is unknown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seq_cons clhphlcphhPhphu..p.sa.Dss.............................GL....ls............pp..........................plp+lhlslDso.pllccAlp......ts.sshllsHHP...l.ha................pshcplssp......htphlhpLlc.s...........sIslauhHTshDss.s.GhNshLA.chL.....slp.........shpsht......................................................................................................................thuhGhl.Gplsp.s....hohpphhthlpppl.th.........tt......lphs.........shspplp.....+VA..lsuGuGs..phlt..pAhptss..D..lalTG-l...........paHsshpA..ppt.....G......ls..llssGHatoEphhhpt.....ltchLppp.ht.......................l 552// 553